Development differential accumulation. Medical search. Frequent questions

In differential gene and miRNA expression studies, we identified a number of key developmental genes and miRNA-mRNA target modules previously described in relation to their developmental regulatory role in the cereal panicle, notably the miR156/529/535-SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) gene regulatory module. (bvsalud.org)
The differential accumulation of H5 reflected (i) an increase in the transcriptional activity of the H5 gene occurring at the erythroblast stage, (ii) an apparent longer half-life of H5 mRNA, and (iii) a higher stability of the protein. (unibas.ch)
Although the transcription rates of the H5 and beta A-globin genes were comparable, differential accumulation of beta A-globin mRNA led to a 30- to 170-fold-higher copy number of the beta A-globin mRNA as the cell matured. (unibas.ch)
However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. (thermofisher.com)

Norepinephrine transporter, organic cation transporters, and multidrug and toxin extrusion proteins play differential roles in tumor targeting, systemic elimination, and accumulation in normal tissues. (aspetjournals.org)
Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
Sequential sampling of heavily infected trees revealed marked seasonal patterns, with differential accumulation in woody stem and leaf tissues and, most notably, within fruit in the early stages of development from bloom to pit hardening. (uibk.ac.at)
Arthropathy is due to iron accumulation in joint tissues. (medscape.com)
Lack of these enzymes allows for the accumulation of complex carbohydrates in the body's cells and tissues and in the cellular organelles, the lysosomes. (medscape.com)

the effects of hypoxia and fibrosis may also play a role in obesity complications via notably ectopic-lipid accumulation in non-adipocyte cells. (springer.com)
However, lipid accumulation in non-specialized cells is deleterious and can contribute to cell death resulting in the development of pathology such as NASH (Non-Alcoholic Steatohepatitis) a liver injury associated with obesity [ 12 ]. (springer.com)
A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)

Before a specific type develops, symptoms include lagging motor development and often persistent infantile reflex patterns, hyperreflexia, and altered muscle tone. (msdmanuals.com)

These regions contain a number of key genes that regulate panicle development in O. sativa and their interspecific genomic variations may explain the phenotypic effects observed. (bvsalud.org)
Previous studies suggested the importance of several AP2/ERF transcription factor-encoding genes in the control of panicle development, including the AINTEGUMENTA/PLETHORA-like (euANT/PLT) genes. (bvsalud.org)
DFR and BZ1 structural genes and some bHLH, MYB, WD40, AP2, and bZIP TF family members enhance the accumulation of two pelargonidin derivatives. (biomedcentral.com)

Interleukin-6 (IL-6) seems to regulate both plasmacytoma development in BALB/c mice and oil granuloma formation in C57BL/6 mice during pristane-induced inflammation [ 10 , 12 ]. (hindawi.com)
Greater abdominal visceral fat accumulation was observed in mice fed with AD compared to those fed a chow diet or VD. (biomedcentral.com)
BAL cytology indicated a robust and early (day 1) accumulation of neutrophils - slightly weaker in MPO k/o mice vs w/t animals ( Fig. 1d ), followed by a sequential appearance of macrophages in both groups of animals (with a peak at day 7) (data not shown) [4] . (cdc.gov)

Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. (bdbiosciences.com)
Although treatment with curcumin, garcinol or the garcinol derivative LTK-14 hampered MCF7 cell proliferation, differential effects of these compounds on histone modifications were observed. (biomedcentral.com)
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. (biomedcentral.com)
Only approximately 5% of compounds showed differential toxicity responses in the cell lines with no obvious correlation to the known in vivo organ toxicity. (nih.gov)

In addition to its effects on histone modifications, garcinol was found to block CBP/p300-mediated acetylation of the C-terminal activation domain of p53, but resulted in enhanced acetylation of p53K120, and accumulation of p53 in the cytoplasmic compartment. (biomedcentral.com)

Microplastic-associated PCBs are placed in a differential bioavailability framework by comparing the results to several other natural and anthrogenic particles, including wood, coal, and biochar. (researchgate.net)

Select organ toxicity potentially results from compound accumulation in a particular tissue, cell types within organs, metabolism, and off-target effects. (nih.gov)
A contract to evaluate the practicality and permissibility of modern laser-based technology for remotely detecting and mapping potentially explosive methane accumulations. (cdc.gov)
What other potentially traumatic experiences in childhood, when compared to the traditional ACEs, have 1) similar impacts on children's development and well-being and 2) similar impacts on subsequent negative outcomes and should therefore be included as (and measured as) ACEs? (cdc.gov)

Differential homing mechanisms regulate regionalized effector CD8alphabeta+ T cell accumulation within the small intestine. (bdbiosciences.com)

Assessments of chloride and potassium balance in urine could serve as an additional diagnostic tool for the differential diagnosis of thiazide-associated hyponatremia. (medscape.com)

Obesity is defined as an increase of adipose tissue mass in the body and its accumulation in peripheral organs that leads to metabolic abnormalities such as type 2 diabetes (T2D), insulin resistance and hyperlepidemia [ 1 , 2 ]. (biomedcentral.com)
Obesity is defined as an excess accumulation of white adipose tissue associated with a low grade inflammation which is one contributor to obesity complications such as diabetes. (springer.com)
In the first one, local adipose tissue hypoxia could induce fibrosis accumulation which in turn through adipocyte dysfunctions might provoke adipose tissue inflammation. (springer.com)

In 2020, he co-led the development of a COVID-19 registry for the T1D Exchange which has published and submitted several manuscripts describing the experience of US patients with T1D who experience COVID-19. (cuanschutz.edu)

Indeed the visceral WAT which is more inflamed with higher accumulation of macrophages [ 7 ] has more detrimental effects than the subcutaneous WAT [ 11 ]. (springer.com)

4) Periodic lulls in amalgamation tend to be compensated for by stagflation, which appears as a crisis at the societal level, but which contributes significantly to differential accumulation at the disaggregate level. (wikipedia.org)
Stagflation, which appears as a crisis at the societal level, contributes significantly to differential accumulation at the disaggregate level, that is, of dominant capital groups accumulating faster than smaller businesses. (wikipedia.org)
Obesity is defined as an expansion of white adipose (WAT) tissue that is associated with low grade inflammation which possibly contributes to the development of health complications such as diabetes, liver pathologies, dyslipidemia, cardiovascular diseases as well as some cancers [ 2 - 4 ]. (springer.com)

The hybridization between F. nilgerrensis (white fruits) and F. × ananassa (red fruits) resulted in an interspecific decaploid hybrid ('Tokun') with a pink fruit color [ 8 ], suggesting that clarifying the genetic basis of anthocyanin accumulation may lead to critical insights into the metabolic mechanism underlying strawberry fruit color formation, with implications for improving fruit quality. (biomedcentral.com)
In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
This differential reproductive success gradually alters the genetic makeup of the population, leading to the evolution of new species over extended periods of time. (darwinism-watch.com)

Change in Population Characteristics: As generations pass, the population gradually changes as a result of the differential reproductive success of individuals with different traits. (darwinism-watch.com)

Indeed, WAT remodeling eventually associated with a limited capacity to adequately expand might induce lipid spill over and this triglyceride accumulation in other depots such as liver or muscle. (springer.com)

the process that governs the early embryonic patterning of the Drosophila body plan is now the best understood example of a complex cascade of transcriptional regulation during development [ 14 , 15 ]. (biomedcentral.com)
Unveiling the central regulation of pubertal development. (medscape.com)

Salinity induced metabolite responses resulted in differential accumulation of flavonoids and antioxidant metabolites in shoots and roots suggesting improved antioxidant capacity in providing salt-adaptive phenotype of tef seedling. (aber.ac.uk)

Diabetes, often requiring insulin therapy, occurs due to progressive iron accumulation in the pancreas. (medscape.com)

The focus of Dr. Berg's work is on the signaling proteins and pathways regulating T lymphocyte development, differentiation, activation, and migration, with a strong emphasis on T-cell receptor (TCR) signaling. (cuanschutz.edu)

This mini-review focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response and toxicity. (aspetjournals.org)

Yet to do so was to accept development only at the pace at which the peasantry voluntarily expanded its output - the peasant would control the generation of the agricultural surplus, and thus the pace of urban capital accumulation. (marxists.org)

Cell and tissue specific gene expression is a defining feature of embryonic development in multi-cellular organisms. (biomedcentral.com)
RNA in situ hybridization has the potential to reveal both spatial and temporal aspects of gene expression during development. (biomedcentral.com)
There are several reasons for choosing Drosophila melanogaster as an organism for the global study of gene expression during embryonic development. (biomedcentral.com)

SATURN aimed to respond to an urgent need, as stated in the EU Council conclusions (June 2008) on AMR, in which the EU "stresses the need of research in the area of AMR, e.g. to increase the understanding of the mechanisms and underlying risk factors that advance the development of AMR and to increase the knowledge of the effectiveness of current and future control measures. (europa.eu)

Over the past decades, many countries have implemented significant reforms to foster domestic capital market development. (worldbank.org)
The clinical features of Sanfilippo syndrome, including the significant CNS component (brain and spinal cord), result from the progressive lysosomal accumulation of the GAG heparan sulfate. (medscape.com)

Moreover, concerns are raised with the use of contaminated water in agriculture and vegetable production as this can lead to food contamination and human exposure to toxins as well as impairment in crop development and productivity. (us.es)

Without the proper enzymatic degradation of the mucopolysaccharides, clinical symptoms, such as auditory and visual defects, cardiovascular pathologies, hepatosplenomegaly, and dysostosis multiplex, occur due to their accumulation in organ systems. (medscape.com)

Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)

Trotter] is an important 'cash crop' of Ethiopia grown mainly for human food, and development of elite tef cultivars with better performance is vital to Ethiopian farmers and breeders. (aber.ac.uk)

Elevated accumulation of lineage-specific pseudogenes after divergence from generalist populations and possible metabolic acclimation in a representative swine isolate indicates possible emergence of host adaptation. (cdc.gov)

The concept of differential accumulation emphasizes the powerful drive by dominant capital groups to beat the average and exceed the normal rate of return. (wikipedia.org)
But then if capital is not 'tangible', how should its accumulation be measured? (wikipedia.org)
Differential accumulation theory sees stagflation oscillate inversely with periods where mergers and acquisitions are dominant as a major strategy of dominant capital groups to "beat the market" or exceed the normal, average rate of return on investments. (wikipedia.org)
To study whether reforms have had the intended effects on capital markets, the authors analyze the impact of six capital market reforms on domestic stock market development and internationalization using event studies. (worldbank.org)
In particular, we study the extent to which one can account for international income differences with differences in policies that distort capital accumulation. (repec.org)
In models with home production, such policies not only reduce capital accumulation but also change the mix of market and nonmarket activity. (repec.org)
In fact, the Swedish capital-income ratio was similar to that in the U.S., but the savings and growth rates were much lower in Sweden than in the U.S. Rapid income growth following industrialization and increasing savings rates were also important factors behind the development of the capital-income ratio and the inheritance flow during the twentieth century. (repec.org)
In 1913, Rosa Luxemburg's The Accumulation of Capital offered a unique contribution to the Marxist theory of imperialism partly because she drew on primary accounts of Africa's super-exploitation, with nuanced attention to the social formation emerging in South Africa. (cadtm.org)
First, Luxemburg's Accumulation gives us the basic tools to work through why there is a "ceaseless flow of capital from one branch of production to another, and finally in the periodic and cyclical swings of reproduction between overproduction and crisis" (2003, 76). (cadtm.org)

Ultimately, for both areas, the results of the proposed research should aid the development of effective strategies for multilevel interventions to that seek to promote health and/or lessen the burden of disease. (nih.gov)
Collectively, these data give a much clearer picture of symptom development in ' Ca. P. pruni'-infected P. persica and provide several avenues for further research in determining how ' Ca. P. pruni' interacts with its host to elicit the observed symptoms. (uibk.ac.at)
Its aim is to provide timely, authoritative introductions to current thinking, developments and research in carefully selected topics. (lidsen.com)
Inherited Wealth over the Path of Development: Sweden, 1810-2010 ," Working Paper Series 1033, Research Institute of Industrial Economics. (repec.org)
Amiad's greatest achievement is its research, development and the production of suction-scanning screen technology. (suyum.az)

A differential response in the development of obesity complications exists depending on WAT depot distribution. (springer.com)
In this review, we aim to describe the relationships and discussed sequence of events associated with hypoxia, ECM remodeling and inflammation in the development of obesity and associated complications. (springer.com)

Molecular Therapy - Methods and Clinical Development. (lu.se)

Differential accumulation is an approach for analysing capitalist development and crisis, tying together mergers and acquisitions, stagflation and globalization as integral facets of accumulation. (wikipedia.org)
Stock Market Development under Globalization : Whither the Gains from Reforms? (worldbank.org)

In the process, Luxemburg described and also theorized how settler colonialism's primitive accumulation was not a once-off affliction. (cadtm.org)
Instead it was, and remains , a systematic way to arrange capitalist and non-capitalist relations to the benefit of the former, as a means of addressing internal contradictions within the accumulation process, albeit in a context of growing resistance. (cadtm.org)
Pathogenesis of neonatal jaundice includes physiologic process of bilirubin accumulation or pathological mechanism. (wikidoc.org)
In recent years, efforts have been made to identify such liabilities earlier in the drug development process, through utilization of in silico and cytotoxicity models. (nih.gov)

The differential pairing results in autoimmunity with distinct morphological outcomes. (ubc.ca)

Fibrosis is characterized by an excessive accumulation of extracellular matrix components which could result in tissue dysfunction. (springer.com)
Those arguments were constructed during the critical period of primitive accumulation, and as a result, Luxemburg considered the context for land and natural resource dispossession, migrant labor, and ethno-patriarchal rule. (cadtm.org)

A goal of Dr. Akturk's lab is to identify risk factors to develop diabetes and develop screening algorithms to prevent morbidity and mortality related to diabetic ketoacidosis and understand PD-1 pathway in possible prevention of the development of childhood onset type 1 diabetes. (cuanschutz.edu)
[ 69 ] The type of mutations for hereditary hemochromatosis, ferritin level, or the presence of cirrhosis were not predictive for diabetes mellitus development. (medscape.com)

Applicants proposing Centers focused on cancer-related disparities are must include intervention development/testing as one of required projects. (nih.gov)
The lack of source information for most foodborne infections substantially challenges understanding of the epidemiology of foodborne illnesses and development of intervention measures for their prevention and mitigation. (cdc.gov)

We introduce home production into the neoclassical growth model and examine its consequences for development economics. (repec.org)
Plants are exquisitely environmentally responsive, dynamically adjusting their growth and development according to the prevailing environmental conditions. (ens-lyon.fr)
It is part of our wider strategy to achieve responsible growth where economic development and businesses' role in improving health and wellbeing go hand in hand. (who.int)

Each avenue of breadth and depth can be divided into pursuing differential accumulation through "internal" or "external" means. (wikipedia.org)
This gives us four categories of differential accumulation: internal breadth by amalgamation (buy or join other businesses), external breadth through greenfield investment (build new factories), internal depth via cost-cutting (make workers work harder or find ways to reduce the price of inputs), and external depth through stagflation (raise prices faster than the competition). (wikipedia.org)

Despite substantial income differentials between urban and rural areas, individuals do not migrate as the higher income is devoured by higher living costs (associated with rental housing in the urban areas). (lu.se)

Differential Survival and Reproduction: In the struggle for survival, individuals with certain advantageous traits are more likely to survive and reproduce successfully. (darwinism-watch.com)
Accumulation of Favorable Traits: Over time, as more individuals with advantageous traits survive and reproduce, the frequency of those traits increases in the population. (darwinism-watch.com)

Homework in Development Economics: Household Production and the Wealth of Nations ," Journal of Political Economy , University of Chicago Press, vol. 108(4), pages 680-687, August. (repec.org)
Inherited wealth over the path of development: Sweden, 1810-2010 ," Working Paper Series, Center for Labor Studies 2014:7, Uppsala University, Department of Economics. (repec.org)
Wealth Concentration over the Path of Development: Sweden, 1873-2006 ," Scandinavian Journal of Economics , Wiley Blackwell, vol. 111(1), pages 151-187, March. (repec.org)

On the other hand, intra or extra hepatic cholestasis lead to accumulation of conjugated bilirubin causing conjugated hyperbilirubinemia. (wikidoc.org)

Our study highlights the role of flavonoid accumulation following salt stress on tef seedlings and further these findings could be used as targets for selective tef breeding. (aber.ac.uk)

These data provide insight into the development of chronic inflammation induced by noninfectious substances. (hindawi.com)
Cumulatively, these data aid in accurate sampling and management decision-making and furthers our understanding of disease development. (uibk.ac.at)
1989). In addition, differential analysis including daily excretion data revealed a pattern of fractional particle clearance rate of the ultrafine iridium particles similar to that of micrometer- sized particles reported by Snipes et al. (cdc.gov)

Departments in development of the new Alcohol Strategy. (who.int)

Reports on the U.S. Bureau of Mines development and testing of an instrinsically safe methane monitor based on differential absorption of infrared light. (cdc.gov)

This differential distribution of receptors on the presynaptic neuron is regulated by a target and does not require the physical presence of neurons that release the neuromodulators. (jneurosci.org)

Then, in combination with the differential evolution algorithm, the dynamic water environment capacities of each control unit were further discussed. (mdpi.com)

A defining feature of multi-cellular organisms is their ability to differentially utilize the information contained in their genomes to generate morphologically and functionally specialized cell types during development. (biomedcentral.com)

A gene's expression pattern can be defined as a series of differential accumulations of its products in subsets of cells as development progresses. (biomedcentral.com)

The health consequences of anaemia can include poor pregnancy outcome, impaired physical and cognitive development, increased risk of morbidity in children and reduced work productivity in adults. (who.int)

Hence these models can generate larger differences in output than standard models for a given policy differential. (repec.org)

Diffing function is combined together with folding/reducing functionality to allow convenient direct accumulation of changes. (ocaml.org)

Anatomy37

Organisms22

Diseases3

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Psychiatry and Psychology1

Phenomena and Processes77

Disciplines and Occupations2

Technology, Industry, Agriculture3

Information Science4

Health Care4

MRNA4

Tissues5

Lipid accumulation3

Patterns1

Genes3

Mice3

Compounds4

Cytoplasmic1

Bioavailability1

Potentially3

Regulate1

Diagnosis1

Adipose tissue3

20201

Visceral1

Contributes3

Genetic3

Reproductive1

Liver1

Regulation2

Responses1

Insulin1

Proteins1

Toxicity1

Pace1

Gene3

Mechanisms1

Significant2

Impairment1

Pathologies1

Differentiation1

Cultivars1

Metabolic1

Capital9

Research5

Obesity2

Clinical Development1

Globalization2

Process4

Results1

Result2

Diabetes2

Intervention2

Growth3

Internal2

Urban1

Individuals2

Economics3

Lead1

Study1

Data3

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Monitor1

Distribution1

Evolution1

Cell types1

Cells1

Physical1

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Direct1