Development of vaccines for bacterial. Medical search. Frequent questions

Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens. (frontiersin.org)
Here, we review the many functions of autophagy in bacterial infections with a focus on macrophages, the first line of host defenses, and the replicative niche of numerous pathogens. (frontiersin.org)
Because several bacteria may be implicated in BRD, it is also our objective to use this project as a platform for developing vaccines against additional BRD-associated bacterial pathogens. (genomealberta.ca)
A holistic approach will be integral to tackling the AMR pandemic - how is industry ensuring the development of new tools & which interventions are best suited to our priority pathogens? (terrapinn.com)
Meningitis can be caused by many different pathogens, but the highest global burden is seen with bacterial meningitis. (who.int)
Meningitis can be caused by many different pathogens which include bacteria, viruses, and fungi, but the highest global burden stems from bacterial meningitis. (who.int)
Hence, there is a need for the accelerated development of new agents to treat and prevent infections caused by AMR pathogens ( WHO, 2021 ). (frontiersin.org)
This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
A Drug Target Protein (DTP) Database has been developed having mainly in silico predicted potential drug target proteins and non human homologous genes in bacterial human pathogens. (scialert.net)
Currently 10 bacterial pathogens are considered as initials of the database with their general information (disease caused, common symptoms, available drugs etc). (scialert.net)
Vibrio anguillarum , Flexibacter ovolyticus and atypical Aeromonas salmonicida are the major bacterial pathogens. (int-res.com)
Typical bacterial pathogens that cause CAP include Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis . (medscape.com)
The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)
The goal of the collaboration is to advance the development of existing sub-optimal and novel prototype vaccines against socio-economically important viral and bacterial pathogens of Atlantic salmon, Rainbow trout, Common carp, Sea bass, Sea bream and Turbot. (abdn.ac.uk)
Initiate antibiotics to provide empiric coverage of the most likely bacterial pathogens in the context of the clinical setting. (medscape.com)
Our laboratory is focused on understanding host-pathogen interactions, with emphasis on respiratory pathogens, and to use this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection, especially in this era of increasing antibiotic resistance. (lu.se)
Emerging Bacterial and Mycotic Diseases Newly identified bacterial, mycobacterial, mycotic, and actinomycotic pathogens and known pathogens with unusual patterns of drug resistance constitute the focus of the Emerging Bacterial and Mycotic Diseases Branch. (cdc.gov)
Laboratory sections serve as international resources to identify and characterize bacterial and fungal pathogens. (cdc.gov)

EVX-B3 aims to address a serious global medical issue, targeting a pathogen associated with repeated infections, increasing incidence and often serious medical complications, and for which no vaccines are currently available. (bigcountryhomepage.com)
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. (frontiersin.org)
Bacterial infections kill over 7 million people each year and the development of new and better vaccines will reduce this devastating burden of disease. (birmingham.ac.uk)
The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and development of novel anti-infectives. (frontiersin.org)
The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
The "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) project is part of the European Innovative Medicines Initiative (IMI) Antimicrobial Resistance (AMR) Accelerator. (frontiersin.org)
The goal of the Accelerator is to progress the development of new medicines to treat or even prevent resistant bacterial infections. (frontiersin.org)
It said on Wednesday it is continuing work on a vaccine against E.coli bacterial infections. (theglobeandmail.com)
As a scientist for Emergent BioSolutions, she worked on developing diagnostics, vaccines, and pharmaceuticals for chronic bacterial infections and infectious diseases. (nih.gov)
Turns out the masks cause bacterial infections in the mouth, throat and lungs, leading to worsened cases of Covid and pneumonia. (naturalnews.com)
It is estimated that around a million children less than 5 years old die annually due to invasive infections associated to Streptococcus pneumoniae, even when there are two polysaccharides vaccines in children under 2 years. (univalle.edu.co)
Neutrophils play an essential role in fighting bacterial infections by surrounding and destroying invading bacteria (phagocytosis). (rarediseases.org)
Due to low levels of neutrophils, affected individuals may be more susceptible to recurring bacterial infections that, in some patients, may result in life-threatening complications. (rarediseases.org)
Individuals with congenital forms of severe chronic neutropenia are especially susceptible to various bacterial infections that affect the skin, digestive (gastrointestinal) tract and respiratory system, with the source of bacteria usually from the patient's own skin and gut flora. (rarediseases.org)
Such bacterial infections vary in severity and, in some patients may result in life-threatening complications. (rarediseases.org)
Importantly, patients with congenital neutropenia still have normal immunity to viruses and so are no more susceptible to viral infections than the average person and can receive all immunizations, including live virus vaccines. (rarediseases.org)
Bacterial infections of respiratory and gastrointestinal mucosae : based on a symposium of the SGM held in September 1987 / edited by W. Donachie, E. Griffiths, J. Stephen. (who.int)
2) The direct bactericidal activity of HAMLET, a human milk protein-lipid complex, against various bacterial species as well as its adjuvant activity in sensitizing bacteria to a broad range of common antibiotics to provide novel therapeutic strategies against respiratory and other infections with antibiotic-resistant bacteria. (lu.se)

To develop an effective vaccine, Evaxion has initiated discovery activities for EVX-B3 using both its EDEN™ and RAVEN™ AI platforms to identify protective antigens capable of eliciting both a humoral (antibody) and cellular response to the pathogen. (bigcountryhomepage.com)
EDEN™ is a proprietary AI platform capable of rapidly identifying those antigens that will trigger a robust and highly protective immune response against virtually any bacterial infectious disease. (bigcountryhomepage.com)
Once established, target antigens will be used to develop a vaccine offering cattle protection against M. haemolytica -associated BRD. (genomealberta.ca)
Using genetic engineering, scientists could make viral proteins (antigens) in the lab in bacterial or other cultures. (davidicke.com)
Reconstitution of this pathway enabled the fermentation-free production of Hib vaccine antigens starting from widely available precursors and detailed characterization of the enzymatic machinery. (bvsalud.org)
Antigenic shift refers to the relatively rare development of new combinations of H and/or NA antigens, which result from reassortment of subunits of the viral genome. (msdmanuals.com)

RAVEN™ is a proprietary AI platform that rapidly identifies vaccine candidates against existing, emerging, and mutating viral diseases. (bigcountryhomepage.com)
Current vaccines against viral infection are challenged by fading efficacy and evasion by mutating viruses. (bigcountryhomepage.com)
The universal flu vaccine remains elusive, but there are several strategies that scientists can take to develop one, including closer monitoring of viral evolution. (nature.com)
In anticipation of vaccine development and use, CDC recently began national surveillance for the viral agents of gastroenteritis. (cdc.gov)
We offer flu shots and other vaccines to prevent serious bacterial and viral illnesses. (cookchildrens.org)
The pathophysiology of erythema multiforme (EM) is still not completely understood, but it is probably immunologically mediated and appears to involve a hypersensitivity reaction that can be triggered by a variety of stimuli, particularly bacterial, viral, or chemical products. (medscape.com)
Also tell your doctor if you have any type of untreated bacterial, fungal, parasitic, or viral infection anywhere in your body. (medlineplus.gov)

The resulting recommendations for standard design parameters are presented in this document and will provide the basis for the development of a harmonized and bench-marked efficacy studies in preclinical murine pneumonia model. (frontiersin.org)
Complications of influenza infection include secondary bacterial pneumonia and exacerbation of underlying chronic health conditions. (cdc.gov)
OKLAHOMA CITY - A new vaccine candidate to provide broad protection against pneumonia, developed by a researcher at the University of Oklahoma College of Medicine, is being given to humans for the first time in a Phase I clinical trial. (ou.edu)
It is exciting because, theoretically, this vaccine should protect against most of the 90 or so different variants (serotypes) of streptococcal pneumonia that we know about. (ou.edu)
The promise of Tweten's vaccine is that it takes a different approach than the handful of pneumonia vaccines now on the market. (ou.edu)
In addition, Tweten's vaccine should cost less to manufacture than other pneumonia vaccines, which would make it more affordable for developing countries. (ou.edu)
This pneumonia vaccine candidate represents a milestone for Dr. Tweten's laboratory, for the OU College of Medicine, and for the OU Health Sciences. (ou.edu)
The success of the PAI strategy to improve health has lead to improve the development of new vaccines to battle other health diseases, such as pneumonia, meningitis, hepatitis A, varicella and rotavirus. (univalle.edu.co)
1) Biofilm formation during bacterial colonization and how the composition of the respiratory microbiota as well as environmental factors (host inflammation, virus infection) modulate or trigger transition from colonization to infection, such as otitis media, pneumonia and sepsis. (lu.se)
Pneumococcal Disease As the most common bacterial cause of otitis media in children and a major cause of bacterial pneumonia, sepsis, and meningitis in adults, Streptococcus pneumoniae is responsible each year for at least one-third of the 24 million outpatient visits for otitis media and for 500,000 cases of pneumonia and meningitis in the United States. (cdc.gov)

COPENHAGEN, Denmark, Sept. 18, 2023 (GLOBE NEWSWIRE) -- Evaxion Biotech A/S (NASDAQ: EVAX) ("Evaxion" or the "Company"), a clinical-stage biotechnology company specializing in the development of AI-powered immunotherapies, today announced the initiation of a novel pipeline program, EVX-B3, an AI-designed vaccine candidate against an undisclosed bacterial pathogen. (bigcountryhomepage.com)
In June 2023, VRBPAC recommended the vaccine composition be updated to a 2023-2024 formulation to target the XBB.1.5 Omicron subvariant. (medscape.com)
Waning immunity from the bivalent mRNA COVID-19 vaccine or previous infection against Omicron subvariants (eg, BA.2.86, EG.5, FL.1.5.1) that emerged mid-2023 prompted development of a new formulation for 2023-2024. (medscape.com)
Both revised mRNA vaccine with the XBB.1.5 composition (ie, Spikevax and Comirnaty ) received supplemental approval for adolescents and adults in September 2023. (medscape.com)
On September 12, 2023, the CDC recommended everyone aged 6 months and older get an updated COVID-19 vaccine to protect against potentially serious outcomes of COVID-19 disease this fall and winter. (medscape.com)
The following tables summarize the 2023-2024 COVID-19 vaccine schedule, including those who are immunocompromised. (medscape.com)
In an e-mailed response on Wednesday, Johnson & Johnson confirmed plans to exit some of its vaccine research and development programmes, which it said it had initially disclosed in its 2023 second-quarter results. (theglobeandmail.com)
In June 2023, the FDA revoked emergency-use authorization for the vaccine at Janssen's request. (theglobeandmail.com)
The global vaccine market size was estimated at USD 124.2 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 1.4% from 2023 to 2030. (grandviewresearch.com)
Excluding the impact of COVID-19, the vaccine market is expected to grow at a CAGR of 8.6% from 2023 to 2030. (grandviewresearch.com)
In the U.S., the COVID vaccine market is anticipated to go commercial by the second half of 2023 as the stock purchased by the federal government will be exhausted. (grandviewresearch.com)
For instance, in March 2023, Moderna announced that its COVID vaccine market price will increase to around USD 110 to USD 130 per dose. (grandviewresearch.com)
For instance, in February 2023, Moderna announced interim results from its phase 3 trial for mRNA-1010, which is a seasonal flu shot under development. (grandviewresearch.com)

In today's increasingly interdependent world, acting together against vaccine-preventable diseases of public health importance and preparing for the possible emergence of diseases with pandemic potential will contribute significantly to improving global health and security. (who.int)
De Telegraaf reported that 2,500 people worked at Janssen in the Netherlands, a quarter of which were in the section specializing in infectious diseases and vaccines. (theglobeandmail.com)
Treatment resistance for infectious diseases is growing quickly, and chemotherapeutic toxicity in cancer means that vaccines must be made right away to save humanity. (researchgate.net)
Over time, the range of vaccines available worldwide has been growing steadily, with the creation of new vaccines aimed at diseases that typically impact lower-income countries. (grandviewresearch.com)
The success of mRNA-based COVID-19 vaccines has given impetus to the development of mRNA platforms for the prevention of various infectious diseases such as flu and RSV. (grandviewresearch.com)
The subunit vaccines segment is estimated to have the fastest CAGR during the forecast period, owing to the increasing incidence of infectious diseases, the rising demand for safe & effective vaccines, and the growing focus on preventive healthcare. (grandviewresearch.com)
The growing need for more effective vaccines against diseases such as cancer, autoimmune disorders, and allergies is also driving the demand for subunit vaccines. (grandviewresearch.com)
For instance, in November 2022, Curevo Vaccine (Curevo), a clinical-stage biotechnology company that aims to develop safe and effective vaccines to reduce the burden of infectious diseases, announced the completion of a Series A1 funding round worth $26 million. (grandviewresearch.com)
Considering the current scenario, the theme for this year's lecture series is "Diseases, Pandemic and Vaccines" . (ncbs.res.in)
A strong public health infrastructure at national, $4,360,695 state, and local levels is vital to sustaining high vaccination coverage levels and low incidence of vaccine prevent- able diseases. (cdc.gov)
New Vaccine Surveillance Network (NVSN): conducts active, population-based surveillance of pediatric infec- tious diseases and assesses the effectiveness of pediatric vaccines in the US. (cdc.gov)
The EIP network gathers laboratory and population-based information for many vaccine-preventable, invasive bacterial and respiratory diseases, as well as diseases for which vaccines are in development. (cdc.gov)
Division of Bacterial and Mycotic Diseases --------------------------------------------------------------------------- The Division of Bacterial and Mycotic Diseases (DBMD), National Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), is dedicated to preventing and controlling the many emerging, re-emerging, drug-resistant, and other important bacterial and mycotic diseases in the United States and around the world. (cdc.gov)
DBMD and Emerging Infectious Diseases Changes in society, technology, our environment, and microorganisms themselves are affecting the occurrence of bacterial and mycotic diseases. (cdc.gov)
A major branch effort is development and evaluation of vaccines, a key factor in preventing many diseases of both children and adults. (cdc.gov)
The branch works with CDC's National Immunization Program and other federal and state agencies to study vaccine-preventable diseases and to evaluate the effectiveness of newly developed vaccines. (cdc.gov)
Genetic and immunologic studies have helped branch researchers evaluate specific disease-causing factors in organisms such as those causing Brazilian purpuric fever and bacterial meningitis and have paved the way for the development of vaccines to prevent these and other diseases. (cdc.gov)

Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis , whereas natural infection protects against both. (mdpi.com)
The live attenuated vaccine BPZE1 was developed to mimic immunogenicity of natural infection without causing disease, and in preclinical models protected against pertussis disease and B. pertussis colonization after a single nasal administration. (mdpi.com)
[1-5] Aspirin and other salicylate-containing medications are contraindicated for children and adolescents with influenza-like illness, as their use during influenza infection has been associated with the development of Reye syndrome. (cdc.gov)
Typhoid is a bacterial infection caused by Salmonella enterica serovar Typhi and is a serious threat in many low- and middle-income countries. (news-medical.net)
Currently approved vaccines are carbohydrate-based, meaning they prompt the immune system to recognize part of the sugar coating found on Streptococcus pneumoniae , thereby protecting against infection. (ou.edu)
However, these vaccines protect against 23 variants of the bacteria at most, which leaves open the possibility of infection from 60-plus other variants. (ou.edu)
We use the results from these studies to develop vaccines and other strategies to protect individuals from infection. (lu.se)

Evaxion's Chief Scientific Officer, Birgitte Rønø, states: "We are thrilled to announce our upcoming collaboration, aimed at jointly investigating the capabilities of our AI platforms to design a groundbreaking vaccine targeting this specific pathogen. (bigcountryhomepage.com)
Mannheimia haemolytica is an important bacterial pathogen associated with bovine respiratory disease (BRD) in cattle. (genomealberta.ca)
However, the researchers need to know exactly which component of the bacterial envelope actually induces immunity to the pathogen. (mpg.de)
Addition of the synthetic sugar molecule to the current pneumococcal vaccine Prevnar 13, expanded the protection in vaccinated animals from 13 to 14 serotypes including the dangerous ST8 pathogen. (mpg.de)
The utility of database is for drug designing and vaccine development for selected pathogen. (scialert.net)
The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)
Bacterial capsules have critical roles in host-pathogen interactions. (bvsalud.org)

The Global Alliance for Vaccines and Immunization (GAVI), together with its fundraising arm The Vaccine Fund (VF), has also set milestones for selective immunization goals. (who.int)

She worked as a senior scientist for Human Genome Sciences, focusing on purification process development activities, scale-up, and analytical assay development from preclinical to Phase III. (nih.gov)
In preclinical studies, Tweten's vaccine appeared to protect against nearly all Streptococcus pneumoniae variants. (ou.edu)

Current technologies for DNA sequencing allow for rapid bacterial genome analysis and comparison of similarities and differences between strains. (genomealberta.ca)
This major advance paves the way for the development of vaccines through the generation of attenuated bacterial strains. (cirad.fr)
The vaccines showed superior results against influenza A strains but fell short against certain influenza B strains. (grandviewresearch.com)
Our only real option to controlling these new resistant strains of typhoid in a timely way is through the vaccine. (news-medical.net)

They also showed that 'toxoidation' of whole bacteria with formaldehyde - the method all manufacturers used to produce the highly neurotoxic pertussis vaccine - did not work on Bordetella pertussis because there are no free amino groups on the toxin of over 200 amino acids. (wikipedia.org)
For many years scientists have used the characteristic sugar molecules on the surface of bacteria as a component of vaccines. (mpg.de)
Coupled with carrier proteins, these molecules are effective vaccines that are much simpler to prepare in the laboratory than the isolation of conventional vaccines from bacteria. (mpg.de)
In nature, it is required for the biosynthesis of teichoic acid in Gram-positive bacteria, which is an appealing target epitope for the development of new vaccines. (bvsalud.org)

Tweten's vaccine, in contrast, uses a genetically modified, inactive version of a Streptococcus pneumoniae toxin called pneumolysin, against which the immune system makes antibodies. (ou.edu)
Unlike the current vaccines, which prompt the immune system to respond to specific variants, we believe our vaccine will protect against the majority of Streptococcus pneumoniae serotypes. (ou.edu)

Briefly, they cloned the pertussis toxin, mapped the antigenic epitopes using antibodies from individuals, who had the disease and or were vaccinated with the old whole-cell vaccine, and attached these antigenic peptides onto the diphtheria toxin as a carrier and adjuvant in one. (wikipedia.org)

The objective was to develop a vaccine that could be manufactured using modern cell-culture techniques, to conduct clinical trials sufficient to obtain regulatory approval and to create and maintain a stockpile of 40 million doses of the vaccine over 20 years. (globenewswire.com)
Currently, the researchers aim to develop a vaccine for humans together with Vaxxilon AG, a Max Planck Institute spin-off company. (mpg.de)

Vaccines that bring about strong T cell responses have been established to provide prolonged and enduring immunity and the ability to block continued transmission. (southernresearch.org)
Dr. Lederman, President and Chief Executive Officer of Tonix, commented that their hope "is to produce a vaccine that will provide long term immunity with a single dose using a proven technology that can be readily scaled up" to manufacture and distribute quickly. (southernresearch.org)

Bacterial Vaccine Polypeptides: Can We Eliminate Otitis Media and Antibiotic Use in Infants? (terrapinn.com)

J&J said during second quarter earnings in July it would cease development of vaccines for respiratory syncytial virus (RSV), hepatitis, and HIV. (theglobeandmail.com)

While there are effective vaccines currently available, they are very expensive to the end user, and they don't protect against all the bacterial serotypes that can cause disease. (ou.edu)
One of the vaccines, the most extensively assessed, has seven serotypes that cause more than 85% of the disease in United Sates, but have a lower coverage in Colombia 1 . (univalle.edu.co)
The serotypes in this vaccine are 4, 23F, 6B, 19F, 18C, 14 and 9V, which have an average coverage of 62% for pneumococcal invasive disease in Colombia. (univalle.edu.co)

Central to this research is the fight against bacterial resistance to antibiotics. (cirad.fr)

they're called subunit vaccines. (davidicke.com)

Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms. (mdpi.com)

With the introduction of the NmA conjugate vaccine, MenAfriVac® between 2010 and 2020, more than 325 million people aged between 1 and 29 years have been vaccinated in 24 of the 26 Member States in the African meningitis belt. (who.int)
On the 16th of November, 2020, Tonix Pharmaceuticals Holding Corp., a clinical-stage biopharmaceutical company, announced preliminary results for a live attenuated COVID-19 vaccine candidate engineered to express the SARS-CoV-2 (CoV-2) spike protein after vaccination. (southernresearch.org)
Starting in the Summer of 2020, snake-oil pushers immediately started saying it was the same technology used in polio and smallpox vaccines, that it works great, so why not for covid? (davidicke.com)

The vaccines were also granted Emergency Use Authorization (EUA) for children aged 6 months through 11 years. (medscape.com)

A new study, published today in the New England Journal of Medicine , finds a single dose of typhoid conjugate vaccine (TCV) - the only typhoid vaccine licensed for children as young as 6 months - is safe and 84 percent effective in protecting against typhoid in Blantyre, Malawi. (news-medical.net)
Malawi's Ministry of Health is excited about the results of the typhoid conjugate vaccine trial - it will bring great relief, will save lives, prevent morbidity, and help make the 2030 Sustainable Development Goals a reality across the continent. (news-medical.net)
To estimate the economic impact of the introduction of heptavalent pneumococcal conjugate vaccine (PCV-7) in high risk populations of Colombia. (univalle.edu.co)
The introduction of the Heptavalent Pneumococcal Conjugate Vaccine in populations of high risk is highly cost effective in Colombia. (univalle.edu.co)

For example, 'Two mRNA vaccines developed by Pfizer-BioNTech and Moderna are effective against the coronavirus. (researchgate.net)
Pfizer/BioNTech and Moderna are the two companies that have launched mRNA COVID vaccines in the market. (grandviewresearch.com)

In the last few years, mRNA used as a vaccine with rapid, scalable, and cost-effective production during the corona pandemic [2]. (researchgate.net)
Support also maintains public health preparedness for response to a vaccine-preventable national emergency, such as a pandemic or biologic attack. (cdc.gov)
Influenza investments improve vaccine impact, enhance detection and response, and assess risk and pandemic readiness throughout the United States. (cdc.gov)
CDC's support for Connecticut contributes to the critical U.S. system to better identify and respond to threats from seasonal and pandemic influenza and the development of newer, better flu vaccines. (cdc.gov)

This Phase I study is an exciting milestone for Matrivax, and a major step forward in the development of a vaccine that has potential to be a technological breakthrough in vaccination options against pneumococcal disease," said Enda Moran, chief executive officer of Matrivax. (ou.edu)
Our low-cost manufacturing platform and the prospect of a single-component, broad-coverage vaccine can translate directly into a much-needed low-cost vaccine for pneumococcal disease. (ou.edu)
One of the possible ways of action is to introduce the vaccine in high risk populations, low birth weight, that have a much higher incidence of pneumococcal disease compared with normal weight children 3 - 5 . (univalle.edu.co)

The announcement is the latest step in an effort to introduce more methods for detection of bacterial endotoxins, an important early step in the process for vaccine development and other injectable therapeutics. (usp.org)

On June 10, 2005, a tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) formulated for use in adults and adolescents was licensed in the United States for persons aged 11--64 years (ADACEL ® , manufactured by sanofi pasteur, Toronto, Ontario, Canada). (cdc.gov)
With Per Askelöf and Stefan B. Svenson, Bartfai created the first acellular pertussis (whooping cough) vaccine that is part of the current triple vaccine. (wikipedia.org)

Antigenic changes also necessitate frequent updating of influenza vaccine components to ensure that the vaccine is matched to circulating viruses. (cdc.gov)
The influenza vaccine should be given annually to everyone aged ≥ 6 months who does not have a contraindication. (msdmanuals.com)

This resulted in wider accessibility of newly developed vaccines across different regions. (grandviewresearch.com)

You'll also have the opportunity to use our specialist facilities, including computational methods to analyse large biological datasets to answer the 'big' questions in microbiology, from bacterial epidemiology to evolution. (bath.ac.uk)

of these 365 (41.3%) were confirmed positive for bacterial meningitis. (who.int)

In 2019, the final meta-analysis was published, i.e., a summary of all studies with mRNA vaccines. (davidicke.com)

It gives a full rundown of the current NP-based vaccines, their potential as adjuvants, and the ways they can be delivered to cells. (researchgate.net)

Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. (mdpi.com)

The new study found that the vaccine prevented typhoid in Malawi - where the incidence of typhoid is high. (news-medical.net)

With this international patent, CIRAD ensures it will retain the rights to this discovery in order to guarantee the accessibility of vaccines for the poorest countries. (cirad.fr)

To approach implementation of prototype vaccines by optimizing vaccination strategies, thus shortening the route to exploitation. (abdn.ac.uk)
Reactive vaccination with in-country stock of C containing polysaccharide and conjugate vaccines were conducted in 3 wards in Zamfara State and 1 ward in Jigawa State. (who.int)
Investments in Connecticut support national efforts to improve influenza prevention through vaccination and $948,991 col ect data that helps decide the makeup of the next season's flu vaccine. (cdc.gov)

Occasionally we make changes to our programmes in response to, for example, feedback from students, developments in research and the field of studies, and the requirements of accrediting bodies. (bath.ac.uk)

By 2005, 50% of the poorest countries with the highest disease burden and adequate delivery systems will have introduced Hib vaccine. (who.int)
These new vaccines have shown to have high efficacy and safety, and promise to reduce even more the burden of disease in human populations. (univalle.edu.co)
This event, tied to the high cost of the vaccine, should encourage carefulness in the analysis of the burden of disease of the possible introduction of the vaccine and the balance of the possible benefits of its introduction versus the cost. (univalle.edu.co)

Johnson & Johnson's JNJ-N Janssen division, which helped to develop its single-dose COVID-19 vaccine, will close much of its vaccine research and development operations in the Netherlands, newspaper De Telegraaf reported. (theglobeandmail.com)

In September 2000, we were awarded a contract by the US Government to develop a new smallpox vaccine based on the vaccine that was successfully used in the global eradication program. (globenewswire.com)
In October 2001, following the tragic events of September 11, the US Government decided to create a stockpile of smallpox vaccine large enough to provide a dose for every US citizen. (globenewswire.com)
It expanded and accelerated our first contract to provide 54 million doses by the end of 2002, and invited tenders to manufacture additional supplies of smallpox vaccine. (globenewswire.com)
On November 29, 2001, in partnership with Baxter, Acambis was awarded a second contract, worth $428m, to supply 155 million doses of smallpox vaccine by the end of 2002. (globenewswire.com)
Under these two contracts, we will be producing a total of 209 million doses of smallpox vaccine for the US Government. (globenewswire.com)

I engaged in a lot of career development activities, including obtaining Fellowship of the Higher Education Academy (FHEA) in recognition of my teaching work (lectures, small group teaching and research supervision). (imperial.ac.uk)
We began work on the research and development ("R&D") element of the contract and rapidly identified our vaccine candidate, designated ACAM1000, to take forward into clinical trials. (globenewswire.com)
Synthetic carbohydrate vaccines represent a paradigm shift within vaccine research,' says Seeberger. (mpg.de)
The French agricultural research and international cooperation organization working for the sustainable development of tropical and Mediterranean regions. (cirad.fr)
The clinical trial in Malawi was led by Professor Melita Gordon of the University of Liverpool and the Malawi-Liverpool-Wellcome Trust (MLW) Clinical Research Programme, in partnership with the Blantyre Malaria Project (BMP) and the University of Maryland School of Medicine's (UMSOM) Center for Vaccine Development and Global Health (CVD). (news-medical.net)
Professor Henry Mwandumba, Acting Director of the Malawi-Liverpool-Wellcome Trust Clinical Research Programme added: 'The outcome of the typhoid vaccine trial bears testament to what can be achieved through global research collaboration. (news-medical.net)
The research that created the vaccine candidate comes from the laboratory of Rodney Tweten, Ph.D., a George Lynn Cross Professor of Research in the Department of Microbiology and Immunology in the OU College of Medicine. (ou.edu)
Darrin Akins, Ph.D., vice president of research at OU Health Sciences, said the clinical trial for Tweten's vaccine candidate underscores the importance of basic science research in making discoveries that may ultimately save lives. (ou.edu)
Birmingham, Ala. - Southern Research today broke ground on a flagship biotech center that will anchor the development of 200,000 square feet of new or renovated wet lab space for life sciences. (southernresearch.org)
It has brought together leading European research groups that are experts on the fish Immune system and enterprises from the biotech and veterinary sectors that aim to commercialize fish vaccines for European fish farming. (abdn.ac.uk)
200,000 also provides an infrastructure for further public health vaccine research, including post-licensure vaccine efficacy evaluations and analyses of the effectiveness of prevention policies. (cdc.gov)
Continuing to advance scientific research and explore new interventions, like vaccines or post-exposure prophylaxis (PEP) strategies to prevent bacterial STIs. (cdc.gov)

Despite the global delivery of roughly 15 billion doses through different mechanisms as of October 2022, only 12% of this total came from COVAX, a worldwide global alliance for equitable access to Covid vaccines. (grandviewresearch.com)
The mRNA segment dominated the vaccine market with a share of 39.12% in 2022. (grandviewresearch.com)
Parenteral administration is highly preferred for administering vaccines and hence the segment dominated the vaccine market with a share of 97.09% in 2022. (grandviewresearch.com)
Malawi will now roll out the TCV vaccine nationally, starting with a mass campaign for all children aged 9 months through to 15 years, followed by introduction into the national Expanded Programme of Immunisation, from 2022 onwards. (news-medical.net)

19A, a serotype not within the earlier vaccine, was noticed. (ncccam.com)
of this, serotype 19A is included within the present 13 serotype vaccine. (ncccam.com)

vaccine trials for rotavirus are in progress. (cdc.gov)

Due to the urgent need for this vaccine, large-scale manufacture is being conducted in parallel with the clinical trial and regulatory program, with a view to making regulatory submissions to the US Food and Drug Administration ("FDA") in 2003. (globenewswire.com)

Acambis is the prime contractor and Baxter will assist with the bulk manufacture of the vaccine. (globenewswire.com)
They are more precise, effective and easier to manufacture than conventional vaccines. (mpg.de)

Anatomy11

Organisms38

Diseases35

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes22

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

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Named Groups1

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Antigens6

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202313

Diseases17

Infection7

Pathogen7

Global Alliance for1

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Bacteria4

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Immunity2

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Serotypes3

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20203

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Conjugate vaccine4

Pfizer-BioNTech and Moderna2

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Influenza vaccine2

Newly developed vaccines1

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20191

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Smallpox5

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20224

Serotype2

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