• Aim To investigate the usefulness of carotid atherosclerosis assessment in cardiovascular risk stratification of patients with psoriatic disease compared with the Framingham Risk Score (FRS). (bmj.com)
  • The prevalence of atherosclerosis in the carotid artery among these patients is undoubtedly greater, therefore becomes advantageous for dentists to pay attention to observing calcified atheromas in cephalometric radiographs. (bvsalud.org)
  • The etiology of atherosclerosis is unknown, but there are multiple factors that contribute to atherosclerotic plaque progression. (medscape.com)
  • Dr. Howard Weintraub, a cardiologist at NYU Langone Medical Center , says that once you're diagnosed with atherosclerosis, the most you can do is prevent progression and further complications. (healthline.com)
  • The goals of therapy should include arresting atherosclerosis or even reversing its progression. (medscape.com)
  • We have shown that relatively low doses of THC initiated after manifestation of clinically detectable artery lesions significantly inhibit atherosclerosis progression in mice," write Dr Sabine Steffens (University Hospital, Geneva, Switzerland) and colleagues in the April 6, 2005 issue of Nature . (medscape.com)
  • Furthermore, the inhibitory effects of THC on atherosclerosis progression are abolished in the presence of a CB2-receptor antagonist. (medscape.com)
  • The researchers hypothesized that THC could alter inflammatory processes crucial in atherosclerosis, thus limiting disease progression. (medscape.com)
  • Cite this: Oral cannabinoid therapy reduces progression of atherosclerosis - Medscape - Apr 07, 2005. (medscape.com)
  • In this study, we sought to investigate the effect of the recently developed TNAP inhibitor SBI-425 on atherosclerosis plaque calcification and progression. (nih.gov)
  • Progression of atherosclerosis to such life-threatening complications as a heart attack or stroke requires emergency treatment. (msdmanuals.com)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • In this work, recently published in the journal ACS Nano ( 'A Comparative Study of Ultrasmall Calcium Carbonate Nanoparticles for Targeting and Imaging Atherosclerotic Plaque' ), the team compared various nanoparticles specifically designed for different features of atherosclerosis (such as calcification or inflammation), which provide useful information about the phase or stage of plaque development. (nanowerk.com)
  • Chronic unresolved vascular inflammation is a critical factor in the development of atherosclerosis. (frontiersin.org)
  • Diabetes is also associated with chronic inflammation, which can contribute to the development of atherosclerosis. (sharecare.com)
  • Other factors, such as chronic systemic inflammation that has been tightly linked to accelerated atherosclerosis partially explain the increased CV risk. (bmj.com)
  • These results, they said, demonstrate that hypocretin loss during disrupted sleep contributes to inflammation and atherosclerosis. (nih.gov)
  • The initial screening for cardiovascular toxicity was conducted applying a custom-designed TaqMan array for genes known to play an important role in the mechanisms of atherosclerosis such as inflammation, oxidative stress, and coagulation. (cdc.gov)
  • 3) To examine whether there are associations between gene expression, lipidomics, extracellular matrix and inflammation in human atherosclerotic plaques (from our unique biobank) in relation to the risk of developing cardiovascular events and thus find new markers or treatment modalities. (lu.se)
  • Heavy drinking, on the other hand-more than 14 drinks per week for men and more than 9 drinks per week for women-can contribute to atherosclerosis and increase your risk for serious health problems and even death. (sharecare.com)
  • Triglycerides, another type of blood fat, also may contribute to atherosclerosis. (sparrow.org)
  • What are the symptoms of atherosclerosis? (medlineplus.gov)
  • In the early stages, atherosclerosis often does not cause any symptoms. (medlineplus.gov)
  • At onset there are usually no symptoms, but if they develop, symptoms generally begin around middle age. (wikipedia.org)
  • Mild atherosclerosis usually doesn't have any symptoms. (mayoclinic.org)
  • Atherosclerosis symptoms usually don't happen until an artery is so narrowed or clogged that it can't supply enough blood to organs and tissues. (mayoclinic.org)
  • The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
  • Signs and symptoms of atherosclerosis may develop gradually, and may be few, as the plaque gradually builds up in the artery. (hopkinsmedicine.org)
  • The symptoms of atherosclerosis may look like other heart conditions. (hopkinsmedicine.org)
  • The study, presented Wednesday at the Alzheimer's Association International Conference in Paris, focused on people with rare, inherited forms of the disease who develop it relatively young, with symptoms beginning in the patients' 30s, 40s, and 50s. (technologyreview.com)
  • Since atherosclerosis often doesn't have symptoms, how do you know if you have it? (sharecare.com)
  • If a person is deprived of iodine in his diet, he develops an enlarged thyroid gland, called a goiter and symptoms of an underactive thyroid or hypothyroidism. (healthy.net)
  • To simultaneously identify and treat atherosclerosis without triggering an immune response, Dhar and Bhabatosh Banik, Ph.D., a postdoctoral fellow in her lab, created an MRI-active HDL mimic. (acs.org)
  • For men, erectile dysfunction (ED) is an early warning sign that you may be at higher risk for atherosclerosis and its complications. (medlineplus.gov)
  • Atherosclerosis can cause other health problems, or complications. (medlineplus.gov)
  • Managing a moderate weight can lower your risk of developing complications due to atherosclerosis. (healthline.com)
  • Compared with healthy people, heart disease patients who have had strokes or other complications of atherosclerosis carry fewer microbes that make anti-inflammatory compounds. (sciencenews.org)
  • I'm less concerned with diagnosing atherosclerosis than I am with treating risk factors and preventing serious complications," he says. (sharecare.com)
  • Atherosclerosis (AS) is one of the most common complications of diabetes. (wjgnet.com)
  • 3. An important phenomenon of CVD in developing countries is the trend of complications occurring at younger ages. (who.int)
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Smoking is the single most damaging and most preventable cause of atherosclerosis and vascular events. (sharecare.com)
  • Understanding the potential impact of poor sleep and circadian health on blood cell formation and vascular disease opens new avenues for developing improved treatments," Twery added. (nih.gov)
  • Early diagnosis and treatment can stop atherosclerosis from worsening and prevent a heart attack, stroke or another medical emergency. (mayoclinic.org)
  • Sometimes the first symptom of atherosclerosis is a heart attack or stroke or even sudden coronary death," says Steven Borzak, MD, a cardiologist affiliated with JFK Medical Center in Atlantis, Florida. (sharecare.com)
  • Other medications can also be used to reduce the risk of developing stroke such as those that reduce blood cholesterol levels (statins). (news-medical.net)
  • Blood vessel blockage due to atherosclerosis is a common cause of heart attack and stroke. (msdmanuals.com)
  • Diabetes researcher and cardiologist Isabel Goncalves at LUDC is collaborating with ultrasound researchers Tobias Erlöv and Magnus Cinthio at the Faculty of Engineering at Lund University to develop methods that can help identify people who are at risk of developing a stroke because of dangerous plaques. (lu.se)
  • They hope that their method can improve the clinical assessment of patients at high risk of developing a stroke. (lu.se)
  • A team from the Lipid Research Laboratory at the Rambam Medical Center in Israel standardized freeze-dried powder made from fresh California grapes.Thirty mice bred to develop the condition were assigned to consume either water alone (control), 150 mug total polyphenols per day in the form of grape powder or the equivalent amount of glucose and fructose (placebo) in drinking water for 10 weeks. (nutraingredients-usa.com)
  • These immunosuppressive properties of THC were confirmed in vitro, with spleen cells extracted from the mice showing limited proliferation and impaired production of interferon-, a cytokine involved in atherosclerosis, and reduced leukocyte migration. (medscape.com)
  • More unexpectedly, TNAP inhibition reduced the blood levels of cholesterol and triglycerides, and protected mice from atherosclerosis, without impacting the skeletal architecture. (nih.gov)
  • Bornfeldt's lab demonstrated that in diabetic mice, lipids are more important than glucose in accelerating atherosclerosis. (asbmb.org)
  • Researchers at the University of Tübingen have developed a new method to better study atherosclerosis in mice. (phys.org)
  • To learn more about the impact of this deficiency on cardiovascular disease, the researchers focused on a group of mice that were genetically engineered to develop atherosclerosis. (nih.gov)
  • Over time, the mice with disrupted sleep developed progressively larger arterial lesions compared to the other mice. (nih.gov)
  • Specifically, the sleep-disrupted mice developed arterial plaques, or fatty deposits, that were up to one-third larger than the mice with normal sleep patterns. (nih.gov)
  • The researchers also showed that sleep-deficient, atherosclerotic mice that received hypocretin supplementation tended to produce fewer inflammatory cells and develop smaller atherosclerotic lesions when compared to mice that did not get the supplementation. (nih.gov)
  • Thus, fullerene exposure of wild type mice, not prone to develop atherosclerosis, resulted in a cardiovascular stress response which may provide a predisposition to atherogenesis. (cdc.gov)
  • But in recent research, as scientists conducted CT scans on mummies from the Aleutian Islands to ancient Egypt, they realized that heart disease and atherosclerosis were prevalent throughout antiquity , in people who had dramatically different diets and lifestyles, he said. (livescience.com)
  • Atherosclerosis, a common complication of diabetes and the cause of heart attacks and strokes, arises when white blood cells squeeze in between an artery and its smooth-muscle sheath. (asbmb.org)
  • However, it is not well understood why Type 1 diabetes, which arises when the immune system attacks the pancreatic beta cells, and type 2 diabetes, which develops after insulin-secreting pancreatic b-cells are overstressed, can accelerate atherosclerosis. (asbmb.org)
  • You study how diabetes accelerates atherosclerosis. (asbmb.org)
  • At that time there weren't any good animal models to study diabetes-accelerated atherosclerosis, the process that leads to cardiovascular disease. (asbmb.org)
  • As a graduate student, I learned a lot about diabetes, and I decided to pursue studies in atherosclerosis by moving to the University of Washington to train with Russell Ross , who was a leader in atherosclerosis research. (asbmb.org)
  • we generated a new mouse model that we still use a lot to study mechanisms whereby diabetes promotes atherosclerosis. (asbmb.org)
  • When your cells don't take in insulin like they should, your blood sugar level rises and you can develop type 2 diabetes . (healthline.com)
  • Risk factors for developing atherosclerosis include high blood pressure (hypertension), high blood cholesterol (hypercholesterolaemia), obesity, type-2 diabetes mellitus as well as excessive alcohol consumption. (news-medical.net)
  • No participant with diabetes mellitus (DM) at baseline developed isolated AAA (0/44), whereas DM was associated with an increased risk of isolated AD (HR 2.57, 95% CI 2.08-3.18). (lu.se)
  • About a quarter of patients who develop atherosclerotic plaques have diabetes, so this is a group that can be helped by our technology in the future. (lu.se)
  • At the doctor's office, questions about a person's family health history often can help health care professionals determine the risk of developing chronic conditions, including heart disease, high blood pressure and diabetes. (cdc.gov)
  • E-LDL is recognised by the C1q subunit of C1 and triggers direct C1 activation, suggesting that complement activation by E-LDL may play a crucial role in the pathogenesis of atherosclerosis. (europa.eu)
  • Systemic inhibition of TNAP protects from atherosclerosis, by ameliorating dyslipidemia, and preventing plaque calcification. (nih.gov)
  • A CIC biomaGUNE team led by Ruiz-Cabello, together with Ikerbasque research professor Susana Carregal -both members of the biomedical research networking center CIBERES-, has developed contrast agents to achieve the selective molecular imaging of atherosclerotic plaques using ultrasmall amorphous calcium carbonate nanoparticles. (nanowerk.com)
  • The plaques that develop in atherosclerosis can rupture, causing a blood clot. (sparrow.org)
  • These clots/plaques arise due to the process of atherosclerosis or cardiovascular disease. (news-medical.net)
  • Atherosclerosis, the most common type, means hardening related to plaques, which are deposits of fatty materials. (msdmanuals.com)
  • In atherosclerosis, fat accumulates in the arterial walls creating atherosclerotic plaques. (lu.se)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • Cardiovascular immunotherapy has therefore become a recent focus for treatment, with the objective to develop approaches that can suppress excessive inflammatory responses by modulating specific immune cell populations. (frontiersin.org)
  • FM-depots therefore present a customizable delivery platform to both develop and test nanomedicine-based approaches for anti-inflammatory cardiovascular immunotherapy. (frontiersin.org)
  • Atherosclerosis is generally considered to be a chronic inflammatory process. (europa.eu)
  • People with sleep apnea are more likely to develop insulin resistance , a condition in which the cells don't respond as well to the hormone insulin. (healthline.com)
  • Initially, the atherosclerosis was a bit of a surprise, because much research has linked heart disease to the couch-potato lifestyle and calorie-rich foods of the modern world, Zink said. (livescience.com)
  • In addition, Hawthorn berry is believed to help relax the smooth muscles around the heart, making it less likely to develop arrhythmias. (vitanetonline.com)
  • As a human body develops, the heart and fist grow at about the same rate. (encyclopedia.com)
  • The most important cardiovascular diseases (CVDs) in the African Region are those related to atherosclerosis, cardiomyopathies and rheumatic heart disease. (who.int)
  • This year, a solar energy system for schools in developing countries and a new treatment for patients suffering from heart attacks were crowned winners. (lu.se)
  • Alexandru Schiopu's project develops a revolutionary treatment for patients suffering from heart attacks. (lu.se)
  • The potential social and economic benefits of a treatment that effectively reduces the consequences of heart attacks can be considered extremely high and the intention is to further develop the project towards clinical testing. (lu.se)
  • Many affected individuals develop malignant tumors, especially SARCOMA. (bvsalud.org)
  • These subjects didn't have any cardiovascular disease when the plasma samples were collected, but they were followed over time so that we knew who developed a myocardial infarction later on. (asbmb.org)
  • The study findings can allegedly help develop therapeutic targets for the prevention and treatment of premature cardiovascular disease in lupus patients. (healthjockey.com)
  • CONTEXT: As atherosclerotic plaque invades the arterial wall, it develops a network of tiny new blood vessels. (diagnosticimaging.com)
  • IMPLICATIONS: The use of this novel paramagnetic nanoparticle may enable physicians not only to identify arterial plaque through its angiogenic blood supply, but also to track the effectiveness of anti-atherosclerosis therapies. (diagnosticimaging.com)
  • Plaque from the artery of a mouse model of atherosclerosis that experienced a normal sleeping pattern (left) and an image of arterial plaque from a mouse model that underwent sleep fragmentation (right). (nih.gov)
  • "Grapes contain an abundance of powerful antioxidants that appear to inhibit an array of critical factors that can cause atherosclerosis," ​ said principal investigator Bianca Fuhrman, senior scientist at the Lipid Research Laboratory. (nutraingredients-usa.com)
  • Our results demonstrate the potential of this simple yet groundbreaking nanoprobe, which could inspire new designs of contrast agents for atherosclerosis and other types of diseases, and offer the possibility of formulating new theranostic agents (that can be used for therapeutic as well as diagnostic purposes)," they concluded. (nanowerk.com)
  • Our results have important potential implications in the development of new therapeutic strategies against atherosclerosis. (europa.eu)
  • The development of atherosclerosis is complicated, but the primary event seems to be repeated, subtle injury to the artery's inner lining (endothelium), through various mechanisms. (msdmanuals.com)
  • 1) To study the mechanisms of atherosclerosis and their time line using C14 dating method. (lu.se)
  • A modified version of the AHA classification was developed by our laboratory to include important pathologic lesions responsible for luminal thrombosis other than plaque rupture, such as plaque erosion and calcified nodule. (medscape.com)
  • It is also emerging as an important factor in atherosclerosis: complement activation, and formation of the terminal C5b-9 membrane attack complex of complement were shown to occur in atherosclerotic lesions. (europa.eu)
  • New article: Can a high sugar intake predispose you to develop atherosclerosis? (lu.se)
  • Scientists have now developed a nanoparticle that functionally mimics nature's own high-density lipoprotein (HDL). (acs.org)
  • High cholesterol and atherosclerosis often go hand-in-hand. (sharecare.com)
  • Though atherosclerosis is an artery problem, microscopic denizens of the intestines may play a surprising role in how the disease plays out. (sciencenews.org)