Herein we report the design, synthesis, and biological assessment of a series of novel indolinone-based benzenesulfonamides (8a-k, 11a-d, 15a-d, and 16) as potential dual inhibitors for cancer-associated hCA IX/XII and VEGFR-2. (bvsalud.org)
EGFR2
New 5-cyano-6-oxo-pyridine-based sulfonamides (6a-m and 8a-d) were designed and synthesized to potentially inhibit both the epidermal growth factor receptor (EGFR) and carbonic anhydrase (CA), with anticancer properties. (bvsalud.org)
Then, the possible CA inhibition against the human CA isoforms I, II, and IX was investigated, together with the EGFR inhibitory activity, with the most powerful derivatives. (bvsalud.org)
Series2
Rational design and a SAR study of this class of compounds led to a new series of quinazoline derivatives with single-digit nanomolar potency. (northwestern.edu)
[ 9 ] obtained a series of 9 flavonoid derivatives of 1-(2-hydroxyphenyl)-3-aryl-1,3-propanediones. (encyclopedia.pub)
Molecule1
a ) 4,7-Dichloroquinoline design inspired by the natural molecule, chloroquine. (nature.com)
Preparation methods1
The present invention relates to pyrazole fused-ring derivatives, their preparation methods, and use thereof in medicine. (justia.com)
Effects1
The effects of the 5-cyanopyridine derivatives 6e and 6l on cell-cycle disruption and the apoptotic potential were then investigated. (bvsalud.org)
Shown1
The flavonoids have a protector effect from ultraviolet light and microbial damage, and some synthetic derivatives have shown insecticide activity. (encyclopedia.pub)
Natural1
Some synthetic derivatives from natural metabolites, such as flavonoid derivatives containing chromone (4 H -Benzopiran-4-one), are another kind of insecticide. (encyclopedia.pub)
Nucleus1
An acetylhydrazide derivative containing a quinazoline nucleus has been utilized to design and synthesize a series of 2,4-disubstituted quinazolines via reaction with several carbon electrophiles including 4-methoxybenzaldehyde and carbon disulfide as well as acetyl and benzoyl chloride. (heterocycles.jp)
Anticancer Activity1
we report the design, synthesis, and anticancer activity evaluation of new 2, 4-disubstituted quinazolines. (japsonline.com)
Molecules1
Recently, quinazolines were reported as versatile template molecules for the inhibition of a wide range of tyrosine kinases. (japsonline.com)
Effective1
Increased understanding of the action of these established and clinically accepted agents would provide a basis for the design of safe, effective therapeutic regimens in the treatment of prostatic diseases. (mssm.edu)
Potential1
This review discusses the current knowledge of the action of quinazoline-derived α 1 -adrenoceptor antagonists in the benign and malignant prostate and their potential therapeutic use in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer. (mssm.edu)