Development of hepatocellular carcinoma. Medical search. Frequent questions

Acquired hepatitis C virus infection from blood product transfusions is an important risk factor because the risk of hepatocellular carcinoma is highest in patients with chronic hepatitis C and cirrhosis (2-8% per year). (medscape.com)
Among 15-20% of NASH cases progress to cirrhosis, the latter being a recognized risk factor for the development of HCC (128). (bestpfe.com)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (wikipedia.org)
The development of HCC is attributed to fibrosis and cirrhosis, which occur in the setting of chronic liver injury and inflammation. (wikipedia.org)
citation needed] Young adults afflicted by the rare fibrolamellar variant of hepatocellular carcinoma may have none of the typical risk factors, such as cirrhosis and hepatitis. (wikipedia.org)
NAFLD can be classified based on histological progression: non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), NASH cirrhosis, and NASH-related hepatocellular carcinoma (HCC) [2]. (termedia.pl)
1,2 Sustained inflammation, hepatocyte necrosis and regeneration, and fibrotic deposition lead to development of cirrhosis. (ajmc.com)
Chronic liver disease and cirrhosis (scarring) are the most important risk factors for the development of HCC. (naturalpedia.com)
Kao, WY & Su, CW 2018, ' Letter: the role of direct-acting anti-virals in determining the risk of hepatocellular carcinoma development in patients with hepatitis C virus-induced cirrhosis ', Alimentary Pharmacology and Therapeutics , 卷 47, 編號 8, 頁 1230-1231. (tmu.edu.tw)
Cirrhosis can also happen due to too much drinking, which ultimately lead to development of HCC. (ccimindia.org)
The A1AT deficiency is a genetic disorder that can lead to the development of cirrhosis and HCC. (ccimindia.org)
Perhaps because of the younger ages of the patients and the lack of coexisting cirrhosis, patients with fibrolamellar carcinoma are often treated aggressively. (medscape.com)
Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)
NASH triggers the development of fibrosis, cirrhosis, and / or hepatocellular carcinoma (HCC). (ehu.eus)
This virus is the prototype of the genus Hepacivirus and a major cause of liver cirrhosis and hepatocellular carcinoma around the world. (cdc.gov)
Although the initial phase of the disease is asymptomatic, hepatitis C is largely feared because it causes chronic infection in 80% of cases, possibly leading to cirrhosis, primary hepatocellular carcinoma or end-stage liver disease (2). (who.int)
Hepatocellular carcinoma (HCC) usually occurs in patients with cirrhosis and is common in areas where infection with hepatitis B and C viruses is prevalent. (msdmanuals.com)
It has been estimated that more than 25% of these carriers will die from primary hepatocellular carcinoma or cirrhosis of the liver (3). (cdc.gov)
In general, chronic inflammation is associated with persistent cell damage and consecutive regeneration, potentially leading to changes such as fibrosis and cirrhosis and eventual hepatocellular carcinoma. (medscape.com)
In liver disease, cirrhosis and hepatocellular addition, transfusion services and labora- carcinoma [ 1,2 ]. (who.int)
Cirrhosis is associated with increased risk in the development of hepatocellular carcinoma (HCC), the most common primary liver cancer. (lu.se)

abstract = "Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. (nycu.edu.tw)

Fujiwara N, Friedman S, Goossens N and Hoshida Y: Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine. (spandidos-publications.com)
The Hepatobiliary Cancer Laboratory is engaged in ongoing basic science research projects that study diagnosis, treatment and prevention of hepatocellular carcinoma and hepatobiliary cancers. (mayo.edu)

Immune-checkpoint inhibitors (ICIs) are now widely used for the treatment of patients with advanced-stage hepatocellular carcinoma (HCC). (nature.com)
These concepts all have the potential to better identify patients who are most likely to benefit from ICIs and to promote the development of new treatment approaches. (nature.com)
Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial. (nature.com)
Ultrasonography to screen patients at high risk for hepatocellular carcinoma. (medscape.com)
A single-centre cohort study was performed to identify the independent factors associated with the overall survival (OS) of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization with drug-eluting beads (DEB-TACE). (biomedcentral.com)
Steatosis affects the natural course of HCV infection: it is associated with fibrosis, a possible mediator of increased risk to develop type 2 diabetes, it impairs the response to antiviral treatment in HCV-3 patients and might constitute a risk factor for the development of hepatocellular carcinoma. (natap.org)
The aim of this retrospective multicentric study was to compare the tumour response rates of Balloon-occluded Transarterial Chemoembolisation (B-TACE) to non-B-TACE using propensity score matching (PSM) in patients with hepatocellular carcinoma and to investigate the clinical benefit, such as lower rates of TACE re-intervention achieved using B-TACE. (springer.com)
FORT LEE, N.J., Sept. 19, 2023 (GLOBE NEWSWIRE) -- Elevar Therapeutics, Inc., a majority-owned subsidiary of HLB Co., Ltd. and a fully integrated biopharmaceutical company dedicated to elevating treatment experiences and outcomes for patients who have limited or inadequate therapeutic options, today announced a new partnership with the Benefactors Council of Blue Faery: The Adrienne Wilson Liver Cancer Association , a leading hepatocellular cancer (HCC) advocacy group. (kfor.com)
Elevar is inspired by Blue Faery's efforts to raise understanding of and advocate for patients with hepatocellular carcinoma and their families," said Elevar Vice President of Medical Affairs Bill Strickland. (kfor.com)
For instance, in April 2017, the U.S. Food & Drug Administration expanded the indications of regorafenib (Stivarga) manufactured by Bayer HealthCare Pharmaceuticals Inc., for treatment of patients with hepatocellular carcinoma. (medgadget.com)
North America is expected to hold a dominant position in the global hepatocellular carcinoma drugs market over the forecast period, and this can be attributed to rising prevalence of the disease and the growing number of clinical trials undertaken by the manufacturers to address the unmet medical needs of the patients in the region. (medgadget.com)
For instance, in February 2017, Daiichi Sankyo, a pharmaceutical company in Japan completed the Phase-3 study of tivantinib indicated for patients with hepatocellular carcinoma treated with other therapies. (medgadget.com)
Also, in 2015, Novartis Pharmaceuticals initiated the Phase 2 trials to compare the safety and efficacy for dovitinib and sorafenib in adult patients with advanced hepatocellular carcinoma. (medgadget.com)
Development of an optimal therapy for a subset of patients with locally recurrent hepatocellular carcinoma (HCC), following local therapy such as ablative therapy (AT) and trans-arterial chemoembolization (TACE), is a point of major concern. (sages.org)
Hepatocellular carcinoma (HCC) usually affects patients aged 50-70 years but earlier onset (25-40 years) may occur in hepatitis B endemic areas. (biomedcentral.com)
Also, the market is adjoined with various clinical stage biotechnology companies focusing on the development as well as commercialization of the TIL therapy for the cancer patients. (researchandmarkets.com)
Although the natural history of MAFLD may include the development of hepatocellular carcinoma (HCC), only a small percentage of patients develop it. (ehu.eus)
Most studies of hepatocellular carcinoma have involved patients of Asian descent. (medscape.com)

Rodent primary hepatic stellate cells (HSCs), mouse liver tumor-initiating stem cell-like cells (TICs), and human hepatocellular carcinoma (HCC) cell lines were exposed to Wnt signaling inhibitors and changes in gene expression patterns were analyzed. (nih.gov)
To determine metabolites that drive the development of human hepatocellular carcinoma (HCC). (lu.se)

We investigated whether and how SCD promotes liver fibrosis and tumor development in mice. (nih.gov)
Two studies have reported that alcohol interacts with steatosis in the development of fibrosis [23,47]. (natap.org)

Liver biopsy is the most important procedure to consider when hepatocellular carcinoma is suspected and when imaging results coupled with the AFP level do not provide a conclusive diagnosis. (medscape.com)
Abdominal computed tomography (CT) scanning is the preferred examination for the detection, diagnosis, staging, and postoperative follow-up evaluation of fibrolamellar carcinoma. (medscape.com)
Infection with human papillomavirus increases the probability of developing carcinoma of the cervix, which is the second leading cause of cancer- related mortality in females worldwide, killing some 240 000 women per year.1 Making a correct diagnosis of a sexually transmitted infection is essential for the provision of appropriate and effective treatment. (who.int)
These findings help to unravel etiological pathways in the development of this lethal cancer, contributing vital information towards its prevention and possibly earlier diagnosis. (who.int)
Imaging Techniques for the Diagnosis of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis. (medscape.com)

We then provide an overview of current biomarker use and developments in the past 5 years, including gene signatures, circulating tumour cells, high-dimensional flow cytometry, single-cell RNA sequencing as well as approaches involving the microbiome, radiomics and clinical markers. (nature.com)
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma. (nature.com)
Bruix J, Gores GJ and Mazzaferro V: Hepatocellular carcinoma: Clinical frontiers and perspectives. (spandidos-publications.com)
Nevertheless, the concrete role and clinical significance of ARG1 in the progression of hepatocellular carcinoma (HCC) remain unclear. (hindawi.com)
SGN-1 is under clinical development by Guangzhou Sinogen Pharmaceutical and currently in Phase I for Hepatocellular Carcinoma. (pharmaceutical-technology.com)
GlobalData's Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). (pharmaceutical-technology.com)
The most important clinical event associated with poor survival was the development of early ascites after DEB-TACE-1 (median OS, 17 months), which was closely related to the history of ascites, albumin and hemoglobin but not to tumour load or to response to therapy. (biomedcentral.com)
As Elevar Therapeutics enters the final stages of clinical development for its promising HCC therapy, Blue Faery is delighted to welcome the company to our Benefactors Council," said Andrea Wilson Woods, president, founder and founding director of Blue Faery. (kfor.com)
Moreover, growing clinical research along with the approval of novel drugs by the regulatory agencies for treating hepatocellular carcinoma is projected to foster the growth of the market. (medgadget.com)
In recent years also, the explosion that the market is experiencing in terms of research and drugs in the clinical pipeline is also leading towards accelerated market growth and future frontiers development. (researchandmarkets.com)
As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)

The 2 pathologic subtypes are classic hepatocellular carcinoma and fibrolamellar carcinoma . (medscape.com)
Fibrolamellar hepatocellular carcinoma, or fibrolamellar carcinoma , is a rare primary malignant neoplasm of the liver that constitutes 0.8-16% of all hepatocellular malignancies. (medscape.com)
[ 8 ] Fibrolamellar carcinoma occurs in a younger population than does HCC , and it is typically not associated with underlying liver disease or elevated serum levels of alpha-fetoprotein tumor markers. (medscape.com)
[ 9 ] Also, fibrolamellar carcinoma may have a slightly better prognosis than HCC . (medscape.com)
Contrast-enhanced computed tomography (CT) scan of fibrolamellar carcinoma demonstrates a large, heterogeneously enhancing mass in the right lobe of the liver, with a hypoattenuating central scar and punctate, central calcification. (medscape.com)
The 2 pathological subtypes are classic hepatocellular carcinoma and fibrolamellar carcinoma. (medscape.com)

Hepatocellular carcinoma (HCC) is an aggressive hepatic neoplasm that most commonly affects adults. (medscape.com)
These studies indicate an adipogenic lifestyle alone is sufficient for the development of nonalcoholic steatohepatitis, hepatic stem cell activation, and hepatocarcinogenesis in wild-type mice. (ox.ac.uk)
Cancer due to tumour formation by the hepatic cells of the liver is known as hepatocellular carcinoma (HCC). (ccimindia.org)
The prevalence of these infections ultimately causes hepatic cell damage and leads to tumour development. (ccimindia.org)

Hepatocellular carcinoma in children: results of the first prospective study of the International Society of Pediatric Oncology group. (medscape.com)

Hepatocellular carcinoma (HCC) is a primary liver cancer characterized by high invasiveness, metastasis , and poor prognosis , which lacks effective treatments . (bvsalud.org)
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). (bvsalud.org)

Hepatocellular carcinoma (HCC) has been regarded as the fifth most common cancer worldwide with a low prognosis. (hindawi.com)
Hepatocellular carcinoma (HCC), the third major cause of cancer-related death, is the fifth most common cancer worldwide [ 1 ]. (hindawi.com)
Bates E: Ion channels in development and cancer. (spandidos-publications.com)
1 Hepatocellular carcinoma (HCC) has been the fastest rising cause of cancer-related deaths in the United States, increasing by 2% to 3% annually. (ajmc.com)
Hepatocellular carcinoma (HCC), more commonly known as liver cancer, is a primary liver malignancy and is one of the leading causes of cancer-related deaths in the U.S. and worldwide. (naturalpedia.com)
Hepatocellular carcinoma primarily targets the liver, which lead to a cancer-related death. (naturalpedia.com)
Hepatocellular carcinoma (HCC), more commonly known as liver cancer, is a primary liver malignancy. (naturalpedia.com)
Hepatocellular carcinoma (HCC) is termed as a common and aggressive malignancy, which ranks as the second leading cause of the cancer-related deaths, annually leading to more than 110,000 mortalities worldwide [ 1 - 3 ]. (hindawi.com)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. (wjgnet.com)
It was also under development for the treatment of osteosarcoma and penile cancer. (pharmaceutical-technology.com)
Hepatocellular carcinoma (HCC) is a type of liver cancer that arises from the cell of liver or hepatocytes. (medgadget.com)
Also, according to Addis Ababa University, 2017, hepatocellular carcinoma (HCC) accounted for 854,000 new cases of liver cancer and 810,000 related deaths in 2015. (medgadget.com)
According to the survey by the Health Science Department, University of California, Los Angeles, (UCLA), 2017, hepatocellular carcinoma (HCC) accounts for three-quarters of liver cancers in the U.S. with an estimated 40,000 Americans diagnosed with liver cancer in 2017 and more than 28,000 deaths are reported from the disease. (medgadget.com)
Also, in April 2018, Eli Lilly and Company completed the Phase 3 research study of Cyramza (ramucirumab) as a single agent in the second-line treatment of people with hepatocellular carcinoma, also known as liver cancer. (medgadget.com)
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with more than 80 % of cases found in endemic areas of hepatitis B such as Africa or East Asia. (biomedcentral.com)
Hepatocellular carcinoma (HCC) is a major contributor to the global cancer burden, with rising global frequency of cases, and in some regions of the United States and several parts of the Western world also rising incidence and mortality rates over the past decade shown in [ Fig. 1 ] (2010-2019). (thieme-connect.com)
According to the World Health Organization (WHO), hepatocellular carcinoma (HCC) is the fifth most common cause of cancer worldwide [ 1 ]. (techscience.com)
Liver cancer: New metabolic targets for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and colorectal metastases in the liver. (ehu.eus)
Obesity and MAFLD, despite being closely related, are two independent risk factors for the development of liver cancer. (ehu.eus)
It is therefore crucial for the development of hepatocellular carcinoma (HCC) - the most common type of liver cancer. (imperial.ac.uk)
In a new study, scientists from the Section of Nutrition and Metabolism at the International Agency for Research on Cancer (IARC) have uncovered diverse metabolic perturbations associated with the development of hepatocellular carcinoma, a primary cancer of the liver with limited treatment options and poor survival. (who.int)
The analyses, which compared blood levels of metabolites in the cancer cases with those in the healthy matched controls, revealed major alterations in the levels of 92 separate metabolites in the development of hepatocellular carcinoma. (who.int)
Primary Liver Cancer Primary liver cancer is usually hepatocellular carcinoma (HCC). (msdmanuals.com)
Development of a Gene-Based Prediction Model for Recurrence of Colorectal Cancer Using an Ensemble Learning Algorithm. (cdc.gov)
Liver cancer, particularly hepatocellular carcinoma (HCC), is the fifth most frequently occurring cancer worldwide and the third most common cause of cancer mortality. (medscape.com)

The presenting signs and symptoms, epidemiology, biology, and current therapeutic strategies for hepatocellular carcinoma follow. (medscape.com)

Although children and adolescents are unlikely to have chronic liver disease, congenital liver disorders increase the likelihood of developing hepatocellular carcinoma. (medscape.com)
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. (pharmaceutical-technology.com)

Recent studies have shown that ferroptosis plays an important regulatory role in the occurrence and development of many diseases and has become the focus and hotspot of research on the treatment and prognosis improvement of related diseases (Fig. 1 ). (nature.com)
An Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma. (cdc.gov)

Figure 3 Cumulative incidence of hepatocellular carcinoma according to the history of treatment for hepatocellular carcinoma. (wjgnet.com)
Figure 4 Cumulative incidence of hepatocellular carcinoma according to alpha-fetoprotein levels. (wjgnet.com)
Figure 5 Cumulative incidence of hepatocellular carcinoma according to des- gamma-carboxy prothrombin levels at 24 wk after the completion of interferon-based therapy. (wjgnet.com)
Hepatocellular carcinoma (HCC) has become the leading cause of deaths that are caused by all cancers worldwide [1] and the incidence and mortality of HCC are increasing at a faster pace than other cancers, which trend will continue through at least 2030 in United States [2]. (researchsquare.com)
The growing incidence of global hepatocellular carcinoma cases around the globe is a major factor augmenting market growth. (medgadget.com)

Therefore, research on hepatocellular transformations in initiation and development of HCC and identifying effective biomarkers for novel therapeutic option are still emergency challenges. (researchsquare.com)

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce chronic inflammation and risk of many cancers, but their effect on risk of hepatocellular carcinoma (HCC) and death due to chronic liver disease (CLD) has not been investigated. (medscape.com)

Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC. (wikipedia.org)
Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. (researchsquare.com)

The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (wikipedia.org)
A suspected contributor to this increased risk is circulating insulin concentration such that diabetics with poor insulin control or on treatments that elevate their insulin output (both states that contribute to a higher circulating insulin concentration) show far greater risk of hepatocellular carcinoma than diabetics on treatments that reduce circulating insulin concentration. (wikipedia.org)
Risk factors for the development of HCC have been identified and are clearly described. (wjgnet.com)
Chaitanya Thandra K, Barsouk A, Saginala K, Sukumar Aluru J, Rawla P, Barsouk A. Epidemiology of non-alcoholic fatty liver disease and risk of hepatocellular carcinoma progression. (termedia.pl)
Low or high level of circulating insulin is also a risk factor for developing hepatocellular carcinoma. (ccimindia.org)
The major risk factors associated with HCC development and progression include chronic hepatitis B or C virus infections, high alcohol consumption, and activation of oncogenes [ 2 ]. (techscience.com)
After congenital Hepatitis B infection the life time risk of developing hepatocellular carcinoma is 50% for men and 20% for women. (medscape.com)
expense of currently available assays for Persons with persistent HCV infection are blood screening results in a lack of or in- at high risk for development of chronic consistent testing of blood donations. (who.int)

McGlynn KA, Petrick JL and El-Serag HB: Epidemiology of hepatocellular carcinoma. (spandidos-publications.com)

In summary Ymac-1 can be a useful SHC cell model for novel biomarker and therapy development. (nycu.edu.tw)
Treatment for hepatocellular carcinoma mainly includes radiation therapy, ablation therapy combined with chemotherapy and targeted drug therapy. (medgadget.com)

Attached is a request for a technology assessment that we need in order to develop a Medicare national coverage determination for liver transplantation for malignancies other than hepatocellular carcinoma. (cms.gov)

Evidence-based recommendations on radiofrequency ablation of hepatocellular carcinoma. (nice.org.uk)
NICE has also produced guidance on microwave ablation for hepatocellular carcinoma and for the treatment of metastases of the liver . (nice.org.uk)

With hepatitis, the body needs repeated blood transfusions, but the accidental coexistence of hepatitis and haemophilia leads to a loss of coagulability, which leads to the development of HCC. (ccimindia.org)
Prenatal screening of all pregnant women would identify those who are HBsAg- positive and thus would allow treatment of their newborns with hepatitis B immune globulin (HBIG) and hepatitis B (HB) vaccine, a regimen that is 85%-95% effective in preventing the development of the HBV chronic carrier state (2,4-6). (cdc.gov)

Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. (ox.ac.uk)

Hepatocellular carcinoma (HCC) is the most common liver-derived malignancy with a high fatality rate. (wjgnet.com)

Updated efficacy and safety data from IMbrave150: atezolizumab plus bevacizumab vs. sorafenib for unresectable hepatocellular carcinoma. (nature.com)
Sorafenib in advanced hepatocellular carcinoma. (nature.com)
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial. (nature.com)

The burden for hepatocellular carcinoma (HCC) attributed to nonalcoholic fatty liver disease (NAFLD) continues to grow in parallel with rising global trends in obesity. (thieme-connect.com)

In 2003, the Health Assembly adopted resolution WHA56.30, taking note of the global health-sector strategy for HIV/AIDS,1 and the next year, in resolution WHA57.12, endorsed the strategy to accelerate progress towards the attainment of international development goals and targets related to reproductive health. (who.int)
It recognizes that prevention and control of sexually transmitted infections are core aspects of sexual and reproductive health, as stated in the strategy to accelerate progress towards the attainment of international development goals and targets related to reproductive health. (who.int)
Understanding changes in metabolism related to the development of diseases can help us identify new drug targets and therapeutic avenues. (lu.se)

However, our search of the literature did not produce a significant volume of literature, or literature of sufficiently sound methodology, to permit our staff to make a determination regarding liver transplantation for other malignant diagnoses, such as metastatic disease, bile duct carcinoma and epithelioid hemangioendothelioma. (cms.gov)

Slotta JE, Kollmar O, Ellenrieder V, Ghadimi BM, Homayounfar K. Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives. (wjgnet.com)
These findings provide new insights into early metabolic perturbations and mechanisms leading to the development of hepatocellular carcinoma. (who.int)

Dr. Roberts and his research team are studying SULF inhibitors to treat hepatocellular carcinoma and SULF1/2 roles in cholangiocarcinoma. (mayo.edu)

How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
The absence of NFAT2 and Egr2 in carcinoma tissues reminded us that NFAT2 may be a promising therapeutic target for hepatocellular carcinoma treatment. (researchsquare.com)
Through this study, the research team is detecting the function of UCK2 and determining whether this gene can be a potential target for treatment of hepatocellular carcinoma. (mayo.edu)
Also, in 2017, the U.S. FDA granted accelerated approval for nivolumab (Opdivo) drug developed by Bristol-Myers Squibb for the treatment of hepatocellular carcinoma. (medgadget.com)
The Asia Pacific is expected to gain significant traction in the global hepatocellular carcinoma drugs market owing to the growing number of research and development activities undertaken by the manufacturers in the region in order to develop effective therapies for the treatment of Hepatocellular carcinoma. (medgadget.com)

How can ferroptosis promote the development of inflammation? (nature.com)
L-Carnitine - This naturally occurring amino acid was found to prevent the development of HCC, as it protects the liver from free radicals caused by inflammation. (naturalpedia.com)

Llovet J, Montal R, Sia D and Finn R: Molecular therapies and precision medicine for hepatocellular carcinoma. (spandidos-publications.com)
Although the role of miR-192 in HCC development has been recognized, the underlying molecular mechanism is still poorly understood. (bvsalud.org)
Our group therefore studies several factors in order to understand the molecular mechanisms of disease development. (lu.se)

Nevertheless, children with biliary atresia , infantile cholestasis , glycogen-storage diseases , and a wide array of cirrhotic liver diseases are predisposed to developing hepatocellular carcinoma . (medscape.com)
Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. (cancerindex.org)

SCD expressed by HSCs promoted liver tumor development in mice. (nih.gov)
Hepatocellular neoplasms were observed in 6 of 10 ALIOS mice after 12 months. (ox.ac.uk)
Butyl-benzyl-phthalate and di-2- ethylhexyl-phthalate induced development of leukemia in rats and hepatocellular carcinomas in mice, respectively. (cdc.gov)

Stearoyl-CoA desaturase (SCD) synthesizes monounsaturated fatty acids (MUFAs) and has been associated with the development of metabolic syndrome, tumorigenesis, and stem cell characteristics. (nih.gov)
The researchers identified 129 cases of hepatocellular carcinoma and an equal number of matched controls from within the EPIC cohort and analysed their blood metabolic profiles using the IARC metabolomics platform. (who.int)

According to GlobalData, Phase I drugs for Hepatocellular Carcinoma have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. (pharmaceutical-technology.com)

Anatomy10

Organisms10

Diseases74

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment65

Phenomena and Processes32

Disciplines and Occupations1

Information Science5

Named Groups1

Health Care23

Geographicals3

Cirrhosis21

Abstract1

Prevention of hepatocellular carcinoma2

Patients18

Human hepatocellular carcinoma2

Fibrosis2

Diagnosis5

Clinical11

Fibrolamellar carcinoma6

Hepatic4

Oncology1

Metastasis2

Cancer25

Symptoms1

Likelihood2

Prognosis2

Incidence5

Biomarkers1

Cancers1

Tumors3

Risk8

Epidemiology1

Therapy2

Malignancies1

Ablation2

Hepatitis2

Murine1

Malignancy1

Sorafenib3

NAFLD1

Targets3

Malignant1

Findings2

Inhibitors1

Treatment5

Inflammation2

Molecular3

Cirrhotic2

Mice3

Metabolic2

Phase1