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  • experimental diabetic
  • In experimental diabetic mice, macrophage accumulation and activation are associated with prolonged hyperglycaemia, glomerular immune complex deposition, increased chemokine production, and progressive fibrosis [ 2 , 3 ]. (hindawi.com)
  • angiotensin
  • Blockade of the renin-angiotensin system, first demonstrated with ACE inhibition in 1993 ( 9 ), confirmed many times since that time ( 10 ), and recently extended to include the angiotensin II receptor blocker (ARB) class ( 11 , 12 ) is the accepted cornerstone of treatment in diabetic nephropathy. (diabetesjournals.org)
  • We audited the long-term effect of blocking the renin-angiotensin-aldosterone system (RAAS) with an ACE inhibitor (ACEI) or angiotensin II receptor blocker (ARB) in microalbuminuric type 1 diabetic patients on progression of microalbuminuria and development of DN. (springer.com)
  • For example, not only do angiotensin receptor blockers, and angiotensin-converting enzyme (ACE) inhibitors work to lower blood pressure, but they also counter the effects of renal disease in diabetic and non-diabetic patients. (wikipedia.org)
  • persistent
  • RESEARCH DESIGN AND METHODS -We conducted a prospective longitudinal study of 23 diabetic subjects with persistent MA and 209 diabetic subjects without MA who attended diabetes clinics at the University of Michigan Medical Center in 1989 and 1990. (diabetesjournals.org)