Dextrans. Medical search. Frequent questions (2)

Dextran is a complex branched glucan (polysaccharide derived from the condensation of glucose), originally derived from wine. (wikipedia.org)
Dextran, a neutral and hydrophilic polysaccharide, was functionalized with maleimide or vinyl sulfone groups which are able to form covalent bonds with nucleophilic thiols via a thiol-Michael addition reaction. (universiteitleiden.nl)
Whatever the dextran used, complete silylation of the polysaccharide chain could be achieved by adequate selection of the experimental conditions. (univ-lorraine.fr)
Dextran is a branched polysaccharide made of many glucose molecules joined into chains of varying lengths. (the-medical-dictionary.com)

Dental plaque is rich in dextrans. (wikipedia.org)

Dextran is a complicating contaminant in the refining of sugar because it elevates the viscosity of sucrose solutions and fouls plumbing. (wikipedia.org)
Dextran is now produced from sucrose by certain lactic acid bacteria of the family lactobacillus. (wikipedia.org)
Dextran is naturally produced from Sucrose by some bacteria and occurs as slimes in fermenting vegetables and dairy products. (mfa.org)
Dextran is synthesized from sucrose by Leuconostoc mesenteroides streptococcus, and are also produced by bacteria and yeast. (the-medical-dictionary.com)

However, the mechanism by which RUT ameliorates dextran sulfate sodium (DSS)-induced IBD is largely unknown. (nih.gov)

Dextran can be used as a stabilizing coating to protect metal nanoparticles from oxidation and improve biocompatibility. (wikipedia.org)
No cytotoxicity was noticed when the focus of Fe3O4-dextran-anti-HCG nanoparticles was 37.5 g/mL. (fabretp.org)
Agarose gel electrophoresis evaluation of binding tests demonstrated that after treatment with sodium periodate, Fe3O4-dextran-anti-HCG nanoparticles possess a reasonable potential to soak up DNA, as well as the protection test demonstrated that nanoparticles can secure DNA from DNase I digestion effectively. (fabretp.org)
Aldehyde Fe3O4-dextran-anti-HCG nanoparticles can transfect reporter genes, as well as the transfection performance of the nanoparticles is certainly higher than that of liposomes ( 0.05). (fabretp.org)
Fe3O4-dextran-anti-HCG nanoparticles can focus in choriocarcinoma cells and in transplanted choriocarcinoma tumors. (fabretp.org)
Conclusions: The outcomes concur that Fe3O4-dextran-anti-HCG nanoparticles possess potential being a protected, effective, and choriocarcinoma-specific concentrating on gene vector. (fabretp.org)
Outcomes size and Morphology of Fe3O4-dextran-anti-HCG nanoparticles Fe3O4-dextran-anti-HCG nanoparticle option is Furosemide atramentous and transparent. (fabretp.org)
Open up in another window Body 1 Transmitting electron micrograph of magnetic iron oxide (Fe3O4)-dextran-anti-HCG nanoparticles. (fabretp.org)
The iron content material of Fe3O4-dextran-anti-HCG nanoparticles is certainly 37.5 g/mL. (fabretp.org)
Toxicity of Fe3O4-dextran-anti-HCG nanoparticles As proven in Desk 1, the inhibitory price of nanoparticles at 56.25 and 75 g/mL is greater than control ( 0.05). (fabretp.org)
Desk 2 Transfection performance of anti-HCG monoclonal antibody destined to nanoparticle 0.05) (Desk 3), indicating that Fe3O4-dextran-anti-HCG nanoparticles work being a gene vector. (fabretp.org)
Oddly enough, the performance of gene transfection using Fe3O4-dextran-anti-HCG nanoparticles is certainly greater than that noticed using liposomes ( 0.05). (fabretp.org)
These results indicate that Fe3O4-dextran-anti-HCG nanoparticles are even more soaked up by choriocarcinoma cells readily. (fabretp.org)
In-vitro and in-vivo assessment of dextran-appended cellulose acetate phthalate nanoparticles for transdermal delivery of 5-fluorouracil. (bvsalud.org)
The results showed that the optimized CAP nanoparticles (CNs) and dextran -coated CAP nanoparticles represented core-corona nanoparticles with the mean diameter of 75 ± 3 and 79 ± 2 nm, respectively, and entrapment efficiency was 82.5 ± 0.06 and 78.2 ± 0.12, respectively. (bvsalud.org)
Dextran -coated nanoparticles (FDCNs) and CAP nanoparticles (FCNs) showed in vitro 5-FU release upto 31 h and 8 h, respectively. (bvsalud.org)

Outside of these features, larger dextrans, which do not pass out of the vessels, are potent osmotic agents, thus have been used urgently to treat hypovolemia[citation needed]. (wikipedia.org)
The larger dextrans (>60,000 Da) are excreted poorly from the kidney, so remain in the blood for as long as weeks until they are metabolized. (wikipedia.org)
The larger dextrans are excreted poorly from the kidney and therefore remain in the blood for as long as weeks until they are metabolized. (the-medical-dictionary.com)

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. (sigmaaldrich.com)
Dextran is labeled with fluorescein (FITC) through conjugation reaction of dextran amine and isothiocyanate of FITC, Ex/Em wavelength 494/518 nm. (creativepegworks.com)
CM-Dextran Fluorescein is a carboxymethyl (CM) Dextran labeled with fluorescein (FITC). (creativepegworks.com)

FITC-dextran is used extensively in microcirculation and cell permeability research utilizing microfluorimetry. (sigmaaldrich.com)
FITC-dextran has been used to study plant cell wall porosity and capillary permeability. (sigmaaldrich.com)
Plasma proteins have been shown not to bind to FITC-dextran. (sigmaaldrich.com)
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. (sigmaaldrich.com)
Small FITC-dextrans are also used to measure processes such as endocytosis. (sigmaaldrich.com)
FITC-Dextran 250 (FD 250) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. (sigmaaldrich.com)
Sigma typically tests the solubility of FITC dextrans in water at concentrations at or above 25 mg/ml. (sigmaaldrich.com)
In vivo, FITC-dextran is stable for more than 24 hours. (sigmaaldrich.com)
The functionality of the matured microvasculature networks was demonstrated through the enhancement of cell-cell adhesion, angiogenesis process, and perfusion tests with microparticles, FITC-dextran, and whole mouse blood. (lu.se)

This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by α-1,4 or α-1,6 linkages. (wikipedia.org)
Dextran in intravenous solution provides an osmotically neutral fluid that once in the body is digested by cells into glucose and free water. (the-medical-dictionary.com)

The functionalized dextran polymers are liable to be crosslinked to generate 3D networks. (universiteitleiden.nl)

Sigma D8906-10G Dextran Sulfate Sodium Salt from Leuconostoc spp. (capitolscientific.com)
Dextran sulfate sodium is the sodium salt of dextran sulfate. (unipex.com)

Still, no difference has been detected in antithrombotic effectiveness in comparison of intra-arterial and intravenous administration of dextran. (wikipedia.org)
Close to 70% of dextran-40 is excreted in urine within the first 24 hours after intravenous infusion, while the remaining 30% are retained for several more days. (wikipedia.org)
and in certain intravenous fluids to solubilize other factors, such as iron (in a solution known as Iron Dextran). (wikipedia.org)
Intravenous solutions with dextran function both as volume expanders and means of parenteral nutrition. (wikipedia.org)
Still, no difference has been detected in antithrombotic effectiveness in comparison of intraaterial and intravenous administration of dextran. (the-medical-dictionary.com)

Solutions of fluorescently-labelled dextran can be perfused through engineered vessels to analyze vascular permeability Dextran is used to make microcarriers for industrial cell culture Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. (wikipedia.org)
Study on the experimental ulcerative colitis model induced by dextran sulfate sodium in rats: Estimation of mucosal erosions by the alcian blue-staining method. (sciencegate.app)
Study on the experimental ulcerative colitis(UC) model induced by dextran sulfate sodium(DSS) in rats. (sciencegate.app)
In the present study we examined the protective potential of exogenously administered human umbilical cord derived mesenchymal stem cells (UCMSCs) against Dextran Sulfate Sodium (DSS) induced acute colitis in immunodeficient NOD.CB 17 - Prkdc scid /J mice with particular attention to endoplasmic reticulum (ER) stress. (biomedcentral.com)

TRITC-lysine dextrans are synthesised from well-characterised dextran fractions derived from Leuconostoc mesenteroides. (tdblabs.se)

Dextrans are available in multiple molecular weights ranging from 3 kDa to 2 MDa. (wikipedia.org)
Native dextran has been found to have a molecular weight (MW) in the range of 9 million to 500 million. (sigmaaldrich.com)
Avg. Molecular Weight: >500,000 (Dextran starting material), Contains 0.5-2% phosphate buffer. (capitolscientific.com)
Fluorescence microphotolysis was used to measure nucleocytoplasmic flux in single rat hepatocytes for a series of dextrans ranging in molecular mass from 3 to 150 kd. (harvard.edu)
The highest silylation yields were obtained with the lowest molecular weight dextrans. (univ-lorraine.fr)
It was observed that T g values of partially silylated dextran were maintained between 120 and 140 8C, independently of the dextran molecular weight. (univ-lorraine.fr)
Iron Dextran Injection is a sterile solution containing ferric hydroxide in complex with a low molecular weight dextran fraction equivalent to 100mg elemental iron per ml with 0.5% phenol as a preservative. (advacarepharma.com)
Dextrans are available in multiple molecular weights ranging from 10,000 Da to 150,000 Da. (the-medical-dictionary.com)

Dextran is a polymer of anhydroglucose. (sigmaaldrich.com)
Degree of substitution: 1 mol % substitution and at least one dye molecule per dextran polymer. (creativepegworks.com)
In one embodiment, the nanocage is covalently attached to a polymer shell (e.g. a dextran shell). (justia.com)

Before you receive your first dose of iron dextran injection, your doctor will give you a test dose of medication and watch you carefully for at least 1 hour for any signs of an allergic reaction. (medlineplus.gov)
You may be at a higher risk of having an allergic reaction to iron dextran injection. (medlineplus.gov)
You may experience a delayed reaction to iron dextran injection, beginning 24 to 48 hours after receiving a dose of medication and lasting for approximately 3 to 4 days. (medlineplus.gov)
The silylation reaction of dextran with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) in DMSO was studied as the ®rst step of the synthesis of new amphiphilic polyester-grafted dextrans. (univ-lorraine.fr)
According to the experimental conditions, i.e. dextran molar weight, medium temperature and reaction time, HMDS/OH ratio, addition of a catalyst and co-solvent, partially or totally silylated dextrans were recovered. (univ-lorraine.fr)

The remaining (163) linkages account for the branching of dextran. (sigmaaldrich.com)

citation needed] Dextran can be used in an ATPS for PEGylation Dextran is used in the osmotic stress technique for applying osmotic pressure to biological molecules. (wikipedia.org)

Dextran coupled with a fluorescent molecule such as fluorescein isothiocyanate can be used to create concentration gradients of diffusible molecules for imaging and allow subsequent characterization of gradient slope. (wikipedia.org)

The inhibitory effects of the doenjang prepared with the grain-type meju using mixed starter cultures were investigated in azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colon carcinogenesis mice model. (carcinogenesis.com)

Novel drug delivery platforms, including dextran-albumin hydrogels and dextran-poly(ethylene glycol)-albumin hydrogels, were established in which human serum albumin acts simultaneously as an affinity-based drug carrier and crosslinker. (universiteitleiden.nl)

The dextran fractions are first labelled with lysine and thereafter exposed to TRITC under mild conditions to form TRITC-lysine-dextran. (tdblabs.se)

Iron dextran injection may cause severe or life-threatening reactions while you receive the medication. (medlineplus.gov)
You will receive this medication in a medical facility and your doctor will watch you carefully during each dose of iron dextran injection. (medlineplus.gov)
You should only receive iron dextran injection if you have a condition that cannot be treated with iron supplements that are taken by mouth. (medlineplus.gov)
Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in people who cannot be treated with iron supplements taken by mouth. (medlineplus.gov)
Iron dextran injection is in a class of medications called iron replacement products. (medlineplus.gov)
Iron dextran injection comes as a solution (liquid) to inject into the muscles of the buttocks or intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
Your doctor will determine how often you receive iron dextran injection and your total number of doses based on your weight, medical condition, and how well you respond to the medication. (medlineplus.gov)
or any of the ingredients in iron dextran injection. (medlineplus.gov)
AdvaCare Iron Dextran Liquid Injection is manufactured in our facilities located in China/India/USA. (advacarepharma.com)
It is important to note that AdvaCare's iron dextran injection is for veterinary purposes only, and altho' there are types similar medications for human use, you should only use medications prescribed by a veterinary doctor or animal care specialist for an animal. (advacarepharma.com)
As with all veterinary medicine, some unwanted effects can occur from the use of iron dextran injection. (advacarepharma.com)
Consult with an animal care specialist about any other medications that are being taken by the animal, and their medical history, before their treatment with iron dextran liquid injection. (advacarepharma.com)

Whereas conjugation of MP with dextran in both prodrugs substantially decreased the clearance of the drug by ∼200‐fold, the accumulations of the drug in the liver, spleen, and kidneys were significantly increased by conjugation. (uri.edu)

Dextran chains are of varying lengths (from 3 to 2000 kilodaltons). (wikipedia.org)

The aim of this research was transdermal delivery of 5-fluorouracil ( 5-FU ) using dextran -coated cellulose acetate phthalate (CAP) nanoparticulate formulation. (bvsalud.org)

The antithrombotic effect of dextran is mediated through its binding of erythrocytes, platelets, and vascular endothelium, increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. (wikipedia.org)
Dextrans also reduce factor VIII-Ag Von Willebrand factor, thereby decreasing platelet function. (wikipedia.org)

The MW of dextran is measured by one or more of the following methods: low angle laser light scattering, size exclusion chromatography, copper-complexation and anthrone reagent colorometric reducing-end sugar determination and viscosity. (sigmaaldrich.com)

As the MW increases, dextran molecules attain greater symmetry. (sigmaaldrich.com)

Anaphylactic-type reactions, including fatalities, have followed the parenteral use of iron dextran. (drugs.com)
Use iron dextran only in patients no amenable to oral iron therapy. (drugs.com)
Iron dextran is an iron replacement product that is used to treat iron deficiency, such as anemia (not enough iron in the blood) or blood loss in patients with certain conditions (eg, hemophilia, gastrointestinal bleeding). (drugs.com)
Use of iron dextran is not recommended in children younger than 4 months of age. (drugs.com)
No information is available on the relationship of age to the effects of iron dextran in geriatric patients. (drugs.com)
However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution in patients receiving iron dextran. (drugs.com)
Iron dextran is used to treat anemia (low red blood cells) caused by low iron levels. (upmc.com)
AdvaCare is a GMP manufacturer of Iron Dextran liquid injections. (advacarepharma.com)
Always consult a veterinary doctor or animal care specialist before using iron dextran injections. (advacarepharma.com)
66 newborn piglets of 11 litters were allotted to 6 treatments: 285 mg iron (Fe) as Fe methionine orally either within 12 h after birth or on the 2nd day (FeM1, FeM2), 290 mg Fe as Fe dextran orally either within 12 h after birth or on the 2nd day (FeD1, FeD2), 200 or 100 mg Fe as Fe dextran sc. (agrarforschungschweiz.ch)
Bioavailability was not reduced when the oral administration of iron methionine and of iron dextran was delayed until the 2nd day of life. (agrarforschungschweiz.ch)

After polymerization and ultimate deprotection of the silylated dextran backbone, amphiphilic polyester-grafted dextrans were readily recovered. (univ-lorraine.fr)
TRITC-lysine-dextran dissolves readily in water. (tdblabs.se)

I agree to receive updates via email from Pharmacosmos with insights related to Dextran application areas, new product offerings and special offers. (dextran.kr)

An uncommon but significant complication of dextran osmotic effect is acute renal failure. (the-medical-dictionary.com)

Dextran has traditionally been used in infusion fluid and volume expander products. (xawanlong.net)

This thesis describes the design, characterization and application of dextran based crosslinked network. (universiteitleiden.nl)

Dextran also increases blood sugar levels. (wikipedia.org)

Dextran was discovered by Louis Pasteur as a microbial product in wine, but mass production was only possible after the development by Allene Jeanes of a process using bacteria. (wikipedia.org)
Some bacteria coproduce fructans, which can complicate isolation of the dextrans. (wikipedia.org)

TRITC-lysine-dextran is a dextran derivative carrying both free primary amines and free carboxylates as well as the fluorescent dye Tetramethylrhodamine (TRITC). (tdblabs.se)
TRITC-lysine-dextrans are supplied as a pink powder. (tdblabs.se)
TdB Labs produce TRITC-lysine-dextran from 4 kDa to 500 kDa. (tdblabs.se)
TRITC-lysine-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature. (tdblabs.se)
TRITC-lysine-dextran is a versatile tool for bioconjugation and fixation in living systems. (tdblabs.se)

Dextrans with MW greater than 10,000 behave as if they are highly branched. (sigmaaldrich.com)
Dextrans with MW of 2,000 to 10,000, exhibit the properties of an expandable coil. (sigmaaldrich.com)

fluorescent-labelled dextran can be used to visualize these endosomes under a microscope. (wikipedia.org)

To investigate the use of Riboflavin 0.1% in 20% dextran solution versus its hypotonic formulation during ultraviolet light exposure in corneal collagen crosslinking (CXL) for keratoconus (KC) and ectasia. (arvojournals.org)

Description: Dextran Sulfate is labeled with biotin. (haworksusa.com)

Interestingly, DMSO proved to behave as an ef®cient plasticizer of (partially) silylated dextrans. (univ-lorraine.fr)

All eyes underwent pre-treatment with Riboflavin 0.1% in 20% dextran solution every 2 minutes for 30 minutes. (arvojournals.org)

However, dextran has a very diverse application area ranging from vaccines over ophthalmic use to stabilizer of biological components. (xawanlong.net)

2021-09-27 9011-18-1 Dextran sulfate sodium Distributor. (kingcmx.com)

Although there are relatively few side-effects associated with dextran use, these side-effects can be very serious. (the-medical-dictionary.com)

In this family, dextran-40 (MW: 40,000 Da), has been the most popular member for anticoagulation therapy. (wikipedia.org)

Anatomy2

Organisms2

Diseases4

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Polysaccharide4

Rich in dextrans1

Sucrose4

Ameliorates dextran sulfate1

Nanoparticles16

Larger dextrans3

Labeled with fluorescein3

FITC9

Glucose2

Polymers1

Sodium Salt2

Intravenous5

Colitis4

Leuconostoc1

Molecular8

Polymer3

Reaction5

Linkages1

Applying osmotic1

Fluorescein isothiocyanate1

Mice1

Hydrogels1

Fractions1

Injection12

Conjugation1

Lengths1

Cellulose1

Platelet2

Viscosity1

Molecules1

Iron11

Readily2

Pharmacosmos1

Acute1

Infusion1

Characterization1

Increases1

Bacteria2

TRITC5

10,0002

Fluorescent1

Formulation1

Description1

Behave1

Solution1

Application1

Distributor1

Effects1

Therapy1