Fatty ratObesityObese ratsGlucoseLeanSerumHyperglycemiaMetabolismMetabolicStreptozotocinAnti-diabeticDyslipidemiaKidneyT2DMDiabetes mellitusMiceLiversRenalMelatoninReceptorsHypothalamicExcretionSulfation patternsComplicationPatientsMaleExperimentalFGF1SecretionTypeConcentrationsCardiovascularModelExhibitLevelsCardiacEffectsIntakeCompositionTreatmentDecreaseIncreaseDietAdministration
Fatty rat1
- The Zucker diabetic fatty rat offered such a model system. (jci.org)
Obesity3
- Researchers in Spain have analyzed the effects of melatonin on obesity, dyslipidemia and high blood pressure in young diabetic obese rats. (sciencedaily.com)
- University of Granada researchers have analyzed in young Zucker diabetic obese rats the effects of melatonin on obesity, dyslipidemia and high blood pressure associated with obesity. (sciencedaily.com)
- In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
Obese rats1
- Rimonabant reduced basal hypersecretion in islets from obese rats and GL-treated low fat rats without reducing the fold upsurge in GSIS. (bioskinrevive.com)
Glucose12
- Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. (uaeu.ac.ae)
- A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. (aspetjournals.org)
- Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. (aspetjournals.org)
- No blood glucose reduction was observed in normoglycemic SD rats treated with tofogliflozin. (aspetjournals.org)
- Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in membrane PKC isozyme protein or kinase activity. (jci.org)
- Oral administration of the potassium salt remarkably improved the plasma glucose levels of female Zucker diabetic fatty rats at 1 mg/kg. (rcsb.org)
- Rosiglitazone reduces blood glucose concentrations and reduces hyperinsulinemia in the ob/ob obese mouse, db/db diabetic mouse, and fa/fa fatty Zucker rat. (globalrph.com)
- Alternatively, such findings may simply reflect the limitations of current anti-diabetic therapies, due to off-target effects that counter the potential benefits of glucose lowering. (ddw-online.com)
- To determine if the CB1 receptor antagonist Rimonabant affected basal or activated insulin secretion we researched isolated islets from low fat siblings and obese Zucker (ZF) and Zucker Diabetic Fatty (ZDF) rats that were Drospirenone incubated for 24 h and exposed to 11 mmol/l glucose plus 0.3 mmol/l palmitate (GL) with or without Rimonabant. (bioskinrevive.com)
- Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. (vdocuments.mx)
- A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. (vdocuments.mx)
- In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
Lean7
- Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. (uni-regensburg.de)
- The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. (uaeu.ac.ae)
- At 6weeks of age, Zucker lean control (ZLC) and Zucker diabetic fatty (ZDF) rats were put on a treadmill with or without running for 1h/session/day for 5weeks. (mcmaster.ca)
- Polar lipids and other metabolites extracted from plasma from lean, diabetic, and obese Zucker rats were analyzed by flow injection using high resolution time of flight mass spectrometry. (chromatographyonline.com)
- As expected basal secretion was significantly elevated in islets from obese or GL-treated lean rats whereas the fold increase in GSIS was diminished. (bioskinrevive.com)
- METHODS AND PROCEDURES Animals Islets were isolated from 7- to 11-week-old male ZF and Zucker diabetic rats and their lean siblings. (bioskinrevive.com)
- The abbreviations used for lean siblings of the obese (153-353 g) and obese diabetic (178-396 g) are ZL and ZL-D respectively. (bioskinrevive.com)
Serum1
- Diabetic rats showed significantly increased serum uric acid (SUA), serum creatinine (SCr), and urea nitrogen (BUN) levels. (hindawi.com)
Hyperglycemia3
- Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. (jci.org)
- Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. (nature.com)
- Paksu MS, Kalkan G, Asilioglu N, Paksu S, Dinler G. Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis. (medscape.com)
Metabolism3
- Conversion of S-adenosyl-L-homocysteine (SAH) to homocysteine increased and the metabolism of homocysteine was reduced under diabetic conditions, and consequently homocysteine accumulated in the elimination phase. (biomedcentral.com)
- Here, we focused on the fact that a high-fat diet affects the metabolism of both methionine and homocysteine in a diabetic rat model [ 14 ]. (biomedcentral.com)
- Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. (biomedcentral.com)
Metabolic3
- Thus, 0we hypothesized that long-term administration of a high-methionine diet to T2DM rats with normal renal function may create metabolic changes, culminating in an elevated level of circulating homocysteine. (biomedcentral.com)
- Melatonin was found to be beneficial for young rats that had not still developed any metabolic or heart disease. (sciencedaily.com)
- The objective of the present study is to determine, through a literature review, the influence of the periodontal disease on the metabolic control of diabetic patients. (bvsalud.org)
Streptozotocin2
- In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. (hindawi.com)
- The type 2 diabetic rat model was induced by high-fat diet (HFD) and low-dose streptozotocin. (cambridge.org)
Anti-diabetic3
- Anti-diabetic activity of chromium picolinate and biotin. (cambridge.org)
- The objective of the present study was to evaluate anti-diabetic effects of chromium picolinate (CrPic) and biotin supplementations in type 2 diabetic rats. (cambridge.org)
- Results of the present study revealed that supplementing CrPic and biotin alone or in a combination exerts anti-diabetic activities, probably through modulation of PPAR-γ, IRS-1 and NF-κB proteins. (cambridge.org)
Dyslipidemia1
- Given its strong safety record, LA may have potential clinical applications for the treatment or prevention of hypertriglyceridemia and diabetic dyslipidemia. (oregonstate.edu)
Kidney3
- However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. (uni-regensburg.de)
- Diabetic kidney disease (DKD) is the leading cause of end stage renal failure (ESRD) worldwide [ 1 ]. (hindawi.com)
- Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
T2DM2
- The aim of the current study was to predict changes in plasma methionine and homocysteine concentrations after simulated consumption of methionine-rich foods, following the development of a mathematical model for MMC in Zucker Diabetic Fatty (ZDF) rats, as a representative T2DM animal model. (biomedcentral.com)
- New therapeutics must therefore address the multi-factorial nature of T2DM, and aim to treat diabetic patients at an earlier stage of the disease, if pharmacological interventions hope to halt the epidemic. (ddw-online.com)
Diabetes mellitus1
- Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. (uaeu.ac.ae)
Mice2
- Some of the renal protective effects of Fx were clarified in animal models with diabetes, such as db/db mice [ 8 ] and diabetic Zucker rats [ 9 ]. (hindawi.com)
- Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor gamma agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. (nih.gov)
Livers2
- Rat livers were extracted for detecting gene expression, content, and bioactivity of XO. (hindawi.com)
- Livers from LA-treated rats exhibited elevated glycogen content, suggesting dietary carbohydrates were stored as glycogen rather than becoming lipogenic substrate. (oregonstate.edu)
Renal2
- Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect. (hindawi.com)
- In the present study, we investigated the effects of Fx on renal injury in STZ-induced diabetic rats with the aim to search novel therapeutic method for DKD. (hindawi.com)
Melatonin2
- Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. (uaeu.ac.ae)
- This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats. (uaeu.ac.ae)
Receptors1
- Cannabinoid CB1 and CB2 receptors have been identified in isolated mouse rat and human pancreatic islets with CB1 receptors mainly expressed in non-β-cells and CB2 receptors expressed in both β- and non-β cells (24-27). (bioskinrevive.com)
Hypothalamic3
- Fig. 2: T2D-ZDF rats exhibit abnormal hypothalamic CS/DS-GAG sulfation patterns. (nature.com)
- Using LC-MS/MS, we provide the first description of hypothalamic CS-GAG sulfation patterns and show that in T2D-ZDF rats, levels of the ∆4S- isomer is increased, whereas ∆6S- and ∆2S6S-CS isomers are decreased, differences predicted to disrupt protein-GAG interactions involved in neurite outgrowth and favor tissue stiffening. (diabetesjournals.org)
- To determine if ARC PNNs are targets for the antidiabetic effect of fibroblast growth factor 1 (FGF1), we performed intracerebroventricular (icv) injection of FGF1 in ZDF rats and report that both the hypothalamic CS-GAG sulfation patterns and content of ARC PNNs are normalized 24 d after treatment. (diabetesjournals.org)
Excretion1
- Daily urinary albumin (UAE), uric acid (UUA), and creatinine (UCr) excretion were also significantly increased in these rats. (hindawi.com)
Sulfation patterns1
- Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. (nature.com)
Complication1
- Diabetic encephalopathy (DE) is a complication of diabetes that leads to cognitive and behavioral decline. (biomedcentral.com)
Patients4
- Cardiovascular problems are the major cause of morbidity and mortality in diabetic patients. (hmaward.org.ae)
- Insulin stimulates albumin gene expression and albumin secretion from hepatocyte in both healthy subjects and diabetic patients. (biomedcentral.com)
- It is important in the prevention of hypoglycaemia, and its inappropriate increase in diabetic patients contributes to the development of hyperglycaemia. (medscape.com)
- Hypertension (blood pressure [BP] ≥140/90 mmHg) is an extremely common condition in diabetes, affecting around 20 to 60% of diabetic patients [ 5 ]. (biomedcentral.com)
Male3
- Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats. (hindawi.com)
- Eight-week-old male Sprague-Dawley rats (Guangdong Medical Laboratory Animal Center, Foshan, China) weighing 200-220 g were adopted for this study. (hindawi.com)
- Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
Experimental1
- [12] Recent studies have also shown that taurine can influence (and possibly reverse) defects in nerve blood flow, motor nerve conduction velocity, and nerve sensory thresholds in experimental diabetic neuropathic rats. (wikidoc.org)
FGF12
- Fig. 3: Effect of a single icv FGF1 injection on Arc PNN assembly and composition in ZDF rats. (nature.com)
- To assess the functional significance of ARC PNN restoration by FGF1, ZDF rats received an icv FGF1 injection followed by bilateral microinjection of either ChABC, a PNN digesting enzyme, or its vehicle control into the ARC. (diabetesjournals.org)
Secretion2
- Needlessly to say basal secretion was considerably raised in islets from obese or GL-treated low fat rats whereas the collapse upsurge in GSIS was reduced. (bioskinrevive.com)
- Nonetheless it reduced GSIS in islets from low fat rats without influencing basal secretion. (bioskinrevive.com)
Type3
- Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or 12/15-LO) which is an ortholog of, and metabolically equivalent to, human 15-LO-1 in that it forms predominantly 15(S)-HpETE with 12(S)-HpETE as a minor product. (wikipedia.org)
- It is essential to understand the mechanisms that underlie cardiac muscle dysfunction in type II diabetic heart, which would allow new therapeutic strategies and early intervention', Prof. Chris Howarth, Department of Physiology, Faculty of Medicine and Health Sciences, UAE University, said. (hmaward.org.ae)
- The first group was for Non-Infected Rats, and the second group was for type 2 Zucker Diabetic Fatty Rats. (hmaward.org.ae)
Concentrations1
- Using our model, we performed simulations to compare the changes in plasma methionine and homocysteine concentrations between ZDF and normal rats, by multiple administrations of the methionine-rich diet of 1 mmol/kg, daily for 60 days. (biomedcentral.com)
Cardiovascular2
- Moreover, cardiovascular disease (CVD) is 2-4 times higher in diabetics (2). (ddw-online.com)
- The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Model1
- Therefore, this rat model is more appropriate for researches on hyperuricemia in diabetic conditions. (hindawi.com)
Exhibit1
- Imaging of ARC PNNs, which are comprised of the chondroitin sulfate (CS) proteoglycan aggrecan and attached CS glycosaminoglycans (GAGs), show that T2D-ZDF rats exhibit a 66.4% and 77.3% decrease in aggrecan in the medial and lateral ARC areas, respectively, compared to normoglycemic controls. (diabetesjournals.org)
Levels2
- Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. (uaeu.ac.ae)
- The levels of methionine and homocysteine were elevated approximately two- and three-fold, respectively, in ZDF rats, while there were no changes observed in the normal control rats. (biomedcentral.com)
Cardiac1
- Moreover, it did not cause a plasma volume increase or a cardiac enlargement in Wistar-Imamichi rats, even at 100 mg/kg. (rcsb.org)
Effects3
- In this study, we observed the effects of a physical exercise on COX-2 immunoreactivity in the hippocampus using immunohistochemistry in rats. (mcmaster.ca)
- The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)
- A manuscript was submitted detailing a study investigating the effects of doxorubicin in Zucker diabetic fatty rats. (hesiglobal.org)
Intake2
- Furthermore, there was less body weight gain and food intake with S-Amlodipine and Pioglitazone combination in Zucker fa/fa rats. (biomedcentral.com)
- A research group at the School of Nursing, Eulji University, in Korea, found that inhaling fennel essential oil promoted food digestion and lowered caloric intake in rats. (globalhealing.com)
Composition1
- In the ARC of T2D-Zucker Diabetic Fatty (ZDF) rats, we have identified significant changes in the composition and abundance of extracellular perineuronal nets (PNNs) that enmesh glucoregulatory neurocircuits. (diabetesjournals.org)
Treatment1
- Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction. (ku.dk)
Decrease1
- Taurine has also been shown in diabetic rats to decrease weight and decrease blood sugar. (wikidoc.org)
Increase1
- Similar increase in UA concentration was seen in STZ-induced diabetic rats in other studies [ 12 , 13 ]. (hindawi.com)
Diet1
- Five-week-old Zucker Diabetic Fatty (ZDF) rats were fed a diet containing (R)-alpha-lipoic acid (LA, approximately 200mg/kg body weight per day) for 5 weeks. (oregonstate.edu)
Administration1
- On the other hand, the repeated oral administration of celecoxib to 4-week-old ZDF rats significantly decreased the neuroblasts in the subgranular zone of the dentate gyrus. (mcmaster.ca)