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Creatine KinaseCreatineCreatine Kinase, MM FormCreatine Kinase, BB FormCreatine Kinase, Mitochondrial FormIsoenzymesCreatine Kinase, MB FormClinical Enzyme TestsPhosphatidylinositol 3-KinasesPhosphocreatineMAP Kinase Signaling SystemProtein-Serine-Threonine KinasesProtein KinasesSerumArginine KinaseMusclesProtein Kinase InhibitorsCalcium-Calmodulin-Dependent Protein Kinasessrc-Family KinasesL-Lactate DehydrogenaseMyocardiumElectrophoresis, Cellulose AcetateProtein Kinase CMuscle, SkeletalKineticsTime Factorsp38 Mitogen-Activated Protein KinasesRhabdomyolysisAdenosine TriphosphateCyclic AMP-Dependent Protein KinasesMitogen-Activated Protein Kinase 1Pyruvate KinaseMagnetic Resonance SpectroscopyMolecular Sequence DataSerum AlbuminRabbitsAdenylate KinaseAdenosine Diphosphatep21-Activated KinasesMitogen-Activated Protein Kinase KinasesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein Kinase 3Guanidinoacetate N-MethyltransferaseBiological MarkersMuscular DiseasesAmino Acid SequenceMyoglobinProtein-Tyrosine KinasesPhosphorylationAmidinotransferasesCyclin-Dependent KinasesCDC2 Protein KinaseAspartate AminotransferasesMAP Kinase Kinase KinasesMyocardial InfarctionBase SequenceMitochondria, HeartCasein Kinase IIeIF-2 KinaseCasein KinasesElectrophoresis, Agar GelChromatography, High Pressure LiquidProtein BindingRibosomal Protein S6 KinasesBrainEnergy MetabolismAutoanalysisSignal TransductionMyositisSex Determination ProcessesMutationMAP Kinase Kinase 1Binding SitesThymidine KinaseReceptor Protein-Tyrosine KinasesBlotting, WesternTroponin TReference ValuesCell LineCells, CulturedExtracellular Signal-Regulated MAP KinasesRNA, MessengerTroponin IMAP Kinase Kinase 4Enzyme ActivationTransfectionSensitivity and SpecificityPhosphotransferases (Alcohol Group Acceptor)Mitogen-Activated Protein KinasesCalciumMuscular Dystrophies1-Phosphatidylinositol 4-KinaseCDC2-CDC28 KinasesSubstrate SpecificityRecombinant ProteinsDose-Response Relationship, DrugHydrogen-Ion ConcentrationRats, Sprague-DawleyElectrophoresis, Polyacrylamide GelGlycogen Synthase Kinase 3
EnzymeLactateProteinTroponinMyocardialCreatinineBiochemicalPhosphokinaseBilirubinDiagnosisIsoenzymeMAPKLevelsConcentrations of serumBiomarkersCaffeineAspartateHuman serumEnzymesAssaysElevationsQuantitationMetabolismSignificantlyCalciumPatientsPlasmaCholesterolClinicalDiagnosticEvaluationLipidSamplesMusclesDamageSensitivityChemicalBoneIndicator
Enzyme8
  • Serum elevations of ALT activity are rarely observed except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
  • Creatine Kinase MB (CK-MB) is an enzyme present in the cardiac muscle with a molecular weight of 87.0 kDa.1 Creatine Kinase is a dimeric molecule formed from two subunits designated as "M" and "B" which combine to form three different isoenzymes, CK-MM, CK-BB, and CK-MB. (nal-vonminden.com)
  • Creatine kinase (CK) is an enzyme, found primarily in muscle and brain tissue, which exists as three dimeric isoenzymes: CK-MM (CK-3), CK-MB (CK-2), and CK-BB (CK-1) − built from subunits designated M and B. The CK-MB isoenzyme, which has a molecular mass of approximately 87 kilodaltons, accounts for 5% to 50% of total CK activity in myocardium. (evexiadiagnostics.com)
  • Determination of MIF serum levels were performed by enzyme-linked immunosorbent assay and MIF ELISA Kit. (hindawi.com)
  • CPK stands for creatine phosphokinase, and it is an enzyme that helps turn creatine into phosphate which is burned for energy. (healthy-heart-guide.com)
  • The CPK enzyme, also called creatine kinase (CK), is found throughout your body, mostly in your skeletal muscle as well as your brain and your heart. (healthy-heart-guide.com)
  • Creatine kinase (CK) is a dimer enzyme with four different forms: mitochondrial isoenzyme and cytosolic isoenzyme CK-MM (muscle type), CK-BB (brain type) and CK-MB. (xhfhj.com)
  • A high sensitivity enzyme immunoassay for the quantitative determination of C-reactive protein (CRP) concentration in serum. (drg-international.com)
Lactate4
  • Fatigue-related biochemical responses of serum lactate, ammonia, glucose, creatine kinase (CK), and blood urea nitrogen (BUN) were measured following the swimming exercise. (medsci.org)
  • WWBV+DHEA supplementation also decreased serum lactate, ammonia and BUN levels, while increasing glucose levels following the 15-min swim test. (medsci.org)
  • Levels of creatine kinase (CK) and lactate dehydrogenase (LDH) in serum were determined. (biomedcentral.com)
  • Lactate dehydrogenase (LDH) and creatine kinase‑MB (CK‑MB) release, infarct size, cardiac function, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, malondialdehyde (MDA), intracellular reactive oxygen species (ROS), and DJ‑1 protein expression levels were assessed. (spandidos-publications.com)
Protein11
  • Anti-inflammation of the extract was analyzed via determination of TNF-α and IL-6 in serum, and expression of TNF-α, IL-6, COX-2 and p-ERK protein in hearts. (biomedcentral.com)
  • Heme oxygenase-1 (HO-1) and p-NF-κB protein expression in hearts, superoxide dismutase (SOD) activity and malondialdehyde (MDA) level in serum were used to evaluate the anti-oxidative properties of the extract. (biomedcentral.com)
  • In addition, the extract increased SOD activity in serum, HO-1 protein expression in hearts, and decreased TNF-α, IL-6, COX-2, p-NF-κB and p-ERK1/2 protein expression. (biomedcentral.com)
  • Phosphoinositide-3 kinase (PI3K) is a key signaling protein in cell metabolism, and serine/threonine kinase (Akt) is the primary target molecule downstream of PI3K. (springeropen.com)
  • We hypothesized that helium induces pre- and postconditioning in CABG-patients, affecting signaling molecules protein kinase C-epsilon (PKC-ε), p38 mitogen activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK-1/2) and heat shock protein 27 (HSP-27) within cardiac tissue, and reducing postoperative troponin levels. (biomedcentral.com)
  • This noble gas induced cardioprotective effect was abolished on a cellular level by blockers of protein kinase C (PKC) and p38 mitogen activated protein kinase (p38 MAPK) [ 3 ]. (biomedcentral.com)
  • The aim of the present study was to investigate the effect of streptozotocin-induced diabetes mellitus and lipoic acid treatment on serum paraoxonase-1 and paraoxonase-3 protein levels and paraoxonase, arylesterase and lactonase activities.36 rats were equally and randomly divided into 4 groups as control, lipoic acid, diabetes and diabetes+lipoic acid. (scite.ai)
  • Serum PON1 and PON3 protein levels were measured by western blotting. (scite.ai)
  • Serum paraoxonase, arylesterase and lactonase activities were determined by the measuring initial rate of substrate (paraoxon, phenylacetate and dihydrocoumarin) hydrolysis.Streptozotocin-induced diabetes mellitus caused a significant decrease whereas lipoic acid treatment caused a significant increase in serum PON1 and PON3 protein levels and paraoxonase, arylesterase and lactonase activities. (scite.ai)
  • These observations provide evidence that supplementation with vitamin C may blunt the adaptive mobilization of this vitamin from the adrenals during exercise-induced oxidative stress and may be associated with an enhancement of the acute phase protein response and attenuation of the exercise-induced increase in serum cortisol. (thieme-connect.com)
  • There is also the serum myoglobin test, another heart protein that will leak into the blood stream if there is any damage to the heart muscle. (healthy-heart-guide.com)
Troponin5
  • However, previous CMR-based studies in MD patients have also suggested that cardiac serum markers such as troponin or brain-natriuretic peptide (BNP) that are helpful to diagnose and monitor cardiac disease in many ischemic as well as non-ischemic cardiomyopathies, are of limited clinical value in MD patients [ 9 , 10 ]. (biomedcentral.com)
  • Serum cardiac troponin I (cTnI), and creatine kinase MB (CK-MB) were measured. (springeropen.com)
  • Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I. Clin Chem. (evexiadiagnostics.com)
  • High dose tildipirosin increased cardiac damage parameters including creatine kinase-MB mass and partially troponin I within the first day, and high dose tildipirosin decreased statistically significant the thiobarbituric acid reactive substances levels on 1 and 3 d compared with ND group. (biomedres.info)
  • Creatine kinase-MB mass (CK-MB mass) and troponin I (TnI) levels are evaluated for cardiac damage or cardiotoxicity, at the same time Thiobarbituric Acid Reactive Substances (TBARS) levels can be measured to determine the oxidative stress and the cellular membrane damage [ 19 ]. (biomedres.info)
Myocardial6
Creatinine1
  • The test is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal, renal, and postrenal uremia. (cdc.gov)
Biochemical4
  • Therefore, this study aimed to investigate gut microbiota and serum biochemical indicators in horses with Chlamydial infection (IG) and healthy horses (HG). (bvsalud.org)
  • HG: 6) before morning feeding for the determination of gut microbiota and serum biochemical parameters. (bvsalud.org)
  • In addition, the abundance of 18 genera of bacteria was associated with the level of five serum biochemical indicators. (bvsalud.org)
  • In the current research, it was aimed that determination of biochemical, hematologic, cardiac and oxidative stress parameters following normal (4 mg/kg, SC) and high dose (8 mg/kg, SC) administration of tildipirosin in sheep. (biomedres.info)
Phosphokinase2
  • In the case of alcohol induced liver disease, rheumatoid arthritis (RA), connective tissue diseases , Cushing's disease and acute viral hepatitis, creatine phosphokinase levels may be lower than normal. (healthy-heart-guide.com)
  • Serum creatine phosphokinase (CPK) activity was determined in 726 patients and correlated with psychiatric diagnosis. (northwestern.edu)
Bilirubin1
  • Liver disease or liver injury as indicated by abnormal liver function tests such as AST, ALT, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), or serum bilirubin in the presence of normal serum creatine kinase (CK). (ucbraid.org)
Diagnosis3
  • Hence, the identification of novel serum biomarkers for diagnosis and monitoring of cardiomyopathy in MD patients (e.g. as a gatekeeper for subsequent CMR studies) is a clinically important, however, still unsolved challenge. (biomedcentral.com)
  • Together with pH determination, bicarbonate measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with acid-base imbalance in the respiratory and metabolic systems. (cdc.gov)
  • Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time. (mdpi.com)
Isoenzyme1
  • CK-MB is the isoenzyme of Creatine Kinase most involved in the metabolism of cardiac muscle tissue.2 The release of CK-MB into the blood following MI can be detected within 3-8 hours after the onset of symptoms. (nal-vonminden.com)
MAPK1
  • Helium preconditioning did not significantly alter the primary outcome (molecular levels of kinases PKC-ε and HSP-27, ratio of activated p38 MAPK or ERK ½). (biomedcentral.com)
Levels16
  • RESULTS: The results showed that total globulin (GLB), alanine aminotransferase (ALT), and creatine kinase (CK) levels were significantly increased in IG compared with HG. (bvsalud.org)
  • Serum creatine kinase levels (CK) can vary among healthy subjects, even when correcting for muscle mass. (medscape.com)
  • [ 11 ] Importantly, the plasma reference levels of CK-MB are different from serum reference levels. (medscape.com)
  • 0.01) decreased serum CK-MB and cTnI, cardiac levels of MDA, HIF-1α, p62 and LC3IIB along with an increase in GSH-px activity compared with ISO group. (springeropen.com)
  • Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. (hindawi.com)
  • The aim of the present study was to investigate both the possible role of SA-rich inflammation-sensitive proteins and the cell damage due to elevated serum TSA levels in AMI. (scite.ai)
  • Since the transfer of free SA to lipoproteins is required for an increase in serum LSA levels, and free SA for this transfer can be provided by the secretion of SA from the cell, it is obvious that the shedding or secretion of SA from the cell membrane surface or release of cellular SA from cells into the bloodstream due to cell damage after AMI also occur after AMI. (scite.ai)
  • 4 Attwood E C, Robey E D, Ross H, Bradley F, Kramer J J. Determination of platelet and leucocyte vitamin C and the levels found in normal subjects. (thieme-connect.com)
  • The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). (hindawi.com)
  • 1 CRP is one of the acute-phase proteins, the serum or plasma levels of which rise during general, nonspecific response to a wide variety of diseases. (drg-international.com)
  • Few nonpsychotic and chronically psychotic patients had elevated serum CPK levels. (northwestern.edu)
  • Reproducibility and repeatability were determined from sera with various levels of anti-HMGCR autoantibodies. (biomedcentral.com)
  • Anti-HMGCR-positive patients had high creatine kinase (CK) levels (mean 6,630 IU/L) and only 40% of them had been exposed to statins. (biomedcentral.com)
  • People who have lower creatine levels when they start taking creatine seem to get more benefit than people who start with higher levels. (medlineplus.gov)
  • Taking creatine by mouth daily can increase creatine levels in the brain in children and young adults with conditions called GAMT deficiency or AGAT deficiency. (medlineplus.gov)
  • But taking creatine doesn't seem to improve brain creatine levels in children who have a disorder in which creatine isn't transported properly. (medlineplus.gov)
Concentrations of serum1
  • The concentrations of serum SA-rich inflammation-sensitive proteins, namely alpha1-antitrypsin, alpha2-macroglobulin and ceruloplasmin were determined immunoturbidimetrically. (scite.ai)
Biomarkers1
  • Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. (mdpi.com)
Caffeine4
  • Serum caffeine concentration determinations do not influence management. (medscape.com)
  • While a near infinite combination of ingredients can exist, most multi-nutrient formulations contain a combination of key ingredients such as creatine monohydrate, amino acids, betaine, selected botanicals and plant extracts, carbohydrates, and caffeine [ 3 - 6 ]. (medsci.org)
  • Caffeine and creatine taken together may make symptoms of Parkinson disease worse. (medlineplus.gov)
  • If you have Parkinson disease and take creatine, use caffeine with caution. (medlineplus.gov)
Aspartate1
Human serum1
Enzymes1
Assays1
  • [ 3 ] However, the reference range for serum CK-MB in adults is also varied among laboratory assays as shown in the table below. (medscape.com)
Elevations1
  • Immediately on completion of the race transient elevations occurred in the concentrations of circulating neutrophils, monocytes and platelets, IL-6, cortisol, CRP, and creatine kinase in both groups. (thieme-connect.com)
Quantitation1
Metabolism1
Significantly1
  • Extract pretreatment significantly decreased the level of serum CK and LDH, reduced the generation of inflammatory cytokines such as TNF-α and IL-6, and also reduced serum level of MDA in the LPS + extract group compared with the LPS group. (biomedcentral.com)
Calcium2
Patients4
  • Before instituting gemfibrozil therapy, every attempt should be made to control serum lipids with appropriate diet, exercise, weight loss in obese patients, and control of any medical problems such as diabetes mellitus and hypothyroidism that are contributing to the lipid abnormalities. (drugcentral.org)
  • CA242 is a sialylated carbohydrate antigen that can be recognized by CA242 monoclonal antibody.It is a mucin-type glycoprotein that is low in the serum of healthy people and patients with benign diseases. (xhfhj.com)
  • Eighty-three of 209 acutely psychotic patients (39.7%) had increased serum CPK activity. (northwestern.edu)
  • Some patients with alcoholic psychoses or cerebral arteriosclerosis had elevated serum CPK activity. (northwestern.edu)
Plasma2
  • The NADAL® CK-MB Test is a simple test that utilizes a combination of anti-CK-MB antibody coated particles and capture reagent to detect CK-MB in whole blood, serum or plasma. (nal-vonminden.com)
  • 7 Bieri J G, Tolliver T J, Catignani G L. Simultaneous determination of retinol and α tocopherol in serum & plasma by liquid chromatography. (thieme-connect.com)
Cholesterol2
  • Gemfibrozil is a lipid regulating agent which decreases serum triglycerides and very low density lipoprotein (VLDL) cholesterol, and increases high density lipoprotein (HDL) cholesterol. (nih.gov)
  • The study involved subjects with serum non-HDL-cholesterol of over 200 mg/dL and no previous history of coronary heart disease. (nih.gov)
Clinical1
  • The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. (hindawi.com)
Diagnostic1
Evaluation1
  • The determination of serum urea nitrogen is the most widely used test for the evaluation of kidney function. (cdc.gov)
Lipid1
  • Periodic determination of serum lipids should be obtained, and the drug withdrawn if lipid response is inadequate after three months of therapy. (drugcentral.org)
Samples2
  • In total, 2816 serum samples were collected from 12 provinces in China. (bvsalud.org)
  • Procedures -Records were retrieved from a database containing results of serum samples tested for acetylcholine receptor antibodies. (avma.org)
Muscles1
Damage1
Sensitivity1
  • In this field, electrochemical immunosensors have demonstrated to offer interesting alternatives against conventional strategies due to their simplicity, fast response, low cost, high sensitivity and compatibility with multiplexed determination, microfabrication technology and decentralized determinations, features which made them very attractive for integration in point-of-care (POC) devices. (mdpi.com)
Chemical1
Bone1
Indicator1
  • A possible role of serum LSA as an indicator of the shedding or secretion of SA from the cell or cell membrane surface in AMI was also evaluated. (scite.ai)