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  • immune
  • This proposal is based on the novel finding that common marmosets, a species of New World primates that is prone to develop an MS-like immune-mediated CNS illness after immunization with myelin antigens, can be infected with HHV6. (dana.org)
  • A "two-hit" infection with HHV-6A appears to result in neurological deficits and pathologically, CNS inflammatory demyelination similar to human MS. Affected animals appear to develop immune reactivity to myelin antigens, indicating the possibility that mechanisms of mimicry may be involved in pathogenesis. (dana.org)
  • Possible cytotoxicity of lymphocytes from HHV6-infected animals towards antigen-sensitized targets and capacity for immune viral clearance or neutralization will be explored. (dana.org)