Loading...
  • Docking
  • In this chapter we present a workflow for experimental data guided docking of small molecules into protein homology models of neurotransmitter transporter. (springer.com)
  • Jones G, Willett P, Glen RC et al (1997) Development and validation of a genetic algorithm for flexible docking. (springer.com)
  • Jurik A., Seddik A., Ecker G.F. (2016) Experimental Data Guided Docking of Small Molecules into Homology Models of Neurotransmitter Transporters. (springer.com)
  • Tuccinardi T, Calderone V, Rapposelli S et al (2006) Proposal of a new binding orientation for non-peptide AT1 antagonists: homology modeling, docking and three-dimensional quantitative structure-activity relationship analysis. (springer.com)
  • vertebrate
  • During vertebrate hematopoietic development, common myeloid progenitors give rise to separate precursors for cells of the granulocyte/macrophage and erythrocyte/megakaryocyte lineages. (bloodjournal.org)
  • 13 This conservation of the fundamental mechanisms controlling erythropoiesis between mammals and zebrafish 4 raises the possibility that this powerful genetic system could be applied to uncover new classes of genes required in the normal development of granulocyte/macrophage cell lineages during vertebrate myelopoiesis. (bloodjournal.org)
  • Muscles
  • To better understand the unique morphology and the evolution of the jaw apparatus in Acipenseridae, we investigated the development of the muscles of the mandibular and hyoid arches of the Siberian sturgeon, Acipenser baerii. (docme.ru)
  • structural
  • For many years structural studies of the angiotensin II type 1 receptor (AT1R) solely relied on mutagenesis experiments combined with homology modeling. (springer.com)
  • A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases. (embl.de)
  • This new DNA-binding motif shares structural homology with T4 RNase H, E. coli endonuclease III and Bacillus subtilis DNA polymerase I. The structural homology suggests a mechanism for substrate recognition by these enzymes. (embl.de)
  • Here, we determined the structural flexibility of the CDR-H3 loop for thousands of recent homology models of the human peripheral blood cell antibody repertoire using rigidity theory. (frontiersin.org)
  • evidence
  • Merkley, R. & Ansari, D. (in press) Why numerical symbols count in the development of mathematical skills: evidence from brain and behaviour . (uwo.ca)
  • ancestor
  • Herein we present an outline and preliminary description of the components of the axial skeleton, choosing ichthyological terms that are considered standard because they convey information on homology, the continuity of information from ancestor to descendant. (zfin.org)
  • models
  • In this chapter the binding modes of olmesartan in the crystal structures and the homology models are compared utilizing mutagenesis data. (springer.com)
  • lung
  • Homology company is working on bone marrow, liver, lung, eye and central nervous system applications. (forbes.com)
  • shift
  • Heterochrony is thus a "phyletic change in the timing of development, such that features of ancestors shift to earlier or later stages in the ontogeny of descendants" (Gould, 1992). (thefreelibrary.com)
  • present
  • I will present the interface between the two, whose requirements drove the development of our new language Sail. (mpi-sws.org)
  • After a thorough review and analysis of the history and meaning of heterochrony proposed by previous authors, Gould (1977: 2) redefined heterochrony as "changes in the relative time of appearance and rate of development for characters already present in ancestors. (thefreelibrary.com)
  • stages
  • In later stages of development, hematopoiesis moves to the aorta-gonad-mesonephros region and the fetal liver, 15 whereas in adults definitive hematopoiesis occurs in the bone marrow where all blood cell lineages are produced. (bloodjournal.org)
  • explain
  • In this article, we articulate the PRM view of homology and explain why it is recommended over the other two views. (deepdyve.com)
  • Virtual
  • Rataj K, Witek J, Mordalski S et al (2014) Impact of template choice on homology model efficiency in virtual screening. (springer.com)
  • complex
  • Specifically we are describing the development of the vertebrae (centra, neural and hemal arches, neural and hemal spines, and ribs), the Weberian apparatus (a complex structure consisting of bones modified from the first four vertebrae), and the median fins. (zfin.org)