• 1 2 Another appetite suppressant, fenfluramine, and its d -isomer, dexfenfluramine (a phenyl-ethylamine derivative), have also been linked in case reports to the development of pulmonary hypertension. (ahajournals.org)
  • The FDA withdrew fenfluramine and its derivative dexfenfluramine Redux from the market after the products were linked to heart problems Phentermine is still available today Its one of the most commonly used weight loss drugs in the United States. (europeanfinancialreview.com)
  • Dexfenfluramine, marketed as dexfenfluramine hydrochloride under the name Redux, is a serotonergic anorectic drug: it reduces appetite by increasing the amount of extracellular serotonin in the brain. (wikipedia.org)
  • Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain's synapses. (pharmacycode.com)
  • It was later superseded by sibutramine, which, although initially considered a safer alternative to both dexfenfluramine and fenfluramine[citation needed], was likewise removed from the US market in 2010. (wikipedia.org)
  • Dexfenfluramine was, for some years in the mid-1990s, approved by the United States Food and Drug Administration for the purposes of weight loss. (wikipedia.org)
  • Weight gain was prevented with MTEP (3 mg/kg), and weight and adiposity loss was seen with MTEP (10 mg/kg) and dexfenfluramine. (aspetjournals.org)
  • Weight loss from related dexfenfluramine into a smoking agree that live the herb healthy this? (joshhomes.org)
  • The active ingredient is dexfenfluramine hydrochloride. (egeneralmedical.com)
  • Each capsule contains 15 mg dexfenfluramine hydrochloride. (egeneralmedical.com)
  • Dexfenfluramine hydrochloride, a white to off-white crystalline powder, is designated chemically as (S)-N-ethyl-alpha-methyl-3-(trifluoromethyl) benzeneethanamine hydrochloride and has a molecular weight of 267.7. (egeneralmedical.com)
  • Dexfenfluramine is freely soluble in water, alcohol, chloroform, and methanol The pKa of dexfenfluramine hydrochloride is 10. (egeneralmedical.com)
  • If you know of a relevant reference for Dexfenfluramine hydrochloride, please let us know . (tocris.com)
  • Do you know of a great paper that uses Dexfenfluramine hydrochloride from Tocris? (tocris.com)
  • 5. These results show that dexfenfluramine causes contraction of isolated porcine pulmonary arteries only at concentrations higher than 3 x 10(-6) M, and that chronic treatment with dexfenfluramine potentiates the endothelium-dependent relaxations to serotonin and aggregating platelets in the porcine pulmonary artery without affecting their direct effect on the smooth muscle. (nih.gov)
  • Comparative study of fluoxetine, sibutramine, sertraline, and dexfenfluramine on the morphology of serotonergic nerve terminals using serotonin immunohistochemistry. (cdc.gov)
  • In contrast, dexfenfluramine and MDMA depleted brain serotonin and produced morphological changes in the serotonin nerve network. (cdc.gov)
  • Dexfenfluramine and MDMA, on the other hand, markedly deplete brain serotonin and also produce morphological changes. (cdc.gov)
  • Banas et al (2011) Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. (tocris.com)
  • Fenfluramine (Pondimin®- AH Robins) and dexfenfluramine are anorexients that induce the release and inhibit the reuptake of serotonin ( 7 , 8 ). (ispub.com)
  • Dexfenfluramine, the 'd-isomer' of fenfluramine, is chemically related to fenfluramine and acts as an appetite suppressant by stimulating the release of serotonin from nerve cells in the brain and by reducing the reuptake of the released serotonin. (settlementdietdrugs.com)
  • Higgins et al (2001) Influence of the 5-HT 2C receptor antagonist SB242,084 on behaviour produced by the 5-HT 2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. (tocris.com)
  • Methods and Results Using the whole-cell, patch-clamp technique, we found that aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in smooth muscle cells taken from the small resistance pulmonary arteries of the rat lung. (ahajournals.org)
  • In the isolated, perfused rat lung, aminorex, fenfluramine, and dexfenfluramine induce a dose-related increase in perfusion pressure. (ahajournals.org)
  • Epidemiologically, the appetite suppressants that are clearly associated with PPH are mainly fenfluramine, dexfenfluramine, and aminorex, which caused an epidemic of PPH during the late sixties in central Europe 8 . (ersjournals.com)
  • We compared the effects of treatment with high doses of fluoxetine, sibutramine, sertraline, and dexfenfluramine for 4 days on brain serotonergic nerve terminals in rats. (cdc.gov)
  • Fluoxetine, sibutramine, sertraline and dexfenfluramine all produced a significant reduction in body weight. (cdc.gov)
  • Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine. (tocris.com)
  • With the recall of the obesity drug dexfenfluramine on Sept. 15, MIT lost a revenue source previously expected to bring in at least one million dollars per year in royalties. (mit.edu)
  • The bulk of the research on the treatment of obesity with dexfenfluramine was conducted at MIT by Richard J. Wurtman, professor of neuroscience, and his wife Judith, a research scientist in the Department of Brain and Cognitive Sciences. (mit.edu)
  • The effect of pretreatment with dexfenfluramine on dexamphetamine and apomorphine stereotypies of the oral movement variety and on catalepsy induced by haloperidol and small doses (0.05 and 0.1 mg/kg ip) of apomorphine was studied in rats . (bvsalud.org)
  • However, 1 h pretreatment with 5-HT releasing doses of dexfenfluramine ie 5 and 10 mg/kg ip, antagonized dexamphetamine stereotypy and potentiated catalepsy induced by haloperidol and small doses of apomorphine . (bvsalud.org)
  • Our results, that dexfenfluramine at 2.5, 5 and 10 mg/kg ip neither induced catalepsy nor antagonised apomorphine stereotypy, indicate that dexfenfluramine at these doses does not block the postsynaptic striatal D2 and D1 DA receptors. (bvsalud.org)
  • However, 5 and 10 mg/kg doses of dexfenfluramine , through the released 5-HT , inhibit the synthesis and release of DA from the nigrostriatal DAergic neurons and thus antagonise dexamphetamine stereotypy and potentiate catalepsy induced by haloperidol and small doses of apomorphine . (bvsalud.org)
  • The other two drugs commonly used in the treatment, fenfluramine and dexfenfluramine, were withdrawn from the marke t . (nytimes.com)
  • More recently, pulmonary hypertension has been described in some patients taking other amphetamine-like, anorexic agents: fenfluramine and its d -isomer, dexfenfluramine. (ahajournals.org)
  • 1 Seminal patient case reports linked the Food and Drug Administration-approved indication for the anorexic agents, fenfluramine and dexfenfluramine, with primary pulmonary hypertension and subsequently spawned trials that evaluated the mechanism, incidence, and risk factors of this adverse effect, culminating in their withdrawal from the market. (ajhp.org)
  • Effects of dexfenfluramine on dopamine dependent behaviours in rats. (bvsalud.org)
  • We also investigated whether dexfenfluramine induces catalepsy in rats . (bvsalud.org)
  • Diet-induced obese (DIO) and age-matched lean rats were treated for 12 days with MTEP (3 or 10 mg/kg/day s.c.), dexfenfluramine (3 mg/kg/day s.c.), or vehicle. (aspetjournals.org)
  • Daily and cumulative food intakes were reduced in DIO rats by MTEP and dexfenfluramine. (aspetjournals.org)
  • Dexfenfluramine at 2.5, 5 and 10 mg/kg ip did not induce catalepsy and did not antagonise apomorphine stereotypy. (bvsalud.org)
  • 1. Studies were designed to investigate the responses of isolated pulmonary arteries from control pigs or pigs chronically treated with dexfenfluramine (7.2 mg/kg per day orally for 4 weeks). (nih.gov)
  • Fenfluramine and dexfenfluramine are appetite suppressants that were in widespread use in the United States. (cdc.gov)
  • 1 2 Another appetite suppressant, fenfluramine, and its d -isomer, dexfenfluramine (a phenyl-ethylamine derivative), have also been linked in case reports to the development of pulmonary hypertension. (ahajournals.org)
  • We accepted studies involving obese patients treated with any of the following appetite suppressants: fenfluramine, dexfenfluramine, and phentermine. (springer.com)
  • Between 1994 and 1997, American Home Products Corporation, now Wyeth, marketed and sold fenfluramine and dexfenfluramine, prescription weight loss drugs. (findlaw.com)
  • This litigation involves claims regarding the health effects of two related prescription drugs--fenfluramine and dexfenfluramine. (settlementdietdrugs.com)
  • Dexfenfluramine was, for some years in the mid-1990s, approved by the United States Food and Drug Administration for the purposes of weight loss. (wikipedia.org)
  • Hence, we wanted to investigate the effects of dexfenfluramine, which has been newly introduced as an anorexigenic drug in Turkey, on mean pulmonary artery pressures. (cumhuriyet.edu.tr)
  • In addition, dexfenfluramine had been marketed in Europe for over 10 years without displaying a link between the drug and heart valve problems. (mit.edu)
  • Since the initial case report by Bennett and Eltringham however, there have been no further reports of adverse events related to a anesthetic interaction with either fenfluramine or dexfenfluramine and unfortunately no definitive drug interaction studies have been conducted. (ispub.com)
  • The drug in question was dexfenfluramine, which was removed from the commercial market 18 months after its subsequent U.S. Food and Drug Administration approval owing to the development of valvular heart disease and primary pulmonary hypertension in a subset of patients ( 3 , 4 ). (diabetesjournals.org)
  • 3. Dexfenfluramine (10[-9] to 10[-6] M) did not affect vascular tone, but at higher concentrations caused contractions that were not affected by indomethacin, methiothepin, the presence of endothelium or by the chronic treatment. (nih.gov)
  • Seven percent of the 1159 patients who received dexfenfluramine in double-blind, placebo-controlled clinical trials discontinued treatment because of an adverse event. (edu.sy)
  • The following Table 3 lists treatment-emergent adverse events from several double-blind, placebo-controlled trials that occurred at a frequency of 2% or more among patients treated with dexfenfluramine and occurred at least as frequently as the placebo group, regardless of relationship to study medication. (edu.sy)
  • In early September, FDA received echocardiographic reports from five independent, unpublished echocardiographic prevalence surveys of patients who had received dexfenfluramine or fenfluramine alone or in combination with phentermine ( Table_1 ). (cdc.gov)
  • Subsequently, reports of fenfluramine- or dexfenfluramine-associated valvulopathy increased. (cdc.gov)
  • Unlike fenfluramine however, dexfenfluramine is not contraindicated in patients undergoing anesthesia. (ispub.com)
  • Since MITowns the patent on dexfenfluramine, the Institute received royalties, typically one to five percent of sales. (mit.edu)
  • When it occurs, the onset typically complain of being fenfluramine or dexfenfluramine. (asianave.com)
  • Dexfenfluramine releases 5-HT from brain 5-HTergic neurons . (bvsalud.org)
  • Therefore, in this analysis, a case of fenfluramine- or dexfenfluramine-associated cardiac valvulopathy was defined as documented AR of mild or greater severity and/or MR of moderate or greater severity after exposure to these drugs. (cdc.gov)
  • Dexfenfluramine, the biologically active dextro-rotatory stereoisomer of fenfluramine, has been available in Europe for many years and was recently approved by the FDA in the United States ( 9 ). (ispub.com)
  • 1 By not making this distinction, it appears that all the agents cited by the authors represent a similar risk when used with dexfenfluramine. (jamanetwork.com)