• intercalated discs
  • Biopsies from patients with ARVC consistently show abnormalities in intercalated discs, with decreased numbers of desmosomes and widening of intercellular gaps between adjacent cardiomyocytes, suggesting that this disease is a disease of intercalated discs. (wikipedia.org)
  • defects
  • Arrhythmogenic right ventricular dysplasia (ARVD), also called arrhythmogenic right ventricular cardiomyopathy, is an inherited heart condition caused by desmosome defects in heart muscle cells. (biologydictionary.net)
  • increases
  • Sparsely located desmosomes are detected already in the samples from the youngest fetuses, and during the maturation the density of desmosomes increases [ 2 , 4 ]. (hindawi.com)
  • Specific depletion of PKC with an antisense oligonucleotide increases the number of cells with calcium-independent desmosomes. (soton.ac.uk)