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  • reductase
  • The 1-alkyl-DHAP is then reduced to 1-O-alkyl-2-hydroxy-sn-glycerophosphate (GPA) by an acyl/alkyl-DHAP reductase located in both peroxisomal and endoplasmatic reticulum (ER) membranes. (wikipedia.org)
  • ASCT
  • In the HDR2 trial, patients with relapsed HL without disease progression after two courses of DHAP were randomized to receive additional sequential HDCT or to directly proceed to HDCT with BEAM followed by ASCT. (linkos.cz)
  • dose
  • In this retrospective analysis of the HDR2 trial, the clinical impact of dose density of DHAP was evaluated. (linkos.cz)
  • Dose density of DHAP reinduction therapy is an independent prognostic factor with regard to PFS and OS in relapsed HL patients. (linkos.cz)
  • These results support the mandatory use of G-CSF in this setting as well as an investigation of thrombopoietin analogues during DHAP reinduction therapy in order to maintain dose density. (linkos.cz)
  • start
  • At the end of this rest period, you start your second cycle of R-DHAP. (macmillan.org.uk)
  • DHAP cycle interval was defined as the time interval between day 1 of the first course and start of the second DHAP course. (linkos.cz)
  • cycle
  • Kaplan Meier and Cox regression analyses were used to estimate the prognostic value of the DHAP cycle interval and of hematotoxicity on progression free survival (PFS) and overall survival (OS) after relapse. (linkos.cz)
  • The impact of different variables on the length of DHAP cycle interval was examined with linear regression analysis. (linkos.cz)
  • course
  • DHAP-associated grade 4 hematotoxicity had a significant impact on the length of DHAP course intervals (P=0.022 in multivariate linear regression analysis). (linkos.cz)
  • Additionally, hematotoxicity grade 4 is a significant factor contributing to prolonged DHAP course intervals and has a negative impact on PFS and OS. (linkos.cz)
  • therapy
  • Phase II Randomized Study With R-DHAP +/- Bortezomib as Induction Therapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL) Patients Eligible to Transplantation. (centerwatch.com)
  • We determined the prognostic significance of MYC rearrangement in patients with relapsed/refractory DLBCL prospectively treated by R-ICE or R-DHAP followed by highdose therapy and autologous stem cell transplantation. (diva-portal.org)