• The association between peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) polymorphisms and type 2 diabetes mellitus (T2DM) has been investigated in several studies, but these studies yielded contradictory results. (nih.gov)
  • Naomi Berrie Diabetes Center and the Department of Medicine, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York 10032, USA. (nih.gov)
  • V. Rattan, C. Sultana, Y. Shen, and V. K. Kalra, "Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1," American Journal of Physiology-Endocrinology and Metabolism , vol. 273, no. 3, part 1, pp. (hindawi.com)
  • [ 99 ] In June 2018, the FDA extended the MiniMed 670G's approval to children aged 7-13 years with type 1 diabetes. (medscape.com)
  • Because the drug was the first GLP-1 agonist that could be taken once a day, sales projections in 2013 were €500M per year by 2018. (wikipedia.org)
  • Rodents and humans exhibit a physiological ripple of apoptotic beta-cell death shortly after birth, which induces an adaptive autoimmune response towards islet-antigens, both in diabetes-prone non-obese diabetic (NOD) mice and in mice that do not develop diabetes. (nih.gov)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient," Diabetologia , vol. 56, pp. 1605-1614, 2013. (hindawi.com)
  • The first successful trial of human islet allotransplantation resulting in long-term reversal of diabetes was performed at the University of Pittsburgh in 1990. (wikipedia.org)