Hill, AB 2018, ' The immune response to CMV infection and vaccination in mice, monkeys and humans: recent developments ', Current Opinion in Virology , vol. 28, pp. 161-166. (elsevierpure.com)
10. Persistent infection drives the development of CD8+ T cells specific for late lytic infection antigens in lymphocryptovirus-infected macaques and Epstein-Barr virus-infected humans. (nih.gov)
16. Rhesus lymphocryptovirus infection during the progression of SAIDS and SAIDS-associated lymphoma in the rhesus macaque. (nih.gov)
Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future. (ox.ac.uk)
The hyperinflammation, either during an active COVID-19 infection, or in the case of MIS-C/PIMS, weeks after the COVID-19 infection may cause symptoms similar to the cytokine storms some adults get with COVID, but at this time, it has not been connected to any systemic autoinflammatory diseases (SAIDs). (saidsupport.org)
Timing of the development of MIS-C/PIMS seems to happen after a COVID-19 infection when antibodies to the virus are developing. (saidsupport.org)
Rhesus2
The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV. (elsevierpure.com)
2. Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques. (nih.gov)
Antiviral1
Infectious disease, in turn, continues to be a major health concern and leading cause of morbidity and mortality worldwide, despite major advances in our understanding of the immune system, improvements in sanitation practices, and use of antibiotics, vaccines, and antiviral drugs. (nih.gov)
Humans1
The AIDS epidemic thrust these centers into the limelight because of the search for an animal model for AIDS in humans and because of an outbreak of disease with varying manifestations, later named Simian AIDS (SAIDS), which occurred at some of these centers in the late 1970s and early 1980s. (nih.gov)
Monkeys1
We comparatively assessed several vaccine vector delivery systems-three formulations of a plasmid DNA vector, the modified vaccinia Ankara (MVA) virus, and a replication incompetent adenovirus type 5 (Ad5) vector-expressing the SIV gag protein for their ability to elicit such immune responses in monkeys. (nih.gov)
Vector1
The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine. (nih.gov)
Models2
This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. (elsevierpure.com)
Dr Gay points out the importance of animal models in basic research, especially in AIDS, not only in understanding the development of the disease but also in the testing of drugs and vaccines. (nih.gov)
Recent1
The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. (ox.ac.uk)
Step1
These carefully selected proteins provide broad coverage of the low abundant plasma proteome, and this is just the first major step in the development of Olink's planned NGS-based library. (drugdiscoverynews.com)