• The rhizome part of T. govanianum has a high amount of steroidal saponins such as borassoside E and upon hydrolysis yield >2.5% diosgenin which is used for the preparation of steroidal and sex hormones (Shivam et al. (wikipedia.org)
  • Qualitative and quantitative determination of steroidal saponins in Trillium govanianum by UHPLC‐QTOF‐MS/MS and UHPLC‐ELSD. (wikipedia.org)
  • Thus, the present work describes development and validation of a new, simple and sensitive reversed phase HPLC method for determination of diosgenin of Solanum nigrum and standardization of extracts and marketed Ayurvedic formulations containing Solanum nigrum in terms of diosgenin. (ijpsr.com)
  • Qualitative and quantitative estimation of Diosgenin in coded ayurvedic formulation and its ingredient Trigonella foenum-graecum Linn. (springeropen.com)
  • A reversed phase high performance liquid chromatography coupled with diode array detector (HPLC-DAD) was developed and validated to quantitate diosgenin in berries of Solanum nigrum using C18 analytical column as stationary phase and acetonitrile: water (92: 08, v/v) as mobile phase. (ijpsr.com)
  • Many HPLC methods have been reported for determination of diosgenin in various species of genus Dioscorea . (ijpsr.com)
  • Diosgenin is a naturally-occurring steroidal saponin present in Solanum nigrum (Solanaceae). (ijpsr.com)
  • Diosgenin serves as important starting material for the production of corticosteroids, sexual hormones, oral contraceptives as well as other steroidal drugs. (ijpsr.com)
  • Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. (hindawi.com)
  • Our recent research further showed that diosgenin, as a main metabolite from DN, was found and quantified in the plasma from the experimental rat group orally receiving DN [ 8 ]. (hindawi.com)
  • Thus, we hypothesized that diosgenin is a bioactive metabolite related to the antimyocardial ischemia (MI) activity of DN. (hindawi.com)
  • The developed and validated method was applied for quantitative determination of diosgenin in extracts and formulations containing Solanum nigrum . (ijpsr.com)
  • It is reported that Dioscorea bulbifera extract, which is similar to the DN extract that both are rich in diosgenin, improves vascular function by superoxide dismutase (SOD) and catalase (CAT) activity. (hindawi.com)
  • A simple, new and correct high performance liquid action technique was developed for coinciding determination of Clonazepam and Paroxetine in tablet dosage form by employing a C18 Intersil 250 × 4.6 millimeter column and mobile section consisting of Acetonitrile: 0.1 % OPA (65: 35 v/v). The analysis was performed at a flow rate of 0.8 ml/min. (ajrconline.org)
  • The proposed method was applied successfully for the determination of Meloxicam in tablets with average recovery of 99.62±0.88 and 100.4±0.768. (ajrconline.org)
  • The proposed method was found to be robust in terms of % w/w of diosgenin. (ijpsr.com)
  • For the AChE inhibitory effect, only tannic acid, gallic acid, diosgenin and isoguvacine were found to be active, whereby tannic acid was more potent than Ac.Cr. (jcimjournal.com)
  • X-ray diffraction (XRD) and nuclear magnetic resonance (NMR) were the two most widely used techniques for the determination of macromolecular structures at high resolution, but both have limitations relating to particle size, the hydrophobic nature of macromolecules, and the amount of sample available. (technologynetworks.com)
  • However, mechanism of action associated with the analgesic activity of diosgenin is not yet delineated. (ac.ke)
  • The present study aimed to investigate the effect of diosgenin on mammalian target of rapamycin(mTOR), fatty acid synthase(FASN), hypoxia inducible factor-1α(HIF-1α), and vascular endothelial growth factor A(VEGFA) expression in liver tissues of rats with non-alcoholic fatty liver disease(NAFLD) and explore the mechanism of diosgenin on lipogenesis and inflammation in NAFLD. (bvsalud.org)
  • Efficient Hydroalcoholic Extraction for Highest Diosgenin Content from Trillium Govanianum (Nag chhatri) and it's in Vitro Anticancerous Activity. (wikipedia.org)
  • 9. Determination of total antioxidant activity in three types of local vegetables shoots and the cytotoxic effect of their ethanolic extracts against different cancer cell lines. (nih.gov)
  • Diosgenin is a natural steroid sourced from plants and exhibits good analgesic and anti-inflammatory activity. (ac.ke)
  • Determination of androgenic:anabolic ratio is typically performed in animal studies, which has led to the marketing of some compounds claimed to have anabolic activity with weak androgenic effects. (agapegym.org)
  • A sensitive liquid chromatography - electro spray ionization mass spectrometry (LC-ESI-MS) method is developed and validated for rapid determination of Esomeprazole in human plasma. (ajrconline.org)