OveractivityContractionIntra-detrusor injection of botulinum toxinInstabilityUrodynamicBotulinumImpaired detrusor contractilityNeurogenic bladderOveractive BladderUrinationPelvicIncontinenceSphincterDysfunctionInnervationPatientsUrethral pressureContractionsUrotheliumUrinaeSpontaneous activityMuscleUrineComplianceAbnormalityIntravesicalDecreaseActivityNerveTissue
Overactivity29
- Detrusor injections with botulinum toxin type A are an effective treatment for neurogenic detrusor overactivity, lasting for 9-12 months. (nih.gov)
- Repeat injections in patients with severe neurogenic detrusor overactivity and incontinence were studied. (nih.gov)
- We studied the role of muscarinic receptor subtype on urothelium and detrusor in rats with detrusor overactivity induced by bladder outlet obstruction (BOO). (urotoday.com)
- Detrusor overactivity induced by BOO in rat is mainly mediated by M3 muscarinic receptor in detrusor, and by M2 and M3 muscarinic receptors in urothelium. (urotoday.com)
- It seems to need to ascertain the existence of M2 and M3 muscarinic receptors in the detrusor overactivity induced by BOO in rat. (urotoday.com)
- Detrusor overactivity. (qxmd.com)
- Detrusor overactivity in the absence of outlet obstruction is common in the elderly. (qxmd.com)
- These patterns matched 12 women and 3 men 66 to 96 years old (mean age 79 years) who were segregated independently as a detrusor overactivity group by prospective urodynamic evaluation. (qxmd.com)
- Physiotherapy with Physio.co.uk can help to significantly to reduce symptoms that are result from neurogenic detrusor overactivity in men. (physio.co.uk)
- What causes neurogenic detrusor overactivity in men? (physio.co.uk)
- What are the symptoms of neurogenic detrusor overactivity in men? (physio.co.uk)
- If you suffer from neurogenic detrusor overactivity, there are a number of treatment options that aim to reduce any of your current symptoms. (physio.co.uk)
- Your physiotherapy programme with Physio.co.uk will help you overcome the problems you have been experiencing, prevent future problems, reduce any embarrassment associated with neurogenic detrusor overactivity and help you to return to normal everyday living. (physio.co.uk)
- Recently, application of BoNT-A in LUTD have become more common since the approval of intravesical BoNT-A injection for patients with both overactive bladders (OAB) and neurogenic detrusor overactivity (NDO) by regulatory agencies in many countries. (mdpi.com)
- Objective(s): To develop a multivariable model using both clinical examination findings and validated questionnaires' scores for predicting the presence of detrusor overactivity observed during ambulatory urodynamic monitoring in women with urinary incontinence. (metu.edu.tr)
- Neurogenic detrusor overactivity was noted in all 9 children with reflux. (auanet.org)
- Overactive Bladder Syndrome and Detrusor Overactivity: Is There a Strong Relation between the Symptoms and Urodynamic Findings? (istanbul.edu.tr)
- Aim: Overactive bladder (OAB) and detrusor overactivity (DO) may interfere because one may cause the other. (istanbul.edu.tr)
- To investigate the effects of concomitant injections of botulinum toxin-A (BoNT-A) into the detrusor and external urethral sphincter muscles in suprasacral spinal cord injured patients with detrusor overactivity and detrusor sphincter dyssynergia. (medicaljournalssweden.se)
- Male suprasacral spinal cord injury patients (n = 20) with neurogenic detrusor overactivity and detrusor sphincter dyssynergia who emptied their bladder by reflex voiding and were unwilling to increase the frequency of intermittent catheterization. (medicaljournalssweden.se)
- For spinal cord injury patients with neurogenic detrusor overactivity and detrusor sphincter dyssynergia who are unwilling, or for whom it is inconvenient, to increase CIC frequency and who want to preserve spontaneous voiding, this treatment may provide an optional alternative. (medicaljournalssweden.se)
- Detrusor botulinum toxin type A (BoNT-A) injection has become the standard of care for bladder overactivity associated with neurological pathology in recent years. (medicaljournalssweden.se)
- OnabotulinumtoxinA (Onabot/A) represents the only neurotoxin-A recommended as second‐line treatment for refractory neurogenic detrusor overactivity incontinence (NDOI) in patients with spinal cord injury (SCI) or Multiple Sclerosis (MS), whose efficacy and safety have been demonstrated in powered, multicentre, randomized, controlled trials and in many open label studies [1]. (uroweb.org)
- Ni J, Wang X, Cao N, Si J, Gu B. Is repeat Botulinum Toxin A injection valuable for neurogenic detrusor overactivity. (uroweb.org)
- INTRODUCTION: Treatment options for refractory neurogenic detrusor overactivity (NDO) in children include botulinum toxin type A (BTX-A) and augmentation cystoplasty (AC). (elsevierpure.com)
- Symptoms of neurogenic bladder range from detrusor underactivity to overactivity, depending on the site of neurologic insult. (medscape.com)
- Urodynamic evaluation is optional, and finding detrusor overactivity or pelvic floor dysfunction may suggest an alternative diagnosis. (medscape.com)
- Auricular acupuncture in patients with detrusor overactivity : A pilot study. (qigonginstitute.org)
- Patients suffering detrusor overactivity. (who.int)
Contraction7
- Urination involves either sustained contractions or short intermittent contractions of the detrusor along with contraction of the muscles in the urethra, the duct from the urinary bladder that conducts urine from the body. (britannica.com)
- DSD refers to an involuntary detrusor contraction that is accompanied by an involuntary external sphincter contraction. (physio-pedia.com)
- Spinobulbospinal pathways are believed to be disrupted as a result, failing to inhibit spinal guarding reflexes, incorrectly activating Onuf's nucleus, causing EUS contraction to occur during detrusor contraction, and elevating detrusor pressures. (physio-pedia.com)
- This study assessed the time course of changes to detrusor autonomic innervation, smooth muscle (SM) content and cholinergic-mediated contraction post-BPNI. (lu.se)
- b) Antimuscarinic agents: Darifenacin: Darifenacin has selectivity for M3 receptors that's the extra essential receptor for detrusor contraction, which may LPAR5 Antagonist Gene ID possibly maximize efficacy and lower adverse occasions related using the antagonism of other receptor subtypes (27). (lckinhibitor.com)
- The PMC coordinates the urethral sphincter relaxation and detrusor contraction to facilitate urination. (medscape.com)
- The prime effector of continence is the synergic relaxation of detrusor muscles and contraction of the bladder neck and pelvic floor muscles. (medscape.com)
Intra-detrusor injection of botulinum toxin3
- Functional Polymorphism in the ADRB3 Gene, Encoding the Beta-3 Adrenergic Receptor, and Response to Intra-Detrusor Injection of Botulinum Toxin-A in Women with Overactive Bladder. (urotoday.com)
- The aim of our study was to analyze the possible association between the ADRB3:rs4994 polymorphism and the patient-perceived response to a single intra-detrusor injection of botulinum toxin-A in Polish women with overactive bladder. (urotoday.com)
- Our results do not support the hypothesis that ADRB3:rs4994 polymorphism is associated with the response to the intra-detrusor injection of botulinum toxin-A in Polish females with overactive bladder. (urotoday.com)
Instability4
- Ambulatory monitoring and electronic measurement of urinary leakage in the diagnosis of detrusor instability and incontinence. (ox.ac.uk)
- The ability of conventional artificial filling urodynamic studies (CMG) and ambulatory monitoring during natural bladder filling (AM) to detect phasic detrusor activity (detrusor instability) and incontinence was studied in 52 patients suspected on clinical grounds of having bladder dysfunction, but in whom a CMG had not provided an adequate explanation of their symptoms. (ox.ac.uk)
- Detrusor instability (DI) was found on AM in 31 patients who were not unstable on conventional CMG using the criteria of the International Continence Society: DI was diagnosed on filling in 20 patients and on provocation in a further 11. (ox.ac.uk)
- Incontinence was demonstrated by electronic nappy testing in 23 patients: 13 had urge incontinence due to DI, 7 had genuine stress incontinence alone and 3 had both genuine stress incontinence and detrusor instability. (ox.ac.uk)
Urodynamic1
- Using International Continence Society standards, participants will learn to identify and interpret components of urodynamic testing including: detrusor (bladder) filling, compliance, capacity, sensation and stability, and bladder emptying (electromyography/sphincteric function). (suna.org)
Botulinum1
- Here we introduce a new virtual reality (VR) based simulation system for training the urological procedure of intra-detrusor botulinum toxin (Botox®) injections into the bladder. (umn.edu)
Impaired detrusor contractility2
- There was superimposed widespread degeneration of muscle cells and axons in 8 specimens, which matched the subgroup of patients with impaired detrusor contractility. (qxmd.com)
- Superimposed degeneration is proposed as the structural basis of impaired detrusor contractility, when also present. (qxmd.com)
Neurogenic bladder1
- Application of botulinumtoxin into detrusor in patients with neurogenic bladder - which is the optimal indication group of patients? (amedi.sk)
Overactive Bladder1
- Overactive Bladder Syndrome and Detrusor. (istanbul.edu.tr)
Urination3
- The detrusor muscle remains relaxed to allow the bladder to store urine, and contracts during urination to release urine. (wikipedia.org)
- During urination, the detrusor muscle is contracted via parasympathetic branches from the pelvic splanchnic nerves to empty the bladder. (wikipedia.org)
- This abnormality results in the brain being unable to inhibit the detrusor muscles that control the bladder and urination. (physio.co.uk)
Pelvic1
- The detrusor relaxes when the pelvic nerve afferents are regulated by sympathetic output during normal filling, while keeping the bladder neck sphincter's tone in check. (physio-pedia.com)
Incontinence3
- Neurogenic detrusor activity in men causes urinary incontinence which is the uncontrollable release of urine out of the bladder. (physio.co.uk)
- The detrusor muscles therefore contracts more frequently causing the involuntary release of urine from the bladder ( urinary incontinence ). (physio.co.uk)
- The most common reason for urgency urinary incontinence is when detrusor muscles contract spontaneously. (medicalnewstoday.com)
Sphincter10
- During normal micturition, the detrusor muscle of the bladder and the striated smooth muscle of the urethral sphincter work synergistically. (physio-pedia.com)
- The urethral sphincter relaxes during this process, and the detrusor contracts to push the bladder's urine into the urethra. (physio-pedia.com)
- The pontine micturition centre, a specialised region in the caudal brainstem, is in charge of controlling this synergy between the detrusor muscle and the external urethral sphincter. (physio-pedia.com)
- The detrusor contracts with synergistic relaxation of the external urinary sphincter (EUS) to lower urethral pressure while simultaneously increasing detrusor pressure, allowing urine to escape. (physio-pedia.com)
- Association with Detrusor Sphincter Dyssynergy. (auanet.org)
- Vesicoureteral Reflux in Children with Cerebral Palsy: Incidence and Association with Detrusor Sphincter Dyssynergy. (auanet.org)
- Detrusor sphincter dyssynergy was noted in 8/9 (89%) children with VUR. (auanet.org)
- Cystoscopic guidance of 200 U BoNT-A injections into the detrusor muscle and 100 U into external urethral sphincter muscles were applied. (medicaljournalssweden.se)
- Concomitant detrusor and external urethral sphincter BoNT-A injections may decrease detrusor and urethral pressure without increasing postvoid residual ratio and diaper pad use. (medicaljournalssweden.se)
- Our study demonstrates that a combination of detrusor and urethra sphincter BoNT-A injections may relieve detrusor and urethral pressures without increasing intermittent catheterization (IC) frequency. (medicaljournalssweden.se)
Dysfunction1
- We conducted a prospective study to examine the ultrastructure of muscle cells, interstitium and nerves of the detrusor in biopsies from 35 elderly subjects to identify structural correlates of various urodynamically defined forms of voiding dysfunction. (qxmd.com)
Innervation3
- The few available studies on structure of the overactive detrusor generally have dealt only with its innervation. (qxmd.com)
- 7 It is concluded that NPY-innervation of rat urinary bladder is largely confined to the detrusor muscle and is abundant and mainly non-adrenergic. (herts.ac.uk)
- 8 The results are consistent with the hypothesis that intrinsic NPY in the rat detrusor innervation contributes to the motor transmission in two ways: by promoting non-cholinergic motor transmission and by inhibiting prejunctionally the cholinergic transmission. (herts.ac.uk)
Patients1
- After robot-assisted laparoscopic prostatectomy, total anatomic reconstruction (TR) with the additions of a circumapical urethral dissection, a dynamic detrusor cuff trigonoplasty, and placement of a suprapubic catheter was performed in 49 patients from June to July 2012. (mssm.edu)
Urethral pressure1
- All participants experienced a significant mean reduction in maximal detrusor pressure and maximal urethral pressure profile, and a mean significant increase in maximal cystometric bladder capacity 12 weeks after concomitant injections. (medicaljournalssweden.se)
Contractions4
- On this basis, a bipartite myogenic mechanism is proposed to account for the involuntary contractions yet allow neurally triggered unitary voiding contractions in the overactive detrusor. (qxmd.com)
- hese receptors inhibit ordinary and involuntary detrusor contractions. (lckinhibitor.com)
- 1 nM) enhanced the force and frequency of spontaneous contractions and generated a rise in the resting tone of the detrusor. (herts.ac.uk)
- The urinary bladder U&LP and detrusor respond to a variety of prostaglandin agonists, with their activation resulting in direct contractions, as well as increases to spontaneous contractile activity. (biomedcentral.com)
Urothelium4
- Muscarinic receptors can also be existing in bladder urothelium and suburothelium, and there is a suggestion that Ach release from the urothelium and by suburothelial cholinergic fibers may perhaps influence detrusor perform (twenty, 21). (lckinhibitor.com)
- This study assessed the actions of PGE 2 , PGF 2 , PGD 2 , TXA 2 , and PGI 2 on urinary bladder urothelium with lamina propria (U&LP), and detrusor smooth muscle. (biomedcentral.com)
- Prostaglandins are synthesised in both the bladder urothelium with lamina propria (U&LP) and in detrusor smooth muscle in response to stretch, nerve stimulation, U&LP damage or other inflammatory mediators [ 10 , 11 ]. (biomedcentral.com)
- Specifically, of interest is to determine how the actions of the prostaglandins affect urothelium with lamina propria that is separated from the detrusor smooth muscle. (biomedcentral.com)
Urinae1
- The detrusor muscle, also detrusor urinae muscle, muscularis propria of the urinary bladder and (less precise) muscularis propria, is smooth muscle found in the wall of the bladder. (wikipedia.org)
Spontaneous activity3
- 1 Immunohistochemical and isolated organ bath techniques were used to detect the presence of neuropeptide Y (NPY) in the rat urinary bladder and to determine its effect on tone, spontaneous activity and contractile responses of the detrusor muscle to electrical field stimulation, acetylcholine and alpha,beta-methylene ATP (alpha,beta-MeATP). (herts.ac.uk)
- It is further concluded that the enhancing effect of NPY on detrusor spontaneous activity and tone is caused by Ca2+ influx through nifedipine-sensitive Ca2+ channels and is not mediated through acetylcholine or cyclo-oxygenase-sensitive eicosanoids or ATP. (herts.ac.uk)
- Only 34% ( n = 48) of all detrusor preparations exhibited spontaneous activity prior to the addition of any agonist at a frequency of 2.03 ± 0.12 cpm. (biomedcentral.com)
Muscle8
- The fibers of the detrusor muscle arise from the posterior surface of the body of the pubis in both sexes (musculi pubovesicales), and in the male from the adjacent part of the prostate. (wikipedia.org)
- In older adults over 60 years in age, the detrusor muscle may cause issues in voiding the bladder, resulting in uncomfortable urinary retention. (wikipedia.org)
- The mucosa of the urinary bladder may herniate through the detrusor muscle. (wikipedia.org)
- Protrusion junctions and abutments are proposed as a possible manifestation of a process of muscle cell de-differentiation associated with natural aging, as well as the mediator in overactive detrusor of electrical coupling of muscle cells, in lieu of their normal mechanical coupling curtailed by marked reduction of intermediate cell junctions. (qxmd.com)
- Neurogenic detrusor activity, also known as detrusor hyperreflexia is when the detrusor muscle of the bladder contracts more frequently and involuntarily. (physio.co.uk)
- The impairment of the signalling systems between the bladder and the brain is caused by a disruption of the nerves supplying the detrusor muscle. (physio.co.uk)
- 2 A very rich presence of NPY-immunoreactive nerve fibres was found mainly within the bundles of detrusor muscle cells. (herts.ac.uk)
- When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
Urine1
- This voiding reflex causes the urethral sphincters to open while facilitating the detrusor to contract and expel the urine. (medscape.com)
Compliance1
- Bladder augmentation, also called augmentation cystoplasty, is a surgical procedure used in adults and children who lack adequate bladder capacity or detrusor compliance. (medscape.com)
Abnormality1
- Neurogenic detrusor activity in men or detrusor hyperreflexia is a neurological abnormality that impairs the signalling systems between the central nervous system and the bladder. (physio.co.uk)
Intravesical1
- In 1929, Gruber noted that the incidence of VUR varied based on the length of the intravesical ureter and muscularity of the detrusor backing. (medscape.com)
Decrease3
- Increase of cystometric capacity was achieved from 194.8 to 317 ml and decrease of detrusor pressure from 76.2 to 33.8 cmH2O. (amedi.sk)
- Increase of cystometric capacity from 221.7 to 318.5 ml and decrease of detrusor pressure from 58.5 to 23.3 cmH2O. (amedi.sk)
- A slight decrease in detrusor pressure during voiding was suggested. (nih.gov)
Activity2
- Your physiotherapy programme with Physio.co.uk will focus on goals that are personal to you and therefore there is no standard way in which to treat neurogenic detrusor activity in men. (physio.co.uk)
- Theobald RJ Jr. Differing effects of NG-monomethyl L-arginine and 7-nitroindazole on detrusor activity. (atsu.edu)
Nerve1
- TH nerve terminals surrounding the detrusor decreased in all BPNI groups, whereas VAChT and nNOS terminals decreased 14 and 30 days post-BPNI. (lu.se)
Tissue1
- Studies were carried out using isolated tissue baths, where strips of porcine bladder U&LP or detrusor were exposed to varying concentrations of prostaglandin agonists (1 μM and 10 μM). (biomedcentral.com)