MorbiditySepsisSeveritySepticRespiratory failurePredicting in-hospital mortalityComplicationsLungsMultiorgan failureSignificantly associatedNecrosisSyndromePeritonitisRate of mortalityClinicalPatientsInternal organsAbdominal organsHigher mortalityBlood vesselsMulti-organOptimal cut-off valuePulmonaryHemorrhageTherapeutic100,0000.001DiagnosisIncidenceAppropriate antibioticsLiverCritically ill childrenInjurySystemicPathologySurgicalAcute renal fCrudeInfectionToxicitySubsequentWuhanTimelyRatesHigh riskPrognosisCoagulationMultivariateIdentifyAdmissionViralShockDeathVascular
Morbidity24
- A better understanding of intra-abdominal abscess pathophysiology and a high clinical index of suspicion should allow earlier recognition, definitive treatment, and reduced morbidity and mortality. (medscape.com)
- Although this report might still underestimate the extent of overall heat-related morbidity and mortality, the inclusion of hyperthermia as a contributing factor to death provides a more comprehensive view of the actual effects of heat-related illnesses. (cdc.gov)
- It is a major cause of maternal and neonatal morbidity and mortality in low- and middle-income countries and affects millions of hospitalized patients in high-income countries, where rates of sepsis are climbing rapidly. (who.int)
- Recreational use of ecstasy is associated with a definite morbidity and mortality. (erowid.org)
- It is a serious complication of infection, particularly in low- and middle-income countries where it represents a major cause of maternal and neonatal morbidity and mortality. (who.int)
- Strategies and interventions to reduce SCD-related morbidity and mortality should focus on adequate management of these vulnerable groups. (who.int)
- Success in implementing identified interventions will depend on the commitment of Member States to integrate SCD prevention and control in national health plans, and provide an environment conducive for various stakeholders to contribute to the reduction of SCD prevalence, morbidity and mortality. (who.int)
- The SCT is widespread in the WHO African Region;3 the S gene prevalence in at least 40 countries varies between 2% and 30%, resulting in high SCD-related morbidity and mortality. (who.int)
- Despite recent advances in surgical techniques and intensive care, operative mortality and morbidity rates in these patients remain prohibitive in around 15-30% of cases ( 1 - 4 ). (iiarjournals.org)
- Infection is a leading cause of morbidity and mortality among dialysis patients ( 10 ) possibly due to their often immunocompromised state, thought to be based on abnormalities of cellular, humoral and phagocytic immunity malfunctions ( 11 - 13 ). (iiarjournals.org)
- Conclusions: CDI represents an important problem in hospitalized patients and confers them an additional morbidity and mortality risk. (bvsalud.org)
- Acute pancreatitis is a serious disease, with highly persistent morbidity and mortality ( 1 ). (aai.org)
- Disease caused by Streptococcus pneumoniae (pneumococcus) remains an important cause of morbidity and mortality in the United States, particularly in the very young, the elderly, and persons with certain high-risk conditions. (cdc.gov)
- Sepsis is a leading cause of death in the US and worldwide, and represents a major cause of morbidity and mortality, for which there is no effective cure. (grantome.com)
- Currently, morbidity and mortality caused by surgical drainage of pseudocysts is 25% and 5%, respectively. (ahealthgroup.com)
- Self-poisoning through paraquat ingestion is a major cause of morbidity and mortality in the Asia-Pacific region [ 3 ]. (biomedcentral.com)
- Morbidity and Mortality Weekly Report. (cdc.gov)
- metropolitan morbidity and mortality conference (MMC). (bvsalud.org)
- In 2012 a hybrid electronic medical registry (HEMR) was introduced to capture routine data and to generate reports on morbidity and mortality. (bvsalud.org)
- The adverse events were divided into 875 'pathology-related' morbidities and 439 'error-related' morbidities.CONCLUSIONS:The development of the MMC led to increased reporting of morbidity and mortality. (bvsalud.org)
- Its prompt management has been advocated to prevent associated morbidity and mortality. (bvsalud.org)
- Clinical pattern a significant risk for morbidity and mortality. (who.int)
- Road Traffic Accident represents a significant risk for morbidity and mortality in Ethiopia, of which head injury and multiple sites injury increase injury severity. (who.int)
- Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
Sepsis14
- Sepsis, also known as septicemia, septicaemia, or blood poisoning, is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. (wikipedia.org)
- Severe sepsis causes poor organ function or blood flow. (wikipedia.org)
- Signs of established sepsis include confusion, metabolic acidosis (which may be accompanied by a faster breathing rate that leads to respiratory alkalosis), low blood pressure due to decreased systemic vascular resistance, higher cardiac output, and disorders in blood-clotting that may lead to organ failure. (wikipedia.org)
- Sepsis arises when the body's response to infection injures its own tissues and organs. (who.int)
- Appropriate treatment of sepsis requires not only treatment of the underlying infection, but in parallel requires life-saving medical interventions such as fluid resuscitation or vital organ support. (who.int)
- The final stage of sepsis can lead to septic shock, multiple organ failure, and death. (kth.se)
- Rapid diagnosis of sepsis is crucial as there is an exponential increase in mortality for every hour delay in the appropriate antibiotics administration. (kth.se)
- Also known as blood poisoning among lay people, sepsis is a last-ditch effort by your immune system to fight an infection in your body, which can lead to multiple organ failure and death unless promptly treated. (arizonahomeopathic.org)
- Impaired endothelial and microvascular function due to decreased endothelial NO bioavailability is a potential mechanism linking increased plasma ADMA with organ failure and death in sepsis. (edu.au)
- A total of 250 critically ill pediatric patients diagnosed with sepsis were retrospectively analyzed to identify routinely measured predictors for in-hospital mortality at the peak level of C-reactive protein. (springeropen.com)
- The severe endothelial dysfunction that results in organ failure is now considered a hallmark of severe sepsis. (grantome.com)
- These concepts will be considered in the context of the pulmonary endothelium and the development of acute lung injury, as lung injury arguably represents the most common clinical manifestations of organ injury in sepsis. (grantome.com)
- While mortality rates from sepsis have fallen by 21% since 2012, there is still more to be done and I am confident this campaign will play its part in equipping the public with a better understanding of the signs and symptoms. (gov.scot)
- Calum McGregor, NHS Lanarkshire consultant acute physician and National Clinical Lead for Acute Care with Healthcare Improvement Scotland said: "Sepsis can lead to shock, multiple organ failure and even death. (gov.scot)
Severity6
- Patients with De Ritis ratio ≥ 1.218 were significantly associated with mortality, severity, higher AST and IL-6, however with lower ALT. (researchsquare.com)
- Researchers use multiple independent variables (eg, age, injury severity) to predict the dependent variable (or outcome). (medscape.com)
- Baseline plasma ADMA was independently associated with 28-day mortality (Odds ratio [95% CI] for death in those in the highest quartile (?0.66 ?mol/L) = 20.8 [2.2-195.0], p = 0.008), and was independently correlated with severity of organ failure. (edu.au)
- Mortality of peritonitis is directly related to the severity of the disease. (icliniq.com)
- the peak concentration of cases, deaths, and indicators of lethality, mortality evidenced even after one year of pandemic, characterizes the severity of the COVID-19 pandemic, still in entire evolution in the State Espirito Santo and Brazil. (bvsalud.org)
- The rate of mortality among ICU- severity and outcome of the disease. (who.int)
Septic7
- It can lead to septic shock, multiple organ failure and death, if not recognized early and managed promptly. (who.int)
- It has an aggressive character, rapidly extensive and mutilating by widespread musculocutaneous necrosis, with increased mortality because it is quickly associated with general septic phenomena with the establishment of multiple organ failure (MOF) ( 1-3 ). (spandidos-publications.com)
- Interleukin-1 (IL-1) is a mediator in some critical conditions such as septic shock and multiple organ failure. (nih.gov)
- In particular, hypofibrinogenemia is distinctive for a high mortality rate in septic critically ill children. (springeropen.com)
- Severe cases are often the result of multiple organ failure, similar to that occurring in patients with septic shock ( 1 , 2 ). (aai.org)
- Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. (research.com)
- Septic shock can cause multiple organ dysfunction syndrome (multiple organ failure) including respiratory system failure and may cause death. (burn-injury-resource-center.com)
Respiratory failure3
- A week later, the patient came back for a post-ICU consult, she was conscious, eupneic, stable, and exhibiting no signs of neither cardiac nor respiratory failure. (hindawi.com)
- As these patients usually do not die of respiratory failure but of the development of multiple organ failure, no single treatment that may attenuate the lung injury is likely to be responsible for the increased survival. (bmj.com)
- However, severe hyperbilirubinemia could induce oxidative stress and cell apoptosis, which cause respiratory failure, thrombocytopenia, and even neurological dysfunction, and consequently promote multiple organ dysfunction syndrome (MODS) and increase patient in-hospital mortality. (biomedcentral.com)
Predicting in-hospital mortality2
- This study evaluated the predictive value of blood lactate levels at admission and determined the cut-off values for predicting in-hospital mortality in the critically ill pediatric population. (biomedcentral.com)
- The optimal cut-off value of peak TB on predicting in-hospital mortality was 121.2 μmol/L. Patients with post-operation TB ≥ 121 μmol/L was associated with worse long-term survival as well. (biomedcentral.com)
Complications4
- This helps avoid the potential complications of invasive ventilation, which can reduce the length of stay, and may decrease mortality in the ICU. (draeger.com)
- A cohort study by Hemmila et al that included 2,373,130 trauma patients reported statistically significant hospital improvements in major complications and venous thromboembolism, as well as improvements in mortality or hospice after participation in regional collaborative trauma quality improvement programs. (medscape.com)
- The development of abdominal compartment syndrome is a very urgent and life-threatening condition with high mortality since it is often accompanied by numerous complications and multiple organ failure. (srce.hr)
- Hyperbilirubinemia is one of the common complications after cardiac surgery and is associated with increased mortality. (biomedcentral.com)
Lungs2
- Abdominal compartment syndrome is a characteristic condition with an intraabdominal pressure higher than 12 mmHg, dilatation of the abdomen accompanied by multiorgan failure, especially the kidney, lungs and cardiovascular system. (srce.hr)
- The John Varga Lab (ScleroLab) investigates systemic sclerosis (SSc), a progressive rheumatic disease that damages the skin, lungs, blood vessels, and other organs, and is associated with substantial mortality. (umich.edu)
Multiorgan failure2
- Circulatory shock is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate. (springer.com)
- Nevertheless, pharmacology progress comes with a variety of side effects, of which cytokine release syndrome (CRS) is a potential complication of some immunotherapies that can lead to multiorgan failure if not diagnosed and treated accordingly. (bmj.com)
Significantly associated1
- Multivariate analysis revealed that the amount of paraquat ingested and clinical presentations, particularly pulmonary and cardiovascular system disorders, were significantly associated with mortality. (biomedcentral.com)
Necrosis2
- The size of the necrosis is a very strong predictor of the mortality in patients with necrotizing pancreatitis. (ahealthgroup.com)
- Bacterial contamination of the necrosis greatly increases the rate of mortality. (ahealthgroup.com)
Syndrome4
- Other patients at greater risk because of decreased responsiveness to polysaccharide antigens or more rapid decline in serum antibody include those with functional or anatomic asplenia (e.g., sickle cell disease or splenectomy), Hodgkin's disease, lymphoma, multiple myeloma, chronic renal failure, nephrotic syndrome, and organ transplantation. (cdc.gov)
- Multiple organ dysfunction syndrome - is a process during which the function of many organs is altered due to serious, life-threatening disease. (ahealthgroup.com)
- Even nowadays, multiple organ failure syndrome still causes high mortality, therefore it needs special attention. (csgh.info)
- The severe acute respiratory syndrome coronavirus 2 from 10% to around 44%, varying according to age and the (SARS-CoV-2) that is responsible for coronavirus dis- presence of comorbidities that resulted in multi-organ ease 2019 (COVID-19) resulted in systemic inflammatory failure ( 8-11 ). (who.int)
Peritonitis1
- This high mortality rate is largely due to perforation-caused peritonitis, which affects patients systemically and can lead to multiple organ failure ( 5 ). (iiarjournals.org)
Rate of mortality1
Clinical2
- However, trauma mortality prediction in individual patients by any scoring system is limited and is in general no better than good clinical judgment. (medscape.com)
- In contrast to these reports, a recently published clinical study conducted in a retrospective cohort suggested that the blood lactate concentration at PICU admission predicts mortality independent of the pediatric index of mortality (PIM) [ 14 ]. (biomedcentral.com)
Patients19
- The primary outcome was the proportion of patients who died either before hospital discharge or within 90 days after study enrollment (i.e., the 90-day in-hospital mortality rate), adjusted for predefined covariates and baseline differences between groups with the use of a Cox model. (nih.gov)
- Hyperlactatemia upon admission is a documented risk factor for mortality in critically ill adult patients. (biomedcentral.com)
- Although critical care in pediatric patients has changed dramatically over the last several decades, there has been no consistent marker for obtaining predictions of mortality in a general population of critically ill children. (biomedcentral.com)
- 6 ] developed a nomogram model based on a combination of initial BUN ≥4.6 mmol/L and D-dimer ≥0.845 μg/mL to identify patients at high risk for in-hospital mortality. (biomedcentral.com)
- Conclusion: High mortality rate of HD patients with colorectal perforation may be due to high age and rectal perforation in which cases it is technically difficult to perform operation. (iiarjournals.org)
- One of the leading causes of preventable mortality in trauma patients is injuries to the abdomen that go unnoticed. (spinal-injury.net)
- Objective: To identify the risk factors for mortality in hospitalized patients with CDI. (bvsalud.org)
- That was one message at a session on heart failure in older patients at the American Geriatrics Society (AGS) 2023 Annual Scientific Meeting. (medscape.com)
- Physical rehabilitation that begins during the hospital stay and continues for 3 months after also could help frail, older patients who are hospitalized for acute decompensated heart failure with HFpEF, Pastva said, citing her research and that of other groups . (medscape.com)
- Improvement in outcomes of patients who received ECPR requires a multidisciplinary approach to protect organ function and limit organ injury before and during cardiac support. (biomedcentral.com)
- Hospital mortality was 3%: 3 patients died from multiple organ failure. (usma.ru)
- Maze 3 procedure in conjunction with the correction of the MV pathology does not increase mortality and is effective for 80% of patients. (usma.ru)
- Mortality from pneumococcal disease is highest in patients with bacteremia or meningitis, patients with underlying medical conditions, and older persons. (cdc.gov)
- In some high-risk patients, mortality has been reported to be greater than 40% for bacteremic disease and 55% for meningitis, despite appropriate antimicrobial therapy. (cdc.gov)
- In AAD patients with severe post-operation hyperbilirubinemia, older age, lower MAP, increased blood transfusion, stage 3 AKI, the use of ECMO, and the increased peak TB lead to increase in-hospital mortality. (biomedcentral.com)
- For patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), recent study suggested that severe hyperbilirubinemia (5 times the normal upper limit) instead of mild bilirubin significantly increased patient mortality and a maximum bilirubin of 25.5 mg/dl was associated with 99% mortality [ 14 ]. (biomedcentral.com)
- However, the mortality of patients with severe post-operation hyperbilirubinemia remained significant divergence. (biomedcentral.com)
- These findings have important implications for physicians in predicting the prognosis and mortality of paraquat poisoning patients. (biomedcentral.com)
- Patients are at high risk of severe disease progression with ARDS and/or multiple organ failure, and at high risk of mortality. (who.int)
Internal organs2
- While seat belts help prevent more serious injuries like those to the head and chest, they pose a risk to internal organs like the pancreas and intestines that might be pushed against the spine. (spinal-injury.net)
- Kermanshah Province in sponse to COVID-19 infection, activation of T cells along the west of the country borders Iraq and has extensive with massive production and release of cytokines occur communication with the Iraqi Kurdistan region, which with subsequent damage to internal organs, and primari- could be a challenge in disease control. (who.int)
Abdominal organs1
- The spleen and the kidneys are only two of the abdominal organs that might be damaged by a sports injury. (spinal-injury.net)
Higher mortality1
- Men had higher mortality and lethality, especially in older age groups, but the incidence was higher among women. (bvsalud.org)
Blood vessels1
- While most penetrating wounds heal on their own, they may cause serious internal bleeding and damage to nearby organs and blood vessels. (spinal-injury.net)
Multi-organ5
- In the ED setting, it can be difficult to recognize ACS as the primary cause of multi-organ dysfunction. (acep.org)
- Multi Organ Failure associated with the SARS-COV2 a receptor of the same in lung, heart, kidney, testis, liver, lymphocytes and nervous system was confirmed. (inventiva.co.in)
- The Multi organ failure has been characterised by acute lung failure, acute kidney injury, cardiovascular disease. (inventiva.co.in)
- and (4) no obvious contraindication to ECPR including terminal malignancy, irreversible multi-organ failure, or severe neurologic injury. (biomedcentral.com)
- Death often occurs due to severe bleeding or multi organ failure. (ahealthgroup.com)
Optimal cut-off value1
- Blood lactate displayed a sensitivity of 61% and a specificity of 86% in predicting mortality at the optimal cut-off value of 5.55 mmol/l, and the positive and negative likelihood ratios were 4.5 and 0.45, respectively. (biomedcentral.com)
Pulmonary4
- Other potential causes of similar signs and symptoms include anaphylaxis, adrenal insufficiency, low blood volume, heart failure, and pulmonary embolism. (wikipedia.org)
- The main cause of death is pulmonary tissue damage and multiple organ failure. (biomedcentral.com)
- Our study highlights that the amount of paraquat ingested, along with the presence of pulmonary and cardiovascular system disorders, can serve as prognostic indicators for mortality rates in cases of paraquat poisoning. (biomedcentral.com)
- Moderate-to-severe poisoning often leads to acute renal failure, acute hepatitis, acute lung injury, and progressive pulmonary fibrosis. (biomedcentral.com)
Hemorrhage2
- that cause hemorrhage, multiple organ failure, and high mortality rates. (msdmanuals.com)
- General references Marburg and Ebola are filoviruses that cause hemorrhage, multiple organ failure, and high mortality rates. (msdmanuals.com)
Therapeutic1
- Necrotizing fasciitis of the chest wall is a very rare pathology, but with significant mortality, representing a therapeutic challenge. (spandidos-publications.com)
100,0001
- Percentage case-fatality and mortality and incidence rates per 100,000 population were calculated. (bvsalud.org)
0.0012
- 0.001) were independent risk factors for mortality in critically ill children. (biomedcentral.com)
- 0.001), the amount of blood transfusion after surgery ( P = 0.019), mean arterial pressure (MAP) in the first postoperative day ( P = 0.012), the use of extracorporeal membrane oxygenation (ECMO) ( P = 0.02), and the peak total bilirubin (TB) concentration ( P = 0.023) were independent risk factors of in-hospital mortality. (biomedcentral.com)
Diagnosis2
- In 2016, a shortened sequential organ failure assessment score (SOFA score), known as the quick SOFA score (qSOFA), replaced the SIRS system of diagnosis. (wikipedia.org)
- The objective of this presentation is to guide any practitioner towards diagnosis of renal crisis in the face of sudden multiple organ failure resulting from progressive systemic sclerosis. (scirp.org)
Incidence4
- Thus, it is of paramount importance to identify trends in incidence, lethality, and mortality to elucidate the epidemiological parameters of the first and second wave to develop pandemic planning. (bvsalud.org)
- This study aims to analyze the incidence, mortality, and lethality by COVID-19 in the State of Espírito Santo from March 2020 to June 2021. (bvsalud.org)
- The effective reproduction number (Rt), the incidence, mortality and lethality were estimated, then the trend analysis according to the wave period were classified in increased, decreased, or flat. (bvsalud.org)
- We found that the first wave of COVID-19 in the analyzed region was marked by stationary lethality trends, increasing mortality and incidence trends and in the second wave, despite the incidence growing trends, mortality showed stationary trends, with lethality with decreasing trends. (bvsalud.org)
Appropriate antibiotics1
Liver3
- Liver cirrhosis is a high risk factor for COVID-19 mortality. (researchsquare.com)
- Diagnostics: malignant hypernatremia with a high plasma osmolarity associated with an acute anuric renal failure, hydro electrolytic disorders, an abnormal liver function, a fever of central origin and a stroke. (scirp.org)
- With a large volume of distribution (1.2-1.6 l/kg), it is distributed to all organs, particularly the liver, kidney, and lung. (biomedcentral.com)
Critically ill children2
- However, the predictive significance of a single lactate measurement at admission for mortality in the general population of critically ill children remains uncertain. (biomedcentral.com)
- A high blood lactate level at admission is independently associated with and predictive of in-hospital mortality in the general population of critically ill children. (biomedcentral.com)
Injury2
- As a consequence, perfusion and oxygen delivery is altered and tissues are exposed to the same injurious factors, leading to parenchymal cell injury and dysfunction, and ultimately organ failure. (grantome.com)
- In-hospital mortality, long-term mortality, acute kidney injury (AKI), and the requirement of continuous renal replacement therapy (CRRT) were assessed as endpoints. (biomedcentral.com)
Systemic1
- Acute pancreatitis is one of the noted causes of multiple organ failure but the mechanism by which local inflammation progresses to systemic disease is unknown. (nih.gov)
Pathology1
- Necrotizing fasciitis of the chest wall is a rare pathology, but is a life-threatening condition with a high mortality rate. (spandidos-publications.com)
Surgical1
- He was admitted to the surgical intensive care unit of the CHRU La Cavale Blanche of Brest on 12 September, 2015 for decompensated diabetic ketoacidosis, acute renal failure and hemolytic anemia. (scirp.org)
Acute renal f1
Crude1
Infection2
- In this study, we used an IL-1 receptor antagonist (IL-1ra) to investigate whether multiple organ failure due to acute pancreatitis is mediated by IL-1, as in other causes such as severe infection, trauma, and major surgery. (nih.gov)
- One steroid suggest delaying vaccination mortality as a consequence of susceptibility to infection and multiple organ failure. (iccv2013.org)
Toxicity1
- We report a case of ecstasy toxicity with severe multiple organ failure, who went on to make a full recovery after prolonged hospitalization. (erowid.org)
Subsequent2
- This, in turn, leads to a proinflammatory state with subsequent organ damage. (bmj.com)
- Paraquat, one of the most widely used herbicides, poses a significant risk of mortality through self-poisoning and subsequent multiple organ failure. (biomedcentral.com)
Wuhan2
- The mortality of critical illness was high in Wuhan. (medrxiv.org)
- CoV-2), was first documented in Wuhan, Hubei ity and mortality. (who.int)
Timely1
- Early recognition of children who are at high risk for mortality allows for timely changes in therapy and improves the overall outcomes. (biomedcentral.com)
Rates1
- The high mortality rates associated with paraquat poisoning can be attributed to the lack of effective treatment. (biomedcentral.com)
High risk1
Prognosis1
- A hypernatremia sever ity is often associated with a poor prognosis, especially if it is associated with multiple organ failure. (scirp.org)
Coagulation2
- Organ failure maybe the result of increased level of inflammatory mediator levels, endothelial dysfunction, coagulation problems, and infiltration of inflammatory cells into the organs are all contributing factors. (inventiva.co.in)
- Disseminated intravascular coagulation (DIC) - is a process during which multiple blood clots appear within the bloodstream. (ahealthgroup.com)
Multivariate1
- Multivariate binary logistic regression and Receiver Operating Characteristic (ROC) curves were performed to evaluate the impact of abnormal laboratory findings to predict mortality. (researchsquare.com)
Identify1
- MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
Admission1
- The Pediatric Risk of Mortality III (PRISM III) scores were calculated during the first 24 hours after admission. (biomedcentral.com)
Viral1
- Among 51 participants with multiple viral detections, rhinovirus to seasonal coronavirus (8, 14.8%) was the most common viral detection pairing. (cdc.gov)
Shock1
- Although treatment with recombinant human IL-1ra did not affect the degree of local pancreatic insult, it significantly reduced mortality, improved urine output as an indicator of the state of shock, and ameliorated the accumulation of neutrophils into the lung in a rat experimental pancreatitis model. (nih.gov)
Death2
Vascular1
- The hallmarks of SSc are autoimmunity, vascular damage and dysrepair, metabolic changes, and fibrosis leading to organ failure. (umich.edu)