Development drosophila proteins. Medical search. Frequent questions

The function of the Drosophila extramacrochaetae ( emc ) gene has been characterized almost exclusively in relation to the pat-terning of the fly's sensory organs (chaetae and other types of sensilla). (biologists.com)
The ci gene in ciD is controlled by the ubiquitous pan promoter and encodes a hybrid Ci protein that carries the N-terminal region of Pan. (uzh.ch)
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene. (wikipedia.org)
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. (wikipedia.org)
Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a protein that in humans is encoded by the SND1 gene. (wikipedia.org)
A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
The scientists used the Drosophila wing because it is an excellent model to describe how cells behave when a certain gene is mutated and to determine and test how this mutation affects adjacent cells. (sciencedaily.com)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
We have cloned the oho31 gene of Drosophila melanogaster and determined its nucleotide sequence. (rupress.org)
The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)
We further show that splicing mediated by SF1 and Hrb87F is necessary for Z-disc stability and proper myofibril development, and strong knockdown of either gene results in impaired localization of kettin to the Z-disc. (uni-muenchen.de)
Further, several GWAS candidates were regulatory genes that may participate in the regulation of stress responses, and gene ontologies related to development and morphogenesis were enriched, suggesting many of these genes influence thermal tolerance through effects on development and physiological status. (frontiersin.org)
This gene is highly similar to the antennapedia (Antp) gene of Drosophila. (nih.gov)
Genetic studies have shown that esc protein is required in early embryos at about the time that other PcG proteins become engaged in homeotic gene repression. (umn.edu)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
He studies the Sonic Hedgehog gene and its role in development. (learner.org)
The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
Drosophila embryonic dorsal-ventral polarity originates in the ovarian follicle through the restriction of pipe gene expression to a ventral subpopulation of follicle cells. (princeton.edu)
The work presented in this PhD thesis focuses on the study of awd (abnormal wing discs) gene function during the development of Drosophila melanogaster. (unibo.it)
The haploinsuffcient dVHL (von-Hippel Lindau) gene is the Drosophila homolog of the human VHL tumour suppressor gene. (unibo.it)
The DLG4 gene provides instructions for making a protein that plays a role in nerve cells (neurons) in the brain. (medlineplus.gov)
This gene provides instructions for making a protein that is responsible for modifying other proteins, including Wnt proteins. (medscape.com)
PORCN , a member of the porcupine (PORC) gene family, encodes transmembrane endoplasmic reticulum proteins that target Wnt signaling proteins. (medscape.com)
Drosophila melanogaster porcupine and its mouse homologue PORCN gene encode transmembrane bound endoplasmic reticulum proteins needed for the secretion of Wnt (Wingless and INT-1) proteins. (medscape.com)
In Drosophila melanogaster , the PORCN gene is involved in the processing of the wingless protein. (medscape.com)
Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)

What will happen to an embryo that doesn't have any BICOID protein? (dnafromthebeginning.org)
Without the bicoid protein, as in the null mutant, anterior structures do not form properly and the embryo eventually dies. (dnafromthebeginning.org)
These photos show a wild-type Drosophila embryo that developed with normal BICOID levels and a mutant that did not have any BICOID. (dnafromthebeginning.org)
We show that the ankyrin repeats , in its entirety, and the hitherto uncharacterized Mib-specific domains (MIB), are important for the major function of Mib2 in skeletal and visceral muscles in the Drosophila embryo . (bvsalud.org)
Drosophila Embryo:dorsal-ventral specifiction. (osu.edu)
The first main topic is modeling, analysis, and discovery of Bone Morphogenetic Protein signaling networks in Drosophila stem cells maintenance and embryo development. (purdue.edu)
By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
They focused on one protein, Bicoid (Bcd), which is expressed in a gradient with highest levels at the end of the embryo that will become the mature fly's head. (livescience.com)
All three proteins are expressed in gradients with highest levels in the middle part of the embryo, and thus are positioned in exactly the opposite orientation compared to the Bcd activation gradient. (livescience.com)

Here, we demonstrate the utility of Drosophila as a genetic model system to investigate basic developmental mechanisms of RBP function in myogenesis. (uni-muenchen.de)
A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary. (oeaw.ac.at)
The genetic makeup of the Drosophila piRNA pathway. (oeaw.ac.at)
To test our hypotheses, we measured the critical thermal minimum (CT min ) and critical thermal maximum (CT max ) of 100 lines of the Drosophila Genetic Reference Panel (DGRP) and used GWAS to identify loci that explain variation in thermal limits. (frontiersin.org)
A Genetic Screen in Drosophila To Identify Novel Regulation of Cell Growth by Phosphoinositide Signaling. (ncbs.res.in)
My research is based on the need to understand the genetic mechanisms that control the establishment of the circuitry of the nervous system and for insights into the normal and pathological function of proteins that contribute to neurodegenerative disease. (kcl.ac.uk)
New York University biologists explored this process by studying the fruit fly Drosophila, a powerful model for studying genetic development as it is amenable to precise genetic manipulations. (livescience.com)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

Expression of these proteins is spatially and temporally regulated during embryonic development. (nih.gov)
To generalize and quantify these promising results, a broader collection of 19 well-defined CRMs from 9 Drosophila genes known to be required for proper embryonic development was compiled. (sdbonline.org)
Wnt signaling is critical for normal embryonic development of the skin, bones, and other structures. (medscape.com)
Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
Wnt proteins are key regulators of embryonic development. (medscape.com)

Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. (nih.gov)
For example, 34% of the transiently expressed genes fall into three groups, with increased transcript levels between 2.5-12, 11-20, and 15-20 h of development, respectively. (nih.gov)
Found in the cell membrane, this protein activates a signalling pathway that regulates the expression of genes that make the cell divide, grow, migrate, specialise or die. (sciencedaily.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Here, using the model species Drosophila melanogaster , we used a combination of Genome Wide Association mapping (GWAS) and transcriptomic profiling to characterize whether genes associated with thermal tolerance are primarily involved in dynamic stress responses or preparatory processes that influence physiological condition at the time of thermal stress. (frontiersin.org)
To fully understand this process it will be necessary to identify additional genes involved in wiring, define their expression patterns over the course of development and elucidate their cellular functions and molecular interactions. (kcl.ac.uk)
For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. (nih.gov)
The Drosophila extra sex combs (esc) protein, a member of the Polycomb group (PcG), is a transcriptional repressor of homeotic genes. (umn.edu)
In Drosophila , the BX-C cluster contains the three most posterior Hox genes, where their collinear activation incorporates progressive replacement of histone modifications, reorganization of 3D chromatin architecture and sequential activation of boundary elements and cis -regulatory regions. (biorxiv.org)
The morphogen theory posits that proteins controlling traits are arranged as gradients, with different amounts of proteins activating genes to create specified physical features. (livescience.com)
By examining DNA sequences associated with these target genes, the researchers discovered binding sites for three other proteins-Runt, Capicua, and Kruppel-which all act as repressors. (livescience.com)

SND1 also interacts with G3BP (stress granule protein) and AEG-1. (wikipedia.org)
Cactin, a conserved protein that interacts with the Drosophila IkB proteinCactus and modulates its function. (osu.edu)
By manipulating Cln3 function in Drosophila we have identified that it interacts with Notch and JNK signalling (Tuxworth et al. (kcl.ac.uk)
At synapses, the DLG4 protein interacts with other proteins to regulate a process called synaptic plasticity, which allows synapses to change and adapt over time in response to experiences. (medlineplus.gov)

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
This domain has previously been shown to bind to the b-catenin homolog Armadillo (Arm), raising the possibility that Wg input, in addition to Hh input, modulates the activity of the hybrid CiD protein. (uzh.ch)
We show that the butterfly homolog provides esc function in Drosophila, indicating that the sequence similarities reflect functional conservation. (umn.edu)
Ignesti, Marilena (2017) Uncovering the Relationship between Endocytosis and Awd, the Drosophila Homolog of Nme Metastasis Suppressor Proteins , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)

Genetics of Development Expert Interview Transcript: John Incardona, Ph.D. (learner.org)
and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics. (lu.se)

also called myosin heavy chain 95F (Mhc95F), or 95F MHC), which is a motor protein necessary for the morphogenesis of epithelial tissues during Drosophila development. (nih.gov)
How signaling proteins generate a multitude of information to organize tissue patterns is critical to understanding morphogenesis. (biorxiv.org)

Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. (harvard.edu)
Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos. (kit.jp)

The description of the new role of Notch, found in the fly Drosophila melanogaster , and the mechanism that regulates this function have been published in the journal Current Biology , which belongs to the Cell group. (sciencedaily.com)
Protein kinase D regulates metabolism and growth by controlling secretion of insulin like peptide. (ncbs.res.in)
IP3R mediated Ca(2+) release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress. (ncbs.res.in)
In Drosophila , FGF produced in wing-disc cells regulates the development of the disc-associated air-sac-primordium (ASP). (biorxiv.org)

article{5f173e96-c6fe-4b5f-8f37-b070076bc387, abstract = {{The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)

The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. (silverchair.com)
However, the mechanisms regulating lipid metabolism and the storage of lipid during development are less well characterized. (silverchair.com)
Our work therefore reveals a signalling mechanism by which the effect of insulin on lipid metabolism could be regulated independently of some of its other functions during development and adulthood. (silverchair.com)
The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. (medscape.com)

It contributes to synaptic transmission and development at the Drosophila neuromuscular junction. (nih.gov)
Optogenetic upregulation of cyclic adenosine monophosphate during the day increases sleep intensity at night, whereas loss of function of a molecule involved in synaptic pruning, the fragile-X mental retardation protein, increases sleep intensity during the day. (jneurosci.org)
Our results show that sleep is not homogenous in insects, and suggest that waking behavior and the associated synaptic plasticity mechanisms determine the timing and intensity of deep sleep stages in Drosophila . (jneurosci.org)
Most of the variants impair the normal function of the DLG4 protein by decreasing its ability to interact with the other proteins involved in synaptic plasticity or decreasing its ability to help synapses send signals. (medlineplus.gov)

Scientists reveal a surprising new function of Notch protein that contrasts with the one known to date. (sciencedaily.com)
Scientists headed by ICREA researcher Marco Milán, at the Institute for Research in Biomedicine (IRB Barcelona), reveal a surprising new function of Notch protein that contrasts with the one known to date. (sciencedaily.com)
Notch activity is required for the correct development of organisms and for the maintenance of tissues in adults. (sciencedaily.com)
The same pathways responsible for the development and growth of organisms are involved in the transformation of healthy cells into cancerous ones," says Marco Milán, so "all new data on the modulation of Notch activity, the first step in the chain, may be relevant for the design of effective therapies. (sciencedaily.com)
Marco Milán's group has now discovered that the presence of Notch proteins in the cell membrane is also required to inactivate the pathway. (sciencedaily.com)
In order for the Notch pathway to be activated, ligand-type proteins from neighbouring cells bind to the Notch receptor. (sciencedaily.com)
The researchers have discovered the self-repression mechanism of Notch in Drosophila and it should be checked now whether this also operates in mice and humans. (sciencedaily.com)
It is well established that the Notch pathway controls the development of T lymphocytes, cells of the immune response system found in blood. (sciencedaily.com)
Overexpression of RAB8 rescued NOTCH activation after ICMT knockdown both in U2OS cells expressing NOTCH1 and in fly wing vein development. (sdbonline.org)

SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. (wikipedia.org)
We report that esc protein is highly conserved in housefly (72% identical to Drosophila esc), butterfly (55% identical), and grasshopper (56% identical). (umn.edu)

The proper regulation of RNA processing is critical for muscle development and the fine-tuning of contractile ability among muscle fiber-types. (uni-muenchen.de)
The focus of our research is to investigate the regulation of signal transduction in development. (purdue.edu)

2009) and increases in its activity interferes with the normal function and development of the neuromuscular junction (Tuxworth et al unpub obs). (kcl.ac.uk)

Screening more than 200,000 fragments covering the coding sequences of all transcription-related proteins in Drosophila melanogaster, this study identified 195 RDs in known repressors and in proteins not previously associated with repression. (sdbonline.org)
Hb, Kr, and Kni are zinc-finger gap proteins that act primarily as repressors in specific embryonic domains. (sdbonline.org)

Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin. (silverchair.com)

profiling of the substrate repertoire of RHBDL2 has identified a number of additional type I membrane proteins substrates, including BCAM, SPINT1, and CLCP1. (wikipedia.org)

Development, Growth & Differentiation. (wikipedia.org)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

The activities of the two pathways depend on each other during Drosophila embryogenesis. (uzh.ch)

If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)

Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)

Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. (uzh.ch)

Planar polarity is evident in the coordinated orientation of ommatidia in the Drosophila eye. (nih.gov)
Using mosaic analysis and RNAi in the model organism Drosophila melanogaster, we show that Dystroglycan is required cell-autonomously for cellular polarity in two different cell types, the epithelial cells (apicobasal polarity) and the oocyte (anteroposterior polarity). (lu.se)

Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
Drosophila is thus a powerful model to gain disease-relevant insight into cellular and molecular phenotypes observed when expression levels of splicing factors, spliceosome components and splicing dynamics are altered. (uni-muenchen.de)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)

We have identified that the Drosophila Cln3 shares many properties with the vertebrate form, it is localised to the endosomal-lysosomal compartment in many cell type and found at the synapse. (kcl.ac.uk)
However, little is known about its function in vertebrate development. (nature.com)
Pipe protein expressed in vertebrate tissue culture cells localizes to the endoplasmic reticulum. (princeton.edu)

Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster , revealing a crucial role for cell-surface activation of the downstream effector kinase Akt in many of these processes. (silverchair.com)
Septins tune lipid kinase activity and PI(4,5)P turnover during G-protein-coupled PLC signalling in vivo. (ncbs.res.in)

During development, growing axons are guided to their appropriate targets by extracellular cues, the response to which depends crucially on the repertoire of receptors expressed by each axon and the intracellular mechanisms that transduce and regulate the response to these cues. (kcl.ac.uk)

Endogenous Trol GFP strain produces a functional Perlecan protein. (elifesciences.org)
However, the functional parts of a Drosophila eye are present. (dnafromthebeginning.org)
In this study, we have examined the mechanistic aspects of Mib2 function by performing a detailed functional dissection of the Mib2 protein . (bvsalud.org)
Functional analysis of these new alleles , including in vivo imaging, demonstrates that Mib2 plays an additional important role in the development of adult thorax muscles , particularly in maintaining the larval templates for the dorsal longitudinal indirect flight muscles during metamorphosis. (bvsalud.org)
We highlight common and distinctive functional features of these expression groups and identify a coupling between downregulation of transcript levels and targeted protein degradation. (nih.gov)
By mapping the groups to the protein network, we also predict and experimentally confirm new functional associations. (nih.gov)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
Identification and functional characterization of muscle satellite cells in Drosophila. (ncbs.res.in)
Fry protein is composed of an N-terminal Furry domain (FD) with HEAT/Armadillo repeats followed by five regions without any recognizable functional domains. (nature.com)
This includes selective binding of proteins, structural change after binding and the functional implications. (lu.se)

Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. (lu.se)

Defective development of the embryonic radial ray (eg, aplasia, hypoplasia, fusion, other anomalous development) results in a wide spectrum of phenotypes, including triphalangeal or absent thumbs, foreshortened arms, and phocomelia. (medscape.com)

The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. (oeaw.ac.at)

Identification of the essential protein domains for Mib2 function during the development of the Drosophila larval musculature and adult flight muscles. (bvsalud.org)
2017. Identification and structural characterization of the precursor conformation of the prion protein which directly initiates misfolding and oligomerization. . (ncbs.res.in)
Identification of Miranda Associated Proteins and RNA in Drosophila melanogaster Neuroblasts. (uni-muenchen.de)

Jar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. (nih.gov)

MUKHERJEE,A,B. "Cells in vivo and in vitro from osteopetrotic mice homozygous for c-src disruption show suppression of synthesis of osteopontin, a multifunctional extracellular matrix protein. (osu.edu)

Together with CLIP-190 (CAP-Gly domain-containing/cytoplasmic linker protein 190), Jar may coordinate the interaction between the actin and microtubule cytoskeleton. (nih.gov)
The esc protein consists primarily of multiple copies of the WD repeat, a motif that has been implicated in protein-protein interaction. (umn.edu)
We suggest that these regions might mediate physical interaction with esc partner proteins. (umn.edu)
Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. (kit.jp)
We study the interaction between proteins in biological fluids as well as single proteins to nanomaterials of different kinds. (lu.se)

Perlecan conservation and localization within the Drosophila PNS. (elifesciences.org)
Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
Khd1p, a protein with multiple roles in mRNA localization and telomeric silencing. (uni-muenchen.de)
Similarly, Pipe protein exhibits an altered subcellular localization in the follicle cells of females mutant for windbeutel. (princeton.edu)

Early Drosophila development depends on the correct distribution of maternal proteins in anterior/posterior (A/P) and the dorsal/ventral (D/V) axis. (dnafromthebeginning.org)
The A/P axis is set up by a protein called BICOID that is expressed in a anterior-to-posterior gradient. (dnafromthebeginning.org)

This study used Drosophila melanogaster wing vein and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT ( Ste14 in flies). (sdbonline.org)

Homology modeling using the crystal structure of another WD repeat protein, the G-protein β- subunit, predicts that esc protein adopts a β-propeller structure. (umn.edu)

Drosophila as a model system to study axonal guidance and neurodegenerative disease. (kcl.ac.uk)

The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)
Phospholipid transport protein function at organelle contact sites. (ncbs.res.in)
Site-directed mutagenesis of specific loops, predicted to extend from the propeller surface, identifies conserved parts of esc protein required for function in vivo. (umn.edu)

But some biologists have raised questions about the theory, which contends that physical features are necessarily tied to absolute concentrations of proteins within the morphogen gradient. (livescience.com)
We aim to study low concentrations of nanoparticles down to single particles in biologically relevant concentrations of proteins. (lu.se)

Through a better knowledge of how neural development normally occurs and how neurodegenerative pathologies develop we hope to provide information to aid neural regrowth and combat neural disease and injury. (kcl.ac.uk)
Neural stem cells in development and cancer. (uni-muenchen.de)

We have begun to combat this by investigating the role of the transmembrane protein Cln3, which is affected in the most common form of NCL, using Drosophila. (kcl.ac.uk)
The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)

Thereafter, the OHO31 protein is predominantly expressed, albeit at reduced levels, in proliferating tissues. (rupress.org)

RNA binding proteins (RBPs) regulate the diverse steps in RNA processing, including alternative splicing, which generates fiber-type specific isoforms of structural proteins that confer contractile sarcomeres with distinct biomechanical properties. (uni-muenchen.de)
Structural organization of RDGB (retinal degeneration B), a multi-domain lipid transfer protein: a molecular modelling and simulation based approach. (ncbs.res.in)
2017. Graded Structural Polymorphism in a Bacterial Thermosensor Protein. . (ncbs.res.in)

2017. The long 3'UTR mRNA of CaMKII is essential for translation-dependent plasticity of spontaneous release in Drosophila melanogaster. . (ncbs.res.in)

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders. (ncbs.res.in)

However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). (nature.com)
This image shows the embryonic expression pattern of a Drosophila protein called HAIRY (seen in yellow). (dnafromthebeginning.org)
A strong reduction in the expression of oho31 by a P element inserted in the 5' untranslated region of the oho31 transcript or a complete inactivation of oho31 by imprecise P element excision leads to malignant development of the hematopoietic organs and the genital disc, as shown by their growth autonomy in transplantation assays. (rupress.org)

STP, serine/threonine protein phosphatase. (rupress.org)

Isoprenylcysteine carboxyl methyltransferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GTPases. (sdbonline.org)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

This question has become increasingly relevant since Drosophila became a model of choice for investigating molecular processes associated with sleep in health and disease ( van Alphen and van Swinderen, 2013 ). (jneurosci.org)
In addition my research group has developed the use of Drosophila as a model system to identify the normal and pathological roles of proteins associated with neurodegenerative disease. (kcl.ac.uk)

ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters. (oeaw.ac.at)
The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila. (oeaw.ac.at)

The exon junction complex is required for definition and excision of neighboring introns in Drosophila. (oeaw.ac.at)

Mechanisms of Development, 78(1-2):141-151. (uzh.ch)
Mechanisms of Development. (osu.edu)

Drosophila willistoni (Sturtevant, 1916) is a species of the willistoni group of Drosophila having wide distribution from the South of USA (Florida) and Mexico to the North of Argentina. (scielo.br)
To further investigate the domain organization of esc protein, we have isolated and characterized esc homologs from divergent insect species. (umn.edu)

During development, intercellular communication of morphogens is critical for embryonic cells to determine their positional identity, directionality, and interactions in an organized pattern to sculpt tissue. (biorxiv.org)
Alternative views have suggested physical features are not necessarily the result of a specified number of proteins, but, rather, come from more complex interactions between multiple gradients that work against one another. (livescience.com)

Anatomy37

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