AnaplasmaLyme DiseaseGariniiSpirochetesBacteriaGenospeciesAfzeliiEhrlichiaPrevalenceSpirocheteCausative agentPathogensSpeciesAssayPolymerase chain reMiyamotoiBabesiaBacteriumGenomeSpirochaetalesAntibodyPresenceHelicobacterMayoniiRickettsialesSpecimensMolecularGenesGeneReagentsHostsTickborneIndirectInfection ratesClinicalTransmission
Anaplasma10
- Detection of Leishmania infantum DNA and antibodies against Anaplasma spp. (cabi.org)
- Co-detection of Bartonella henselae, Borrelia burgdorferi, and Anaplasma phagocytophilum in Ixodes pacificus ticks from California, USA. (medscape.com)
- Hojgaard A, Lukacik G, Piesman J. Detection of Borrelia burgdorferi , Anaplasma phagocytophilum and Babesia microti , with two different multiplex PCR assays. (cdc.gov)
- Several pathogens including tick-borne pathogens ( Borrelia/Borreliella , Anaplasma , Neoehrlichia , Rickettsia ) and opportunistic bacteria ( Williamsia ) were transmitted to the skin microbiome and some of them disseminated to the blood or spleen of the mice. (biomedcentral.com)
- Ixodes persulcatus (n = 125) and Dermacentor reticulatus (n = 84) ticks from Western Siberia, Russia, were tested for infection with Borrelia, Anaplasma/Ehrlichia, Bartonella, and Babesia spp. (cdc.gov)
- I. persulcatus ticks were infected with Borrelia burgdorferi sensu lato (37.6% +/- 4.3% [standard deviation]), Anaplasma phagocytophilum (2.4% +/- 1.4%), Ehrlichia muris (8.8% +/- 2.5%), and Bartonella spp. (cdc.gov)
- Also, the infection rates and distributions of these symbionts were compared to the horizontally transmitted pathogens Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum , and Neoehrlichia mikurensis . (biomedcentral.com)
- Data collected from clinical observations , hemograms, serology and detection of Anaplasma phagocytophilum , either by microscopy or by DNA amplification and typing, were placed in a time line. (biomedcentral.com)
- An active Anaplasma -infection can be diagnosed by microscopic detection of morulae in granulocytic white blood cells or by demonstrating emerging specific antibodies (seroconversion) [ 17 ]. (biomedcentral.com)
- Detection of Anaplasma DNA in peripheral blood is more sensitive presenting before and after morulae. (biomedcentral.com)
Lyme Disease25
- Geographic uniformity of the Lyme disease spirochete ( Borrelia burgdorferi ) and its shared history with tick vector ( Ixodes scapularis ) in the northeastern United States. (cdc.gov)
- Lyme disease is a multisystem disease that has a subacute and chronic course, and is caused by the bacterium Borrelia burgdorferi, which is transmitted by the tick to the host through its bite. (com.mk)
- Under-Detection of Lyme Disease in Canada. (nih.gov)
- In Europe, several reservoir hosts for Lyme disease-associated Borrelia spp. (biomedcentral.com)
- The challenge of detecting Lyme disease lies in the evasiveness of the Borrelia burgdorferi bacteria. (drexel.edu)
- This altered response is key to the team's approach to early detection of Lyme disease. (drexel.edu)
- Overall, 15 (36%) of 42 I. scapularis adults collected from 41 mammalian hosts (dogs, cats, humans) were positive for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (s.l. (canlyme.com)
- Lyme disease, known commonly outside the U.S. as Lyme borreliosis, is caused by infection with tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex. (health.mil)
- In North America, the vast majority of Lyme disease is caused by B. burgdorferi sensu stricto, 1 although other presumably pathogenic genospecies have been isolated. (health.mil)
- Detection of antibodies to Borrelia burgdorferi, the causative agent of Lyme disease, by indirect fluorescent antibody test. (tamu.edu)
- Lyme Borreliosis (Borrelia burgdorferi) DNA is not typically detected in peripheral blood, even when Lyme disease is the cause of clinical signs. (tamu.edu)
- Caused by infection with the spirochetal (helical) bacteria Borrelia burgdorferi, Lyme disease is primarily transmitted to humans , as well as dogs , horses and other domesticated animals, by the bite of infected ticks . (newworldencyclopedia.org)
- Lyme disease is caused by spirochetal bacteria from the genus Borrelia , which has well over 300 known genomic strains. (newworldencyclopedia.org)
- The Borrelia species known to cause Lyme disease are collectively known as Borrelia burgdorferi sensu lato, and have been found to have greater strain diversity than previously estimated. (newworldencyclopedia.org)
- Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. (ucf.edu)
- Dr. Mollie Jewett, head of the Division of Immunity and Pathogenesis Research at the College of Medicine's Burnett School of Biomedical Sciences, focuses her research on earlier detection and better treatments for Lyme disease, which causes fever, headache, fatigue and a characteristic skin rash. (ucf.edu)
- A blood test that determines if Lyme disease bacteria is present (antibodies for borrelia burgdorferi). (nh.gov)
- Deer keds are blood-feeding flies from which several human and animal pathogens have been detected, including the causative agent of Lyme Disease (Borrelia burgdorferi). (usda.gov)
- Deer keds, such as Lipoptena cervi Linnaeus (Diptera: Hippoboscidae), are blood-feeding flies from which several human and animal pathogens have been detected, including Borrelia burgdorferi sensu lato Johnson (Spirochaetales: Borreliaceae), the causative agent of Lyme disease. (usda.gov)
- In other words Borrelia burgdorferi, Borrelia afzellii and Borrelia garinii that cause Lyme disease in America and Europe are all genetically similar to each other and have similar tick vectors. (medicpdf.com)
- Lyme disease is caused by Borrelia burgdorferi, a bacteria which can lie dormant for months or years, making it difficult to diagnose. (westcliniconline.com)
- Lyme disease is caused by the bacterium, Borrelia burgdorferi. (westcliniconline.com)
- [ 10 ] In each location, the Ixodes tick vector for Babesia is the same vector that locally transmits Borrelia burgdorferi , the agent implicated in Lyme disease. (medscape.com)
- Lyme disease is a bacterial infection caused by Borrelia burgdorferi that is transmitted through the bite. (medlineplus.gov)
- Another related species, Borrelia mayonii (B. mayonii), has also been shown to cause Lyme disease in the upper midwestern United States (3,4). (cdc.gov)
Garinii5
- 2-5 Pathogen diversity is greater in Europe, where B. burgdorferi sensu stricto, B. afzelii , B. garinii , B. bavariensis , and B. spielmanii are established contributors to the burden of human disease. (health.mil)
- Quidel Corporation, a provider of rapid diagnostic testing solutions, cellular-based virology assays and molecular diagnostic systems, announced today that it has received CE Mark to market Quidel's Sofia 2 Lyme+ FIA to be used with the Sofia 2 Fluorescent Immunoassay Analyzer for the rapid differential detection of human IgM and IgG antibodies to Borrelia burgdorferi, Borrelia garinii, and Borrelia afzelii from serum and plasma specimens. (news-medical.net)
- B. burgdorferi sensu stricto (predominant in North America, but also in Europe), B. afzelii, and B. garinii (both predominant in Eurasia). (newworldencyclopedia.org)
- At present, diagnostic tests are based only on B. burgdorferi sensu stricto (the only species present in the United States), B. afzelii, and B. garinii. (newworldencyclopedia.org)
- Urutan B. garinii (NC_017804.1), B. burgdorferi sensu stricto (CP002950.1), B. bissettii (CP002761.1), B. afzelii (NZ_JALGSO010000002.1), B.valaisian (NC_012177.1) 49 jujukan telah diselaraskan untuk perbandingan homologi dan dibina untuk analisis pokok evolusi. (chenyanglobal.com)
Spirochetes3
- To do so, we performed next-generation RNA sequencing on doxycycline-treated spirochetes and treated spirochetes following regrowth, comparing them to untreated B. burgdorferi . (frontiersin.org)
- Kit Pengesanan PCR HCY™ Borrelia Burgdorferi ialah ujian kuantitatif pendarfluor untuk pengesanan spirochetes Borrelia burgdorferi yang ditakrifkan secara sempit (B. burgdorferisensu srricto) dalam sampel seperti air kencing, darah dan tisu. (chenyanglobal.com)
- Dr. Pedowtiz's project aims to develop a new rapid diagnostic test to target active Borrelia spirochetes directly by using a peptide conjugated biosensor for the direct detection. (bayarealyme.org)
Bacteria11
- But current diagnostic tests are not very reliable - they use indirect methods, measuring antibodies the body produces against the Borrelia bacteria that cause the disease. (acs.org)
- Digitally colorized scanning electron microscope image depicting a grouping of numerous, Gram-negative anaerobic Borrelia burgdorferi bacteria derived from a pure culture. (health.mil)
- One of the most striking features of B. burgdorferi as compared with other bacteria is its unusual genome, which is far more complex than that of its spirochetal cousin Treponema pallidum, the agent of syphilis. (newworldencyclopedia.org)
- Cervids, which are the primary hosts of deer keds, are not natural reservoirs of B. burgdorferi, and it has been suggested that deer keds may acquire bacterial pathogens by co-feeding near ticks that are infected with the bacteria. (usda.gov)
- Borrelia burgdorferi and it is a highly motile spirochete that belongs to a genus of bacteria that are notorious for giving rise to variant strains. (medicpdf.com)
- Borrelia are bacteria that are associated with dozens of tick and louse-borne Relapsing Fevers that are found throughout the world. (medicpdf.com)
- The hallmark attribute that most Borrelia bacteria have in common is their ability to adapt, change and infect host animals that in turn infect many species of ticks and lice. (medicpdf.com)
- The Lyme bacteria Borrelia burgdorferi likes to preferentially express certain genes and suppress others. (medicpdf.com)
- Dr. Andrew Pachner infected mice with Borrelia burgdorferi and later extracted the bacteria from the blood and from the brains of the infected mice. (medicpdf.com)
- This is more bad news as this suggests that the CNS of primates is an isolated and protective incubator for Borrelia bacteria. (medicpdf.com)
- The bacteria form "biofilms" - a slimy protective coating that keep the bacteria safe from detection and antibiotics. (westcliniconline.com)
Genospecies4
- The present study investigated the prevalence of Borrelia burgdorferi sensu lato (s.l.) genospecies in Ixodes ricinus ticks collected in Hanover, Northern Germany, in 2010. (biomedcentral.com)
- Additional B. burgdorferi sensu lato genospecies are suspected of causing illness, but are not confirmed by culture. (newworldencyclopedia.org)
- Apart from this group of closely related genospecies, additional Borrelia species of interest include B. lonestari, a spirochete recently detected in the Amblyomma americanum tick (Lone Star tick) in the U.S. [7] B. lonestari is suspected of causing STARI (Southern Tick-Associated Rash Illness), also known as Masters disease in honor of its discoverer. (newworldencyclopedia.org)
- Ixodes ricinus ticks and genospecies of Borrelia burgdorferi sensu lato complex. (szu.cz)
Afzelii1
- Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. (cdc.gov)
Ehrlichia2
- Prevalence of Dirofilaria immitis , Ehrlichia canis , and Borrelia burgdorferi in pet dogs, racing greyhounds, and shelter dogs in Florida. (cabi.org)
- Borrelia burgdorferi s.l. and Ehrlichia canis in a dog kennel in south-central Romania. (cabi.org)
Prevalence1
- NHANES offers a unique opportunity to estimate the prevalence of reactive serologic tests as an estimate of the prevalence of syphilis infections in the general population, to identify and confirm risk factors for syphilis, to confirm the risk for HIV infection and HIV-related neurologic disease among Americans with syphilis, and to monitor trends in prevalence as syphilis detection and treatment programs are established and expanded. (cdc.gov)
Spirochete1
- The spirochete was named Borrelia burgdorferi in his honor. (newworldencyclopedia.org)
Causative agent3
- Detection of Bacillus anthracis, the causative agent of anthrax, by culture. (tamu.edu)
- Detection of antibodies to Blastomyces dermatitidis, the causative agent of blastomycosis, by agar gel immunodiffusion. (tamu.edu)
- Detection of antibodies to Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, by indirect fluorescent antibody test. (tamu.edu)
Pathogens2
- Studies have shown that the gut microbiota of the black-legged tick, I. scapularis , modulates the integrity of the peritrophic matrix that separates the lumen from the digestive cells of the gut and subsequently affects the establishment of Borrelia pathogens [ 7 ]. (biomedcentral.com)
- We know for example that if you rank all the known Borrelia pathogens in a phylogenetic tree based on related genetics, you will find many disease causing pathogens that cause similar symptoms will often end up close together in related groups on the phylogenetic family-tree. (medicpdf.com)
Species5
- Rougemont M, Van Saanen M, Sahli R, Hinrikson HP, Bille J, Jaton K. Detection of Four Plasmodium Species in Blood from Humans by 18S rRNA Gene Subunit-Based and Species-Specific Real-Time PCR Assays. (cdc.gov)
- Detection of Borrelia species, including B. burgdorferi, B. hermsii, B. parkeri, and B. turicatae by real time PCR. (tamu.edu)
- Enhanced Detection and Characterization of Spotted Fever Group Rickettsia Species in Dogs and Ticks with Focus on a Novel Rickettsia Species Infecting Clinically Ill Dogs in the U.S. (akcchf.org)
- Detection of Leptospira species by real time PCR. (tamu.edu)
- This means the function of the majority of the genes in the Borrelia species has yet to be determined. (medicpdf.com)
Assay3
- Detection and identification of Plasmodium is done with a real-time PCR assay as described by Rougemont et al 2004. (cdc.gov)
- Detection of Babesia microti is done with a real-time PCR assay using B. microti -specific primers and TaqMan probe as described by Hojgaard et al 2014. (cdc.gov)
- The Borrelia assay is a 2 hour, 96-well indirect ELISA for the qualitative or quantitative determination of Borrelia IgM antibodies in human serum, plasma and CSF samples. (bmgrp.com)
Polymerase chain re3
- Aim: We looked for the evidence of Borrelia infection in patients with morphea by serologic means and by polymerase chain reaction (PCR) analysis of skin biopsy samples. (units.it)
- High sensitivity detection of human malaria parasites by the use of nested polymerase chain reaction. (cdc.gov)
- Schmidt BL, Aberer E, Stockenhuber C, Klade H, Breier F, Luger A. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in the urine and breast milk of patients with Lyme borreliosis. (healingwell.com)
Bacterium2
- [9] The genome of B. burgdorferi includes a linear chromosome approximately one megabase in size, and 21 plasmids (12 linear and 9 circular)-the largest number of plasmids (double-stranded DNA molecules separate from the chromosomal DNA ) found in any known bacterium [10] . (newworldencyclopedia.org)
- This year when the genomic sequence of Borrelia burgdorferi was determined, it came as quite a shock that most of the genes in this large bacterium had no known counterparts or similarities to other known bacterial genes. (medicpdf.com)
Genome3
- Qiu WG , Schutzer SE , Bruno JF , Attie O , Xu Y , Dunn JJ , Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. (cdc.gov)
- Conclusions: The amplification of DNA with PCR analysis seems to open new prospects for the detection of Borrelia genome in tissues. (units.it)
- First results of a national external quality assessment scheme for the detection of SARS-CoV-2 genome sequences. (cdc.gov)
Spirochaetales1
- Presence of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) in southern Kettle Moraine State Forest, Wisconsin, and characterization of strain W97F51. (cdc.gov)
Antibody1
- In a next step, the conjugate (HRP-conjugated rabbit anti-human IgM antibody) is pipetted into the wells and reacts with the anti-Borrelia IgM antibodies present in the sample. (bmgrp.com)
Presence2
- In the present study we were able to demonstrate the presence of B. burgdorferi DNA in patients with morphea, even in seronegative patients. (units.it)
- Recent studies have shown that Borrelia burgdorferi can form antibiotic-tolerant persisters in the presence of microbiostatic drugs such as doxycycline. (frontiersin.org)
Helicobacter1
- HP -Kit for the detection of Helicobacter pylori. (elta90.com)
Mayonii1
- 1 Currently, there are no serologic tests available for B. mayonii infection, but cross-reactivity with B. burgdorferi testing may occur. (cdc.gov)
Rickettsiales1
- In the latter year, coinfections with Borrelia and Rickettsiales were detected in a total of 7.8% (163/2,100) of collected ticks. (biomedcentral.com)
Specimens1
- DNA has to be extracted from the blood specimens for PCR detection. (cdc.gov)
Molecular1
Genes5
- Our goal was to examine gene transcription by B. burgdorferi following doxycycline treatment in an effort to identify both persister-associated genes and possible targets for antimicrobial intervention. (frontiersin.org)
- Genes upregulated in the treated B. burgdorferi included a number of Erp genes and rplU , a 50S ribosomal protein. (frontiersin.org)
- Studies are underway to determine if these same genes are perturbed in B. burgdorferi treated with doxycycline in a host environment. (frontiersin.org)
- But what does it take for Borrelia burgdorferi to express one of the suppressed genes of an ancient pathogen cousin? (medicpdf.com)
- Borrelia burgdorferi like all Borrelias have genes that are latent but intact. (medicpdf.com)
Gene1
- Co-evolution of the outer surface protein C gene (ospC) and intraspecific lineages of Borrelia burgdorferi sensu stricto in the northeastern United States. (cdc.gov)
Reagents1
Hosts1
- Transmission of B. burgdorferi s.l. from ticks to hosts may occur through different developmental stages of I. ricinus, as transstadial transmission is very efficient. (biomedcentral.com)
Tickborne1
- Before 1975, elements of Borrelia infection were also known as Tickborne meningopolyneuritis, Garin-Bujadoux syndrome, Bannwarth syndrome, or sheep tick fever. (newworldencyclopedia.org)
Indirect1
- The Captia Syphilis-G enzyme immunoassay (EIA) is an indirect method for the detection of IgG antibodies to Treponema pallidum (Pope et al. (cdc.gov)
Infection rates1
- Simultaneously, results obtained in 2010 were compared to infection rates from 2005 to evaluate the development of B. burgdorferi s.l. infection rates in Hanoverian ticks. (biomedcentral.com)
Clinical1
- Background: The possible relationship between Lyme borreliosis and morphea has been suggested by certain clinical, immunological and microbiological findings, but many authors were hot be able to demonstrate Borrelia burgdorferi infection in patients with morphea and cast doubts on an etiological role for B. bungdorferi in this skin lesion. (units.it)
Transmission1
- In the different experiments of this study, skin microbiome alteration and Borrelia/Borreliella transmission were different depending on the tick stages (nymphs or adult female ticks). (biomedcentral.com)