• The rising global burden of diabetes and its complications: estimates and projections to the year 2010. (scielo.br)
  • The eye health care programme in Oman aims to reduce blindness due to diabetes through early detection of eye complications among people with diabetes [2]. (who.int)
  • However, there are nearly 35 000 people diagnosed with diabetes in the 1.9 million Omani population who would need frequent eye check-ups to rule out complications, mainly diabetic retinopathy [3]. (who.int)
  • to study diabetes in genomic medicine would require reasoning from a disease to all its various complications to the genome and back. (parc.com)
  • Dysregulation of the Na/K-ATPase (NKA) in the kidney, cardiovascular system, and peripheral nervous system is believed to contribute to pathogenesis of diabetes mellitus (DM) and its complications. (imrpress.com)
  • Type 1 diabetes mellitus is characterized by destruction of insulin producing-pancreatic cells and, among its symptoms, an impaired immunological function has been observed in many studies having diabetic patients described as more susceptible to infections and complications resulted of them. (usp.br)
  • Streptozotocin (STZ) is widely used to study the pathology of diabetes mellitus and diabetic complications in most strains of rodents [15]. (researchgate.net)
  • Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. (medscape.com)
  • This volume provides extensive reviews on selected subjects of critical importance for understanding the etiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM). (powells.com)
  • Work at this institute and the Steno Memorial Hospital has been dedicated to research in diabetes for decades, and the insti- tutions were appointed WHO Collaborating Centres for Re- search and Training on the Pathogenesis of Diabetes Mellitus in 1983. (powells.com)
  • A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. (harvard.edu)
  • ENT Study of osskular defects in csom and its managements CT correlated study of Anatomic variations of Para nasal sinuses CT Study of Sin nasal inflammatory diseases Medicine Profile and Clinic radiological correlation in patients with stroke score and Guy's Hospital Score Evidence of silent myocardial ischemia in type-l diabetics evaluation by tread mill test. (wikipedia.org)
  • [ 3 ] Despite several thoughtful investigations into the etiology of Freiberg disease, no consensus exists as to what type of disease process this peculiar affliction represents. (medscape.com)
  • It is known that diabetes, type II diabetes mellitus (T2DM) in particular, is often associated with hepatic accumulation of triglycerides in both rodents and humans, which might eventually lead to the development of hepatic steatosis or nonalcoholic fatty liver disease (NAFLD) [ 14 - 16 ]. (hindawi.com)
  • Recently, we demonstrated that deficiency or inhibition of AR caused significant dephosphorylation of hepatic PPAR α , leading to the activation of this transcriptional factor as well significant reduction in serum TG levels in streptozotocin-(STZ-) diabetic mice, an experimental model for type I diabetes mellitus (T1DM) [ 17 ]. (hindawi.com)
  • The aim of this study is to evaluate the clinical files of patients to detect the presence and type of existing periodontal disease, as well as to verify the presence of risk factors such as altered systemic condition and the use of medicines to correlate them with gender and age. (bvsalud.org)
  • miRNAs pose a good prospect in the diagnosis and treatment of type 2 diabetes (T2D). (researchsquare.com)
  • Type 2 diabetes (T2D) is a homeostasis disorder of glucose metabolism caused by insulin resistance (IR) and/or pancreatic β-cells dysfunction, which involves the interaction of genetic, environmental and behavioral factors ( 1 , 2 ) . (researchsquare.com)
  • Type 2 diabetes mellitus (DM2) is a highly prevalent disease, the progression of which depends on high blood glucose levels, which are reflected in the level of glycosylated haemoglobin (HbA1c). (ugr.es)
  • Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta cell failure resulting in uncompensated hyperglycemia, a process replicated in the Zucker diabetic fatty (ZDF) rat. (nature.com)
  • From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. (nature.com)
  • Increased number of islet-associated macrophages in type 2 diabetes. (nature.com)
  • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. (nature.com)
  • And early studies have hinted that the type 2 diabetes drugs Actos and Avandia may help fight heart disease not only by improving blood sugar but also by battling inflammation. (natap.org)
  • They improve blood sugar by reducing insulin resistance, a hallmark of type 2 diabetes. (natap.org)
  • In a newly published study, researchers compared Actos with an older type of diabetes drug that lowers blood sugar in an entirely different way and does not reduce insulin resistance. (natap.org)
  • Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)
  • Type 1 diabetes mellitus is a metabolic disease resulting from the destruction of insulinproducing β cells in the pancreas, that leads to hyperglycemia [1,2,20]. (researchgate.net)
  • Type 1 diabetes mellitus (insulin-dependent diabetes) is characterized by hyperglycemia caused by an insulin deficiency. (researchgate.net)
  • Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
  • Diabetic group ( n = 17): patients with in patients with chronic renal failure and type 2 diabetes without renal involve- under HD, and disturbances in endothelial ment (normoalbuminuria). (who.int)
  • The diagno- function may play a role in vascular com- sis of type 2 diabetes was established plications such as stroke or ischaemic heart before they were screened for the study disease. (who.int)
  • Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. (elsevierpure.com)
  • Blood glucose levels in alloxan-induced type 1 diabetes model mice were also significantly suppressed by feeding the mice with electrolyzed reduced water. (elsevierpure.com)
  • These results suggest that electrolyzed reduced water can prevent apoptosis of pancreatic β-cells and the development of symptoms in type 1 diabetes model mice by alleviating the alloxan-derived generation of reactive oxygen species. (elsevierpure.com)
  • Effects of bariatric surgery on blood and vascular large extracellular vesicles according to type 2 diabetes status. (medscape.com)
  • Approach to the Patient with Youth-Onset Type 2 Diabetes. (medscape.com)
  • Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
  • Glucagon-like peptide 1 Analogues as Adjunctive Therapy for Patients with Type 1 Diabetes: an Updated Systematic Review and Meta-analysis. (medscape.com)
  • Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study. (medscape.com)
  • Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism. (medscape.com)
  • ACE gene polymorphism and atherosclerotic lesion of carotid artery among offsprings of type 2 diabetes mellitus. (cdc.gov)
  • Association of the ACE rs4646994 and rs4341 polymorphisms with the progression of carotid atherosclerosis in slovenian patients with type 2 diabetes mellitus. (cdc.gov)
  • Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. (scielo.br)
  • Results: Altered levels of D-serine in blood have been reported in several neurological and psychiatric disorders: it has been proposed as promising biomarker in schizophrenia, Alzheimer's disease, and amyotrophic lateral sclerosis. (eurekaselect.com)
  • and advancements in science in developed countries have made it possible for people affected by this syndrome to live longer, but an extended life span has brought with it Alzheimer's disease (AD), which exacerbates the cognitive decline in these individuals. (bvsalud.org)
  • In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
  • The most demonstrative clinical expressions of this auto-immunity are Graves' disease and insulin dependent diabetes. (karger.com)
  • Clinical observation registers frequent stressful life events just before the onset of these diseases, but there are few convincing data in the literature. (karger.com)
  • Anamnesis and clinicai examination accomplished in the periodontal clinic can establish some demographic, clinical and systemic disease patterns related to the presence of the periodontal disease in patients seeking treatment at dental school clinics. (bvsalud.org)
  • In Periodontics, the correct record of information on clinical charts is still more crucial because the prevention and treatment of periodontal disease depends on both a correct diagnosis and proper prognosis. (bvsalud.org)
  • Metabolism, Clinical and Experimental. (lu.se)
  • Protocol for xenotransplantation of human skin and streptozotocin diabetes induction in immunodeficient mice to study impaired wound healing. (harvard.edu)
  • Diabetes was induced in 10-week-old control and Arg1-KO T ie2 mice with streptozotocin, and vasomotor responses were studied 10 weeks later. (nih.gov)
  • Three experimental animal models are particularly important for the study of IDDM: the low dose streptozotocin induced diabetes in mice, the BB-rat and the NOD-mouse. (powells.com)
  • A single dose of streptozotocin (60 mg/kg) was given by intraperitoneal route to induce experimental diabetes. (tubitak.gov.tr)
  • In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
  • These compounds have frequently been called dietary antioxidants since in some cases they counteract oxidative damage to biomolecules (Halliwell, 1996), and the possibility exists that increased intakes of these compounds may protect against chronic disease. (nationalacademies.org)
  • The study results indicate that the intraperitoneal administration of 10 mg/kg MEL over 6 weeks may cause amelioration in oxidative stress parameters against diabetes, leading to beneficial effects based on % tail DNA and mean tail moment parameters in rat lymphocytes. (tubitak.gov.tr)
  • Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice. (harvard.edu)
  • A novel approach to define genetic elements associated with diabetes in the BB rat is described, and the role of MHC class II molecules in development of IDDM in mice, rats and humans is reviewed. (powells.com)
  • To understand the role of TLR2 during the development of murine experimental deep dermatophytosis, we employed TLR2 knockout mice. (frontiersin.org)
  • Our data suggest that inhibition of AR in the T2DM db/db mice led to significant activation in hepatic PPAR α and significant reductions in serum triglycerides (TG) and hepatic TG, suggesting that under hyperglycemia, AR/the polyol pathway might be greatly upregulated to contribute significantly to the hepatic regulation of TG metabolism and the development of nonalcoholic steatohepatitis (NASH) or nonalcoholic fatty liver disease (NAFLD). (hindawi.com)
  • abstract = "Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. (elsevierpure.com)
  • Abstract: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused more than five million deaths throughout the world and more than five thousand deaths in Libya, a little is known about the mortality rate and the risk factors for death from this serious infectious disease in Libya. (who.int)
  • These results suggest that no hesitation is warranted in initiating PD for diabetic patients with end-stage renal disease. (springer.com)
  • Comparison of long-term outcomes between peritoneal dialysis patients with diabetes as a primary renal disease or as a comorbid condition. (springer.com)
  • Inhibition of this pathway in vivo prevents the pathologic changes of diabetic nephropathy, supporting a potential role for inhibitors of RhoA/Rho in the treatment of diabetic renal disease. (mcmaster.ca)
  • IFN and IL-10 were signi cantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. (who.int)
  • stage renal disease (ESRD) [ 2 ] and with impaired immunity in HD patients [ 3 ]. (who.int)
  • There are currently no proven therapeutic benefits of coenzyme Q 10 supplementation in diabetes mellitus , neurodegenerative diseases , inherited ataxias , or breast cancer . (oregonstate.edu)
  • AD is a severe progressive neurodegenerative disease, which induces decreasing memory capacity and cognition. (bvsalud.org)
  • It is worth noting that while addressing the hypothesis of the role of class II major histocompatibility glycoproteins in autoimmune diabetes (insulin-dependent diabetes, IDDM) a number of investigators established animal models in which class II molecules were expressed under the control of the rat insulin promoter. (powells.com)
  • The invention expanded the arsenal of medicines that provide delivery of the drug to the blood in an unchanged form, for inhalation administration in the autoimmune diseases treatment. (rudn.ru)
  • The invention relates to the chemical and pharmaceutical industry and concerns capsules with a powder pharmaceutical inhalation composition for the autoimmune diseases treatment. (rudn.ru)
  • The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
  • This work uses a model of experimental T1DM to investigate the intervention of insulin in a model of murine PCM induced by Paracoccidioides brasiliensis , analyzing the process of cell migration (adhesion molecules expression, leukocyte phenotyping), molecular mechanisms (production and secretion of cytokines), intracellular mechanisms (signaling pathways) and phagocytic and microbicidal activities in alveolar macrophages. (usp.br)
  • Information was reviewed regarding the minimum amount of these nutrients required to prevent deficiency diseases, as well as the amounts that might impact on chronic diseases, regardless of whether the effect was an antioxidant effect or not. (nationalacademies.org)
  • The predisposal profile of such diseases is quite well delineated (genetic markers in HLA system, organ-specific T suppressive deficiency). (karger.com)
  • Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. (scielo.br)
  • As the results of the analysis showed that in addition to the common indicators (serum creatinine and creatinine clearance rate), some other underappreciated indicators such as serum cystatin and cumulative days of vancomycin administration, weight and age, neutrophils and hemoglobin were the risk factors for cancer, diabetes mellitus, heptic insufficiency respectively. (frontiersin.org)
  • Berberine has also been shown to lower glucose levels in people with diabetes. (webmd.com)
  • As a result, people with diabetes may find berberine helps lower their blood sugar levels. (webmd.com)
  • Heart disease and stroke are the leading causes of death among people with diabetes, with two out of three diabetes patients eventually dying from one of these conditions. (natap.org)
  • They concluded that people with diabetes who have mild heart disease or any problems with their kidneys could be at greater risk of developing heart failure if they take Actos or Avandia. (natap.org)
  • Taking blond psyllium by mouth can improve blood sugar control in people with diabetes. (medlineplus.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • A planning committee of five scientists was established by the Centers for Disease Control and Prevention and the American College of Sports Medicine to organize a workshop. (cdc.gov)
  • During the ensuing months, the consensus statement was further reviewed and revised and was formally endorsed by both the Centers for Disease Control and Prevention and the American College of Sports Medicine. (cdc.gov)
  • A group of experts was brought together by the Centers for Disease Control and Prevention (CDC) and the American College of Sports Medicine (ACSM) to review the pertinent scientific evidence and to develop a clear, concise 'public health message' regarding physical activity. (cdc.gov)
  • Diabetes mellitus increases the risk of gingivitis and periodontitis. (medscape.com)
  • The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population. (cdc.gov)
  • In addition, it is found that 63.2% of the SARS-CoV-2 deaths were females and 78.9% of them had a positive history of chronic diseases. (who.int)
  • While macrophage-induced inflammation is crucial for the response to pathogen infection, excessive or sustained inflammation can cause tissue damage and may lead to different conditions such as diabetes, cardiovascular diseases, and tumors 2 . (nature.com)
  • Furthermore, D-amino acids seem useful biomarkers for pathologies not related to the central nervous system, such as pancreatic cancer and chronic kidney diseases. (eurekaselect.com)
  • However these enzymes can be increased in non-pancreatic disease, and dogs with confirmed pancr eatitis may also have normal amylase and lipase activity. (ivis.org)
  • Concerning to periodontal disease the prevalence of pocket probing depth (until 4 mm) was equivalent in both genders, and the buccal area of the mouth showed a higher prevalence than the labial area. (bvsalud.org)
  • Systematic and meta- analysis studies on the prevalence of periodontal diseases have demonstrated that these constitute a serious oral health problem. (bvsalud.org)
  • Resource-poor areas are often more heavily affected because of the prevalence of infectious diseases. (who.int)
  • I will end with a consideration of ways we can use genome-scale data to provide new ways to classify disease, and show how this broad recasting of disease nosology allows identification of new therapeutic opportunities, and of the specificity, or lack thereof, of disease biomarkers. (parc.com)
  • The diagnosis, at the early stages, of periodontal diseases as gingivitis which begin between 14 and 21 days of dental biofilm accumulation enable a safer and more efficient treatment 11,12 . (bvsalud.org)
  • Gingivitis proceeds through an initial stage to produce early lesions, which then progress to advanced disease. (medscape.com)
  • Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients. (harvard.edu)
  • Dialysis modality choice in diabetic patients with end-stage kidney disease: a systematic review of the available evidence. (springer.com)
  • Ischemic optic neuropathies are prevalent diseases and important cases of vision loss. (scientificarchives.com)
  • Although regarding Freiberg disease as an osteochondrosis makes sense, it does not fully explain the adult-onset form of the disease, which may reflect a different process altogether, albeit a radiographically similar one. (medscape.com)
  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012 29 (3-4): 443-52. (cdc.gov)
  • Today, berberine is being investigated as a treatment for diabetes, high cholesterol, and even polycystic ovary syndrome (PCOS). (webmd.com)
  • Diabetes mellitus is among the most common and serious endocrine diseases of cats. (vin.com)
  • In a study reported in September of 2003, University of Texas researchers identified six cases of congestive heart failureamong diabetes patients taking the drugs. (natap.org)
  • Research in diabetes has accelerated in two areas, both of which are being reviewed in CTMI. (powells.com)
  • the second is basic research in human investigation, islet cell antigens, and mapping of genes as- sociated with susceptibility to disease. (powells.com)
  • To recognize the awareness month, we spoke with BPS member George Em Karniadakis , Brown University, and his collaborators Xuejin Li , Brown University, and Ming Dao , MIT, about their research related to sickle cell disease. (biophysics.org)
  • What is the connection between your research and sickle cell disease? (biophysics.org)
  • Why is your research important to those concerned about sickle cell disease? (biophysics.org)
  • The general public can now see at every turn the enormous benefits to mankind that have come from experimental research. (animalresearch.info)
  • Whilst in previous years we spent time actively defending our research, we can count the blessings we and our fellow men have secured as the result of the wide adoption of experimental science and offer up thanks for our good fortune in being allowed to use this method. (animalresearch.info)
  • In recent years research has pointed to inflammation as a possible cause of heart disease. (natap.org)
  • However, much subsequent research in this area was focused on the role of pulmonary SGLT transport as a modifier of lung liquid volume [ 3 , 4 ], and the effects of starvation and diabetes on glucose transport [ 1 , 5 ]. (ersjournals.com)
  • Research used quasi-experimental with nonequivalence control group design. (banuainstitute.org)
  • Pattern recognition molecules, such as Toll-like receptors (TLR), play a crucial role against infectious diseases. (frontiersin.org)
  • Tina J. Benoit, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases. (cdc.gov)
  • New Biochemical markers in Critical care in coronary heart disease. (wikipedia.org)
  • Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions. (cdc.gov)
  • Renin-angiotensin system genes polymorphism in Egyptians with premature coronary artery disease. (cdc.gov)
  • Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients. (cdc.gov)
  • Together, these data indicate that inhibition of AR might lead to significant amelioration in hyperglycemia-induced dyslipidemia and nonalcoholic fatty liver disease. (hindawi.com)
  • Diabetic patients with and without chronic lung disease are at increased risk of respiratory infection. (ersjournals.com)
  • For diabetic patients on damage to the vasculature in diabetes [ 6 ]. (who.int)
  • Although Freiberg disease was originally described more than a century ago, the etiology and the most appropriate treatment remain controversial. (medscape.com)
  • The impact of diabetes mellitus on peritoneal dialysis: the Turkey Multicenter Clinic Study. (springer.com)
  • The aim of this study was to evaluate the relations among: age, reasons for dental appointment, systemic conditions, use of medicines and periodontal disease, in patients assisted in the Periodontal Clinic at the Dental School of the Center of Higher Education of Campo Gerais (short Cescage - Ponta Grossa, Brazil), during 2007-2009. (bvsalud.org)
  • A total of 20 patients with AAA were included in this experimental prospective study. (edu.pl)
  • Perspective: This study evaluated, through a multimodal approach, the analgesic effect of buprenorphine in an experimental rat model of painful DPN. (unimi.it)
  • For this purpose, healthcare personnel led a quasi-experimental study of 249 diabetics: 171 in the control group, and 78 in the intervention group. (ugr.es)
  • Ninty subjects were enrolled in this study who attended the Hepatology, Gastroenterology and Internal medicine clinics in Benha University Hospitals between January 2017 and January 2018 and divided into group I included 70 consecutive patients with non-alcoholic fatty liver disease who were diagnosed by ultrasound with or without elevated liver enzymes and group II included 20 healthy control subjects without NAFLD (by ultrasound) with normal liver enzymes. (scirp.org)
  • In conclusion, we demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response. (frontiersin.org)
  • Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease worldwide, it causes chronic hepatitis, which leads to cirrhosis and hepatocellular carcinoma. (scirp.org)
  • We aimed to assess the value of liver fatty acid binding protein (L-FABP) in the diagnosis of non-alcoholic fatty liver disease in comparison to ultrasonography. (scirp.org)
  • Nonalcoholic Fatty Liver Disease, Liver Fibrosis and Utility of Noninvasive Scores in Patients with Acromegaly. (medscape.com)