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  • graft-versus-
  • In vivo examination of the effects of anti-4-1BB monoclonal antibodies (mAbs) on antigen-induced T cell activation have shown that the administration of epitope-specific anti-4-1BB mAbs amplified the generation of H-2 d -specific cytotoxic T cells in a murine model of acute graft versus host disease (GVHD) and enhanced the rapidity of cardiac allograft or skin transplant rejection in mice. (rupress.org)
  • In the classical sense, acute graft-versus-host-disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (wikipedia.org)
  • Graft-versus-host-disease-associated oral cancer may have more aggressive behavior with poorer prognosis, when compared to oral cancer in non-hematopoietic stem cell transplantation patients. (wikipedia.org)
  • malignancies
  • Not only does cutaneous malignancy occur more often in the setting of lymphoid malignancies, these skin cancers have a tendency toward a more aggressive nature, with higher recurrence rates and increased metastatic potential, especially with squamous cell carcinoma and malignant melanoma. (springer.com)
  • Patients with lymphoid malignancies should sun protect on a regular basis, see a dermatologist for regular skin examinations, perform self-skin examinations, and receive education regarding skin cancer. (springer.com)
  • When skin cancers occur in patients with lymphoid malignancies, a prompt treatment strategy in a multi-collaborative nature when necessary should be undertaken to provide the lowest chance of recurrence and bad outcomes. (springer.com)
  • hairs
  • This gives me confidence that we can achieve ambitious goals such as the treatment of wound healing disorders and, longer term, perhaps also the regeneration of tissues, including for example the skin with its hairs and nails or the cornea, without leaving scars. (medicalxpress.com)
  • Since hair naturally grows in follicles in groups of 1 to 4 hairs, transplantation takes advantage of these naturally occurring follicular units. (wikipedia.org)
  • lesions
  • EV is characterized by refractory, disseminated skin lesions resembling flat warts, or presenting as macules of various colors. (springer.com)
  • patients
  • Avermaete A, Altmeyer P, Bacharach-Buhles M. Skin changes in dyalisis patients: a review. (springer.com)
  • The potential target group for skin transplantation as a result of hard-to-heal leg and foot ulcers in Sweden is estimated to be approximately 2 000 patients per year. (sbu.se)
  • PURPOSE: Randomized clinical trial to study the effectiveness of acitretin in preventing skin cancers in patients with at least two previously treated skin cancers who have undergone organ transplantation. (clinicaltrials.gov)
  • Evaluate human papillomavirus (HPV) as a possible etiologic cofactor in the development of cutaneous epidermal dysplasia/carcinoma from skin tissues of these patients. (clinicaltrials.gov)
  • This has been suggested by the parental consanguinity and the sibling involvement observed in some cases, the impaired cell-mediated immunity reported in most patients, and the usual localization of skin cancers in light-exposed areas. (springer.com)
  • These patients often suffer from non-healing skin ulcers , which can be painful, produce an unpleasant smell, and lead to functional impairment. (medicalxpress.com)
  • Skin ulcers are a major health problem that significantly reduces the quality of life and the life expectancy of patients. (medicalxpress.com)
  • No systemic in vivo cytogenetic analysis of irradiated skin fibroblasts has been performed in patients. (biomedcentral.com)
  • A variety of charitable hospitals opened in Birmingham between 1817, when the Orthopaedic Hospital opened, and 1881, when the Skin Hospital served its first patients. (wikipedia.org)
  • vivo
  • We are planning to use those CD4^+CD25^+ T cells generated ex vivo in skin transplantation model to examine whether transfer of those cells can prevent graft rejection. (nii.ac.jp)
  • Diseases
  • Andrews' Diseases of the Skin: Clinical Dermatology. (wikipedia.org)
  • Synthetic pharmaceutical drugs with corticosteroid-like effects are used in a variety of conditions, ranging from brain tumors to skin diseases. (wikipedia.org)
  • However, several billion cells are required to use for transplantation in order to treat and fight diseases. (wikipedia.org)
  • It is used in the treatment of autoimmune diseases (for example rheumatoid arthritis or Behcet's Disease) and in transplantations. (wikipedia.org)
  • inflammation
  • Some animals clearing leukemic cells died of a secondary "wasting disease" consisting of diarrhea, weight loss, skin inflammation, and liver disease. (hindawi.com)
  • vascular
  • Organs that have been successfully printed and implemented in a clinical setting are either flat, such as skin, vascular, such as blood vessels, or hollow, such as the bladder. (wikipedia.org)
  • stem cells
  • But even after just one year, the team has made many important findings, for example in the field of transplantation of skin grown in the laboratory and the characterisation of stem cells that aid the wound healing process. (medicalxpress.com)
  • Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. (wikipedia.org)
  • ulcers
  • In order to develop efficient strategies to combat skin ulcers and hypertrophic scars, we need a better understanding of the mechanisms underlying these wound healing disorders. (medicalxpress.com)
  • NMSC
  • In multivariate analysis, only skin type and total sun burden were independently related to NMSC. (cun.es)
  • In conclusion, risk of posttransplant NMSC may be estimated combining skin type and an easy estimation of total sun burden. (cun.es)
  • GVHD
  • Biomarkers can be used to identify specific causes of GvHD, such as elafin in the skin. (wikipedia.org)
  • Skin GvHD results in a diffuse red maculopapular rash, sometimes in a lacy pattern. (wikipedia.org)
  • patient
  • In FUT, a strip of skin containing many follicular units is extracted from the patient and dissected under a stereoscopic microscope. (wikipedia.org)
  • blood
  • The Xenopus tadpole regenerates its tail, restoring nerve, muscle, skin and blood vessel components ( Deuchar, 1975 ). (biologists.org)