Mesna alone and mesna plus amifostine prevented cellular glutathione depletion. (uaeu.ac.ae)
Chemotherapy5
Amifostine (WR-2721), a phosphoaminothioate, is capable of providing marked protection from both radiation- and selected chemotherapy-induced damage for a wide variety of tissues in both rodents and humans (1, 2, 3, 4, 5, 6) . (aacrjournals.org)
Amifostine is used in chemotherapy and radiotherapy as a cytoprotective adjuvant alongside DNA-binding chemotherapeutic agents. (bvsalud.org)
Only one drug, Amifostine, has been approved to date by the federal Food and Drug Administration, to help protect normal tissue from the side effects of chemotherapy and radiation, and researchers would like to develop new and improved agents. (news-medical.net)
I. To determine the levels of expression of c-KIT and its ligand, stem cell factor (SCF) in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
To determine the levels of expression of AKT2 and its activated form, phospho-AKT2, in archived, formalin fixed, paraffin embedded primary tumors collected prior to the initiation of first-line chemotherapy. (knowcancer.com)
Infusion1
Amifostine administration during mesna infusion caused transient increase in mesna levels. (uaeu.ac.ae)
Metastatic2
OBJECTIVES: I. Assess the efficacy and role of amifostine as a cytoprotection agent with concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck cancer. (knowcancer.com)
The Pediatric Oncology Group study for metastatic Ewing's sarcoma used amifostine and mesna with the alkylating agents. (uaeu.ac.ae)
Cells5
To assess the role of the polyamine transport system in radioprotection by amifostine derivatives, human DU-145 prostate cancer cells were transfected with a cDNA that encodes antizyme (OAZ), a polyamine-inducible protein that suppresses polyamine transport under control of a minimal heat shock promoter. (aacrjournals.org)
Cells were exposed to various amifostine doses (10-200 µg/mL) and methotrexate (2.5 µM) in pretreatment culture condition. (bvsalud.org)
To determine the fate of combined drug thiols, we measured thiol levels in plasma, red blood cells (RBC), and peripheral blood mononuclear cells (PBMC) of four patients. (uaeu.ac.ae)
Over the past 50 years, many radiation protectors have been tested in laboratories to determine their efficacy in preventing radiation damage to normal cells and tissues. (illinoiscancercare.com)
dCK activity of the cells was determined by an enzyme activity assay. (biomedcentral.com)
Tumor2
Using computerized tomography (CT) scans and other scans, radiation oncologists have developed methods for determining the tumor size and shape in 3 dimensions. (illinoiscancercare.com)
Tumor markers are tumor-derived or tumor-associated proteins, antigens, genes or hormones that can also aid in diagnosis, in the measurement of therapeutic response, in locating tumor origin or in determining recurrence. (oncolink.org)
Radiation3
Determine the toxicity and response to cisplatin, paclitaxel and radiation therapy in these patients. (knowcancer.com)
They gave the embryos different doses of ionizing radiation as well as treatment by either Amifostine, which acted as a control agent, or CD60_DF1. (news-medical.net)
Imaging procedures play a vital role in diagnosis, allowing physicians to ascertain the presence of a mass, localize it for biopsy, characterize tissue, and determine anatomical extent of disease in preparation for subsequent therapy (surgery and radiation therapy, for example). (oncolink.org)
Survival3
I. To determine the distribution of the overall survival. (knowcancer.com)
To determine the distribution of progression-free survival. (knowcancer.com)
Cell survival was determined 7, 8, or 9 days after RT by the sulforhodamine B test. (biomedcentral.com)
Effectiveness2
Based on effectiveness and side effects of the medication, your doctor may increase the dose, until the dose that relieves your symptoms is determined. (pharmachoice.com)
Assess volume status frequently (eg, daily or at least every 2 to 3 days) to determine effectiveness and to avoid overdiuresis. (medilib.ir)
Agent2
These findings convey that amifostine can operate as a cytoprotectant agent. (bvsalud.org)
He and his co-workers also want to determine better ways to target the agent to protect specific tissues and organs. (news-medical.net)
Drug1
A drug receives Resolved status when the Drug Shortages Staff (DSS) determines that the market is covered, based on information from all manufacturers. (fda.gov)
Administration1
The quantity of dosage is determined by the manner of administration, as indicated in the table beneath. (withpower.com)
Properties2
Amifostine metabolites WR-1065 and the disulfide WR-33278are thiol-containing polyamine analogues with potent radio- and chemoprotective properties. (aacrjournals.org)
In addition to preventing cytotoxicity, amifostine derivatives display anticarcinogenic (7, 8) and antimutagenic (9) properties in rodent model systems as well as hematopoiesis-promoting effects (10, 11) . (aacrjournals.org)
Studies1
Some studies suggest that amifostine exerts differential cytoprotection in normal versus neoplastic tissues, but this finding remains controversial. (aacrjournals.org)
To determine the frequency and severity of adverse effects of Gleevec in this cohort of patients as assessed by CTC. (knowcancer.com)
Specific1
Selective exclusion of amifostine derivatives by the polyamine transporter could account for differential radio- or chemoprotection in normal versus neoplastic tissues in specific situations. (aacrjournals.org)
Levels1
Amifostine significantly decreased the levels of ROS and LPO while preserving the status of GSH and SOD activity. (bvsalud.org)
Days1
Amifostine IV is administered over 5 minutes on days 1-5. (knowcancer.com)
Cancer1
Hormone receptor status, HER2 status, and cancer grade are also factors in determining whether a cancer is stage I. (lbbc.org)
Cytoprotective4
Amifostine (WR-2721) can be a cytoprotective agent found in radiotherapy for safety against xerostomia1. (ampkpathway.com)
This safety can be selective for regular tissues, since many variations in the biology of tumoral cells prevent either the build up of amifostine in tumor cells or its cytoprotective function6. (ampkpathway.com)
The complicated 59-05-2 IC50 cytoprotective pathways exploited by amifostine could also involve disturbance with genes involved with cell routine rules and apoptosis7. (ampkpathway.com)
Amifostine is a cytoprotective drug that helps prevent the damage caused by certain cancer treatments such as chemotherapy and radiation therapy. (clearsynth.com)
Pharmacokinetics2
Amifostine Thiol Stable Isotopes are commonly used in medical research to study the pharmacokinetics and pharmacodynamics of Amifostine. (clearsynth.com)
14. Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients. (nih.gov)
Cisplatin4
Purpose: To determine the role of amifostine as a protectant against cisplatin-induced ototoxicity in patients with average-risk (AR) medulloblastoma treated with craniospinal radiotherapy and four cycles of cisplatin-based, dose-intense chemotherapy and stem-cell rescue. (elsevierpure.com)
When used, amifostine (600 mg/m 2 /dose) was administered as a bolus immediately before and 3 hours into the cisplatin infusion. (elsevierpure.com)
Conclusion: Amifostine administered before and during the cisplatin infusion can significantly reduce the risk of severe ototoxicity in patients with AR medulloblastoma receiving dose-intense chemotherapy. (elsevierpure.com)
13. Drug-induced DNA modification in buccal cells of cancer patients receiving carboplatin and cisplatin combination chemotherapy, as determined by an immunocytochemical method: interindividual variation and correlation with disease response. (nih.gov)
Protects1
Amifostine selectively protects NCTC cells against rays, whilst HepG2 neoplastic cells are sensitized. (ampkpathway.com)
Organ1
These results shed brand-new light over the system of amifostinecytoprotection and encourage medical study with this agent for the treating major and metastatic liver organ tumor. (ampkpathway.com)
Dose2
The dose of lisinopril for children is determined by the child's body weight. (medbroadcast.com)
Over low dose laser als manier om orale mucositis aan te pakken staat ook een en ander op onze website en in de literatuurlijsten . (kanker-actueel.nl)
Commonly1
Droller and colleagues developed a grading system, which has been commonly used to determine the severity of HC (Table 1). (uic.edu)
Clinical3
Although several interventions are available and they have shown some benefit at preventing or reducing the severity of oral complications related to cancer therapy, well-designed clinical trials are needed to determine which interventions are most efficacious for different categories of patients and cancer therapies. (nih.gov)
They are also used in clinical trials to investigate the safety and efficacy of Amifostine as a radioprotectant and chemoprotectant. (clearsynth.com)
The use of abemaciclib in the early-stage setting depends on reviewing a number of clinical features to determine if a particular patient is high risk for recurrence, and balancing the potential benefit with possible side effects. (lbbc.org)
Treatment2
Amifostine treatment offers multiple results, which all converge for the safety of cells against cytotoxic DNA harm induced by ionizing rays or DNA-damaging chemotherapeutic real estate agents. (ampkpathway.com)
Patients and Methods: The primary objective was to determine whether, in patients with AR medulloblastoma (n = 62), amifostine would decrease the need for hearing aids (defined as ≥ grade 3 ototoxicity in one ear) compared with a control group (n = 35), 1 year from initiating treatment. (elsevierpure.com)