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  • catenins
  • Catenins play roles in cellular organization and polarity long before the development and incorporation of Wnt signaling pathways and cadherins. (wikipedia.org)
  • epidermal
  • Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation? (semanticscholar.org)
  • These findings establish GRHL1 as an important regulator of the Dsg1 genes in the context of hair anchorage and epidermal differentiation, and suggest that cadherin family genes are key targets of the grainy head-like genes across 700 million years of evolution. (intersearch.com.au)
  • Autoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV). (jci.org)
  • Genes
  • We now report that mice lacking the grh homologue grainy head-like 1 (Grhl1) exhibit hair and skin phenotypes consistent with a reduction in expression of the genes encoding the desmosomal cadherin, desmoglein 1 (Dsg1). (intersearch.com.au)
  • Mutations in DSC2 as well as other desmosomal genes are frequent in patients with advanced dilated cardiomyopathy that are undergoing cardiac transplantation. (wikipedia.org)
  • Another group of genes, such as AML1, p300 and HNF3, can upregulate the expression of E-cadherin. (wikipedia.org)
  • PMID
  • CDH16 colocalises with CDH1/E-cadherin on the basolateral plasma membrane of thyrocytes, and might play a role during thyroid development [ PMID: 22028439 ]. (ebi.ac.uk)
  • differentiation
  • The expression of the different types of cadherins in the cell are varying dependent upon the specific differentiation and specification of the organism during development. (wikipedia.org)
  • specific cadherin
  • It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. (wikipedia.org)
  • beta-catenin
  • Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl-heidelberg.de)
  • The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. (wikipedia.org)
  • roles
  • Catenins play roles in cellular organization and polarity long before the development and incorporation of Wnt signaling pathways and cadherins. (wikipedia.org)