• Centrosome separation relies on multiple pathways, including cortical forces and antiparallel microtubule (MT) sliding, which are two activities controlled by the protein kinase aurora A. We previously found that depletion of the human kinetochore protein Mcm21R CENP-O results in monopolar spindles, raising the question as to whether kinetochores contribute to centrosome separation. (rupress.org)
  • Cortical microtubules (the names for the C. elegans katanin catalytic and regu- in plants are arranged in a parallel array and are respon- latory subunits, respectively) as essential for the assembly sible for controlling the direction of cellulose deposition, of the acentriolar female meiotic spindle [ 8,9 ]. (nih.gov)
  • Unlike depolymerization in damage to the mitotic spindle and chromosome seg- from the microtubule ends, severing does not occur regation failure [13 ], underscoring that cellular context is spontaneously in solutions of pure tubulin. (nih.gov)