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Diabetic RetinopathyAlbinismDiabetic NephropathiesRats, WistarPlant ExtractsDiabetes Mellitus, ExperimentalDiabetic AngiopathiesRadiation Injuries, ExperimentalAegleDiabetic FootHibiscusDark AdaptationSemecarpusPhytotherapyAphrodisiacsRubiaceaePregnancy in DiabeticsRetinaLightLipoxygenasesDiabetes Mellitus, Type 2BixaceaeDiabetes Mellitus, Type 1ElectroretinographyMelia azedarachRetinal DegenerationRats, Sprague-DawleyMalondialdehydeStreptozocinPhotoreceptor CellsLipid PeroxidationRats, Inbred StrainsAntioxidantsPhenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) EsterHeterophyidaeBlood GlucoseDisease Models, AnimalTrematodaAsparagus PlantMydriasisOcimumSperm CountDiabetes MellitusAlbinism, OculocutaneousOxidative StressContraceptive Agents, MaleCatalaseDiabetic CardiomyopathiesDiabetes ComplicationsAlbinism, OcularRadiation-Protective AgentsTrematode InfectionsMedicine, African TraditionalRhodopsinMonophenol MonooxygenaseBody WeightNigella sativaLiverThiobarbituric Acid Reactive SubstancesGlutathionePhotoreceptor Cells, VertebrateRats, Mutant StrainsInsulinGlutathione PeroxidaseMethanolRandom AllocationProtective AgentsSuperoxide DismutaseInjections, IntraperitonealPlant PreparationsTissue AdhesionsKidneyCell CountTestisDiabetic DietHypoglycemic AgentsHyperglycemiaOrgan SizeTime FactorsPigmentationAdaptation, OcularPigment Epithelium of EyeStomach UlcerInjectionsDose-Response Relationship, DrugWound HealingMelaninsPlants, MedicinalSperm MotilityHemoglobin A, GlycosylatedAlbuminuriaDiabetic ComaRod Cell Outer SegmentAdministration, OralRetinal VesselsMice, Inbred NODEdemaOptic ChiasmVitreous BodyGlucose
StreptozotocinWISTAR ALBINO RATSExtractOxidativeTissuesMethodsHypoglycemic effectsDiabetesHistopathologicalAlloxan monohydrateAdultExtractsAntioxidantMaleTwentyGlucoseStrainsParametersMechanismsIntraperitoneallyControlToxicityMiceGroupsExperimentalSignificantlyHistologyRabbitsInductionStudyVascularGroupInsulinThyroidEffectsTreatmentBloodFemaleAnimals2017Expression
Streptozotocin10
  • Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
  • Induction of Diabetes Mellitus in Rats Using Intraperitoneal Streptozotocin: A comparison between 2 strains of rats. (gphjournal.org)
  • ten of them are served as a control and forty rats injected with single dose (100 mg/kg) of streptozotocin intraperitoneal. (uwi.edu)
  • In streptozotocin-induced diabetic rat kidney, the present study investigated the effects of the synthetic pyridoindole antioxidant stobadine (STB) on renal total antioxidant potential (AOP) and protein oxidation parameters such as protein carbonyl content (PCC), advanced oxidation protein products (AOPPs) and nitrotyrosine (NT), a marker specific for protein modification by peroxynitrite. (nel.edu)
  • Wistar Albino rats were divided into two groups: normal and streptozotocin-induced diabetic rats. (nel.edu)
  • This study aimed to determine the protective effect of curcumin on streptozotocin (STZ)-induced oxidative stress in various tissues of albino Wister rats. (scialert.net)
  • In the studies of hypoglycemic effects, the subjected animals are being made diabetic using alloxan, streptozotocin (STZ) etc introducing inside injecting intraperitoneally (IP) or intravenously (IV). (scirp.org)
  • After 6 weeks, the rats in the HFD group were injected intraperitoneally streptozotocin once (30 mg/kg). (bvsalud.org)
  • Effect of ginger on bone of streptozotocin induced diabetic rats. (dergipark.org.tr)
  • The effect of Se on testicular steroidogenesis and testicular expression of vascular endothelial growth factor (VEGF) and nerve growth factor-beta (NGF-β) was studied in streptozotocin (STZ)- induced diabetic rats. (sohag-univ.edu.eg)
WISTAR ALBINO RATS1
  • Thirty wistar albino rats wеrе randomly dividеd into fivе groups. (wjpr.net)
Extract17
  • This work was carried out to determine the anti-diabetic effect of aqueous extract of Gymnema sylvestre on the blood sugar level of alloxan-induced diabetic rats. (gphjournal.org)
  • 250mg per kg body weight of aqueous extract of Gymnema sylvestre and 125mg per kg body weight of glibenclimide was administered to rats in groups, IE, CE and ID respectively for 28 days. (gphjournal.org)
  • The findings from this work revealed that, diabetic rats treated with aqueous extract of Gymnema sylvestre had a significant drop in blood sugar level. (gphjournal.org)
  • Diabetic rats treated with the synthetic drug also had a drop in blood sugar level, but not as fast as that of the extract. (gphjournal.org)
  • The non diabetic rats treated with aqueous extract of Gymnema sylvestre maintained normal blood sugar level, possibly because the pancreatic beta-cells were not impaired. (gphjournal.org)
  • The effect of extract of bitter leaf (Vernonia amygdalina) on blood glucose levels of diabetic rats. (gphjournal.org)
  • The result of the study indicates that Musa sapientum sucker extract was effective in improving plasma lipid profile associated with cardiovascular risk factors in alloxan induced diabetic rats. (scialert.net)
  • Different parts of Musa sapientum extract has been reported to posses anti diabetic activity. (scialert.net)
  • In this study the effects of methanolic extract of Musa sapientum sucker on plasma lipid profile changes in alloxan induced diabetic rats was investigated with a view to finding its possible effects on cardiovascular disease induced by hyperglycemia. (scialert.net)
  • The effects of the aqueous leaf extract of Basella alba on haematological and biochemical parameters were studied in Wistar strain albino rats. (researchgate.net)
  • Group I rats served as control and received 10 ml/kg of normal saline, while group II, III and IV received 60, 80 and 100 mg/kg of aqueous leaf extract of B. alba, respectively, for two weeks. (researchgate.net)
  • This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. (ijp-online.com)
  • The extract was gavaged daily to the rats, at doses of 100 and 200 mg/kg along with thioacetamide at a dose of 200 mg/kg twice weekly. (ijp-online.com)
  • The objectives of the study were to evaluate the effect of ethyl acetate extract of Melothria perpusilla (EAEMP) on intestinal absorption of glucose in albino rats. (ijbcp.com)
  • Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. (dergipark.org.tr)
  • Thе methanolic extract of Samanеa saman Wild showеd significant rеduction in blood glucosе lеvеls in albino rats duе to prеsеncе of phytochеmicals such as alkaloids. (wjpr.net)
  • Prophylactic effect of aqueous extract of Sesamum indicum seeds on ethanol-induced toxicity in male rats / B.E. Oyinloye, S.O. Nwozo,2 G.H. Amah, A.O. Awoyinka,4 O.A Ojo, B.O. Ajiboye, and H.A. Tijani / Nutr Res Pract. (2beingfit.com)
Oxidative4
  • The present study tests the ability of both zinc oxide (ZnONPs) and silver (SNPs) nanoparticles to ameliorate the oxidative stress resulted from diabetes in diabetic rats was tested in the present study. (uwi.edu)
  • Recent basic research and clinical data have provided new insights into the role of glycoxidative and nitrosative stresses (both oxidative stress) in diabetic complications, such as diabetic nephropathy, suggesting a different and innovative approach to antioxidant therapy. (nel.edu)
  • Interestingly, feeding curcumin to the diabetic rats controlled oxidative stress by inhibiting the increase in TBARS and protein carbonyls and reversing altered antioxidant enzyme activities without altering the hyperglycemic state in most of the tissues. (scialert.net)
  • So, curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats despite unaltered hyperglycemic status. (scialert.net)
Tissues5
  • This study aims to assess the effectiveness of Metformin on the liver , pancreatic, and kidney tissues of alloxan -induced diabetic albino rats . (bvsalud.org)
  • Still, both tissues of untreated diabetic control mice exhibited lymphocyte infiltration. (bvsalud.org)
  • Malondialdehyde (MDA), total antioxidant capacity (TAC), zinc (Zn) and silver (Ag) concentrations were estimated in the brain tissues of all rats. (uwi.edu)
  • Histopathological examination showed an improvement in the histological structure of pancreas, liver and kidney tissues in the MSCs treated group compared with the degeneration observed in the diabetic untreated group which was in accordance with the biochemical finding. (alliedacademies.org)
  • Effect of dry garlic powder on plasma lipid profile and enzyme activities in some tissues of hypercholesterolemic rats. (agrifoodscience.com)
Methods2
  • METHODS@#Fifty-four male Wistar rats were randomly divided into normal control (NC, n=14) and high-fat diet (HFD) groups (n=40). (bvsalud.org)
  • Methods: Healthy rats (n=32) were divided into 4 groups: untreated-control, astaxanthin-treated (1 mg/kg body weight- BW), fish oil-treated (10 mg EPA/kg BW and 7 mg DHA/kg BW), and fish oil plus astaxanthin-treated. (bvsalud.org)
Hypoglycemic effects2
  • The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. (mdpi.com)
  • Abstract The present study was conducted to evaluate the chemical composition, antioxidant activity and hypoglycemic effects of whole kumquat (Ku) powder in diabetic rats fed a high-fat-high-cholesterol (HFHC) diet. (bvsalud.org)
Diabetes3
  • The current study aimed to investigate the effect of mesenchymal stem cells (MSCs) transplantation as a new strategy for treatment of diabetes in Streptozotacin (STZ) induced diabetic male albino rats. (alliedacademies.org)
  • In rats, hyperlipidemia was induced by feeding High Fat Diet (Lab diet: Dalda: Coconut oil = 4:3:1) and type 2 diabetes was built inside by injecting Alloxan. (scirp.org)
  • Thirty rats with fasting blood glucose higher than 11.7 mmol/L were randomly divided into diabetes (DM) and TSF groups, 15 rats in each group. (bvsalud.org)
Histopathological4
  • The aim was to investigate the effect of dapagliflozin on non-alcoholic fatty liver disease and dyslipidemia in type 2 diabetic rats by studying the histopathological structure of the liver and detecting possible underlying mechanisms for this impact by evaluating the potential anti-inflammatory action of dapagliflozin. (europeanreview.org)
  • and bilirubin were measured, together with morphological and histopathological indices in the liver of healthy and thioacetamide-treated rats. (ijp-online.com)
  • The present study was conducted to evaluate the protective effect of L-carnitine (LC) against possible deleterious effects of cefquinome sulfate (CS) on antioxidant capacity, fertility parameters and histopathological findings of reproductive organs in male rats. (alexjvs.com)
  • It could be concluded that CS induced some undesired effects on antioxidant activity, fertility parameters and histopathological findings which could be ameliorated by LC in male albino rats. (alexjvs.com)
Alloxan monohydrate1
Adult2
  • Adult male rats (8 weeks), weighing 195 to 225 g was made diabetic by injecting STZ (65 mg kg -1 body weight) intraperitoneally. (scialert.net)
  • However, none of these agents produced conification of the vaginal smear of ovariectomized adult rats. (ijp-online.com)
Extracts2
  • In this study, effect of different concentrations of methanolic extracts of Musa sapientum sucker on plasma lipid profile were assessed in alloxan induced diabetic rats. (scialert.net)
  • Diabetic rats given either water or ethanolic curcumin extracts (80 mg kg -1 body weight) in aqueous suspension daily for a period of seven weeks. (scialert.net)
Antioxidant6
  • Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine. (nel.edu)
  • Cumaoglu A, Stefek M, Bauer V, Ari N, Aricioglu A, Karasu C. Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine. (nel.edu)
  • There was a significant elevation in the level of liver and kidney malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in STZ rats which also restored to normal after curcumin treatment. (scialert.net)
  • The antioxidant markers, glucolytic, and gluconeogenic enzymes were significantly ameliorated and the elevated level of kidney biomarkers in the diabetic groups was restored. (hindawi.com)
  • Photoperiodic regulation of lipid peroxidation and antioxidant enzymes in lung of diabetic rat. (slsjournals.com)
  • These findings suggest that photoperiodicaly regulated melatonin might be acting as an antioxidant for the free radical load of lung tissue during diabetic condition. (slsjournals.com)
Male5
  • Twenty mature albino white male rats were allocated at random into two groups. (bvsalud.org)
  • Study of mature leaves of Dregea volubilis on male Sprague-Dawley rats showed degenerative changes in hepatocytes, with elevations in key hepatic enzyme concentrations. (stuartxchange.org)
  • To achieve this goal, thirty male albino rats (160-180 grams) were used in this work. (alliedacademies.org)
  • Sixty male albino rats were used. (ijpsr.com)
  • Therefore, seventy two mature male rats were equally divided into four equal groups as following: The control group of rats was administered two s.c. doses of physiological saline (vehicle of other drugs) (2ml/kg b.wt. (alexjvs.com)
Twenty2
  • Twenty four (24) Wistar strain albino rats were randomly distributed into four groups of six (6) rats each. (researchgate.net)
  • Twenty four healthy albino rats were divided into four groups (control, standard, test I and test II) of six animals each weighing between 120-150g. (ijbcp.com)
Glucose5
  • The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
  • In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of cholesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. (mdpi.com)
  • Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucose and adrenocorticotropic hormone in free moving rats. (nel.edu)
  • Daily feeding of Nelumbo nucifera leaf powder for 21 days resulted significant decrease in the blood glucose levels of alloxan-induced diabetic rats. (scirp.org)
  • Gholami-Ahangaran M, Ostadpoor M, Heidari S H. An Overview of Cinnamon Properties Effects on Blood Glucose and Hemoglobin A1C in Diabetic People. (ac.ir)
Strains1
  • Еithеr sеx of Wistеr strains of albino rats wеrе dividеd in to 5 groups wеrе Group 1 sеrvеd as normal control, Group 2 sеrvеd as alloxan control, Group 3 were administеrеd with standard drug (Glibеnclamidе), Group 4 and Group 5 wеrе administered to diffеrеnt dosеs of mеthanolic еxtract of Samanеa saman (wjpr.net)
Parameters1
  • These elevated blood parameters and enzymatic activities induced by hyperglycemia were significantly restored to near normal by oral administration of curcumin once daily for 7 weeks, as compared to untreated rats. (scialert.net)
Mechanisms3
  • This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
  • Unlike vascular effects, the anti-fibrosis mechanisms of BMPC, specifically under diabetic conditions, are poorly understood. (indexindex.com)
  • OBJECTIVE: Investigating the effect of daily leptin injection on prepubertal female rats and the possible mechanisms by which leptin can affect reproductive axis. (sohag-univ.edu.eg)
Intraperitoneally1
  • The second group of rats were injected intraperitoneally with normal saline . (bvsalud.org)
Control7
  • The dapagliflozin reduced all the above variables significantly in a dose-dependent manner compared to the control diabetic group (p-value = 0.001 for all). (europeanreview.org)
  • Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. (researchgate.net)
  • In contrast, liver and kidney sections from non-diabetic control, non-diabetic, and diabetic animals given 1000 mg/kg/day of Metformin had normal histology . (bvsalud.org)
  • MDA levels were significantly decreased where there is a significant increase in the Zn, Ag and TAC in brain of ZnONPs and SNPs treated rats when compared with diabetic or diabetic + insulin and their control. (uwi.edu)
  • The renal tissue AOP and the levels of AOPPs, PCC and NT were increased in diabetic rats compared with the untreated control animals. (nel.edu)
  • In addition, treatment with ampicillin, neomycin or metronidazole alone significantly increased the uterine wet weight of control rats. (ijp-online.com)
  • Phenoxymethylpenicillin, tetracycline, rifampicin, chloroquine and streptomycin did not produce any significant change either on the uterotropic response of ethinyl oestradiol or on the uterine weight of control rats. (ijp-online.com)
Toxicity1
  • The novel action of drug on the pancreatic beta-cells and absence of acute toxicity may offer a new hope to the diabetics in future. (ijp-online.com)
Mice1
  • We demonstrated that intramyocardial delivery of BMPCs in infarcted diabetic db/db mice significantly down-regulates profibrotic miRNA-155 in the myocardium and improves LV remodeling and function. (indexindex.com)
Groups4
  • 25 experimental animals used were divided into five groups each containing five rats. (gphjournal.org)
  • distributed in to fo ur groups of six (6) rats each. (researchgate.net)
  • Rats in the NC and DM groups were intragastrically administered with saline, and those in the TSF group were given with TSF (2.4 g/kg) once daily for 20 weeks. (bvsalud.org)
  • The animals were divided into three equal groups 20 rats for each. (ijpsr.com)
Experimental1
  • After six weeks, all experimental rats were given a high carbohydrate, high-fat diet. (ijpsr.com)
Significantly1
  • In our previous study, a lesion in the lateral bed nucleus of the stria terminalis (BNSTL) was found to significantly attenuate the elevation of adrenocorticotropic hormone (ACTH) in plasma during microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat hippocampus. (nel.edu)
Histology1
Rabbits1
  • The effect of clonidine hydrochloride has been studied in unanaesthetized albino rats, cats, dogs, guineapigs, pigeons and albino rabbits. (ijp-online.com)
Induction1
  • After seven days of DM induction, diabetic rats were administered Metformin at a dose of 1000 mg/kg/day orally. (bvsalud.org)
Study2
  • A total of 90 albino rats were used in the present study. (bvsalud.org)
  • ZnSO 4 supplemented diet was given to rats mothers of group 2 from the first day of delivery, and it was given to rats immediately after weaning until the end of the study. (ijpsr.com)
Vascular2
  • About 70 to 80% of death in diabetic patients are due to vascular diseases ( Chattopadhyay and Bandyopadhyay, 2005 ). (scialert.net)
  • Wounds can be broadly categorized as acute wounds which are caused by external injury to the skin and include surgical wounds, bites, burns, minor cuts and abrasions, and more severe traumatic wounds such as lacerations and those caused by crush or gunshot injuries or chronic etiology wounds which includes vascular, diabetic, and pressure ulcers [ 1 , 4 ]. (hindawi.com)
Group3
Insulin1
  • They were subdivided into, diabetic + ZnONPs, diabetic + SNPs and diabetic + insulin. (uwi.edu)
Thyroid1
  • Diet supplemented with Kumquat at different concentrations have a hypoglycemic effect and improve the thyroid hormones of both diabetic rats and HFHC diabetic rats. (bvsalud.org)
Effects1
  • The effects of local platelet rich plasma delivery on diabetic fracture healing. (dergipark.org.tr)
Treatment3
  • and thus could serve as a good phytomedicine for diabetic treatment. (scialert.net)
  • 5 ] considered the furanocoumarin byakangelicin to be an inhibitor of aldose reductase for the treatment of diabetic cataract. (hindawi.com)
  • After treatment for seven days, rats were fasted overnight. (ijbcp.com)
Blood1
Female2
  • Anabolic steroids caused structural and immunohistochemical changes within the female rat true vocal fold. (scite.ai)
  • The effect of oral pretreatment of some antimicrobial agents was studied on the uterotropic response of immature female rats to a single oral dose of ethinyl oestradiol. (ijp-online.com)
Animals1
  • Studies in rats have suggested that very young animals absorb more strontium than adults (ATSDR 2001e). (cdc.gov)
20171
  • Available at URL: https://en.wikipedia.org/wiki/Clove[Accessed on December, 2017]. (rjppd.org)
Expression1
  • In vitro studies confirmed that the conditioned media of BMPC inhibited miR-155 expression and profibrotic signaling in mouse cardiac fibroblasts under diabetic conditions. (indexindex.com)