Develop chordoma. Medical search. Frequent questions

The histological appearance of classical chordoma is of a lobulated tumor composed of groups of cells separated by fibrous septa. (wikipedia.org)
A chordoma is a low-grade, slow-growing, but locally invasive and locally aggressive tumor. (medscape.com)
[ 2 ] Although a chordoma is usually a slow-growing tumor, it is locally aggressive and has a tendency to infiltrate into adjacent tissues and organs. (medscape.com)
Chordoma is a slow-growing tumor, and the treatment is difficult because of the location of the disease which is near the nerves of the spinal cord. (vejthani.com)
Benjamin Stanton, PhD, of Nationwide Children's Hospital and The Ohio State University College of Medicine, and his collaborator Jun Qi, PhD, of Dana-Farber Cancer Institute, are developing induced proximity-based precision therapeutics for rhabdomyosarcoma that result in the degradation of the drivers of oncogenic transcriptional programs in this rare pediatric solid tumor. (news-medical.net)
However, some people develop this tumor as a result of a mutation inherited as an autosomal dominant trait. (cancerhealthcenter.com)
Chordomas are often considered a benign tumor because of their slow growth. (indiahealthtour.com)
Because chordomas do not grow rapidly, high doses of radiation are required to kill the tumor cells. (indiahealthtour.com)
Chordomas that are close to critical structures (arteries, brain, brainstem, cranial nerves, dura, spinal nerves), often limit the dose of radiation that can be safely delivered to the tumor. (indiahealthtour.com)
Treatment for both chordomas and chondrosarcomas includes complete surgical excision of the tumor with radiation therapy as a follow-up. (neurosurgeonsofnewjersey.com)
No matter where the tumor is located, an MRI of the entire spine should ordinarily be performed to see if the tumor may have spread to or developed in other areas of the spine. (chordoma-uk.org)
Another imaging test called computed tomography, also called CT or CAT scan , is often recommended in addition to MRI if it is not certain whether the tumor is chordoma. (chordoma-uk.org)
We report a complication of single dose intent to treat SBRT for a sacral chordoma that should serve to remind oncologists that radiation therapy, like surgery, is not without serious potential complications and that surgical resection may still be the best option for patients whose tumor can be treated with en bloc resection. (fortuneonline.org)
Current literature clearly demonstrates that wide en bloc resection with negative surgical margins is the single most important predictor of tumor recurrence and long term survival [1, 2]. (fortuneonline.org)
Primary bone cancer, also known as bone sarcoma , is a tumor that develops from the cells forming the bone. (cuanschutz.edu)
Common types of bone cancer in adults are chondrosarcoma, giant cell tumor, and chordoma. (cuanschutz.edu)
This level of skill is critical for developing the right treatment plan since modern neuropathology is increasingly reliant on constantly evolving molecular diagnostics for these tumor types. (roswellpark.org)
Object Chordoma cells may generate solid-like tumors in xenograft choices that express some molecular features of the mother or father tumor including positivity for brachyury and cytokeratins. (cell-signaling-pathways.com)
These cells were called "DVC-4 cells" (Duke-Veterans Affairs Chordoma-4) as they were from your fourth chordoma tumor resected for cell tradition and growth at that facility. (cell-signaling-pathways.com)
Chordoma is a rare, slow growing malignant tumor arising from remnants of the fetal notochord. (chordoma-uk.org)
Chondroid chordomas must be distinguished from a similar looking tumor known as a chondrosarcoma. (virtualmedstudent.com)
Primary sarcoma and bone cancer develop when a tumor originates and grows inside tissue. (mropa.com)
Chordoma is a primary bone tumor that usually occurs in the base of the skull and bones of the spine. (mropa.com)
For the second surgery on June 10, surgeons removed a cancerous tumor known as a chordoma from the spine of a patient. (hopkinsmedicine.org)

There are no drugs currently approved to treat chordoma, however a clinical trial conducted in Italy using a tyrosine kinase inhibitor imatinib demonstrated a modest response in some chordoma patients. (wikipedia.org)
Chordomas are generally resistant to standard cytotoxic chemotherapy agents, and there are no drugs approved to treat chordoma. (indiahealthtour.com)

There are three histological variants of chordoma: conventional, chondroid and dedifferentiated. (wikipedia.org)
Chondroid chordomas histologically show features of both chordoma and chondrosarcoma. (wikipedia.org)
Chondroid chordomas appear to have a more indolent clinical course. (wikipedia.org)
Chondroid describes chordomas that are difficult to distinguish from chondrosarcoma on histology. (medscape.com)
Chondroid chordomas tend to be less aggressive than conventional chordomas, while dedifferentiated chordomas are more aggressive, faster growing and more likely to metastasize. (indiahealthtour.com)
These chordomas are classically called "chondroid" chordomas because of the chondrocyte-like (ie: cartilage-like) cells and extracellular material within them. (virtualmedstudent.com)

Chordomas and chondrosarcoma constitute the majority of malignant sacral tumors in adulthood. (fortuneonline.org)
The most common types of bone cancers are osteosarcoma, Ewing sarcoma, chondrosarcoma and chordoma. (cuanschutz.edu)
Osteosarcoma and Ewing sarcoma are especially frequent in children and teenagers, while chondrosarcoma and chordoma are mostly seen in adult patients. (cuanschutz.edu)
Chondrosarcoma develops from cartilage cells that are found between bones and joints in the legs, arms or pelvis. (cuanschutz.edu)
PURPOSE: Pre-surgical diagnosis of skull base chondrosarcoma (SBC) is often challenging due to the resemblance to chordoma. (bvsalud.org)

What are the signs and symptoms of chordoma? (chordoma-uk.org)

Chordomas can arise from bone in the skull base and anywhere along the spine. (wikipedia.org)
The location distribution of chordomas is 50% sacral, 35% skull base, and 15% vertebral bodies of the mobile spine (most commonly, the C2 vertebra, followed by the lumbar then the thoracic spine). (medscape.com)
Poorly differentiated chordomas are more common in young adult and pediatric patients, as are skull base chordomas, and show loss of the INI1 gene. (medscape.com)
Chordoma (also known as notochordal sarcoma) is a rare type of primary bone cancer that is commonly found at the bottom of the spine (sacrum) and base of skull. (vejthani.com)
Craig Crews, PhD, is leading a team at Yale School of Medicine to continue developing a TPD approach for treating chordoma, a rare cancer of the spine and skull base. (news-medical.net)
Chordomas are very rare primary bone tumors that can arise at almost any point along the axis of the spine from the base of the skull to the sacrum and coccyx (tailbone). (cancerhealthcenter.com)
Chordomas occur with equal frequency in the skull base, the vertebrae and the sacrococcygeal area towards the bottom of the spine. (cancerhealthcenter.com)
It can develop anywhere in the spine but commonly found in the skull base. (247homeopathy.com)
Chordomas develop from remnants of the notochord, a structure that appears in embryonic stages and guides the growth of the bony skull and spine. (neurosurgeonsofnewjersey.com)
Chordomas can occur anywhere along the spinal axis, but are most common at the top of the spine (the skull base) and the bottom of the spine (the sacrum). (neurosurgeonsofnewjersey.com)
Chondrosarcomas, which are even rarer than chordomas, are tumors of the cartilage that the skull replaces during development, although their exact origin is unclear. (neurosurgeonsofnewjersey.com)
Chordomas and chondrosarcomas often arise near the base of the skull, so symptoms may be caused when they begin to affect the nearby cranial nerves and the brainstem. (neurosurgeonsofnewjersey.com)
Chordomas at the base of the skull occur more commonly in younger people. (chordoma-uk.org)
Chordoma is a rare, slow-growing malignant tumour that develops in the spine and skull bones. (kumarabhinavneurosurgeon.co.uk)
Symptoms typical to a skull-based chordoma include headache, issues with vision such as double vision, and pain in the neck region. (kumarabhinavneurosurgeon.co.uk)
Chordomas can occur anywhere along the spine but are most common in the base of the skull and the lower back. (blkmaxhospital.com)
Chordomas are tumors that grow in the spinal cord, skull, or base of the skull. (blkmaxhospital.com)
Chordoma is a rare type of cancer that affects the bones in the spine and skull. (blkmaxhospital.com)
Osteosarcoma typically starts in parts of the body where bones grow quickly - including leg bones, around the knee, arm bones, around the shoulder - but it can develop anywhere, including the pelvis, the skull, and jaw. (cuanschutz.edu)
This article offers an overview of tumors that develop at the skull base and their surgical management. (medscape.com)
Dermoid and epidermoid tumors are benign lesions of the skull that develop in the cranial vault, paranasal sinuses, orbit, and petrous bone. (medscape.com)
METHODS: This retrospective study included patients with histologically diagnosed SBC and skull base chordoma. (bvsalud.org)
Chordomas represent one of the most challenging subsets of skull base and craniovertebral junction (CVJ) tumors to treat. (neurosurgery-blog.com)
Spinal chordomas are rare, cancerous tumors that grow out of the vertebrae or base of the skull. (hopkinsmedicine.org)
Upon completion of the program, the fellow will be trained to develop academic, tertiary sinus and endoscopic skull base program. (endoscopicskullbasesurgery.com)
The endoscopic skull base program represents a rich educational experience for the developing Rhinologist. (endoscopicskullbasesurgery.com)
A fully endoscopic approach is used for a variety of skull base lesions including pituitary tumors, encephaloceles, cerebrospinal fluid leaks, craniopharyngiomas, Chordomas and meningiomas. (endoscopicskullbasesurgery.com)

Sacral chordomas make up 2 to 4% of all primary bone tumours and 44% of all primary sacral tumours, thus making it the most common malignant sacral tumour. (wikipedia.org)
Chordoma is a clinically and histologically unique malignant neoplasm, and numerous diagnostic considerations must be excluded to establish the correct diagnosis. (medscape.com)
Under the microscope, chordoma cells appear to be benign, but because of their location, invasive nature, and recurrence rate, the tumors are considered to be malignant. (cancerhealthcenter.com)
However, some chordomas behave aggressively and have more malignant characteristics with extensive invasiveness including a small subset of patients (~10%) that develop metastases to distant sites beyond their site of origin. (indiahealthtour.com)

We identified a group of drugs including bortezomib, 17-AAG, digitoxin, staurosporine, digoxin, rubitecan and trimetrexate that inhibited chordoma cell growth, with potencies from 10 to 370 nM in U-CH1 cells, but less potent in U-CH2 cells. (chordoma-uk.org)

Cell Tradition Two chordoma cell lines were acquired for comparative purposes through a materials transfer agreement with the Chordoma Basis: human being chordoma cell lines U-CH1 and U-CH2b (University or college Hospital of Ulm Germany). (cell-signaling-pathways.com)

Symptoms of the presence of chordomas vary with their location and size. (cancerhealthcenter.com)
What are the symptoms for spinal chordoma? (cancerhealthcenter.com)
We briefly present this case of chordoma, discussing the symptoms and signs, the radiological features and management including excision and replacement of the defect with bone graft. (spinalsurgerynews.com)
Furthermore, as the symptoms can mimic other common problems, such as back ache, and given chordoma is so rare, it is often takes a long time for a definitive diagnosis to be made, as most GPs, general physicians and surgeons during their career will never meet a patient with chordoma. (chordoma-uk.org)
If you are experiencing any of the signs or symptoms of chordoma, it's important to seek medical attention right away. (blkmaxhospital.com)
In the meantime, the best way to reduce your risk of chordoma is to be aware of the signs and symptoms and see a doctor right away if you think you might have chordoma. (blkmaxhospital.com)
Chordomas are slow growing tumors and will usually start to cause symptoms in mid-adulthood. (virtualmedstudent.com)
Chordomas of the clivus, the second most common location, can present with headache and if large enough symptoms of brainstem or upper cervical spinal cord compression. (virtualmedstudent.com)
Also, if the tailbone pain is associated with other symptoms, such as weakness, numbness near the groin area, in particular, tingling sensation on your limbs, etc., you should seek medical assistance as these are few of the symptoms of Chordoma, the bone cancer. (zodicengineering.com)

Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. (wikipedia.org)
Chordomas are locally invasive tumors that arise from the remnant of the primitive notochord. (indiahealthtour.com)
approximately 40% of chordomas and chondrosarcomas arise in the clivus. (indiahealthtour.com)
Chordomas arise from embryonic notochordal remnants along the length of the neuraxis at developmentally active sites. (spinalsurgerynews.com)
Chordomas are thought to arise from primitive notochordal remnants along the axial skeleton. (spinalsurgerynews.com)
Chordomas and chondrosarcomas are tumors that arise from developmental cells that are misplaced during development. (neurosurgeonsofnewjersey.com)
These tumors often arise from the paranasal sinuses but may develop in the frontal bone (arising from the area of the frontal sinus), cranial vault, mastoid sinus, or mandible. (medscape.com)

The risk of chordoma is increased if a direct member of the family is diagnosed with the disease. (vejthani.com)
By making healthy lifestyle choices and taking precautions to avoid exposure to known risk factors, patients can lower their risk of chordoma. (blkmaxhospital.com)

Different histologic subtypes of chordoma differ in their prognosis. (medscape.com)

Sacral chordoma is presented with chronic low back pain. (wikipedia.org)
Males aged between 40 and 50 years are twice as more common than women to get sacral chordoma. (wikipedia.org)
In this report we present a case of a gentleman with a sacral chordoma who was offered en bloc resection but elected to proceed with SBRT. (fortuneonline.org)
The patient is a 77-year-old male who five years ago had been treated for a sacral chordoma with SBRT presented to the ED with lumbosacral pain. (fortuneonline.org)

For these reasons chordomas and chondrosarcomas are known as some of the most difficult benign tumors to treat. (neurosurgeonsofnewjersey.com)
We offer the same expert care for patients with benign (non-cancerous) brain tumors including, meningioma, pituitary adenoma, acoustic neuroma, craniopharyngioma, chordoma and many others as well. (roswellpark.org)

The foundation for this work in the Crews lab originated in a successfully completed study funded by a Therapeutic Innovation Award jointly granted by MFCR and the Chordoma Foundation in 2018. (news-medical.net)
The company successfully filed an IND with the US FDA in 2018 for chordoma Phase II trials in the US and EU. (b3cnewswire.com)

About one-third of chordomas are found in the region around the clivus. (cancerhealthcenter.com)
Chordomas generally occur in 3 locations, which are, in descending order of frequency, the sacrum, intracranially at the clivus, and along the spinal axis. (spinalsurgerynews.com)

One was a chordoma, a rare type of bone cancer, and the other was a squamous cell carcinoma of the head and neck. (medscape.com)

We hope this will represent the first step towards the initiation of clinical trials of promising new drugs for paediatric chordoma. (dbwcharity.org)
CONCLUSION: The ADC-based method is helpful in distinguishing SBC from chordoma and readily applicable in clinical practice. (bvsalud.org)
Due to the rarity of the disease, there is limited opportunity to test agents in clinical trials and no concerted effort to develop agents for chordoma in the pharmaceutical industry. (chordoma-uk.org)
Using two confirmed chordoma cell lines, I screened all regulatory-approved drugs for anti-growth activity to determine whether any could be repurposed for clinical use in patients. (dukecancerinstitute.org)

Dedifferentiated chordomas are sometimes treated with chemotherapy to kill rapidly multiplying cells. (indiahealthtour.com)
In cases of advanced chordoma, chemotherapy may slow down the growth of the tumour or temporarily arrest the progression of the disease. (kumarabhinavneurosurgeon.co.uk)
Chordoma can be treated with surgery, radiation therapy, or chemotherapy, depending on the stage of the cancer. (blkmaxhospital.com)

A chordoma occurs when additional notochord cells are enclosed by the developing bones. (neurosurgeonsofnewjersey.com)

So for this case the chordoma located in the cervical spine is regarded as a rare place. (spinalsurgerynews.com)
Typically these back and spine conditions are caused by disease, although some develop after an injury to the cervical spine (vertebra, disk, cartilage, and surrounding soft tissue). (pisceshealth.com)

citation needed] Chordomas are relatively radioresistant, requiring high doses of radiation to be controlled. (wikipedia.org)

It is thought to form from the remnants of the notochord (a preliminary structure present in a developing baby in the womb, which eventually forms the spinal cord). (kumarabhinavneurosurgeon.co.uk)
Spinal cord tumors encompass a diverse array of growths that develop within or near the spinal cord or the spinal canal. (apollohospitals.com)

Familial chordoma are rare, with an estimated rate of 0.4% in all Chordomas. (wikipedia.org)
Ecchordosis physaliphora is a reported finding in approximately 2% of autopsy examinations, whereas chordomas are quite rare. (medscape.com)
As chordoma is so rare it is important to identify all children with chordoma in the UK so that we can learn more about this disease. (dbwcharity.org)
The Drew Barker-Wright Charity organises regular events to help raise funds for chordoma research and to help children and families affected by this rare childhood cancer. (dbwcharity.org)
Chordomas are a very rare type of cancer in children. (247homeopathy.com)
Chordomas are rare tumours arising from notochord cell nests. (spinalsurgerynews.com)
Chordomas are rare tumors that develop from the notochord, a structure in the embryo that gives rise to the spine. (blkmaxhospital.com)
The article detailed revolutionary treatment called HIFU for a rare cancer Chordoma at a hospital part of 'H' group. (zodicengineering.com)
4. I described genetic linkage for a rare familial cancer syndrome characterized by very high penetrance of chordoma. (dukecancerinstitute.org)

Chordoma originates from remnants of embryonic notochord. (vejthani.com)

Most patients with a clival chordoma develop headaches and double vision. (indiahealthtour.com)
In this study, the authors present their experience in treating clival and CVJ chordomas over a 29-year period. (neurosurgery-blog.com)
METHODS The authors conducted a retrospective study of clival and CVJ chordomas that were surgically treated at their institution from 1991 to 2020. (neurosurgery-blog.com)
EEAs should be considered as the gold-standard approach for upper/middle clival lesions based on the satisfactory surgical outcome, but OAs remain important tools for large complex chordomas. (neurosurgery-blog.com)

If children develop genetic condition such as tuberous sclerosis, then the child will have a high risk to develop chordoma. (vejthani.com)

Less than a third of chordomas will show cartilage like features. (virtualmedstudent.com)

In 2015 the first consensus guidelines for the diagnosis and treatment of chordoma were published in The Lancet Oncology. (wikipedia.org)
Overall 5-year survival is approximately 50%, and treatment consists of en bloc surgical resection followed by high-dose conformal radiation therapy (RT) such as proton beam radiation. (medscape.com)
Surgical en bloc resection with negative margins is the only curative treatment for chordoma. (medscape.com)
Currently, no medical treatment has been approved for treatment of chordoma. (medscape.com)
Currently, surgery is the first-line treatment for chordomas. (indiahealthtour.com)
Some medical centers have multidisciplinary teams of experts who review cases and can help create a coordinated treatment plan for patients with chordomas. (indiahealthtour.com)
Treatment options, cure rates and research for paediatric chordoma fall well beneath other childhood cancers. (dbwcharity.org)
When a chordoma is suspected, you will need magnetic resonance imaging, also called MRI , to help doctors make a diagnosis and plan for treatment. (chordoma-uk.org)
Treatment of a chordoma involves removing the maximum possible amount of tumour tissue via surgery. (kumarabhinavneurosurgeon.co.uk)
Molecularly targeted cancer drugs are also gaining popularity as a treatment approach for chordomas. (kumarabhinavneurosurgeon.co.uk)
There is no one-size-fits-all answer for chordoma treatment, as the best approach depends on the individual case. (blkmaxhospital.com)
In some cases, chordoma may recur after treatment. (blkmaxhospital.com)
When possible, en bloc surgical resection has been the recommended treatment for these tumors. (fortuneonline.org)
The ACF develops and supports research that advances the prevention and treatment of cancer for people and pets. (kansaslifescience.com)
Surgery is the first choice for chordoma treatment, followed by radiotherapy, although postoperative complications remain significant. (chordoma-uk.org)
The gold-standard treatment for chordomas is en-bloc surgical resection with wide margins followed by radiation therapy. (virtualmedstudent.com)
Despite extensive resection followed by proton-beam radiation therapy, the recurrence rate remains high, highlighting the importance of developing efficient treatment strategies. (neurosurgery-blog.com)

In four of these families, duplication of the brachyury gene was found to be responsible for causing chordoma. (wikipedia.org)
Typically, chordomas express the brachyury gene, whereas chondrosarcomas do not express this gene. (medscape.com)
Brachyury seems to play a key role in the pathogenesis of chordoma, although the detailed mechanism remains to be elucidated. (medscape.com)
Outcomes The DVC-4 cells maintained chordoma-like morphology in lifestyle and exhibited Compact disc24 and brachyury appearance information in UNC0631 vitro which were just like those for U-CH1 and U-CH2b. (cell-signaling-pathways.com)
I then confirmed another groups report that a common coding region SNP of the Brachyury gene as well as additional genetic variants are associated with an increased risk for development of chordoma independent of amplification of the Brachyury gen. (dukecancerinstitute.org)

However, chordomas can occur anywhere along the vertebral column. (virtualmedstudent.com)

citation needed] In the United States, the annual incidence of chordoma is approximately 1 in one million (300 new patients each year). (wikipedia.org)
Recently, Gleevec® (imatinib) has been shown to have antitumor effects in some patients with advanced chordomas.Additionally, off-label use of other targeted therapies such as ERBITUX (cetixumab), Iressa (gefinitinib), Tarceva® (erlotinib) have been reported. (indiahealthtour.com)
Patients with chordoma should be treated at specialist centres, whether they be private or through the NHS, where a team of knowledgeable physicians and health care workers are involved in a patient`s care. (chordoma-uk.org)
Patients need to be aware of the risk factors associated with chordoma to take steps to reduce their chances of developing the condition. (blkmaxhospital.com)
RESULTS: Forty-one patients with SBC and 41 with chordoma were included. (bvsalud.org)
Currently, there are no effective drugs available for patients with chordoma. (chordoma-uk.org)

We feel passionately about funding specific projects to help progress chordoma research and improve the chances of survival for other children and their families. (dbwcharity.org)

Chordoma can occur in any age group, from infancy to the very elderly although it is more commonly found in individuals over the age of 40 and most typically in those in their mid-50s. (chordoma-uk.org)
It most commonly develops in the chest wall (shoulder blades or ribs), pelvis, and long bones of the leg. (cuanschutz.edu)
Chordomas are slow growing tumors that are most commonly located at the ends of the vertebral column. (virtualmedstudent.com)

The hospital where a patient is treated will vary depending on the anatomic site of the chordoma. (chordoma-uk.org)

The incidence of chordoma in the general U.S. population is about 8 per 10,000,000 people. (cancerhealthcenter.com)
It occurs in approximately 1 in 800,000 people (incidence) and the number of people currently living with chordoma is approximately 8 per million of the population (prevalence). (chordoma-uk.org)

From this bit of evidence, he correctly surmised the notochordal origin of chordomas. (medscape.com)

Conventional (classic) chordomas are the most common variety and may show areas of dedifferentiation. (medscape.com)

Chordomas are more common in adults than in children. (kumarabhinavneurosurgeon.co.uk)
Chordoma is most often found in adults 30 and older and is twice as common in men as in women. (cuanschutz.edu)
It develops most often in adults older than 30 and is more common in men than women. (mropa.com)

Chordoma near the tailbone can cause pain down your legs and trouble controlling your bladder or bowels. (zodicengineering.com)

Even though chordomas usually are slow-growing tumours, they are locally aggressive with a tendency to infiltrate into adjacent tissues and organs. (spinalsurgerynews.com)

Chordomas and chondrosarcomas can be distinguished from one another by location (chordomas tend to occur along the midline, while chondrosarcomas are shifted to the sides) and through examination under a microscope. (neurosurgeonsofnewjersey.com)
Chordomas tend to grow slowly and often do not spread to other parts of the body. (mropa.com)

There are a handful of families around the world in which a number of family members have developed chordoma: that is, they have a 'familial form' of the disease. (chordoma-uk.org)

The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that can safely be delivered. (wikipedia.org)
Intensity modulated radiation therapy (IMRT), stereotactic radiosurgery and carbon-ion radiotherapy are also sometimes used to treat chordoma. (indiahealthtour.com)

Focused MRIs of the pituitary region, sinuses, temporal bones or internal auditory canals may be indicated to obtain better anatomical detail of a chordoma. (indiahealthtour.com)
Chordoma is a type of cancer that develops in the bones or soft tissues around the spine. (blkmaxhospital.com)
This article focuses on chordoma tumors that affect the bones in the spine. (zodicengineering.com)
Most Ewing tumors develop in bones, but they can start in other tissues and organs. (mropa.com)
Fibrosarcoma develops more often in soft tissues than in bones. (mropa.com)

The most evident signs of chordoma are pain and neurological changes. (kumarabhinavneurosurgeon.co.uk)

Diagnosis of chordoma can only be officially made by looking at the specimen under a microscope. (virtualmedstudent.com)

H. Courtney Hodges, PhD, of the Baylor College of Medicine, and Nate Hathaway, PhD, of the University of North Carolina, are collaborating to develop bifunctional small molecules that can activate SWI/SNF-dependent transcriptional enhancers. (news-medical.net)
To rapidly and efficiently identify small molecules that inhibit chordoma cell growth, we screened the NCGC Pharmaceutical Collection (NPC) containing approximately 2,800 clinically approved and investigational drugs at 15 different concentrations in chordoma cell lines, U-CH1 and U-CH2. (chordoma-uk.org)

Dr. Quinones-Hinojosa's lab is studying how the NKCC1 protein maneuvers the cell during migration and using findings to develop new molecular targets for targeted cancer therapy. (mayo.edu)

As with all brain tumors, imaging studies are essential in the diagnosis of chordomas and chondrosarcomas. (neurosurgeonsofnewjersey.com)

Anatomy5

Diseases9

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Information Science1

Health Care2

Tumor24

Approved to treat chordoma2

Chondroid6

Chondrosarcoma5

Signs and symptoms of chordoma1

Skull27

Malignant4

Inhibited chordoma cell1

Human being ch1

Symptoms9

Arise7

Risk of chordoma2

Subtypes of chordoma1

Sacral chordoma4

Benign2

20182

Clivus2

Type of bone cancer1

Clinical4

Chemotherapy3

Notochord cells1

Cervical spine2

High doses of radiation1

Spinal cord2

Rare9

Remnants1

Clival4

Tuberous1

Cartilage1

Treatment17

Brachyury5

Occur anywhere1

Patients6

Survival1

Commonly3

Hospital1

Incidence2

Notochordal1

Conventional1

Adults3

Tailbone1

Aggressive1

Tend2

Familial form1

Radiation2

Bones5

Neurological1

Microscope1

Small molecules2

Findings1

Brain tumors1