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  • pathway
  • In telomerase-deficient Saccharomyces cerevisiae cells lacking components of the nonsense-mediated mRNA decay (NMD) pathway (Upf1,Upf2, or Upf3 proteins), senescence is delayed, with crisis occurring ∼10 to 25 population doublings later than in Upf + cells. (asm.org)
  • In previous studies designed to better understand how malignant cells escape cellular senescence, we sought to define the genes that control this pathway ( 7 - 9 ). (aacrjournals.org)
  • Our results revealed that, even in the presence of an intact pRb pathway, Kir2.2 expression led to decreased senescence and increased doxorubicin resistance. (aacrjournals.org)
  • Conversely, small interfering RNA (siRNA) against p27 (sip27) and the antioxidant N -acetylcysteine (NAC) effectively blocked the senescence induced by knockdown of Kir2.2, providing support for the involvement of both p27 and ROS in this pathway. (aacrjournals.org)
  • gene expression
  • Publications] Kumazaki,T.: 'Modulation of gene expression during cellular aging of vascular endothelial cells' Hiroshima Journal of Medical Science. (nii.ac.jp)
  • Senescence is INK4A / ARF -dependent and is accompanied by changes in gene expression that are typical of loss of KAT6A function. (fightaging.org)
  • Developmental biology, gene expression in the early zebrafish embryo, role of IGF signalling in zebrafish, molecular and cellular basis of cardiovascular disease in zebrafish. (nuigalway.ie)
  • Consequence
  • These model systems will allow us to not only differentiate changes that are causative from those that are a consequence of senescence escape, but they will also provide a platform for testing drugs and therapies that target malignant cancer growth at its earliest stages. (grantome.com)
  • cancer
  • Will Increased Understanding of Cellular Senescence Lead to an End to Cancer? (fightaging.org)
  • Nonetheless, at the front line of cancer research, any reliable approach that can force cancer cells into senescence is a win. (fightaging.org)
  • Might there be a practical end to cancer somewhere in the senescence research of the next decade or two? (fightaging.org)
  • Senescence, characterized by specific physiologic and morphologic changes, including reduced proliferation, shortened telomeres, a flat and enlarged cell shape, and the appearance of senescence-associated β-galactosidase (SA-β-Gal) activity, is considered a major determinant of treatment outcome in cancer therapy ( 1 - 3 ). (aacrjournals.org)
  • Specifically, we investigated the effects of Kir2.2 expression on the cellular response to doxorubicin in PC-3 human cancer cells. (aacrjournals.org)
  • A thorough understanding of the changes that promote senescence escape will allow us to facilitate development of novel anti cancer strategies and/or improving existing ones. (grantome.com)