• Scientists are seeking technologies that can streamline and speed proteomics studies to clinical applications, reduce time to market for candidate biotherapeutics and address the growing challenge of characterizing novel chemical entities in small-molecule studies," said Iain Mylchreest, vice president, research and development, analytical instruments, Thermo Fisher Scientific. (selectscience.net)
  • We are honored to receive this distinguished award for two of our latest innovations, recognizing the hard work and dedication of our colleagues," said John Lesica, president, chromatography and mass spectrometry, Thermo Fisher Scientific. (biospace.com)
  • Here, experts will cover topics including applied chromatography-free mass spec, analytical toxicology, PFAS analyses, and imaging of polymeric materials. (labx.com)
  • Also present, the LC-MC-9050 quadrupole time-of-flight (Q-TOF) mass spectrometer brings elevated accuracy with high-precision temperature control and stable polarity switching, allowing users to explore more analytical space and new applications. (labx.com)
  • Both liquid handlers and microfluidics coupled with analytical equipment such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) have been showcased as effective for achieving this goal. (technologynetworks.com)
  • Scientists at the University of Sheffield looked to overcome this hurdle by developing an automated small-scale analytical platform workflow, combining purification and aggregation analysis of protein biopharmaceuticals expressed in 96 deep well plate cell cultures.4 Their workflow utilized a liquid handler equipped with a protein-A PhyTip column for purification and a size-exclusion chromatography (SEC) column for aggregate monitoring. (technologynetworks.com)
  • A next-generation, high-resolution mass spectrometer is designed to give proteomics, metabolomics, biopharmaceutical characterization, and small-molecule scientists the analytical performance required for research and high-throughput analyses. (selectscience.net)
  • Analytical platforms such as mass spectrometry and nuclear magnetic resonance (NMR) have emerged as the dominant platforms enabling the robust detection of numerous metabolites. (metabolon.com)
  • Two analytical workflows, subunit multi-attribute monitoring (MAM) and peptide MAM, have emerged to dominate this discussion, and this article is intended to reflect on the active debates over the needs, challenges, and practical limitations for adopting MS-based attribute monitoring for late-development and QC. (chromatographyonline.com)
  • The Thermo Scientific Orbitrap Exploris MX Mass Detector was also a recipient of an R&D 100 Award in the Analytical/Test category . (biospace.com)
  • Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. (biospace.com)
  • Additionally, many of the thermal analysis methods covered below can be coupled with other analytical techniques such as gas chromatography, mass spectrometry, or microscopy in order to provide more accurate results. (excedr.com)
  • In 2015, I finished my PhD research, which was titled "The influence of the sample matrix on LC-MS/MS method development and analytical performance. (neoteryx.com)
  • It seems your team at PRA Health Sciences is focused primarily on providing analytical services for early drug development. (neoteryx.com)
  • Definitive (level 1) identification requires comparing the two or more orthogonal properties such as retention time, m/z, and fragmentation mass spectrum for the metabolite of interest to the same properties of an authentic chemical standard observed under identical analytical conditions. (creative-proteomics.com)
  • While new technologies enable the engineering of high titer cell clones, there is still a need to screen these clones quickly.1 The current paradigm for titer analysis depends on chromatographic approaches which, even with the newest ultra-high-performance liquid chromatography (UHPLC) models, will take minutes to analyze one cell line. (technologynetworks.com)
  • However, despite the impact of ultra-high-performance liquid chromatography (UHPLC),[5-7] such detection techniques are limited in terms of specificity - often resulting in extensive sample cycle times and poor sensitivity, as many compounds lack natural chromophores or fluorophores. (shimadzu-webapp.eu)
  • Annual user meetings include "The future of mass spectrometry plenary panel," where leaders will share their vision for the future and how novel technologies will have the greatest impact on biological insight. (labx.com)
  • The Vanquish Flex system offers flexibility with binary or quaternary solvent blending options providing the most advanced performance to accomplish all applications from method development to routine analysis with HPLC to UHPLC capabilities. (thermofisher.com)
  • Agilent's InfinityLab LC/MSD iQ System for chemists and chromatographers in the company's liquid chromatography-mass spectrometry (LC/MS) portfolio features incorporated instrument health monitoring and is designed to sit beneath a stack of Agilent's InfinityLab HPLC instruments, saving lab space (1). (biopharminternational.com)
  • The most comprehensive metabolite coverage is typically accomplished by leveraging a non-targeted approach using high-performance liquid chromatography (HPLC) coupled with high-resolution accurate mass (HRAM) mass spectrometry, commonly referred to as HPLC-MS, or LC-MS. LC-MS is capable of routine detection of thousands of unique chemical compounds, providing broad coverage of biologically relevant metabolites. (metabolon.com)
  • High-throughput sequencing technologies, next-generation sequencing, and mass spectrometry have revolutionized genomics and proteomics research, leading to increased adoption of related tools. (globenewswire.com)
  • Integrate and streamline high throughput experimentation (HTE) from design to decision. (acdlabs.com)
  • This article highlights a time-saving, complete and fully compliant high-throughput solution for immunosuppressant analysis - created by a combination of liquid chromatography and tandem mass spectrometry (LC-MS/MS) with automated sample preparation and a dedicated reagent kit. (shimadzu-webapp.eu)
  • Tatiana Didenko of Amgen provides an overview of how Amgen analysts use ACD/Labs software to support high-throughput NMR workflows in compound library generation within Discovery. (acdlabs.com)
  • Since joining GSK in 2005, she has held roles of increasing responsibility in a variety of small molecule discovery platform groups, leading teams to deliver high-throughput screening, lead optimisation profiling, assay development and mechanistic biology studies. (labbulletin.com)
  • Melanie has led numerous technology and capability development collaborations, particularly in the application of high-throughput mass spectrometry techniques for screening and compound profiling, a topic on which she has published a number of peer-reviewed articles. (labbulletin.com)
  • With new capabilities for multiplexed quantitative proteomics and native protein characterization, the Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. (thermofisher.com)
  • And as the sensitivity of mass spectrometers has improved, researchers have realized that they can finally achieve single-cell proteomics. (acs.org)
  • Improved detection, versatility, and sensitivity for protein complex subunit analysis and biopharmaceutical characterization with an extended optional mass range up to m/z 16,000. (thermofisher.com)
  • Going beyond the territory we witnessed in 2022, this year's event promises to bring a fresh horizon of innovations and new products-including many in the realm of complex discovery and data deconvolution as well as advances in biotherapeutics characterization and development. (labx.com)
  • We develop and use liquid chromatography-mass spectrometry-based (LC-MS) methods for in-depth characterization and quantification of complex lipids ( lipidome ), polar metabolites ( metabolome ), various exogenous compounds such as food components and drugs ( exposome ), and proteins ( proteome ). (cas.cz)
  • A recent review by the FDA states that the use of mass spectrometry (MS) technologies detailing the characterization of biotherapeutic proteins in regulatory submissions has continued to grow and diversify over the last decade (1). (chromatographyonline.com)
  • The improvements in both capabilities and robustness of liquid chromatography-mass spectrometry (LC-MS) technology for biopharmaceutical analysis has led to its expanding role beyond product characterization in early development, to the monitoring of product and process attributes in late development, manufacturing, and quality control (QC) (2). (chromatographyonline.com)
  • Our enterprise technologies enable automation of molecular characterization, product development, and facilitate chemically intelligent knowledge management, data analytics, and collaboration - within organizations and between partners. (labmate-online.com)
  • Identifying and quantitating unknown emerging contaminants relies on gas chromatography (GC) or liquid chromatography (LC) coupled to high-resolution mass, accurate-mass (HRAM) mass spectrometry. (thermofisher.com)
  • The mass spectrometer was recognized for its ability to offer high resolution accurate mass (HRAM) data for intact analysis of monoclonal antibodies, oligonucleotide mass determination and peptide mapping in drug discovery applications. (biospace.com)
  • WASHINGTON, Sept. 22, 2023 (GLOBE NEWSWIRE) -- As per Vantage Market Research, the Life Sciences Tools market has witnessed significant growth in recent years due to technological advancements and increasing investments in research and development activities. (globenewswire.com)
  • The NJ Mass Spectrometry Discussion Group is pleased to announce the return of our Fall 2023 Annual Vendor Show and Symposium, after our pandemic hiatus. (njacs.org)
  • Achieve the maximum level of confidence in your high-resolution mass spectrometry results for both screening and quantitation using the Thermo Scientific Orbitrap Exploris120 mass spectrometer. (thermofisher.com)
  • Bruker will explore rapidly emerging technologies in the realm of chromatography-free workflows, among other advances. (labx.com)
  • This collaboration includes a non-exclusive joint development of expertise that will provide easy access to medium throughput testing without a decrease in data quality. (hamiltoncompany.com)
  • Automation of all or part of the sample preparation workflow is an attractive solution, allowing significantly higher throughput without increasing staffing levels. (drugdiscoverynews.com)
  • Mass spectrometry (MS-) based attribute monitoring assays have been proposed as key tools to provide the sensitivity, throughput, selectivity, and flexibility required for monitoring critical product and process attributes for biopharmaceutical production and release. (chromatographyonline.com)
  • Double your throughput, deepen your sample knowledge and better utilize your bench space with the Vanquish Duo for Dual LC workflow, a two channel LC, for improved return on investment. (appswebdevelopment.com)
  • Increase your lab's throughput and return on investment with the Vanquish Duo for Tandem LC or LC-MS workflow, an instrument for offline column regeneration, to efficiently use your detector or mass spectrometer and maximize the output. (appswebdevelopment.com)
  • With source architecture shared across all next-generation mass spectrometers, accessing the improvements from the Thermo Scientific Orbitrap Tribrid platform enables increased sensitivity, robustness, minimal optimization and maintenance, and the ability to rapidly switch between sources. (thermofisher.com)
  • Agilent is planning to showcase innovative products and comprehensive workflow solutions designed to increase data quality and streamline productivity. (labx.com)
  • The new AdvanceBio Sialic Acid profiling and quantitation kit from Agilent provides workflows for the robust and rapid preparation of samples for sialic acid analysis, generating reliable downstream LC-FLD and LC-MS data. (drugtargetreview.com)
  • Shimadzu is planning to "kick some mass" with breakfast seminars covering topics such as resource-efficient MALDI MSI, setting up a core facility to enable diverse use workflows, LC, superficial chromatography (SFC), and vacuum differential mobility MS for complex sample analysis, including isomeric and isobaric compound separations. (labx.com)
  • Coupling liquid chromatography to mass spectrometry (LC-MS) is the preferred technique in metabolomics and lipidomics, permitting effective compound separations and detection. (cas.cz)
  • In her current role Melanie leads UK Assay Development and Compound Profiling capabilities, as well as the global Compound Management teams. (labbulletin.com)
  • Dr. Timothy Garrett, associate professor, department of pathology, immunology and laboratory medicine, co-director of the Southeast Center for Integrated Metabolomics, University of Florida, said, "Using the Orbitrap Exploris 240 mass spectrometer has been extremely user friendly, with one-click calibration and method templates for fast instrument setup. (selectscience.net)
  • Our research involves applying mass spectrometry-based techniques to perform metabolomics, lipidomic and proteomic analysis of various biological samples. (cas.cz)
  • Over the last decade, mass spectrometry-based metabolomics and lipidomics have become the key platforms for the comprehensive profiling of polar metabolites and complex lipids in biological samples (plasma, serum, urine, and tissues). (cas.cz)
  • In this MetaboAnalystR 4.0, an unified metabolomics analysis workflow from LC-MS/MS raw spectral processing to a more accurate functional interpretation has been established. (metaboanalyst.ca)
  • The version 4 aims to improve the current global metabolomics workflow by implementing an unified LC-MS/MS workflow from global metabolomics data into functional insights. (metaboanalyst.ca)
  • The Orbitrap Exploris MX Mass Detector is a part of a multi-attribute method (MAM) workflow that is designed for efficient, scalable production, to enable drug safety and to accelerate drug approval so that new drugs become available to patients faster. (biospace.com)
  • Agilent's AdvanceBio Sialic Acid profiling and quantitation kit provides everything you need to confidently identify and quantitate sialic acid species that may be critical quality or product quality attributes (CQAs or PQAs) of glycosylated biopharmaceuticals, and generate downstream liquid chromatography‑fluorescence detector (LC-FLD) or liquid chromatography-mass spectrometry (LC-MS) data you can trust. (drugtargetreview.com)
  • Seamlessly integrate with a mass spectrometry or other detector. (appswebdevelopment.com)
  • Method development and optimization for expert chromatographers. (acdlabs.com)
  • As part of our expanded portfolio of new-generation instruments, the Orbitrap Exploris 240 mass spectrometer delivers the high performance and versatility needed to drive productivity across multiple applications. (selectscience.net)
  • Chromatography labs can now eliminate complexity, increase productivity, and gain certainty with Agilent's new LC/MS which delivers an additional level of detail, ease-of-use, in a space-saving design, and with intelligence built-in," said Monty Benefiel, vice-president, and general manager of Agilent's Mass Spectrometry Division, in a press release. (biopharminternational.com)
  • Drug development and QC organizations have also been driven by the desire for increased process understanding, enhanced product quality, and a desire to achieve gains in organizational productivity. (chromatographyonline.com)
  • These workflows improve your productivity by saving time, reducing cost per sample, increasing capacity without added bench, and using your resources more efficiently. (appswebdevelopment.com)
  • Modern Mass Spectrometers and the Correlation Coefficient - Are They Compatible? (envirosymposium.group)
  • Many do not have expensive mass spectrometers in their labs or mass spec teams on staff to handle these specialized analyses. (biopharminternational.com)
  • Various methods of MFA, including isotopically stationary metabolic flux analysis, isotopically non-stationary metabolic flux analysis, and thermodynamics-based metabolic flux analysis, can be coupled with stoichiometric models of metabolism and mass spectrometry methods with isotopic mass resolution to elucidate the transfer of moieties containing isotopic tracers from one metabolite into another and derive information about the metabolic network. (wikipedia.org)
  • Nuclear magnetic resonance (NMR) techniques and mass spectrometry may then be used to measure metabolite labeling patterns to provide information for determination of pathway fluxes. (wikipedia.org)
  • What's more, since single metabolites can be detected in a mass spectrometer as various derived species, it is important to assign the various derived species to the parent metabolite correctly. (creative-proteomics.com)
  • Or characterize the largest biopharmaceuticals with optional mass range up to m/z 16,000. (thermofisher.com)
  • Multiple fragmentation techniques - CID and HCD with optional UVPD, ETD, PCTR - are available at any stage of MS, with subsequent mass analysis in either the ion trap or ultra-high resolution Orbitrap mass analyzer. (thermofisher.com)
  • Breakfast sessions will range from comprehensive food safety analysis to PFAS to targeted and untargeted workflow discussions. (labx.com)
  • The combination of DART (direct analysis in real-time) ionization and Bruker mass spectrometry technologies allows sample preparation to be sped up significantly, leading to more efficient and economical workflows. (labx.com)
  • The Life Sciences Tools market refers to the need for the instruments, equipment, and software used in research, analysis, and development in the field of life sciences. (globenewswire.com)
  • Thermo Scientific products and technologies provide effective tools and workflows for screening and quantifying known and unknown contaminants from sample preparation to analyte separation, detection and innovative data analysis software. (thermofisher.com)
  • Some known emerging contaminants can be detected and quantitated using single- or triple-quadrupole mass spectrometry (MS) in targeted analysis. (thermofisher.com)
  • Cygnus stated in a press release that its proprietary antibody affinity extraction (AAE) sample preparation method can be combined with mass spectrometry (MS) for this type of analysis. (biopharminternational.com)
  • Life-cycle analysis tools should be used to optimize the provision and use of natural or electrical light, power, nutrients and infrastructure in CEA and/or SpaCEA systems, and to guide research and development into subsystems that bring strong environmental advantages. (bvsalud.org)
  • Conducted by thermogravimetric analyzers, thermogravimetric analysis (TG) continuously measures the mass of a sample's temperature changes over time. (excedr.com)
  • The result of such an analysis is a plot of mass as a function of either time or temperature. (excedr.com)
  • Both maintenance- and set up-free, EASY-IC technique ensures complete confidence with sub-ppm mass accuracy day after day, allowing smaller extraction windows or tolerances to be used for your quantitative and qualitative data analysis, streamlining data decisions - especially when combined with the exceptional resolving power of the Orbitrap Exploris 240 MS. (thermofisher.com)
  • Commentary: Automation-The answer to tedious manual sample preparation for mass spectrometry? (drugdiscoverynews.com)
  • Indeed, several manufacturers now offer complete, end-to-end automation of MS workflows-from initial sample handling through to injection into the MS instrument-but is this "closed box" approach practical, and is it really the best solution for your laboratory? (drugdiscoverynews.com)
  • In such a highly regulated industry, few companies are willing to abandon existing workflows and move to an entirely new sample preparation strategy, due to the cost of revalidation and risks involved. (drugdiscoverynews.com)
  • A far better solution-at least in the short term-is to use open automation solutions which can be tailored to current workflows, allowing laboratories to retain their existing sample preparation pathways and chemistries while removing many of the hands-on tasks and associated risks of human error. (drugdiscoverynews.com)
  • By offering open architecture automation solutions which allow laboratories to keep their existing workflows while still benefiting from the increased process security and reproducibility offered by automation, equipment manufacturers can help to bridge the gap between sample processing and MS instrument speed. (drugdiscoverynews.com)
  • During early-stage development, identifying aggregation in scale-down cell culture systems can be tedious, as the small sample volumes make aggregate detection challenging. (technologynetworks.com)
  • The system offers positive/negative mode switching for comprehensive sample coverage, fast scan speeds and functionalities including Thermo Scientific AcquireX intelligent data acquisition workflow that enable greater automation. (selectscience.net)
  • The system reproducibility in mass accuracy and peak integrated area over several sample batches and several days of acquisition has been impressive. (selectscience.net)
  • The Micro-ESI 9030 detects components by optimizing the ESI probe position in relation to the sample injection port for low flow rates, maintaining microflow chromatography throughout the ion introduction process to the mass spectrometer. (biopharminternational.com)
  • The solution combines liquid chromatography and tandem mass spectrometry (LC-MS/MS) with automated sample preparation and a dedicated reagent kit. (shimadzu-webapp.eu)
  • CMC decision-support software to manage process development data, impurity data, stability data, formulations studies, and track batches of API and drug product. (acdlabs.com)
  • Proper validation is central to any drug development program because it supports data reliability, assay performance and preparation for pharmacokinetic and toxicokinetic studies. (wuxiapptec.com)
  • Hear how Katalyst D2D software has enabled GSK to streamline HTE design and execution and more efficiently capture high-quality data from these experiments. (acdlabs.com)
  • Meet the Orbitrap Exploris 240 mass spectrometer: leading performance, application versatility and intelligent data acquisition enable exceptional data quality that is synonymous with Thermo Scientific Orbitrap technology. (thermofisher.com)
  • Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, such as sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing. (thermofisher.com)
  • Save time spent on user training with Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) wizards for the use with Vanquish Duo Systems. (appswebdevelopment.com)
  • Eureka Lab Division provides the widest range of Chromatography and Mass Spectrometry IVD kits, calibrators, and controls for clinical diagnostics & pharmacology, forensic & occupational toxicology applications on the market. (hamiltoncompany.com)
  • Eureka Lab Division develops, manufactures, and commercializes a comprehensive range of Chromatography and Mass Spectrometry IVD solutions targeted to the clinical, forensic and occupational health market. (hamiltoncompany.com)
  • Mass spectrometry (MS) technology has advanced extremely rapidly over the last decade, with MS techniques now being widely used in life science research, and even finding their way into the clinical setting for diagnostic applications. (drugdiscoverynews.com)
  • Today, AI is being practically used in not only clinical diagnostic laboratories but also clinical research labs, life science labs, and research and development (R&D) labs, and more. (limswiki.org)
  • SCIEX Diagnostics, the in vitro diagnostics division of SCIEX, a global leader in mass spectrometry in the life sciences industry, announced today the launch of the first fully integrated LC-MS system for clinical diagnostics, the SCIEX Topaz System. (mass-spec-capital.com)
  • SCIEX set out with the goal to making mass spectrometry simple for clinical labs, and the outcome is the first integrated LC-MS-based IVD system that is open by design and closed when you need it, said Dr. Aaron Hudson, Sr. Director and GM of SCIEX Diagnostics. (mass-spec-capital.com)
  • The Mobius ® Bioreactor family includes the bench scale (2 mL and 3 L), pilot, clinical and commercial manufacturing (50 - 2,000 L) single-use bioreactors that enable cell culturing capabilities from early process development through commercial batch production. (sigmaaldrich.com)
  • We are a global healthcare partner where we help to develop life-saving and life-improving drugs with our comprehensive clinical development services. (neoteryx.com)
  • These challenges are tackled with technological innovation meant to streamline and optimize the production pipeline. (technologynetworks.com)
  • The InfinityLab LC/MSD iQ System is the simplest and quickest path to robust, reliable, and routine mass-based detection. (biopharminternational.com)
  • Mass spectrometry (MS) is now regarded as a key technique for laboratories delivering robust platforms with highly selective and sensitive detection. (shimadzu-webapp.eu)
  • Therefore, it is critical to ensure the bioanalytical techniques, methods and workflows used to determine concentration levels are robust and universally accepted. (wuxiapptec.com)
  • A method development case study detailing decision steps that resulted in a robust and efficient method reached with the assistance of AutoChrom. (acdlabs.com)
  • Robust ion trapping for MS scans and higher energy collisional dissociation (HCD) MS/MS within the Ion-routing multipole (IRM) combines with reliable Automatic Gain Control (AGC) measurements for controlled injection of the number of ions into the fast-scanning, high-field Orbitrap mass analyzer for premium workhorse quantitative and qualitative performance. (thermofisher.com)
  • The kit produces results 24-times faster than enzyme-linked immunosorbent assay (ELISA), according to the company, which can accelerate lentivirus bioprocess workflows. (biopharminternational.com)
  • Concentrations of metabolites and labeled isotope in metabolites of the extracts are measured by instruments like liquid chromatography-mass spectrometry or NMR, which also provide information on the position and number of labeled atoms on the metabolites. (wikipedia.org)
  • Liquid chromatography (LC) techniques using ultra-violet (UV), photo diode array (PDA) and fluorescent detection (FLD) systems have been used in TDM for several decades. (shimadzu-webapp.eu)
  • Endogenous quantification is a complex process that uses liquid chromatography-mass spectrometry (LC-MS) to analyze biological systems in the disease state and understand how drugs impact them. (wuxiapptec.com)
  • Simplify Your Liquid Handling Workflows with Automat. (labmate-online.com)
  • Automation of solid phase extraction (SPE) is a good example of how freely configurable robotic systems can be used to streamline laboratory processes without having to start from scratch. (drugdiscoverynews.com)
  • Furthermore, many TA instruments now offer automation features which help streamline workflows and allow for researchers to focus on other priorities while analyses are performed. (excedr.com)
  • We provide worldwide sales and support, and bring more than 25 years of experience and success helping organizations innovate and create efficiencies in their workflows. (labmate-online.com)
  • In this presentation, we will discuss the development of in situ/vivo approaches by cellular and subcellular mass spectrometry that enabled our lab to determine the proteomic and metabolomic profile of identified cells in live Xenopus laevis frog embryos developing to tadpoles and neurons in mouse brain tissues. (njacs.org)
  • Demonstration of m/z 16,000 mass range on purified GroEL 800 kDa protein on a single Orbitrap scan at 7500 resolution at m/z 200. (thermofisher.com)
  • Molecular measurements using capillary electrophoresis time-of-flight or orbitrap mass spectrometer platforms revealed proteomic and metabolomic differences between the X. laevis cells that correlated with phenotype. (njacs.org)
  • The Thermo Scientific Orbitrap Exploris 240 mass spectrometer expands the proven Orbitrap Exploris platform and delivers mass accuracy, sensitivity and resolving power across a wide dynamic range. (selectscience.net)
  • Deliver on your objectives with the Thermo Scientific Orbitrap Exploris 240 mass spectrometer by combining application flexibility with the performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. (thermofisher.com)
  • Built on the guiding principles of operational simplicity and reliability, the Orbitrap Exploris 240 MS combines more than 20 years of know-how with high-resolution capability and exceptional and consistent mass accuracy, empowering all users to fast-track their science. (thermofisher.com)
  • We used feedback from customers and service engineers on the Thermo Scientific Orbitrap Exploris 480 mass spectrometer to design a new system from the ground up to deliver the improved reliability and the exceptional performance you expect from Orbitrap mass analyzer technology. (thermofisher.com)
  • Following that mandate, many biopharmaceutical companies began to invest in MS technologies for monitoring both product and process quality attributes in upstream and downstream development, and even for QC lot release applications. (chromatographyonline.com)
  • It is the first automated discrete analyzer designed specifically for enzyme assay applications, streamlining workflows for industrial enzyme manufacturers and enzyme users in the food, beverage, biopharmaceutical, fuel ethanol and chemical, and solid waste management industries. (biospace.com)
  • A significant lack of quantitative knowledge regarding non-Cytochrome P450 (non-CYP) enzymes and transporters in human is the major limitation towards building PBPK models in the drug development which often results inaccurate in vitro to in vivo extrapolation (IVIVE) and poor prediction of interindividual variability of drug metabolism. (njacs.org)
  • Uncharacterized sub-cellular localization of some non-CYP enzymes is another knowledge gap with respect to the development of quantitatively viable in vitro and in silico models. (njacs.org)
  • 8] The capability of MS in the development of assays for individual drugs ("laboratory‐developed tests" - LDTs - or "in‐house" assays) and in multiplexing analyte panels creates new opportunities while expanding the number of drug assays. (shimadzu-webapp.eu)
  • The limitation has been a lack of sufficiently sensitive mass spectrometry technologies that can measure these biomolecules with compatibility for live development, a prerequisite for functional biology. (njacs.org)
  • Our customers in the cell and gene therapy market value the workflow efficiency enabled by Gyrolab solutions, and we look forward to further supporting their efforts to develop the breakthrough therapies they are producing," said Dan Calvo, CEO and president, Gyros Protein Technologies, in a press release. (biopharminternational.com)
  • The new system promises to help drive discovery and identification, with increased accuracy for confident scale-up, while operational simplicity and speed streamline time to results. (selectscience.net)
  • We designed the Startup Hub to give emerging biotech startup companies one central location to access all the resources needed to kickstart and streamline your journey from discovery to manufacturing, from funding and protecting intellectual property to complying with global regulations. (sigmaaldrich.com)
  • Use project-management workflows to define a strategy and implement it with direct instrument control. (acdlabs.com)
  • The heart of the system lies within the innovative ClearCore MD software, a platform which simplifies and streamlines workflows and method development and incorporates features that enhance usability to help new users build proficiency quickly. (mass-spec-capital.com)
  • The innovative ClearCore MD software simplifies and streamlines workflows and method development, bringing the power of SCIEX LC-MS technology to the hands of the routine user. (mass-spec-capital.com)
  • Retention Modeling: Simplifying & Accelerating Method Development for Sm. (labmate-online.com)
  • My research interests and the method development work eventually led to a PhD project, which I worked on in addition to my daily work as a research analyst. (neoteryx.com)
  • In 2019, I accepted my current role of Associate Director of Bioanalytical Science and, as such, I'm responsible for method development of mass spectrometry methods in our laboratory in The Netherlands. (neoteryx.com)
  • With ultra high resolution capability, the Exploris 120 MS eliminates concerns over false positives or negatives by eliminating matrix interferences and delivering high mass accuracy to generate only reliable results. (thermofisher.com)
  • A toolset for rapid, reliable development of LC and GC methods. (acdlabs.com)
  • Asynt, a renowned provider of laboratory equipment, has collaborated with Almac Sciences, a leading specialist in API development and manufacturing, to design and supply a range of bespoke reactor vessels. (labbulletin.com)
  • A strong and vibrant research and development function is the lifeblood of all industries. (vwr.com)
  • A strong, vibrant research and development group is the lifeblood of all industries. (vwr.com)
  • Bio-Rad Laboratories, Inc has launched EconoFit Low-Pressure Prepacked Chromatography Column Packs to support resin screening experiments in the development of protein purification workflows. (labmate-online.com)
  • Metabolites of different nominal mass, metabolites with the same nominal mass but of different molecular formula and monoisotopic mass, and metabolites of the same nominal and monoisotopic masses but with different chemical structures should be discriminated. (creative-proteomics.com)
  • Intuitive, workflow-driven software supports out of the box applications and ease regardless of user or technical skill level. (thermofisher.com)
  • This article will focus on the developments in the use of MS for biopharmaceutical development, manufacturing, and QC, and discuss some of the key pieces that must fall into place before MS-based methodologies can be more widely adopted within regulated (GxP) laboratories. (chromatographyonline.com)
  • Increasing research and development (R&D) activities: The Life Sciences Tools market is influenced by the level of R&D activities in the pharmaceutical, biotechnology, and academic research sectors. (globenewswire.com)
  • Dr. Aron Gyorgypal is a postdoctoral research fellow at Harvard Medical School and Massachusetts General Hospital in Boston, Massachusetts. (technologynetworks.com)
  • Avantor is now supporting customers active in research & development, production and recycling of advanced batteries. (vwr.com)