• The disease should be diagnosed and treated by a health care provider or a team of health care providers who specialize in the medical care of people with gout. (cdc.gov)
  • Fortunately, there are many low-cost self-management strategies that are proven to improve the quality of life of people with gout. (cdc.gov)
  • People with gout have high levels of a substance called urate in the blood (hyperuricemia). (medlineplus.gov)
  • In people with gout, the first episode of inflammation (called a flare) usually affects the big toe or other joints in the foot or ankle. (medlineplus.gov)
  • Without treatment, people with gout can experience frequent flares and joint pain and damage, which can limit mobility and decrease quality of life. (medlineplus.gov)
  • Many people with gout also have other health conditions. (medlineplus.gov)
  • However this does not happen fast enough in people with gout. (arthritisaustralia.com.au)
  • However several studies have shown that people with gout are more likely to eat certain foods. (arthritisaustralia.com.au)
  • We aim to evaluate the effectiveness of use of a personal, self-management, 'smartphone' application (app) to achieve target serum urate concentrations in people with gout. (bmj.com)
  • Most people with gout need to take medication, usually for life, that decreases blood levels of uric acid. (merckmanuals.com)
  • Uric acid stones develop in 20% of people with gout. (medscape.com)
  • Medications to treat gout work in one of two ways: They relieve pain and bring down inflammation, or they prevent future gout attacks by lowering uric acid levels. (healthline.com)
  • Gout is a type of arthritis, which is a group of related disorders caused by episodes of abnormal inflammation in the joints. (medlineplus.gov)
  • Inhibition of pannexin 1 thus reduces inflammation, which is the core pathology of gout. (wikipedia.org)
  • The available pathophysiologic evidence points toward inflammation, the characteristic difference between gout and hyperuricemia, as the likely pathway. (natap.org)
  • Gout occurs when uric acid builds up and forms urate crystals that settle in your joints, causing inflammation and pain. (ultracare-dialysis.com)
  • Inflammation and redness: Gout-affected joints may become swollen, tender, warm and red. (internal-medicine-centers.com)
  • If you are diagnosed with gout, treatment could include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine or corticosteroids to relieve joint inflammation, while other medications may be prescribed to prevent uric acid production or to help the body eliminate uric acid. (internal-medicine-centers.com)
  • A portfolio company of the by North Carolina Biotechnology Center, IMMvention is discovering and developing first-in-class therapies that inhibit the inflammation caused by activation of inflammasomes. (wraltechwire.com)
  • It may directly increase risk because of the impact fructose has on your liver, including promoting fatty liver, inflammation and localized insulin resistance ( 9 , 14 , 15 ). (healthline.com)
  • You may be surprised to learn that many natural remedies for arthritis can be as effective if not more so than prescription and over-the-counter anti-inflammatory drugs, and as such might be a better solution for those that suffer the debilitating joint pain, swelling and inflammation of osteoarthritis, rheumatoid arthritis and gout. (joint-pain.com)
  • Doctors treat acute gout flares with medication that decreases inflammation and relieves pain. (merckmanuals.com)
  • Gout is characterized by intense pain and warmth, as well as inflammation, swelling, and redness that usually only affects a single joint. (liftchairguide.net)
  • These crystals cause the severe acute tissue inflammation which is characteristic of gout. (singaporedoc.com)
  • Uloric is a new drug designed to relieve gout sufferers of their symptoms. (naturalnews.com)
  • 4. Micheal Murray, N.D. recommends gout sufferers consume 1/2 pound of cherries for relief. (naturalnews.com)
  • Now scientists have turned their attention to Montmorency tart cherries to test the potential benefits for arthritis and gout sufferers. (choosecherries.com)
  • We are happy to introduce Joint Pain, a resource for osteoarthritis, rheumatoid arthritis and gout sufferers, as well as those with similar chronic pain conditions. (joint-pain.com)
  • Colchicine is also often given to gout sufferers, however colchicine is not currently approved by the FDA. (liftchairguide.net)
  • Hyperuricemia does not always cause gout. (cdc.gov)
  • Making changes to your diet and lifestyle, such as losing weight, limiting alcohol, avoiding foods high in purines (like red meat or organ meat which can cause gout flares), may help prevent future attacks. (cdc.gov)
  • An international research team identified a novel molecular pathway believed to cause gout and its progression to erosion of joint tissue. (medicalnewstoday.com)
  • However, hyperuricemia doesn't always cause gout. (medicalnewstoday.com)
  • For example it is commonly thought that foods such as citrus foods cause gout. (arthritisaustralia.com.au)
  • however, this doesn't always cause gout, but rather, when excessive uric acid causes the formation of hard crystals in your joints, gout may ensue. (internal-medicine-centers.com)
  • Uric acid is created as a by product of eating foods rich in purines, such as liver or kidney, and eating a diet that is high in purines can cause gout. (liftchairguide.net)
  • For people with frequent flares or chronic gout, doctors may recommend taking certain drugs like allopurinol, febuxostat, and pegloticase. (cdc.gov)
  • In a study of gout flares in patients newly started on urate-lowering therapy, Rashid et al found that 68% of these patients had one or more gout flares during the first 12 months of therapy. (medscape.com)
  • In addition, Hu et al reported that an elevated serum level of cancer antigen 72-4 (CA72-4)-a monoclonally-identified glycoprotein that has been noted to be elevated in adenocarcinomas and inflammatory diseases-is an independent risk factor for gout flares during initiation of urate-lowering therapy. (medscape.com)
  • The risk of gout flares emphasizes the importance of providing close coverage, patient education, and prophylaxis, especially during the first year of urate-lowering therapy. (medscape.com)
  • He described numerous gout flares over the past few months. (the-rheumatologist.org)
  • Colchicine increases uric acid solubility and, after the start of therapy, tophi often reduce in size and severity. (illinois.edu)
  • After management of the acute gout flare, his allopurinol dose was increased, and he was started on daily colchicine for gout flare prophylaxis. (the-rheumatologist.org)
  • Gout is a common form of inflammatory arthritis that is very painful. (cdc.gov)
  • Gout, a common form of inflammatory arthritis, can cause intense pain, swelling, and stiffness in the joints. (medicalnewstoday.com)
  • Gout is a condition that leads to acute inflammatory arthritis. (naturalnews.com)
  • Gout is a type of inflammatory arthritis characterized by sudden, recurrent burning pain, stiffness and swelling in the joints, particularly in the big toe. (internal-medicine-centers.com)
  • Gout, the most common inflammatory arthritis, is associated with premature mortality. (sciencedaily.com)
  • Having gout multiple times can lead to gouty arthritis, a form of arthritis which gets progressively worse. (cdc.gov)
  • Doctors who specialize in gout and other forms of arthritis are called rheumatologists. (cdc.gov)
  • Join a self-management education class, which helps people with arthritis and other chronic conditions-including gout-understand how arthritis affects their lives. (cdc.gov)
  • For people who worry that physical activity may make arthritis worse or are unsure how to exercise safely, participation in physical activity programs can help reduce pain and disability related to arthritis and improve mood and the ability to move. (cdc.gov)
  • If left untreated, gout can eventually lead to gouty arthritis, which is a more severe form of arthritis . (healthline.com)
  • Gout is the most common form of arthritis, with the prevalence increasing worldwide. (nih.gov)
  • A type of arthritis that develops in some people with psoriasis. (arthritistreatmentlab.com)
  • Understanding the type of arthritis you have is important for developing an effective treatment plan. (arthritistreatmentlab.com)
  • Gout is a more severe form of arthritis. (ultracare-dialysis.com)
  • Preliminary studies have explored Montmorency tart cherry juice consumption on gout attacks and arthritis symptoms. (choosecherries.com)
  • For decades, people with arthritis and gout have consumed Montmorency tart cherry juice for relief of symptoms - even though much of the evidence was anecdotal, and some people dismissed the soothing claims as folklore. (choosecherries.com)
  • This condition is known as Gout and causes intense, and sometimes debilitation pain referred to as gouty arthritis. (imagup.com)
  • Moreover, weak immune system and people who suffering with diseases such as, cancer, diabetes, and intravenous drug abuse have a more chance to develop septic arthritis. (medgadget.com)
  • Thus, the increase prevalence of arthritis, diabetes, and cancer patients are raising the chances of occurring Septic arthritis throughout the globe. (medgadget.com)
  • Additionally, between 2013-2015, it was estimated that 54.4 million adults in U.S. annually had some form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia. (medgadget.com)
  • Europe is also considering the huge market for septic arthritis players, owing to the increasing prevalence of patient suffering with immune deficiency disorders, cancer, and diabetes. (medgadget.com)
  • 3. Certain medical conditions can increase the risk: Conditions such as rheumatoid arthritis and gout can increase the likelihood of developing bunions. (dossia.org)
  • IMMvention Therapeutix is focused on improving the lives of patients with inflammatory diseases of huge unmet needs such as rheumatoid arthritis, osteoarthritis, gout, and Alzheimer's. (wraltechwire.com)
  • Although there are literally hundreds of different kinds, osteoarthritis, rheumatoid arthritis and gout are the three most common. (joint-pain.com)
  • 1. Increased Age - Studies show that your risk of developing joint pain and arthritis goes up as you get older. (joint-pain.com)
  • 2. Gender - You are more likely to develop arthritis if you are female than if you are male. (joint-pain.com)
  • There are many several types of arthritis that are more common than gout, but gout is considered to be one of the most painful types of arthritis. (liftchairguide.net)
  • Since gout shares symptoms that are similar to many other types of arthritis, as well as pseudogout, diagnosing gout can be a little tricky. (liftchairguide.net)
  • Gout is estimated to make up about 5% of all reported cases of arthritis. (liftchairguide.net)
  • Also called chronic tears, these occur gradually and can result from damage due to aging or an underlying condition, such as gout or rheumatoid arthritis . (medicalnewstoday.com)
  • Inflammatory conditions such as rheumatoid arthritis and gout can damage the wrist over time. (medicalnewstoday.com)
  • A small retrospective study found that 38.9 percent of people with severe rheumatoid arthritis developed TFCC tears. (medicalnewstoday.com)
  • About 30% of all people who suffer from the skin disease psoriasis develop psoriatic arthritis. (lu.se)
  • Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects. (wikipedia.org)
  • URAT1, a molecular therapeutic target for gout/hyperuricemia, was initially derived from research into hereditary renal hypouricemia (RHUC). (researchgate.net)
  • Gout is the deposition of uric acid crystals in tissues and is often (but not always) associated with chronic renal failure. (illinois.edu)
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. (nih.gov)
  • Dual inhibition of the renin-angiotensin system: increased risk of renal impairment, hypotension, syncope, and hyperkalemia. (nih.gov)
  • In a large study of patients in the United Kingdom, patients with gout had a 29% increased risk of advanced CKD and 210% increased risk of end-stage renal disease compared with patients who did not have gout. (renalandurologynews.com)
  • For many years, several mechanisms including renal hemodynamic alterations, renin-angiotensin-aldosterone system (RAAS) activation, inflammatory pathways, and reactive oxygen species (ROS) were widely studied in DKD, and various corresponding therapeutic agents have been developed [ 2 ]. (hindawi.com)
  • Several clinical studies using hypouricemic agents such as allopurinol showed positive outcomes such as improving renal damage and postponing renal failure in patients with either diabetes or chronic kidney disease (CKD) [ 6 ]. (hindawi.com)
  • A history consistent with chronic urate nephropathy is progressive renal failure in a patient with coexisting gout or uric acid nephrolithiasis and no other identifiable cause for renal failure. (medscape.com)
  • Subgroup analyses showed that a relationship between gout and the risk of acute MI was present among nonusers of alcohol, diuretics, or aspirin and among those who did not have metabolic syndrome, diabetes mellitus, or obesity. (natap.org)
  • mainly due to increase in the population suffering with diabetes, cancer, intravenous drug abuse, and immune deficiency disorders. (medgadget.com)
  • The presence of well-developed technology, high health care spending and Increase prevalence of diabetes have boosted the growth of the market. (medgadget.com)
  • According to the World Health Organization (WHO), in 2015 around 60 million people in the European region are currently suffering with the diabetes and the prevalence of the diabetes is increasing among all ages in the European Region. (medgadget.com)
  • The healthy fats in olive oil help stabilize blood sugar and improve insulin sensitivity, which can be beneficial for those with type 2 diabetes. (alternativemedicine.com)
  • High uric acid is only a 'red flag' for bad general health - occurs in persons who eat more than they need, do not exercise, become over weight and are strong candidates for developing high blood pressure, high cholesterol, diabetes and later on, even heart attack. (ndtv.com)
  • Consuming too much alcohol, red meat and sugary beverages all contribute to high levels of uric acid in the blood or urine, which increases the risk of gout, kidney stones, metabolic syndrome, obesity, diabetes and early death. (sciencedaily.com)
  • June 27, 2020 Progression of kidney disease in type 1 diabetes is correlated with increased amounts of uric acid. (sciencedaily.com)
  • A 45-year-old man with crystal-proven gout, poorly controlled diabetes and chronic kidney disease was lost to follow-up for six years and presented back to the VA clinic in the midst of a gout flare. (the-rheumatologist.org)
  • While it's true that eating large amounts of added sugar may increase your risk of diabetes, sugar intake is just one piece of the puzzle. (healthline.com)
  • This article reviews sugar's role in developing diabetes and provides tips for preventing the disease. (healthline.com)
  • Does Sugar Increase Your Risk of Diabetes? (healthline.com)
  • Many researchers believe that sugar increases diabetes risk both directly and indirectly. (healthline.com)
  • These effects may trigger abnormal insulin production in your pancreas and increase your risk of type 2 diabetes ( 14 , 16 ). (healthline.com)
  • These genetic markers are medically linked with an increased risk of developing diseases such as cancer, diabetes, gout, and cardiovascular diseases, among others. (mgrc.com.my)
  • 1. Before taking metolazone, tell your doctor if you have diabetes, gout, kidney or liver disease, or an allergy to sulfa drugs. (stason.org)
  • People with a high body mass index (BMI) may be at increased risk for rapid cartilage loss and osteoarthritis. (elixirnews.com)
  • This is important because the signs and symptoms of gout are not specific and can look like signs and symptoms of other inflammatory diseases (diseases where joints are swollen). (cdc.gov)
  • If you have gout, you'll probably feel swelling and pain in the joints of your foot, particularly your big toe. (healthline.com)
  • Hard lumps called tophi can eventually develop in your joints and the skin and soft tissue surrounding them. (healthline.com)
  • She had developed urate crystal deposits and had erosion in her joints but did not show high levels of urate in her blood. (medicalnewstoday.com)
  • So this is a novel pathway that probably helps in a major way to explain why some people get gout, and most others don't… and why gout progresses in some people to be a disease that really damages the joints," Terkeltaub said. (medicalnewstoday.com)
  • Further, articular gout (uric acid crystal tophi limited to the joints or peri-joint spaces) may be incredibly uncomfortable, while visceral gout, characterized by gout tophi in the tissues of the viscera, can have severe metabolic consequences and may not be able to be diagnosed easily antemortem. (illinois.edu)
  • Gout is a common and painful condition that affects the joints. (arthritisaustralia.com.au)
  • Untreated gout can cause permanent damage to the joints. (arthritisaustralia.com.au)
  • If gout is not managed well, the time between attacks may get shorter, the attacks more severe and the joints can be permanently damaged. (arthritisaustralia.com.au)
  • If these uric acid crystals settle in your joints, a painful condition known as gout can develop ( 9 ). (healthline.com)
  • Therefore, you are more likely to develop a condition than someone who is not putting as much pressure on his or her weight-bearing joints. (joint-pain.com)
  • Gout is a disorder in which deposits of uric acid crystals accumulate in the joints because of high blood levels of uric acid (hyperuricemia). (merckmanuals.com)
  • The most common joint that is affected by gout is the big toe, although it can be found in other joints as well. (liftchairguide.net)
  • Gout is caused by high levels of uric acid in a persons body, which causes uric acid crystals to begin to form in the joints. (liftchairguide.net)
  • Other joints in the body may also develop gout, although this is a lot less common. (lu.se)
  • Pseudogout is similar to gout in the sense that in both disease states , crystals form in the joints creating sudden joint pain. (lu.se)
  • Researchers believe lubricin, a protein found in joint fluid, may serve as a novel therapeutic target for prevention and treatment of gout. (medicalnewstoday.com)
  • These guidelines are designed to provide clinicians with clinical evidence to enable efficient treatment of gout. (nih.gov)
  • Gout can only be diagnosed during a flare when a joint is hot, swollen, and painful and when a lab test finds uric acid crystals in the affected joint. (cdc.gov)
  • Avoid foods that may trigger a gout flare. (cdc.gov)
  • How does diet affect Gout flare-ups? (imagup.com)
  • Whether this is your first gout attack, or you've had multiple flare-ups, the content on here will, hopefully, set you on the road to being gout-free too. (thegoutsite.com)
  • Gout is a general term for a variety of conditions caused by a buildup of uric acid . (healthline.com)
  • For acute gout, symptoms come on quickly from the buildup of uric acid crystals in your joint and last for 3 to 10 days. (healthline.com)
  • A definitive diagnosis of gout can be made by finding uric acid crystals in cytologic samples of tissues (typically joint aspirates). (illinois.edu)
  • When diagnosed antemortem, there are several therapies that can help manage gout, reduce crystal deposition, and, in some cases, dissolve crystals already in the tissue. (illinois.edu)
  • The only way to diagnose gout with certainty is by your doctor finding urate crystals in fluid taken from your joint. (arthritisaustralia.com.au)
  • However, increased excessively high levels of uric acid in blood results in the formation of uric acid crystals resulting in the development of gout. (imagup.com)
  • Doctors diagnose gout when uric acid crystals are seen in fluid removed from an inflamed joint. (merckmanuals.com)
  • Pseudogout is a disease that shares many of the same symptoms as gout, but is not caused by build ups of uric acid crystals. (liftchairguide.net)
  • Instead, pseudogout is caused as a result of calcium pyrophosphate crystals, which cause a gout like reaction. (liftchairguide.net)
  • Allopurinol can reduce blood uric acid levels, and thus reduce the risk of developing more gout tophi in tissues. (illinois.edu)
  • Our study suggests that exposure to PFAAs may be a risk factor for hyperuricemia and gout. (cdc.gov)
  • Pseudogout is not as common as gout and mainly affects women over the age of 65. (lu.se)
  • Gout tophi deforming the foot of an advanced age male cockatiel. (illinois.edu)
  • The physical examination may reveal subcutaneous tophi or the typical arthritic changes of gout. (medscape.com)
  • For some people, gout is caused by consuming foods that are high in gout-producing purines . (healthline.com)
  • Raw oysters are also high in purines (organic compounds also found in other filter organs like kidney and liver) and can increase a man's risk of developing gout. (askmen.com)
  • Your healthcare provider will also likely recommend a gout diet which limits alcohol and sugary beverages consumed and also limits foods that are high in purines (such as red meat, organ meats and seafood). (internal-medicine-centers.com)
  • Theoretically probenecid can increase the risk of uric acid kidney stones. (wikipedia.org)
  • A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases. (sciencedaily.com)
  • Gout results from elevated serum urate (SU) levels, or hyperuricemia, and is a globally widespread and increasingly burdensome disease. (researchgate.net)
  • Introduction Gout is increasing despite effective therapies to lower serum urate concentrations to 0.36 mmol/L or less, which, if sustained, significantly reduces acute attacks of gout. (bmj.com)
  • We hypothesise that personalised feedback of serum urate concentrations will improve adherence to ULT. (bmj.com)
  • He reported that the risk factors of gout are being male, advanced age, obesity, and alcohol consumption [11]. (researchgate.net)
  • In multivariable regressions in which the above risk factors were used as covariates, gout was found to be associated with a higher risk of acute MI (OR 1.26 [95% CI 1.14-1.40], P (natap.org)
  • The goal of this activity is for members of the healthcare team to be better able to evaluate the interaction between family history and other traditional risk factors for gout. (medscape.org)
  • It's important to treat and prevent future attacks of gout as it can lead to permanent joint and bone damage. (ultracare-dialysis.com)
  • The below tips aim to protect your kidney function to help prevent future attacks of gout or lessen their severity. (ultracare-dialysis.com)
  • In fact, milk is essential if you suffer from gout. (imagup.com)
  • Therefore, if you suffer from gout, it may be a good idea to avoid alcohol and foods that contain high amounts of purine (e.g., bacon, mussels, sardines, veal) to relieve symptoms. (lu.se)
  • What would become the currently known condition of gout stemmed throughout history from an unexplainable pain in the first metatarsophalangeal (MTP) joint, also known as podagra. (researchgate.net)
  • There is no cookie cutter approach to treating the condition of gout but some of the common measures mentioned above are a great place to start. (naturalnews.com)
  • It is unclear whether gout is the cause of a person's increased risk for these conditions, or whether the conditions cause the development of gout, or whether both of these situations occur to influence disease. (medlineplus.gov)
  • Large studies have identified dozens of genes that play a role in the development of gout. (medlineplus.gov)
  • Metabolic disorders or more commonly known as metabolic syndrome is a risk factor in the development of gout. (imagup.com)
  • Alcohol is known not only to increase uric acid production, but also to decrease the body's ability to excrete uric acid through the kidneys. (naturalnews.com)
  • Some may find that the elimination of alcohol is all they needed to do to rid themselves of gout. (naturalnews.com)
  • However, only a vegetarian diet is not enough for a healthier lifestyle, and to avoid gout induced pain, you will need to cut on alcohol, sugar, and processed food as well. (imagup.com)
  • 3. Alcohol and sleep aids may increase the effects of metolazone, causing dizziness or lightheadness. (stason.org)
  • Garrod showed elevated SU concentration in gout patients in 1848 [14], and hyperuricemia has since been established as the cause of gout. (researchgate.net)
  • Work with your favorite compounding pharmacy to get these medications made into tasty suspensions for your patients to improve compliance. (illinois.edu)
  • [ 140 ] In a retrospective study of 16,186 patients with initial serum uric acid levels above 7 mg/dL, Levy and colleagues found that patients with gout who remained on urate-lowering therapy were less likely to develop kidney damage leading to chronic kidney disease than those who were untreated. (medscape.com)
  • Attempts to increase adherence in gout patients have been disappointing. (bmj.com)
  • The control group patients will have access to the same app modified to remove all functions except the Gout Attack Diary. (bmj.com)
  • One such medication, Vioxx, was recalled due to increased risk of stroke and heart attack in patients who were taking the drug for an extended period of time. (joint-pain.com)
  • In the absence of pharmacokinetic studies in patients with stable severe hepatic impairment (Child Pugh grade C) without decompensation, caution should be exercised when ritonavir is used as a pharmacokinetic enhancer as increased levels of the co-administered protease inhibitor may occur. (who.int)
  • Researchers have developed an implantable bioartificial kidney that could help patients with end-stage kidney disease lead a better quality of life. (medscape.com)
  • Race-Free eGFR Validated for Kidney Transplant Patients Researchers have developed and validated a new race-free, creatinine-based equation for estimating glomerular filtration rate specifically designed for kidney transplant recipients. (medscape.com)
  • Probenecid is sometimes used to increase the concentration of some antibiotics and to protect the kidneys when given with cidofovir. (wikipedia.org)
  • When your kidneys do not work the way that they should, it can lead to gout. (ultracare-dialysis.com)
  • Gout is usually caused by your kidneys not flushing uric acid out of your body quickly enough. (arthritisaustralia.com.au)
  • Gout is also sometimes caused by the kidneys inability to break down the uric acid. (liftchairguide.net)
  • Febuxostat (Fx) is a recently developed xanthine oxidase (XO) inhibitor, which has been definitively proved to be effective and safe for gout treatment [ 7 ]. (hindawi.com)
  • Meat-rich diets such as Atkins could increase the risk of developing gout, research has suggested.A 12-year study of over 47,000 men in the New England Journal of Medicine found eating meat and seafood increased the risk of developing gout.But the research suggested eating dairy products reduced the risk(WorldPhotos.com). (wn.com)
  • The study also found a positive association between red meat and a higher risk of gout. (thegoutsite.com)
  • High uric acid levels can increase the risk of developing gout. (livestrong.com)
  • Although high uric acid concentrations are suggested to increase the antioxidant defense system and provide a health advantage to animals without UOX, knockout mice lacking UOX develop pathological complications including gout and kidney failure. (cdc.gov)
  • Gout affects many aspects of daily living, including work and leisure activities. (cdc.gov)
  • A torment on humanity since ancient times, gout typically affects one joint at a time, often the joint at the base of the big toe. (medicalnewstoday.com)
  • Gout normally affects one joint at a time, often the joint of the big toe. (arthritisaustralia.com.au)