The Stony Brook researchers took advantage of this viral property by injecting a stable, attenuated strain of poliovirus directly into neuroblastoma tumors transplanted into 12 mice engineered to contract polio. (eurekalert.org)
To test the virus' ability to destroy neuroblastoma the researchers constructed a transgenic mouse model that allows growth of neuroblastoma cells and carries the human gene for CD155, which codes for the receptor that allows poliovirus to enter cells. (eurekalert.org)
Before the COG trial, the standard treatment for high-risk neuroblastoma was a single-transplant approach that involved high-dose chemotherapy to destroy as many cancer cells as possible, followed by an autologous (self-donating) blood stem cell transplant. (cancer.gov)
Tandem transplants have now become the standard of care for high-risk neuroblastoma. (cancer.gov)
Using Tandem Transplants to Treat Neuroblastoma was originally published by the National Cancer Institute. (cancer.gov)
Stem5
The stem cell transplant is needed because the intense chemotherapy also destroys blood-forming stem cells in the patient's bone marrow. (cancer.gov)
The stem cells used for the transplant are collected from the patient's blood and then given back to the patient once the chemotherapy is completed. (cancer.gov)
In the trial, one group of patients received the standard treatment (chemotherapy and a stem cell transplant followed by another round of chemotherapy and a second, or tandem, stem cell transplant). (cancer.gov)
They include stem cell transplant and immunotherapy for relapsed leukemia (leukemia that comes back after treatment). (nemours.org)
Antibodies2
According to the researchers, any viral particles that make it to the bloodstream would be destroyed by antibodies created through poliovirus vaccination. (eurekalert.org)
This is the removal of antibodies from the blood that are destroying red blood cells. (chkd.org)
Cells5
These are a type of white blood cells that help destroy pathogens, such as bacteria, viruses, and fungi. (medicalnewstoday.com)
Upon encountering bacteria or damaged cells, lymph nodes destroy them and turn them into a waste product. (medicalnewstoday.com)
By its nature, poliovirus destroys the cells it infects in an attempt to replicate copies of itself. (eurekalert.org)
The transplanted cells then repopulate the patient's bone marrow and restore its ability to produce red and white blood cells and platelets. (cancer.gov)
Hemolytic anemia is a group of disorders in which the red blood cells are destroyed faster than the bone marrow can make them. (chkd.org)
Treatment1
Not only did the poliovirus prove effective in destroying the tumors, the treatment with virus also seemed to prevent tumors from recurring. (eurekalert.org)
Attacks and destroys3
Sometimes the body's immune system attacks and destroys a donated kidney. (nih.gov)
In most people with type 1 diabetes, the body's immune system , which normally fights infection, attacks and destroys the cells in the pancreas that make insulin. (nih.gov)
AIDS, or Acquired Immunodeficiency Syndrome, is caused by the human immunodeficiency virus (HIV), which attacks and destroys the immune system, including lymphocytes. (proprofs.com)
Kidney Transplant3
Researchers found that kidney transplant recipients with two copies of a certain DNA sequence deletion had an increased risk of transplant rejection. (nih.gov)
A kidney transplant can greatly improve quality of life for people with kidney failure. (nih.gov)
The researchers first scanned for the 50 common deletions in DNA samples taken from 705 kidney transplant recipients at their hospital. (nih.gov)
Immune system2
But about 20% of donated kidneys are attacked and destroyed by the recipient's immune system. (nih.gov)
Transplant rejection can happen despite daily treatments that suppress the immune system. (nih.gov)
Lymphocytes1
Lymph (clear fluid) and lymphocytes travel through the lymph vessels and into the lymph nodes where the lymphocytes destroy harmful substances. (vicc.org)
Found1
Three vans and eight motorbikes, presumably belonging to the militants, were also found and destroyed during the raid. (ibtimes.com)
Blood1
The researchers then tested blood sera from 300 transplant recipients. (nih.gov)