• Calciphylaxis, also known as calcific uremic arteriolopathy (CUA) or "Grey Scale", is a rare syndrome characterized by painful skin lesions. (wikipedia.org)
  • According to David Cucchiari, MD, and colleagues from the Hospital Clinic of Barcelona in Spain, "calciphylaxis cannot be considered only the consequence of long-standing uraemia, and the term [calcific uremic arteriolopathy] may lead to disagreement and misclassification. (renalandurologynews.com)
  • San Diego, USA and Palma, Spain, October 20, 2016 - Laboratoris Sanifit S.L., a clinical-stage biopharmaceutical company focused on treatments for calcification disorders, today announced successful initiation of the first clinical trial of its lead candidate, SNF472, for the treatment of the orphan disease calciphylaxis (calcific uraemic arteriolopathy, CUA). (sanifit.com)
  • Ecto-5' -Nucleotidase CD73 (NT5E), vitamin D receptor and FGF23 gene polymorphisms may play a role in the development of calcific uremic arteriolopathy in dialysis patients - Data from the German Calciphylaxis Registry. (cdc.gov)
  • Calciphylaxis, or calcific uremic arteriolopathy, is the tissue and vascular calcification that occurs mainly in chronic kidney disease. (docksci.com)
  • Unlike other forms of vascular calcifications (e.g., intimal, medial, valvular), calciphylaxis is characterized also by small vessel mural calcification with or without endovascular fibrosis, extravascular calcification and vascular thrombosis, leading to tissue ischemia (including skin ischemia and, hence, skin necrosis). (wikipedia.org)
  • As we have seen in previous weeks, calciphylaxis is a severe and complex syndrome involving vascular calcification, thrombosis, and skin necrosis. (woundeducators.com)
  • Calciphylaxis is a serious and rare condition characterized by vascular calcification and thrombosis leading to necrosis (cellular death) of the skin and fatty tissue. (sanifit.com)
  • If this happens when calcium is given by an arm IV line it may cause irritation and necrosis of muscle and nerves (calciphylaxis). (endocrinesurgeon.co.uk)
  • Widespread intravascular calcification typical of calciphylaxis lesions occur in the myocardium and prevent normal diastolic filling of the ventricles. (wikipedia.org)
  • Discovery of diffuse intravascular calcification on computed tomography, in addition to a markedly elevated calcium-phosphate product immediately prior to the onset of his ulcers, led to the diagnosis of calciphylaxis. (biomedcentral.com)
  • Calciphylaxis is a rare disorder of intravascular calcification that is primarily observed in patients with longstanding end-stage renal disease (ESRD). (biomedcentral.com)
  • The pathogenesis of calciphylaxis is unclear but believed to involve calcification of the small blood vessels located within the fatty tissue and deeper layers of the skin, blood clots, and eventual death of skin cells due to lack of blood flow. (wikipedia.org)
  • Calciphylaxis is one type of extraskeletal calcification. (wikipedia.org)
  • Calciphylaxis is characterized by the following histologic findings: systemic medial calcification of the arteries, i.e. calcification of tunica media. (wikipedia.org)
  • Severe forms of calciphylaxis may cause diastolic heart failure from cardiac calcification, called heart of stone. (wikipedia.org)
  • Calciphylaxis is not a hypersensitivity reaction (i.e., allergic reaction) leading to sudden local calcification. (wikipedia.org)
  • Vascular calcification prior to transplant surgery could predispose patients to later calciphylaxis, along with trauma, hypotension, and a hypercoagulable state, they explained. (renalandurologynews.com)
  • Acquisition of Sanifit is for the continued clinical development and commercialization of SNF472, a novel, first-in-class intravenously administered inhibitor of vascular calcification, for the treatment of CUA and PAD in patients with end-stage kidney disease. (menafn.com)
  • Vifor Pharma is the ideal partner to take the development of Sanifit's calcification franchise forward and bring these novel treatments to patients as quickly as possible. (menafn.com)
  • This acquisition builds on years of hard work from the entire Inositec team and provides a strong foundation for improving outcomes for patients suffering from cardiovascular and vascular calcification disorders," said Mattias Ivarsson, Founder and Chief Executive Officer of Inositec, adding"Inositec's transition to a clinical-stage company represents an ideal time to partner with Vifor Pharma to accelerate the clinical development of INS-3001. (menafn.com)
  • Systemic corticosteroids should be avoided in calciphylaxis as they may exacerbate arteriolar calcification. (woundeducators.com)
  • Calciphylaxis is a rare, often fatal disease resulting from calcification of dermal arterioles and capillaries. (biomedcentral.com)
  • Joan Perelló, CEO of Sanifit said , "The enrollment of the first patients in this Phase II trial is a significant milestone in the clinical development of SNF472 for calcification disorders. (sanifit.com)
  • Sanifit is focused on the development of its lead candidate SNF472, an experimental drug for the treatment of cardiovascular diseases linked to calcification in patients with End Stage Renal Disease (ESRD) undergoing haemodialysis. (sanifit.com)
  • Patients with calciphylaxis experience painful skin ulcers with a high risk of severe infection and a 50% rate of death within the first year after diagnosis. (sanifit.com)
  • Smoking contributes to the development and persistence of leg ulcers, particularly arterial ulcers, diabetic foot ulcers, and calciphylaxis. (nutritionhealthreview.com)
  • Brandenburg VM, Cozzolino M, Ketteler M. Calciphylaxis: a still unmet challenge. (woundeducators.com)
  • This SNF472 trial is a prospective interventional study targeting unmet medical need in calciphylaxis and we are excited to understand more about the potential for this drug to benefit dialysis patients afflicted with this grievous condition. (sanifit.com)
  • Approximately 1-4% of patients with ESRD experience calciphylaxis and there is currently no US Food & Drug Administration (FDA) or European Medicines Agency (EMA) approved therapy to treat this disorder. (sanifit.com)
  • After a recent series C funding round of $41.3M (€36.6M), Sanifit will start a phase IIb study in ESRD and extend the orphan program in calciphylaxis into phase II/III clinical trials. (sanifit.com)
  • Another hypothesis has been proposed, that vitamin K deficiency contributes to the development of calciphylaxis. (wikipedia.org)
  • The lack of evidence for the benefit of any treatment for calciphylaxis is disappointing, and contributes to the overall dismal prognosis for this condition. (woundeducators.com)
  • If calciphylaxis is suspected, the diagnosis should be confirmed histologically in order to differentiate the condition from other similar vasculopathies which may be presented by the same patient types. (woundeducators.com)
  • Calciphylaxis is a rare but serious disease, believed to affect 1-4% of all dialysis patients. (wikipedia.org)
  • SNF472 is being developed for two indications: reduction of cardiovascular events in dialysis patients and for the treatment of calciphylaxis. (sanifit.com)
  • The Bloch Laboratory at Massachusetts General Hospital investigates the role of the bone morphogenetic protein signal transduction pathway in a broad spectrum of human diseases, including iron overload syndromes, anemia, inflammation, Sjogren's syndrome, non-alcohol related fatty liver disease, calciphylaxis and atherosclerosis. (massgeneral.org)
  • In addition, we are examining the effects of blocking BMP receptors, using small molecule inhibitors, on the anemia of inflammation and the development of atherosclerosis. (massgeneral.org)
  • Calciphylaxis developed during the first year after kidney transplantation in 43.2% of patients. (renalandurologynews.com)
  • Calciphylaxis occurs almost exclusively in patients with advanced chronic kidney disease (CKD), and has a dismal mortality rate of around 80 percent (with a 1-year mortality greater than 50 percent). (woundeducators.com)
  • Parathyroidectomy in the treatment of calciphylaxis has been reported to benefit some patients with primary hyperparathyroidism, but its use remains controversial. (woundeducators.com)
  • A corollary of the case presented here is the need for more effective management of calciphylaxis, especially for patients in whom uncommon sites, such as the penis, are involved. (biomedcentral.com)
  • The recently initiated Phase II study is the first clinical investigation of SNF472 in patients with newly diagnosed calciphylaxis. (sanifit.com)
  • Using data science and digital health to reimagine the discovery and development of medicines to advance our mission of bringing transformative therapies to patients. (janssen.com)
  • He currently serves as Associate Editor (Global Health) for Kidney and Blood Pressure Research and has been involved in the development of clinical practice guidelines for the care of patients with kidney disease in Australia and internationally. (edu.au)
  • Generally hypocalcaemia is treated with oral calcium and vitamin D keeping the blood calcium levels within the normal range and preventing the development of symptoms.Calcium carbonate is the cheapest form of oral calcium. (endocrinesurgeon.co.uk)
  • With such a discouraging prognosis, it is clear that treatment options for calciphylaxis still have some way to go. (woundeducators.com)
  • Calciphylaxis is a rare and devastating disease for which there are currently no evidence-based treatment options available. (sanifit.com)
  • CONCLUSION: HBOT may have a role in the treatment of calciphylaxis with benefits demonstrated in both mortality and wound healing. (bvsalud.org)
  • These lesions may herald the subsequent development of a Stage III-IV pressure ulcer even with optimal treatment. (preszlerlaw.com)
  • Renal & Urology News publishes timely news coverage of scientific developments of interest to nephrologists and urologists, including in-depth coverage of all relevant medical conferences. (renalandurologynews.com)
  • Calciphylaxis in a patient affected by rheumatoid arthritis, chronic renal failure, and hyperparathyroidism: a case report. (docksci.com)
  • Thus, acute ligation or occlusion of the right renal vein is invariably devastating whereas on the left side, gonadal and adrenal veins allow potential for venous collateral development, which in certain circumstances mitigate the complications of occlusion. (abdominalkey.com)
  • Sanifit is a biopharmaceutical company focused on the development of SNF472. (sanifit.com)
  • Ibrutinib is in clinical development for chronic graft versus host disease (cGvHD). (nihr.ac.uk)
  • The early identification and mitigation of modifiable risk factors for the development of chronic kidney disease are important for improved patient outcomes. (ceufast.com)
  • Keith R. Leonard added , "I am pleased to be able to contribute to the development of Sanifit. (sanifit.com)
  • Similar extraskeletal calcifications are observed in some people with high levels of calcium in the blood, including people with milk-alkali syndrome, sarcoidosis, primary hyperparathyroidism, and hypervitaminosis D. In rare cases, certain medications such as warfarin can also result in calciphylaxis. (wikipedia.org)
  • In an article titled, "Smoking Effects on the Skin," published online on the website Aesthetics, Dr. Martin Godfrey, head of research and development at MINERVA Research Labs Ltd, reviewed the research and described what smoking actually does to the skin. (nutritionhealthreview.com)
  • The case-report evidence which is available may be studied as part of an ongoing professional development program, such as wound care certification. (woundeducators.com)
  • Here we report the case of an elderly man who was found to have calciphylaxis of the distal digits and penis, the latter of which is an uncommon site of disease that carries a particularly poor prognosis. (biomedcentral.com)
  • 2) As with many poorly-understood conditions, the key to the management of calciphylaxis therefore lies in strategies to prevent the condition from developing in the first place. (woundeducators.com)
  • The team examined 14 cases of calciphylaxis after kidney transplantation diagnosed at their institution from 1990 to 2020 and 31 cases from the medical literature, published 1969 to 2019. (renalandurologynews.com)
  • Bridging data and decision making: development of techniques for improving the HIV prevention community planning process. (gwu.edu)
  • The trial is led by Prof Vincent Brandenburg, University Hospital RWTH Aachen, Germany, along with a team of internationally recognized calciphylaxis experts in the US, Spain and the UK. (sanifit.com)
  • Calciphylaxis: A review. (woundeducators.com)
  • Review current clinical guidelines, those in development, and guidelines that the AAD has collaborated on. (aad.org)