• Subsequently, inadequate regulation of cell proliferation and defective oncogene and/or suppressor gene expression promote the transition from preneoplastic conditions to neoplasia. (medscape.com)
  • Although antibody deficiency is associated with recurrent encapsulated bacteria infections, T-cell disorders or SCID are associated with opportunistic infections with fungi, viruses, or intracellular bacteria. (medscape.com)
  • Diarrhea with failure to thrive in children with SCID is usually related to infections with viruses such as rotaviruses and adenoviruses. (medscape.com)
  • Persistent opportunistic infections with Candida albicans or P jirovecii and viral infections with varicella-zoster virus, CMV, and Epstein-Barr virus are common. (medscape.com)
  • In addition, a careful family history of risk factors for human immunodeficiency virus (HIV) should be obtained to rule out secondary forms of immunodeficiency. (medscape.com)
  • Unrepaired DNA damage can lead to mutation, development of various diseases or cell death (Bartek et al. (springer.com)