Development chemicals biocatalysts. Medical search. Frequent questions

Enzymes are extremely efficient and highly selective bio-catalysts for chemical synthesis. (selectbiosciences.com)
Biocatalysts Ltd is a biotechnology company based in Cardiff, Wales, developing and manufacturing speciality enzymes at commercial scales for a variety of industries, such as food, flavour & fragrance, life science, pharma and fine chemicals. (sintef.no)
The Bioreactions group is using enzymes as biocatalysts to support the synthesis of chiral building blocks and drug candidates, facilitating Novartis research from early discovery through to development. (novartis.com)
Biocatalysis allows chemists to use enzymes for specific chemical reactions instead of rare and toxic transition metals," Michalak adds. (amgen.com)
Elaine's research focuses on the development of novel enzymes and methodologies that enable entirely new biocatalytic disconnections, and her group focus on overcoming the challenges that hamper the widespread application biocatalysts. (qub.ac.uk)
Enzymes are proteins that act as biological catalysts, which accelerate chemical reactions. (u-szeged.hu)
Enzymes, on the other hand, are sensitive biocatalysts that can partially or totally lose their enzymatic activity as a consequence of any major changes occurring in their surrounding environment. (u-szeged.hu)
This includes the use of biocatalysts such as enzymes or microorganisms for production and remediation processes, for instance the electrochemical hydrogen generation or the removal of anthropogenic micro-pollutants from wastewaters. (uni-bremen.de)
The agreement grants DSM rights to use Codexis's custom biocatalysts and services and secures a supply of Codexis enzymes for commercialization of pharmaceutical manufacturing routes developed by DMS's InnoSyn route-scouting service. (pharmtech.com)
The kits contain 24 enzymes from Codexis's collection of biocatalyst variants from two enzyme classes: ketoreductase and transaminase. (pharmtech.com)
These are based on enzymes and microbes, using the principles of green chemistry in order to produce chemicals and materials from renewable resources. (lu.se)

In the study of biocatalysis, the activity of one of the most commonly used industrial biocatalysts, serine protease, has been explored to provide new insights. (auburn.edu)
The SFI covers relevant areas of business in enzyme development (e.g. discovery and engineering), enzyme based biocatalysis (e.g. new applications areas), and enzyme manufacture by fermentation (piloting, scale-up, assess productivity, economic feasibility, fungal expression systems). (sintef.no)
Biocatalysis will help us to tackle the increasing chemical complexity in pharmaceutical industry especially in areas such as late-stage functionalisation, bioconjugates and post-translational peptide modifications. (novartis.com)
Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug. (novartis.com)
The aim of the proposed work is to enable a substantial increase in the rate and extent of the uptake of biocatalysis processes by industry, i.e. the use of biological catalysts to facilitate chemical reactions. (europa.eu)
Biocatalysis is gaining in significance as it helps to make the building blocks of pharmaceutical ingredients and fine chemicals much more accessible. (rwth-aachen.de)
One key enabler of green chemistry that we are learning and building on is the use of biocatalysis, which employs small quantities of biocatalysts to enable reactions," Oliver explains, "instead of stoichiometric reactions that use large quantities of potentially hazardous reagents, which then go to waste after the reaction is complete. (amgen.com)
Therefore, this COST Action (acronym "CASCAT") aims to enhance the synthetic potential of biocatalysis by coupling biotransformations one to another and integrating them with chemical steps to increase the product purity and yields close to quantitative values. (cost.eu)
The exceptional surface morphology, pore distribution, thermal conductivity, chemical inertness, electrical property and renewability of carbon materials have rendered them suitable for various catalytic processes namely, photocatalysis, electrocatalysis, biocatalysis and chemical catalysis. (eurekaselect.com)
Biocatalysis, chemocatalysis, and other chiral technologies continue to attract the investment dollars of CMOs and fine-chemical companies. (pharmtech.com)
Strengthening capabilities in biocatalysis, chemocatalysis, and other technologies in support of pharmaceutical companies' interest in producing single-enantiomer drugs is an area of investment by select fine-chemical companies, CMOs, and technology providers. (pharmtech.com)
The launch of the selectAZyme line of biocatalysts follows Almac's $4-million investment in biocatalysis R&D. Research areas include new biocatalytic platforms for producing chiral intermediates, hyperactivation of biocatalysts for reducing enzyme loadings, developing drivers for cofactor recycling, and mitigating problems with equilibriums. (pharmtech.com)
In October 2010, Codexis expanded its offerings in biocatalysis by introducing screening kits for a subset of the range of biocatalysts it offers. (pharmtech.com)
In January 2011, Codexis formed a collaboration with Dainippon Sumitomo Pharma (DSP) under which Codexis is supplying biocatalysis screening products and services to DSP for use in selected undisclosed therapeutic products in its development pipeline. (pharmtech.com)

For the development of chemical tools and microbial biocatalysts for sustainable synthesis. (rsc.org)
Chemical synthesis is a key driver of industrial CO 2 emissions worldwide. (rsc.org)
His research focuses on the use of microorganisms for sustainable chemical synthesis. (rsc.org)
They are used as the important biocatalysts for the development of eco-friendly fermentation processes as an alternative to the chemical synthesis. (wikipedia.org)
The research will focus on the immobilisation/stabilisation techniques and will assess the enhancement in performance produced in the main target application of fine chemicals synthesis. (europa.eu)
The catalyst market encapsulates substances that accelerate chemical reactions in various industries such as petroleum refining, chemical synthesis, petrochemicals, and pharmaceuticals. (reportlinker.com)
The application of biocatalysts in the synthesis of fine chemicals and medicinal compounds has grown significantly in recent years. (illinois.edu)
However, with recent advances in protein engineering, catalyst synthesis, artificial metalloenzymes and supramolecular assembly, there is great potential to develop more sophisticated tandem chemoenzymatic processes for the synthesis of structurally complex chemicals. (illinois.edu)
A multidisciplinary approach is required to achieve this goal, involving precursor synthesis, enzyme screening, heterologous protein expression, enzyme mutagenesis, biocatalyst (co)-immobilization, bioreactor design and chiral product analysis. (cost.eu)
Presently, the synthesis methods of NMN mainly include two categories: chemical synthesis and biosynthesis. (bvsalud.org)
This review summarizes the chemical synthesis and biosynthetic pathways of NMN and provides an in-depth investigation on the mining and modification of enzyme resources during NMN biosynthesis, as well as the screening of hosts and optimization of chassis cells via metabolic engineering, which provide effective strategies for efficient production of NMN. (bvsalud.org)
â ¢ The chemical and biological synthesis of NMN are comprehensively reviewed. (bvsalud.org)

Codexis develops optimized biocatalysts that make industrial processes faster, cleaner and more efficient. (prnewswire.com)
The results and methods arrived at shall lead to a thorough understanding of processes in the reaction systems and, in the longer term, facilitate the systematic development of suitable biocatalysts and processes. (rwth-aachen.de)
The INDOX proposal on industrial oxidoreductases aimed to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. (bsc.es)
But when the synthetic chemist joined the biotech company Amgen in Process Development-where scientists create the chemical processes for manufacturing medicines-she found an opportunity to apply her passion for sustainability on a global scale. (amgen.com)
Green chemistry first gained traction in 1990s with the goal of making products using chemical processes that reduce waste, conserve energy and employ alternatives to hazardous substances. (amgen.com)
Margaret Faul, vice president of Manufacturing and Clinical Supply at Amgen, was an early advocate for green chemistry in Amgen's labs, and her pioneering leadership paid off, with Amgen becoming an early member of the Green Chemical Institute Pharmaceutical Round Table and earning industry recognition over the years for its innovative green processes. (amgen.com)
Recently a diverse team of scientists and engineers, working at Amgen's lab sites in both Cambridge, Mass., and Thousand Oaks, Calif., published a review article in the Israel Journal of Chemistry that highlighted real-world examples of work that "contributed to the development of processes that are significantly greener and more environmentally friendly that the corresponding starting points. (amgen.com)
Biotechnology traditionally harnesses biological processes in the development of new technologies and products. (kcl.ac.uk)
Aims to develop new catalytic processes to unlock innovative chemical transformations. (ed.ac.uk)
Whatever your view of Chemical Biology as a field, there is a great deal of evidence that chemistry is uniquely placed to increase our understanding of, and ability to intervene in, biological processes. (biomedcentral.com)
The new four-year project will replace resource and energy-intensive chemical processes currently used in the cosmetic industry through discovering and optimising novel enzymatic biocatalysts. (commnet.eu)
The OPTIBIOCAT researchers will develop highly effective biocatalysts, requiring fewer steps in the production of components as well as lower-temperatures (50-60°C) compared to those of chemical processes (up to 160°C). High temperatures in current chemical techniques need a large amount of making the process expensive as well as environmentally unsound. (commnet.eu)
The original agreements covering the development of these processes were signed in 2009. (pharmtech.com)
The processes need to successfully integrate knowledge about the properties of both the resource used and the biocatalyst, ensuring that reasonable yields and high levels of productivity will be produced and thus good process economy. (lu.se)
With the development of biocatalysts and advanced microbial systems in recent years, entirely new opportunities have been found, and chemical reactions that have previously been too difficult to carry out are now routine processes. (lu.se)

In this context, there is a significant development potential for the combination of bio catalysts with unconventional, i.e. largely non-aqueous, media. (rwth-aachen.de)

In SFI-IB, Biocatalysts' main interests are within enzyme discovery and development, specifically towards biomass conversion. (sintef.no)
Herein, Zymochem, Inc., in partnership with the National Renewable Energy Laboratory (NREL), proposes to develop carbon- and energy-efficient biocatalysts capable of co-conversion of C1- and biomass-derived substrates to a high-volume platform fuel and chemical intermediate. (sbir.gov)
Dr. Fan's primary research interests are advancing technologies for producing fuels and chemicals from renewable resources, including metabolic engineering, biocatalyst development, biomass pretreatment, fermentation process development, and modeling. (postdocjobs.com)
Position Qualifications: A Ph.D. in chemical or biochemical engineering, mechanical engineering, biological systems engineering with a strong background in biomass pretreatment and fermentation is required. (postdocjobs.com)
Microbial consortia represent promising candidates for aiding in the development of plant biomass conversion strategies for biofuel production. (biomedcentral.com)

OPTIBIOCAT brings together a broad interdisciplinary team of researchers, academics and industry experts , with 16 partners from Italy, France, Germany, Greece, Portugal, Sweden, the Netherlands and Finland covering the entire development process, from genome and microbial mining to application. (commnet.eu)

The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation. (bsc.es)

In addition, we are interested in designing new catalytic reactions for the valorisation of sustainable biorenewable chemicals. (ed.ac.uk)
The later primarily comprises experimental analysis and modelling of local effects in multi-phase flows with and without biological or chemical reactions. (uni-bremen.de)

Flow process development usually involves re-use of enzyme through immobilization. (selectbiosciences.com)
The ultimate aim is to produce biocatalytic enzyme nanocomposites as free flowing dry powders that may be stored at room temperature for many months (possible years) and used off the shelf for the manufacture of fine chemicals etc. (europa.eu)
Particularly, there is a growing interest in the development of one-pot tandem catalytic systems combining the reactivity of a chemical catalyst with the selectivity engendered by the active site of an enzyme. (illinois.edu)
FAEs and GEs will be improved by site-directed mutagenesis and directed evolution and the project also aims to mine for completely new FAEs and GEs genes from available genomes, improving the efficiency of fermentation/production and stabilising both the enzyme formulations and the life cycle of the biocatalysts. (commnet.eu)

Synthetic biology has emerged as an elegant solution to this challenge, where microorganisms can be genetically programmed to produce industrial chemicals from renewable feedstocks (for example, sugar and CO 2 ) and 'waste' (like PET plastic, a form of polyester) via fermentation. (rsc.org)

Because of increasing concerns of the exhausting resource and ecological and environmental problems in the petro-based industry, utilization of renewable resources is considered as one of the solutions for sustainable development. (biomedcentral.com)
Her research deals with the development of tailor-made biocatalysts for the production of bulk and specialty chemicals from renewable resources. (lu.se)

I think industrial biotechnology is going to transform the chemical industry. (rsc.org)
Biocatalysts Ltd is a biotechnology company in the project. (sintef.no)
We are known for our work on the chemistry of life and have growing expertise in chemical biotechnology and green chemistry. (kcl.ac.uk)
In the studies towards the major, students acquire advanced knowledge in a specific area of biotechnology, chemical technology or material science and technology. (aalto.fi)
The School of Chemical Engineering trains Masters of Science (Technology) who have the skills and knowledge to work as pacesetters of the fields of biotechnology, chemical technology and material science and technology in various managerial, planning and research duties serving industry or related stakeholders, the scientific community or public sector. (aalto.fi)
Succinic acid is one of the key platform chemicals which can be produced via biotechnology process instead of petrochemical process. (biomedcentral.com)

In order to probe these steps and gain new insights, computational modeling employing computational chemistry and chemical engineering principles from the atomistic to macroscopic levels is a potent tool. (auburn.edu)
Our vision is to improve the environmental footprint of our chemistry as biocatalysts usually operate in aqueous and mild reaction conditions. (novartis.com)
Any time we're doing chemistry, we can have a real impact on the environment," says Oliver Thiel, executive director of Process Development at Amgen. (amgen.com)
While green chemistry has been an important part of process development at Amgen for many years, these efforts have recently returned to the forefront as a key component of the company's 2027 Environmental Sustainability Plan , which aims to achieve carbon neutrality along with significant reductions in water consumption and waste generation. (amgen.com)
A goal of our chemistry of life research is to usher in a new era of functional biology by moving from a descriptive picture of life sciences to a quantitative understanding using chemical principles. (kcl.ac.uk)
We take a whole-scale view to understand how molecules work together to generate cellular life, combining chemical and synthetic biology with biophysical, computational and synthetic chemistry. (kcl.ac.uk)
The Chemical Biology Section of Chemistry Central Journal is pleased to receive manuscripts describing research into all and any aspects of the subject. (biomedcentral.com)
A small sample of the literature being produced by Chemical Biology institutes and departments around the world included articles ranging from enzymology to medicinal chemistry, and from structural biology to single cell proteomics. (biomedcentral.com)

Not only can we design microbes that can now completely decouple chemical manufacturing routes from fossil fuels, we can scale them up, and when we do, they can be carbon-negative. (rsc.org)
LanzaTech uses a biocatalyst to transform emissions into fuels and chemicals. (greencarcongress.com)
Are algae-based fuels, chemicals and materials sustainable? (renewable-carbon.eu)

Codexis' technology is commercialized with leading global pharmaceutical companies and in development for advanced biofuels with Shell and in carbon capture. (prnewswire.com)
Could biocatalysts and biofuels provide the kicker needed to make this class of technologies feasible? (renewable-carbon.eu)

Both topic areas contribute to goals outlined in the DOE Industrial Decarbonization Roadmap , to produce low-carbon, renewable chemicals, and the Sustainable Aviation Fuel Grand Challenge to produce 35 billion gallons of SAF annually by 2050-enough to meet 100% of U.S. aviation fuel demand. (biodieselmagazine.com)
In low and middle income countries, he is focusing on engineering driven solutions to achieve low carbon development solutions for buildings and construction sector. (ed.ac.uk)

We specialize in marketing high purity specialty chemicals to academic, industrial and government research laboratories. (arablab.com)
Join us as we continue delivering excellence in high-purity specialty chemicals. (arablab.com)

Chemical manufacture can therefore become an industrial activity that benefits the environment! (rsc.org)
Efforts are being exerted continuously to promote their use in order to comply with the growing demand for green and sustainable chemical manufacture. (unibas.ch)
In May 2011, the company successfully completed technology transfer of custom biocatalysts for the manufacture of three undisclosed pharmaceutical products to Teva Pharmaceutical Industries. (pharmtech.com)

Besides food industry, some acetic acid bacteria are used as biocatalysts for the industrial production of compounds. (wikipedia.org)

The HUB comprises more than 70 researchers who work on technological solutions for addressing the UN Sustainable Development Goals. (ed.ac.uk)
Unfortunately, when asked to define Chemical Biology, most researchers seem to be lost for an apt description. (biomedcentral.com)
With new articles being added to these collections on a daily basis, the collections serve as an ideal tool to keep researchers updated with new developments in the respective fields. (eurekaselect.com)

This is also the aim of the innovative project OPTIBIOCAT ("Optimised esterase biocatalysts for cost-effective industrial production"), which is backed by around €7 million of EU funding under the FP7-programme. (commnet.eu)
In building their toolboxes, companies are expanding their offerings in biocatalysts through organic growth, industrial partnerships, and academic collaborations. (pharmtech.com)

The product could be a chemical with relatively simple structure (often referred to as a bulk chemical, or platform chemical when produced in large quantities), which will later be transformed into other, often more complicated, structures (fine and speciality chemicals, or polymers). (lu.se)

Several species of acetic acid bacteria are used in industry for production of certain foods and chemicals. (wikipedia.org)
This funding will advance the Biden-Harris administration's goals to address the climate crisis by building a clean and equitable energy economy and driving innovation in renewable energy and chemicals production. (biodieselmagazine.com)
The new EU-project OPTIBIOCAT aims to replace chemical techniques currently used for the production of cosmetics with energy-efficient and eco-friendly biocatalysts. (commnet.eu)
The environmental footprint for the production will be significantly reduced with our innovative biocatalysts," says Vincenza Faraco from the University of Naples, who leads the OPTIBIOCAT consortium. (commnet.eu)
After identifying a CRED at small scale, the company scaled up production and integrated the biocatalytic approach into the API process-development program and manufactured 30 kg for Phase I clinical trials, according to an Almac Oct. 7, 2010, press release. (pharmtech.com)
The production of antibody-based immunoassays is necessary for the assessment of occupational exposure and the development of threshold limit values. (cdc.gov)

In 2012, Stephen was awarded a MRC Career Development Fellowship to conduct postdoctoral research in the laboratory of Jason Chin at the MRC Laboratory of Molecular Biology (LMB) in Cambridge. (rsc.org)
The results of this research are to be used in the adaptation of biocatalysts. (rwth-aachen.de)
Notably, advancements in technology and investment in research and development initiatives open a vast field of potential developments and. (reportlinker.com)
In 2014, Elaine began her independent research career at Manchester Metropolitan University before moving to The University of Nottingham as Assistant Professor of Chemical Biology in 2015. (qub.ac.uk)
Chempure's large inventory of research chemicals allows most orders to be shipped the same day they are received. (arablab.com)
This is reflected particularly in the Konstanz Research School Chemical Biology (KoRS-CB), the DFG Research Group FOR 434, the Collaborative Research Centers 969 and 767, and the Center of Applied Photonics, which is operated conjointly with the Biology and Physics departments. (uni-konstanz.de)
Together with national and international research partners, we work as part of a vibrant network to get to the bottom of the complex interplay of molecules, which determine the lives of each and every organism, and to promote the development of new materials with customized structures and properties. (uni-konstanz.de)
In this context, the department's material science activities are focused on the research and development of hierarchically organized nanofibers, fabricated using the electro-spinning method. (uni-bremen.de)
Another important area of his research is biotechnical methods for conversion of lignin into low molecular weight chemicals. (lu.se)

Several chemicals can be produced using yeast as a biocatalyst. (enhalor.com)

The department is ideally placed to introduce a chemical angle to significantly broaden the reaction space. (kcl.ac.uk)

Many tailor-created proteins with high efficiencies and selectivity's can now be delivered rapidly and on a gram to kilogram scale, with committed information bases and search devices pointed toward making these biocatalysts open to a more extensive academic local area. (alliedacademies.org)

In January 2019, she moved to her current position as Associate Professor of Chemical Biology at University College Dublin. (qub.ac.uk)
Chemical Biology is. (biomedcentral.com)
Chemical Biology is a relatively new field, and as such is not yet simply or succinctly defined. (biomedcentral.com)
Overarching themes and selected recent successes and ideas in chemical biology are described to illustrate broadly the scope of the field, but should not be taken as exhaustive. (biomedcentral.com)
The list of subject groups and departments collaborating on Chemical Biology projects is equally varied, reflecting a tremendous diversity of specialisations contributing to the field. (biomedcentral.com)
Some attempts at definition have focused on what Chemical Biology is not. (biomedcentral.com)
Collaborative partnerships have made Chemical Biology into a subject in its own right. (biomedcentral.com)
It is this partnership, which allows cutting edge chemical concepts and tools to be brought to bear on previously impenetrable biological systems, that is the essence of Chemical Biology. (biomedcentral.com)
It is difficult to choose just a few current examples of exciting Chemical Biology, because recent achievements, like the subject matter, are many and varied. (biomedcentral.com)
With the development of biocatalyst engineering and synthetic biology strategies, bio-preparation has proven to be efficient, economical, and sustainable methods. (bvsalud.org)

He served as the Head of the School of Chemical Engineering between April 2014 - July 2021. (birmingham.ac.uk)

Bio-inspired chemical systems also present innovative routes to new molecules that are critical to tackle societal challenges via routes such as super-charged biocatalysts that can breakdown plastics or quantify pollutants. (kcl.ac.uk)

Chemical genetics, [ 1 ] which relies on selecting small molecules for their ability to induce a biological phenotype or to interact with a particular gene product, is one of the best examples of a methodological development in lead generation. (biomedcentral.com)
Our first major publication on nematicides was our 2015 Nature Comm paper, which described the screening of over 67,000 small molecules for their ability to disrupt C. elegans development and viability. (roylabutoronto.ca)

In 2019, Stephen was a visiting associate in the chemical engineering department at Caltech in the laboratory of Professor Frances Arnold. (rsc.org)
1994), graduated in Chemical Engineering (IST, 1989), Member of the Order of Engineers, associate 24667, Pedro is also one of the founders from Biotrend, a Portuguese company dedicated to the development of bioprocesses. (ulusofona.pt)
Mark graduated from the University of Nottingham in 1995 with a Masters in Chemical Engineering and stayed on to undertake PhD study with Professor Barry Azzopardi in the area of liquid-liquid flows of interest to the oil and gas industry. (birmingham.ac.uk)

It is particularly crucial for fine-chemical producers and contract manufacturers of intermediates and APIs, which face an increasingly competitive market. (pharmtech.com)

Her focus at Amgen was primarily the development and implementation of regulatory strategies, including life-cycle management for biologics in both the oncology and non-oncology therapeutic areas. (qub.ac.uk)
Development of mitigation strategies for greenhouse gas emissions from agri-environment systems. (ed.ac.uk)

Its prosperity has been generally because of a quick extension of the scope of synthetic responses available, made conceivable by cutting edge instruments for chemical revelation combined with high-throughput lab development methods for biocatalyst streamlining. (alliedacademies.org)
This is done in particular through the development of methods allowing to modify and enhance the properties of these natural biocatalysts. (unibas.ch)
Polymer-based graphene composite materials and Graphene nanoribbons, etc by chemical methods. (eurekaselect.com)

Anatomy6

Organisms13

Diseases2

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology1

Phenomena and Processes54

Disciplines and Occupations14

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture12

Information Science10

Health Care19

Enzymes11

Biocatalysis14

Synthesis12

Processes15

Catalysts1

Biomass5

Microbial1

Enzymatic1

Reactions2

Enzyme4

Fermentation1

Renewable resources2

Biotechnology6

Chemistry8

Fuels3

Biofuels2

Carbon2

Specialty chemicals2

Manufacture3

Compounds1

Researchers3

Industrial2

Polymers1

Production6

Research9

Yeast1

Significantly1

Proteins1

Biology10

20211

Pollutants1

Small molecules for their ability2

Engineering3

Fine1

Strategies2

Methods3