AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Insulin ResistanceMetabolic Syndrome XObesityObesity, AbdominalInsulinReceptor, InsulinWaist CircumferenceBody Mass IndexBlood GlucoseWaist-Hip RatioDiabetes Mellitus, Type 2Adipose TissueGlucose Tolerance TestRisk FactorsSyndromeGlucoseTriglyceridesGlucose Clamp TechniqueHyperinsulinismAdiposityPrevalenceInsulin Receptor Substrate ProteinsAdiponectinCross-Sectional StudiesDrug ResistanceIntra-Abdominal FatBody WeightOverweightFatty LiverGlucose IntoleranceAbdominal FatHypoglycemic AgentsFastingLipidsObesity, MorbidMuscle, SkeletalDietary FatsLeptinDrug Resistance, MicrobialMetabolic DiseasesDiabetes MellitusCardiovascular DiseasesAnthropometryBody CompositionDyslipidemiasDrug Resistance, BacterialAdipocytesLiverAsian Continental Ancestry GroupHyperglycemiaHypertensionFatty Acids, NonesterifiedBlood PressureBody ConstitutionBody Fat DistributionDietCholesterol, HDLHomeostasisLipid MetabolismSignal TransductionDrug Resistance, NeoplasmMice, ObeseBiological MarkersPolycystic Ovary SyndromeAdipokinesDiet, High-FatAbdomenGlucose Transporter Type 4Weight LossSex FactorsMice, Inbred C57BLCohort StudiesTime FactorsIslets of LangerhansInsulin-Secreting CellsPediatric ObesityChinaNew OrleansEnergy MetabolismInflammationRats, ZuckerC-Reactive ProteinInsulin, Long-ActingLogistic ModelsResistinDrug Resistance, MultipleVascular ResistanceThiazolidinedionesHyperlipidemiasInsulin AntibodiesTaiwanHypertriglyceridemia3T3-L1 CellsProspective StudiesDisease ResistanceCase-Control StudiesC-PeptideLife StyleLinear ModelsInsulin Antagonists
HypertensionDyslipidemiaDisordersType 2 diabetAbdominalWaist circumferenceCoronary heart dAdiposeAbnormalitiesComponents of metabolic syndromeFeatures of the metabolic syndromePhenotypeHyperinsulinemiaMetabolismCircumferenceMetSPolycysticGlucose intoleranceGeneticSensitivityOverweight and obesityDiagnosisAdipositySubcutaneous fatDiseasesPathogenesisPrevalence of obesityInflammationHyperglycemiaChildren and adolescentsPathwaysSkeletal muscleHypertriglyceridemiaNAFLDDiabetes mellitusEpidemicCondition characterizedAssessmentChildhoodMechanismsClinicalPathophysiologyHormonesAtherosclerosisCardiovascular and metabolic risk factorsLipidTissuesRisk of metabolic syndromeAction of insulinBlood glucoseIncidence of metabolic syndromeContribute to insulin resistanceAssociation with metabolic syndromeIncreasesFatty liverCauses metabolic syndromeTriglycerideAbnormalPCOSOxidativeLevelsVisceral
Hypertension24
Dyslipidemia8
Disorders16
  • Evidence from the conducted studies has revealed that abdominal obesity (assessed based on the waist circumference) plays a very important role in the development of metabolic disorders and in the assessment of cardiovascular risk. (hindawi.com)
  • All of the above-mentioned disorders contribute to metabolic syndrome and are related to the development of type 2 diabetes and ischaemic heart disease. (hindawi.com)
  • Alliance targets 11beta-HSD-1 for the treatment of metabolic syndrome disorders. (genengnews.com)
  • This program addresses several features of the metabolic syndrome, a combination of disorders including abdominal obesity, high blood pressure, and insulin resistance or glucose intolerance, all of which contribute to an increased risk of coronary heart disease, stroke, and type 2 diabetes. (genengnews.com)
  • Characterized by a series of manifestations of hyperandrogenemia, persistent anovulation, and ovarian polycystic changes ( 1 ), polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders that affects 5 to 10% of women of reproductive age ( 2 ). (frontiersin.org)
  • The high-carbohydrate high-fat diet induced an impaired glucose tolerance, insulin resistance, obesity, elevated blood pressure, dyslipidaemia, cardiovascular remodelling such as hypertrophy and fibrosis, increased cardiac stiffness, hepatic disorders such as inflammation and steatosis, along with elevated plasma markers of liver function. (edu.au)
  • My studies show the promising potential of functional foods against life-style associated metabolic disorders. (edu.au)
  • So, in 40 out of 70 percent of people with normal weight, doctors diagnose metabolic disorders. (healsens.com)
  • This syndrome is associated with multiple metabolic alterations andhemodynamic disorders. (biomedcentral.com)
  • The non-alcoholic fatty pancreas can develop due to an unhealthy diet, lack of physical activity, and other lifestyle factors that contribute to obesity and metabolic disorders. (fitnesshacks.org)
  • Children with overweight/obesity secondary to genetic syndromes or hormonal disorders were excluded. (biomedcentral.com)
  • Acquired or inherited defects associated to environmental factors in any part of this system can lead to metabolic disorders such as the syndrome X which is presently a frequent syndrome in industrialized countries. (erudit.org)
  • In addition, if necessary, specific treatment of the metabolic disorders is required. (erudit.org)
  • Obesity is also associated with infertility and menstrual irregularities, incontinence, and psychological disorders such as depression. (symptoma.com)
  • Obese individuals are at high risk for the development of metabolic disorders, including insulin resistance, type II diabetes mellitus and cardiovascular diseases (CVD). (eurekaselect.com)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
Type 2 diabet1
Abdominal8
Waist circumference12
Coronary heart d4
  • The role of low-density lipoprotein in the development of coronary heart disease (CHD) is well recognised. (ox.ac.uk)
  • In addition, a prospective Quebec study has found that even with no increase in blood sugar, elevated insulin levels (i.e., insulin resistance) are associated with a risk of coronary heart disease. (healsens.com)
  • Childhood obesity has been correlated with coronary heart disease, but the correlation with microvascular disease remains unclear. (biomedcentral.com)
  • In the European Region, the Eastern Mediterranean Region and the Region of the Americas this proportion exceeds 50%.1 The mean body mass index has increased over the past 20 years, leading to adverse metabolic effects on blood pressure, cholesterol and triglyceride concentrations, and insulin resistance, thereby increasing the risks of coronary heart disease, ischaemic stroke, type 2 diabetes and polycystic ovarian syndrome. (who.int)
Adipose9
Abnormalities3
Components of metabolic syndrome2
Features of the metabolic syndrome2
Phenotype4
  • We propose that 5αR may regulate GC exposure and therefore may modulate metabolic phenotype in human liver.Primary human hepato. (endocrine-abstracts.org)
  • Adopting a truly translational, bench-to-bedside approach, my work has defined the role of pre-receptor glucocorticoid metabolism within key target tissues upon the development of global metabolic phenotype. (uni-luebeck.de)
  • Most recently, based upon observations in a patient with Cushing's disease without a clinical phenotype, we have identified a novel role for 11β-HSD1 in controlling the response to exogenous glucocorticoid excess raising the potential for therapeutic inhibition of 11β-HSD1 may not only as a treatment for Cushing's disease, but as an approach to the treatment of iatrogenic glucocorticoid excess to limit adverse metabolic effects. (uni-luebeck.de)
  • IR is present in all phenotypes, and insulin sensitivity varies according to the PCOS phenotype. (biomedcentral.com)
Hyperinsulinemia3
  • PCOS can also be accompanied by obesity because central obesity could exaggerate IR and lead to hyperinsulinemia ( 7 ). (frontiersin.org)
  • 2. DM and AD: Shared Pathophysiological Components Hyperinsulinemia and insulin resistance, two of the hallmarks of type II DM (T2DM), have been shown to be important risk factors for elderly cognitive decline [10]. (lacbiosafety.org)
  • The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism. (scienceopen.com)
Metabolism11
  • Most actions of insulin are directed at metabolism (control) of carbohydrates (sugars and starches), lipids (fats), and proteins. (diabeteshealthmatters.com)
  • Metabolic syndrome is an unhealthy metabolism that leads to fatal diseases such as heart attacks, diabetes , and cancer. (healsens.com)
  • He embarked upon a career in Diabetes and Endocrinology and secured an MRC Clinical Training Fellowship in 2000 and obtained his PhD from University of Birmingham studying steroid metabolism and human obesity in 2003. (uni-luebeck.de)
  • He is a professor of Metabolic Endocrinology and consultant endocrinologist based in the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford. (uni-luebeck.de)
  • His work has focussed on glucocorticoid action and metabolism and in particular the role of the pre-receptor metabolizing enzymes to regulate metabolic function. (uni-luebeck.de)
  • Endogenous glucocorticoid (GC) production and metabolism have been implicated based upon parallels with Cushing s syndrome. (endocrine-abstracts.org)
  • The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. (endocrine-abstracts.org)
  • The role of endogenous glucocorticoid (GC) production and metabolism in the pathogenesis of obesity, insulin resistance and type 2 diabetes remains unclear. (endocrine-abstracts.org)
  • Dysregulation of the enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistant states, however longitudinal changes in glucocorticoid metabolism over time have not been investigated. (endocrine-abstracts.org)
  • This study was designed to evaluate the role of pre-receptor glucocorticoid metabolism in the development of insulin resistance and obesity. (endocrine-abstracts.org)
  • The endocrine system-the other communication system in the body-is made up of endocrine glands that produce hormones, chemical substances released into the bloodstream to guide processes such as metabolism, growth, and sexual development. (medscape.com)
Circumference1
  • Waterpipe smoking, sex, low-density lipoprotein and wrist circumference were also associated with metabolic syndrome. (who.int)
MetS5
  • The molecular mechanisms underlying the development of MetS are multifactorial and involve a combination of genetic, environmental, and lifestyle factors. (hilarispublisher.com)
  • However, the wide variation in geographic distribution of MetS emphasizes that the consumption of excess calories and lack of physical activity are the major contributors to the development of the disease. (healsens.com)
  • The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters. (mdpi.com)
  • Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)
  • Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. (biomedcentral.com)
Polycystic2
Glucose intolerance1
Genetic10
  • The mechanisms responsible for insulin resistance syndromes include genetic or primary target cell defects, autoantibodies to insulin, and accelerated insulin degradation. (medscape.com)
  • The cause of insulin resistance is not yet properly understood, but both genetic and environmental factors, including being overweight and physically inactive, are thought to play a major role. (mydr.com.au)
  • The etiology of PCOS is not yet clear, but genetic, environmental and lifestyle factors may contribute to its development ( 9 , 10 ). (frontiersin.org)
  • The identification of genetic and epigenetic drivers of cancer has led to the development of precision medicine approaches that aim to personalize cancer treatment based on the specific molecular alterations driving each individual patient's tumor. (hilarispublisher.com)
  • The development of CVD is influenced by both environmental and genetic factors. (hilarispublisher.com)
  • In this paper, we will review the current literature on the role of genetic variants in the development of CVD. (hilarispublisher.com)
  • Familial partial lipodystrophy, also known as Köbberling-Dunnigan syndrome, is a rare genetic metabolic condition characterized by the loss of subcutaneous fat. (wikipedia.org)
  • Lumbar Spondylosis may be caused due to many factors that can be broadly classified into Mechanical, Congenital or Acquired Anatomic anomalies, Metabolic, Immunologic, Genetic, Nutritional, Ageing and Septic reasons. (atomictherapy.org)
  • We present a 17 year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m(2), that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. (symptoma.com)
  • Genetic and epigenetic changes, hyperandrogenaemia, and obesity aggravate IR. (biomedcentral.com)
Sensitivity4
  • failure of the signals or of the B cells to adapt adequately in relation to insulin sensitivity results in inappropriate insulin levels, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes. (medscape.com)
  • Smoking reduces insulin sensitivity or induces insulin resistanceand enhances cardiovascular risk factors such as elevated plasmatriglycerides, decreases high-density lipoprotein cholesterol and causeshyperglycemia. (biomedcentral.com)
  • The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
  • Therefore, recognizing the strong influence of IR on the occurrence and development of PCOS, accurate assessment of insulin sensitivity in the early stages of PCOS, and effective intervention on IR are essential to reduce the risk of long-term complications. (biomedcentral.com)
Overweight and obesity6
Diagnosis3
  • In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
  • This provides theoretical support for early diagnosis and prevention of metabolic syndrome in the Xinjiang Kazakh population and may provide evidence for people living in Kazakhstan and Uzbekistan. (researchsquare.com)
  • Analysing the smoking habit influence on the IDFcriteria for the metabolic syndrome diagnosis we found that all thevariables show an increasing trend from light to heavy smokers, except forHDL cholesterol. (biomedcentral.com)
Adiposity5
  • The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
  • Excess central adiposity (called apple shape), particularly when it results in a high waist-to-hip ratio (reflecting a relatively low muscle-to-fat mass ratio), increases risk. (msdmanuals.com)
  • Peters noted that previous studies have indeed shown that central adiposity might be a stronger risk factor than overall obesity, but there have been studies that have shown the opposite - that it actually does not matter where adiposity is measured. (medscape.com)
  • The critical new thing in our work is that we've looked at sex differences between both central and overall adiposity and the risk of heart disease and what we found is that central adiposity is actually an even stronger risk factor for heart disease in women than in men," she said. (medscape.com)
  • In both sexes, there was an approximate log-linear relationship between measures of general and central adiposity and the risk for incident MI. (medscape.com)
Subcutaneous fat3
  • 495 FPL also refers to a rare metabolic condition in which there is a loss of subcutaneous fat in the arms, legs and lower torso. (wikipedia.org)
  • The syndrome is less common among people who have excess subcutaneous fat around the hips (called pear shape) and a low waist-to-hip ratio (reflecting a higher muscle-to-fat mass ratio). (msdmanuals.com)
  • the assessment of the prevalence of obesity and subcutaneous fat topography are important resources to support researchers, and practitioners who work directly on improving the quality of life of children and adolescents with Down syndrome. (bvsalud.org)
Diseases7
  • Introduction of primary prophylaxis in those people to limit the development of diabetes mellitus type 2 and cardiovascular diseases should be considered. (hindawi.com)
  • These syndromes may also be associated with immunological diseases and may exhibit distinct phenotypic characteristics. (medscape.com)
  • Under the firms' alliance, a small molecule inhibitor of 11beta-hydroxysteroid dehydrogenase (HSD)-1 has advanced into clinical testing as a treatment of diabetes and metabolic syndrome-related diseases. (genengnews.com)
  • Further, waste products from coffee production are a potential source for new interventions in diet-induced cardiovascular and metabolic diseases. (edu.au)
  • Cumulative weight gain and obesity are associated with increased risk for many diseases and overall mortality. (lifeextension.com)
  • Thus, care with the obesity control in children and adolescents with DS should be redoubled, because excess body fat is one of the characteristics of the syndrome, which can seriously contribute to the increased incidence of several diseases. (bvsalud.org)
  • Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
Pathogenesis5
Prevalence of obesity5
  • Because direct measures of body fat are neither feasible nor available for nationwide assessments of the prevalence of obesity, the National Health and Nutrition Examination Surveys (NHANES), 1 conducted by the National Center for Health Statistics, have been using body mass index (BMI) as a surrogate measure for body fatness. (nationalacademies.org)
  • Thus, reports based on the survey-specific BMI percentiles would always designate 5 percent of children as obese and would fail to detect any true increasing prevalence of obesity across surveys. (nationalacademies.org)
  • In conclusion, the prevalence of obesity is increasing at an alarming rate in many parts of the world. (eurekaselect.com)
  • to evaluate the prevalence of obesity and the body fat topography in children and adolescents from both sexes aged 6 to 19 years old with Down syndrome, residents in the city of Campinas, São Paulo. (bvsalud.org)
  • Since the 80s, studies have shown a higher prevalence of obesity among the various populations in developed and developing countries 4 . (bvsalud.org)
Inflammation4
Hyperglycemia2
  • The second significant factor in the development of this disease is an increase in glucose levels (hyperglycemia). (healsens.com)
  • Insulin therapy is indicated in symptomatic patients with persistent hyperglycemia, the presence of an HbA 1c of more than 9%, or ketoacidosis. (medscape.com)
Children and adolescents7
  • The screening for retinopathy should be proposed to all children and adolescents with overweight/obesity. (biomedcentral.com)
  • A cohort of children and adolescents with overweight or obesity underwent clinical and metabolic assessment and fundus oculi examination, in order to identify clinical and hormonal risk factors for early retinopathy. (biomedcentral.com)
  • A single-centre cross-sectional study was performed on a cohort of consecutive Caucasian Italian children and adolescents with overweight (BMI between + 1.75 and + 2 SDS) or obesity (BMI ≥ + 2 SDS). (biomedcentral.com)
  • Children and adolescents can develop metabolic syndrome, but in these age groups, no strict definition is established. (msdmanuals.com)
  • In children and adolescents with Down syndrome (DS), high obesity levels were also recorded from the 80's to the present days 5,6 . (bvsalud.org)
  • Therefore, the study of the body fat behavior through the assessment of the body composition, occupies an important space in the identification of the levels of obesity in various populations, especially in children and adolescents with Down syndrome. (bvsalud.org)
  • Because type 2 diabetes in children and adolescents is strongly associated with obesity and sedentary lifestyle, any intervention designed to increase physical activity and improve dietary habits should be encouraged. (medscape.com)
Pathways6
  • cellular actions of insulin involve a wide variety of effects on postreceptor signaling pathways within target cells. (medscape.com)
  • Moreover, visceral obesity is the key trigger for most pathways involved in metabolic syndrome. (healsens.com)
  • Although the pathophysiological connections are still not fully elucidated, two main key points have been recognized to explain this association: insulin resistance and inflammatory signalling pathways [9]. (lacbiosafety.org)
  • These altered pathways involve glycogen synthase kinase-3 (GSK-3), the enzyme that phosphorylates tau to create AD neurofibrillary tangles, which has been shown to be downregulated in response to insulin [15]. (lacbiosafety.org)
  • Moreover, overnutrition overwhelms inherent mitochondrial capacity for scavenging excess ROS produced by metabolic processes promoting further upregulation of proinflammatory processes through NF-κB pathways [30]. (encyclopedia.pub)
  • GO and KEGG analysis showed that genes regulated by E2 and/or HFD are mainly responsible for immune response, inflammatory response and metabolic pathways. (scienceopen.com)
Skeletal muscle7
  • Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. (biomedcentral.com)
  • The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study. (biomedcentral.com)
  • An increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters. (biomedcentral.com)
  • Because skeletal muscle is the major site of insulin-mediated glucose utilization (up to 80% in the postprandial state), losses in skeletal muscle mass may lead to metabolic impairments [ 12 ]. (biomedcentral.com)
  • Furthermore, to date, no studies have investigated the relationship between changes in skeletal muscle mass over time and metabolic syndrome development. (biomedcentral.com)
  • Therefore, we investigated whether baseline skeletal muscle mass and its changes over time have independent associations with metabolic syndrome development in a large 7-year longitudinal study. (biomedcentral.com)
  • We have identified a novel mechanism by which glucocorticoids cause insulin resistance in skeletal muscle through serine phosphorylation of insulin receptor substrate 1. (uni-luebeck.de)
Hypertriglyceridemia2
  • Insulin resistance and hypertriglyceridemia occur. (wikipedia.org)
  • These findings suggest that NDGA ameliorates hypertriglyceridemia and steatosis primarily by inhibiting lipogenesis and enhancing fatty acid catabolism in three major insulin responsive tissues by altering the expression of key enzyme genes and transcription factors involved in de novo lipogenesis and fatty acid oxidation. (biomedcentral.com)
NAFLD3
  • Insulin resistance also leads to peripheral lipolysis (breaking down of fat cells in free fatty acids and glycerol) and the resulting overflow of fatty acids leads to the onset of NAFLD. (fitnesshacks.org)
  • Thus, a better management approach for NAFLD and the development of new drugs and therapeutic options are urgently needed. (xiahepublishing.com)
  • We have shown in cross-sectional and intervention clinical studies that 5α-reductase activity is dysregulated in metabolic disease including obesity and NAFLD and have postulated that this represents a compensatory mechanism to protect the liver form the adverse effects of cortisol. (uni-luebeck.de)
Diabetes mellitus1
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
Epidemic2
  • This syndrome is both increasingly common and strongly implicated in the growing worldwide epidemic of type 2 diabetes. (ox.ac.uk)
  • We are living the midst a global epidemic of metabolic disease with rapidly escalating rates of obesity, type 2 diabetes and insulin resistance. (uni-luebeck.de)
Condition characterized3
Assessment3
Childhood5
  • Although metabolic syndrome generally affects older people, it is possible, with increasing childhood obesity, for metabolic syndrome to affect young adults and even adolescents and children. (mydr.com.au)
  • 2000) (see Chapter 3 for a more extensive discussion about the use of terms for childhood overweight and childhood obesity). (nationalacademies.org)
  • This characterization clearly appears to apply to childhood obesity. (nationalacademies.org)
  • Metabolic syndrome and its individual components are detectable during childhood, and both commonly persist throughout adolescence and adulthood ( 3 - 5 ). (cdc.gov)
  • Therefore, identifying metabolic syndrome during childhood is vital to curbing the development and progression of cardiovascular and metabolic disease during adulthood. (cdc.gov)
Mechanisms1
  • IR and compensatory hyperinsulinaemia (HI) are considered major drivers of PCOS pathophysiology and are involved in the development of hyperandrogenaemia and reproductive dysfunction by various mechanisms [ 14 ]. (biomedcentral.com)
Clinical8
  • In clinical practice, no single laboratory test is used to diagnose insulin resistance syndrome. (medscape.com)
  • In insulin resistance, various clinical entities of this state are evident. (medscape.com)
  • The companies will work jointly to identify and advance candidates for clinical development. (genengnews.com)
  • Interestingly, insulin seems to have anti-inflammatory effects directly suppressing proinflammatory cytokines and inducing anti-inflammatory mediators, as exhibited in both preclinical and clinical studies [21]. (lacbiosafety.org)
  • Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (eurekaselect.com)
  • [ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)
  • In addition, the review provides a comprehensive overview of the current progress in the efficacy of insulin sensitization therapy in the management of PCOS, providing the latest evidence for the clinical treatment of women with PCOS and IR. (biomedcentral.com)
  • Furthermore, we aim to summarize and provide an update on the current research status of insulin sensitization therapy for women with PCOS to provide more effective and reasonable clinical treatment. (biomedcentral.com)
Pathophysiology2
  • At the same time, the pathophysiology of this syndrome remains a subject of continuing controversy. (healsens.com)
  • The high prevalence of CAN in patients newly diagnosed with T2D suggests that its pathophysiology is rooted in an earlier stage of metabolic derangement, possibly being prediabetes. (encyclopedia.pub)
Hormones3
  • Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. (scienceopen.com)
  • Obesity wreaks havoc with male and female hormones, disrupting normal cycles and function, and leading to difficulty or inability to conceive. (symptoma.com)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
Atherosclerosis1
  • The retinal microcirculation is affected early in the process of atherosclerosis and it offers the opportunity to indirectly study the effects of obesity on small brain vessels. (biomedcentral.com)
Cardiovascular and metabolic risk factors2
Lipid3
Tissues2
  • Normal metabolic balance is maintained by a complex homeostatic system involving multiple tissues and organs. (erudit.org)
  • This paper aims to summarize recent findings on the involvement of IR in the occurrence and development of PCOS and the mechanism of IR in various tissues. (biomedcentral.com)
Risk of metabolic syndrome2
  • The most effective way for smokers to decrease the risk of metabolic syndrome andcardiovascular disease is to quit smoking [ 15 ]. (biomedcentral.com)
  • Factors, such as socioeconomic status, lack of physical activity, smoking, family history of diabetes, obesity and the western lifestyle, increase the risk of metabolic syndrome (8). (who.int)
Action of insulin1
Blood glucose5
Incidence of metabolic syndrome11
Contribute to insulin resistance1
  • Furthermore, soluble Aoligomers, known as amyloid beta-derived diffusible ligands (ADDLs), contribute to insulin resistance in AD by modifying Rabbit Polyclonal to SIN3B synapse conformation. (lacbiosafety.org)
Association with metabolic syndrome1
  • Compared to the lowest sex-specific SMI tertile at baseline, the highest sex-specific SMI tertile showed a significant inverse association with metabolic syndrome risk (adjusted hazard ratio [AHR] = 0.61, 95% confidence interval [CI] 0.54-0.68). (biomedcentral.com)
Increases5
  • The number of patients with metabolic syndrome increases with age. (hindawi.com)
  • So, the pancreas is notified that it needs to make more insulin, which increases the level of insulin in the blood and causes a louder knock. (diabeteshealthmatters.com)
  • This combination increases the risk of development of cardiovascular disease, fatty liver and type 2 diabetes. (edu.au)
  • Neuropathology of AD is characterized by loss of synapses, while insulin receptor signalling increases synaptic density. (lacbiosafety.org)
  • There is growing evidence that early development of obesity increases cardiovascular risk later in life, but less is known about whether there are effects of long-term excess body weight on the biological drivers associated with the atherosclerotic pathway, particularly adipokines, inflammatory and endothelial markers. (nature.com)
Fatty liver3
Causes metabolic syndrome1
Triglyceride1
Abnormal1
  • Congenital or acquired Anatomical anomalies in musculoskeletal framework that may cause abnormal posture or abnormal weight distribution which results into pressure on spine in wrong fashion gradually facilitates development of Lumbar spondylosis. (atomictherapy.org)
PCOS7
  • This study aimed to examine the associations of dietary and serum omega-3 fatty acids with insulin resistance (IR) and body composition among PCOS patients. (frontiersin.org)
  • Higher levels of dietary and serum omega-3 PUFAs, particularly long-chain omega PUFAs (DPA and DHA), might have beneficial effects on metabolic parameters and body composition among PCOS patients. (frontiersin.org)
  • Excessive insulin level is not only a potential cause of hyperandrogenemia but also one of the high-risk factors leading to metabolic syndromes among those with PCOS ( 6 ). (frontiersin.org)
  • Insulin resistance is usually linked with obesity, but women of normal weight with pcos also have an increased risk of developing insulin. (veganvan.life)
  • PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major cause of PCOS. (biomedcentral.com)
  • Insulin sensitization drugs are a new treatment modality for PCOS. (biomedcentral.com)
  • Lifestyle change is the treatment of choice for all women with PCOS, and insulin sensitization is a promising choice for the chronic treatment of women with PCOS. (biomedcentral.com)
Oxidative1
  • An increase in insulin demand and production secondary to insulin resistance is accompanied by elevated pancreatic endoplasmic reticulum stress initiating pro-oxidative and proinflammatory processes [20, 21]. (encyclopedia.pub)
Levels15
  • Ambient insulin levels, various physiologic and disease states, and drugs regulate insulin receptor concentration or affinity. (medscape.com)
  • It is thought that the underlying causes of metabolic syndrome are central obesity (weight that is carried mainly around the waist) and resistance to insulin (a hormone made by the pancreas that helps control your blood sugar levels). (mydr.com.au)
  • People who have insulin resistance tend to have higher than normal levels of insulin and sugar in their blood, increasing the risk of diabetes. (mydr.com.au)
  • Even a small amount of weight loss can help improve insulin resistance, lower your blood pressure and correct your cholesterol levels. (mydr.com.au)
  • Fasting insulin levels, BMI, and waist-to-hip ratio were associated with one factor. (diabetesjournals.org)
  • Low testosterone and shbg levels predict the development of central obesity and are associated with an increased risk of developing. (veganvan.life)
  • As a result, higher levels of insulin are needed in order for insulin to have its proper effects. (diabeteshealthmatters.com)
  • Initially, this happens after meals - when glucose levels are at their highest and more insulin is needed - but eventually while fasting too (for example, upon waking in the morning). (diabeteshealthmatters.com)
  • Insulin resistance is associated with elevated levels of proinflammatory cytokines such Trigonelline Hydrochloride as C-reactive protein, tumor necrosis factor- (TNF-) plaque deposition and progression, and on the other Trigonelline Hydrochloride side, a reduced AD incidence has been reported in patients under chronic nonsteroidal anti-inflammatory therapy [4]. (lacbiosafety.org)
  • Dietary administration of NDGA decreased plasma levels of TG, glucose, and insulin, and attenuated hepatic TG accumulation. (biomedcentral.com)
  • It may be linked to poor living and working conditions such as exposure to pathogens, or to increased levels of obesity. (biomedcentral.com)
  • However, in simple obesity, circulating glucocorticoid levels are not elevated. (uni-luebeck.de)
  • Patients with Cushing s syndrome develop central obesity, insulin resistance and in some cases type 2 diabetes (T2DM), yet circulating cortisol levels are not elevated in simple obesity. (endocrine-abstracts.org)
  • Since HDL particles carry the "good cholesterol" and are highly anti-atherogenic particles, the lowering of plasma HDL levels in obesity, is of particular concern. (eurekaselect.com)
  • Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (eurekaselect.com)
Visceral1