• Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. (wikipedia.org)
  • Due to this airway irritability, desflurane is infrequently used to induce anesthesia via inhalation techniques. (wikipedia.org)
  • Desflurane, along with enflurane and to a lesser extent isoflurane, has been shown to react with the carbon dioxide absorbent in anesthesia circuits to produce detectable levels of carbon monoxide through degradation of the anesthetic agent. (wikipedia.org)
  • for maintenance of anesthesia in pediatric patients following induction with agents other than Desflurane, USP, Liquid for Inhalation and intubation. (nih.gov)
  • Desflurane, USP, Liquid for Inhalation should be administered only by persons trained in the administration of general anesthesia. (nih.gov)
  • Inhaled desflurane is used to cause general anesthesia (loss of consciousness) before and during surgery in adults. (mayoclinic.org)
  • The results indicate that visual cortex neurons remain responsive to flash stimulation under desflurane anesthesia, but the long-latency component of their response is attenuated in a concentration-dependent manner. (asahq.org)
  • This study compared surgical field condition between propofol/remifentanil (PR) based anesthesia and desflurane/remifentanil (DR) based anesthesia. (ekja.org)
  • Effects of propofol, desflurane, and spinal anesthesia on intraocular pressure during lumbar disc herniation surgery: a randomized controlled study. (bvsalud.org)
  • This study aims to evaluate the effects of total intravenous anesthesia ( propofol ), volatile anesthesia ( desflurane ), and spinal anesthesia on intraocular pressure (IOP) during lumbar disc herniation surgery in the prone position . (bvsalud.org)
  • Our findings suggest that volatile anesthesia ( desflurane ) and spinal anesthesia are linked to lower IOP in the prone position among patients undergoing spinal surgery , in comparison to those receiving total intravenous anesthesia . (bvsalud.org)
  • Desflurane Desflurane is a halogen ether used in general anesthesia. (paperzz.com)
  • We have examined the short-term effects of three volatile anaesthetics, halothane, isoflurane and desflurane, on mucociliary activity in the rabbit maxillary sinus in vivo. (lu.se)
  • Administration of 1.0 MAC of halothane, isoflurane or desflurane caused a temporary increase in mucociliary activity, with mean peak responses of 47.8 (SEM 13.0)%, 44.0 (9.6)% and 45.1 (23.7)% (n = 6), respectively. (lu.se)
  • The second peak at 3-5 min was less pronounced for halothane than for isoflurane or desflurane. (lu.se)
  • the inhalational anesthetic is most often halothane, but other anesthetics (eg, isoflurane , sevoflurane , desflurane ) may also be involved. (msdmanuals.com)
  • This issue is currently controversial because isoflurane appears more suppressive at equiminimum alveolar concentration levels with propofol as background anesthetic, 18 whereas desflurane appears more suppressive at equibispectral index levels with no background anesthetic. (asahq.org)
  • This study attempted to compare the surgical field scores, according to the extent of the preoperative surgical lesions, for a group that used propofol/remifentanil (PR), reported to reduce the amount of bleeding to obtain a visible surgical field to a group that used sevoflurane/remifentanil, and to a group that used desflurane/remifentanil (DR). (ekja.org)
  • A low concentration of desflurane is as useful as propofol for oxygenation during one-lung ventilation in patients undergoing lung cancer surgery, according to a study presented here at ANESTHESIOLOGY 2015, the Annual Meeting of the American Society of Anesthesiologists (ASA). (anesthesiaexperts.com)
  • In the current prospective, randomised study, Izumi Kawagoe, MD, Juntendo University, Tokyo, Japan, and colleagues compared oxygenation with desflurane versus propofol in 160 patients with lung cancer undergoing one-lung ventilation. (anesthesiaexperts.com)
  • Patients were randomised to general anaesthesia maintenance with desflurane and remifentanil or to propofol and remifentanil. (anesthesiaexperts.com)
  • General anaesthesia and thoracic epidural anaesthesia were performed identically in both groups, except for the use of desflurane or propofol, and there was no difference between the groups in demographic variables. (anesthesiaexperts.com)
  • Presentation title: A Low Concentration of Desflurane Is Not Inferior to Propofol in Oxygenation During One-Lung Ventilation in Patients Undergoing Lung Cancer Surgery - a Prospective, Randomized Study. (anesthesiaexperts.com)
  • The patients were randomly divided into 3 groups propofol , desflurane , and spinal. (bvsalud.org)
  • Propofol recipients had significantly higher T3 (prone) IOP compared to desflurane recipients (p = 0.001). (bvsalud.org)
  • In addition, we found that the desflurane (p propofol recipients after adjusting for diabetes mellitus and T1 IOP. (bvsalud.org)
  • The patients were randomly divided into two groups, Group D (desflurane) and Group P (propofol). (clinmedjournals.org)
  • These highlights do not include all the information needed to use DESFLURANE, LIQUID FOR INHALATION safely and effectively. (nih.gov)
  • See full prescribing information for DESFLURANE, LIQUID FOR INHALATION. (nih.gov)
  • Desflurane, USP, Liquid for Inhalation should not be used as the sole agent for anesthetic induction in patients with coronary artery disease or where increases in heart rate or blood pressure are undesirable. (nih.gov)
  • When a steady state hourly amount of anesthetic necessary for 1 minimum alveolar concentration (MAC) at 2 liters per minute (LPM) for Sevoflurane, and 1 LPM for Desflurane and Isoflurane is weighted by the GWP, the clinically relevant quantities of each anesthetic can then be compared. (wikipedia.org)
  • This estimate is extrapolated from only one U.S. institution's anesthetic practices, and this institution uses virtually no Desflurane. (wikipedia.org)
  • However, institutions that utilize some Desflurane and account for nitrous oxide have reported an average of 175-220 kg CO2e per anesthetic. (wikipedia.org)
  • NIOSH announced a request for information with the intent to review and evaluate toxicity data for the halogenated anesthetic agents: of isoflurane, desflurane, and sevoflurane for establishing a REL. (cdc.gov)
  • 4 Desflurane is also the most expensive volatile anesthetic on the market. (asra.com)
  • Procurement, purchasing, and monthly pharmacy supplies of desflurane and sevoflurane were used as metrics of anesthetic use during the one year pre- (November 2017 through October 2018) and post- (December 2018 through November 2019) intervention. (asra.com)
  • The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • Aromatase metabolizes testosterone to 17b- estradiol (E2) and thereby significantly contributes The volatile anesthetic desflurane (DES) effectively reduces cardiac infarct size following experimental ischemia/reperfusion injury in the mouse heart. (uni-wuerzburg.de)
  • We think that, the desflurane group be preferred as a priority with less remifentanil expenditure, lower blood pressure values, higher rSO 2 values, no 20% decrease in rSO 2 values, faster extubation, and statistically significant early recovery. (clinmedjournals.org)
  • Esmolol given during the initial 30 min of reperfusion had no effect on infarct size (54 +/- 4%) but blocked desflurane-induced postconditioning (58 +/- 5%), whereas esmolol administered throughout reperfusion reduced infarct size in the absence or presence of desflurane to 42 +/- 6% and 41 +/- 7%, respectively. (silverchair.com)
  • ICI 118,551 and KN-93 did not affect infarct size (62 +/- 4% and 62 +/- 6%, respectively) but abolished desflurane-induced postconditioning (57 +/- 5% and 64 +/- 3%, respectively). (silverchair.com)
  • H-89 decreased infarct size in the absence (36 +/- 5%) or presence (33 +/- 5%) of desflurane. (silverchair.com)
  • In this study we aimed to analyze the effect of perioperative magnesium sulphate (MgSO4) on minimal alveolar concentration (MAC) of desflurane using bispectral index (BIS) monitoring. (kocaeli.edu.tr)
  • Desflurane application at pharmacological concentrations efficiently upregulated aromatase expression in vivo and in vitro. (uni-wuerzburg.de)
  • Sevoflurane would capture over 70% of the worldwide sevoflurane, isoflurane and desflurane market by 2022. (paperzz.com)
  • On a per-MAC-hour basis, the total life cycle GHG impact of desflurane is more than 20 times higher than Isoflurane and Sevoflurane (1 minimal alveolar concentration-hour). (wikipedia.org)
  • The Western Australian Therapeutic Advisory Group and the Western Australian Drug Evaluation Panel have endorsed the delisting of Desflurane from the WA Statewide Medicines Formulary. (edu.au)
  • Desflurane belongs to the group of medicines known as general anesthetics. (mayoclinic.org)
  • 1-2 In the United States, inhalational anesthetics account for 1% of carbon emissions from healthcare, with desflurane having the largest impact of agents still in use. (asra.com)
  • The aim of the present study was to compare the clinical effects of combination of the anesthetics desflurane, detomidine and medetomidine in horses. (erciyes.edu.tr)
  • We conclude that desflurane efficiently regulates aromatase expression and activity which might lead to increased local estrogen synthesis and thus preserve cellular integrity and reduce cardiac damage in an acute myocardial infarction model. (uni-wuerzburg.de)
  • We conclude that the NK1-mediated response was most pronounced for desflurane which is considered the most airway irritating compound of the three. (lu.se)
  • To ensure a swift and sustained reduction in desflurane use, our clinical practice committee, comprised of departmental leadership in strategy, operations, patient safety, and sustainability, developed a three-pronged strategy. (asra.com)
  • Second, desflurane vaporizers were removed from most anesthetizing locations, except the few commonly used for bariatric and neurologic surgery, where clinical leadership deemed desflurane use may be warranted. (asra.com)
  • It should only be administered using a vaporizer specifically designed and designated for use with desflurane. (nih.gov)
  • I've posted before on why I think the desflurane Tec 6 vaporizer is a good design (it doesn't need to be turned off to be refilled). (wakingupcosts.net)
  • Two cases that would have been uneventful if desflurane and a Tec 6 vaporizer had been used. (wakingupcosts.net)
  • Several additional vaporizers remained available by request, effectively making desflurane use an "opt-in" rather than "opt-out" system. (asra.com)
  • Desflurane has desirable properties for rapid induction and emergence and ease of control with small cardiovascular side effects 23 and minimal toxicity. (asahq.org)
  • Browse Detail Report With TOC @ http://www.hexaresearch.com/research-report/sevofluraneisoflurane-desflurane-industry/ Market Drivers One of the primary factors, triggering expansion in the sevoflurane, isoflurane and desflurane market includes cardiovascular and respiratory diseases affecting the geriatric population. (paperzz.com)
  • The twenty-year global-warming potential, GWP(20), for desflurane is 3714, meaning that one tonne of desflurane emitted is equivalent to 3714 tonnes of carbon dioxide in the atmosphere, much higher than sevoflurane or isoflurane. (wikipedia.org)
  • Desflurane has desirable properties for in vivo neurophysiologic studies, but its effect on cortical neuronal activity and neuronal responsiveness is not known. (asahq.org)
  • The authors studied the effect of desflurane on resting and visual evoked unit activity in rat visual cortex in vivo. (asahq.org)
  • Carefully monitor cardiac rhythm when administering desflurane to susceptible patients. (nih.gov)
  • The inspiratory desflurane concentration during the first 45 minutes of one-lung ventilation in the desflurane group was 3.7 + - 0.6 %, corresponding to 0.6 +- 0.1 MAC. (anesthesiaexperts.com)
  • PaO2 during ventilation tended to be less in the desflurane group. (anesthesiaexperts.com)
  • While this was expected to result in surplus desflurane, the department planned to re-allocate unneeded supplies to other hospitals in our health care system. (asra.com)
  • 20,21 In rats, somatosensory evoked potentials seem to be preserved up to 1 minimum alveolar concentration but abolished at 2 minimum alveolar concentration of desflurane. (asahq.org)
  • In this study, we tested the hypothesis that desflurane effects local estrogen synthesis by modulating enzyme aromatase expression and activity in the mouse heart. (uni-wuerzburg.de)
  • 2010). Comparing the effects of desflurane and isoflurane on middleear pressure. (healthline.com)
  • The effects of Desflurane and Sevoflurane on Nesfatin-1 levels in laparoscopic Cholecystectomy: a randomized controlled trial. (medscape.com)
  • Desflurane medications are a racemate of two enantiomers. (wikipedia.org)
  • Concomitant use of N 2 O, benzodiazepines and/or opioids reduces the MAC of desflurane. (nih.gov)
  • Additionally, sustainability-minded members of the department had been increasingly calling for the reduction of desflurane use, citing its high GWP compared to alternatives. (asra.com)
  • Finally, anticipating a substantial reduction in desflurane use, the supply contract was renegotiated. (asra.com)
  • Anaesthetic machines are fitted with a specialized anaesthetic vaporiser unit that heats liquid desflurane to a constant temperature. (wikipedia.org)
  • 3 The Global Warming Potential (GWP) of desflurane is 15-20 times higher than that of isoflurane or sevoflurane, largely due to its longer atmospheric decomposition time. (asra.com)
  • The Desflurane Tec 6 has a 'low agent' alarm and a 'no output' alarm, in addition to the ability to detect when it has been tipped (and therefore shouldn't be used). (wakingupcosts.net)
  • During this review, desflurane was identified as a high-cost medication with no compelling evidence for use over other available agents. (asra.com)
  • the gas sevoflurane, for example, has a warming effect that is nearly 38 times lower than desflurane. (newstatesman.com)
  • Some drawbacks of desflurane are its low potency, its pungency and its high cost (though at low flow fresh gas rates, the cost difference between desflurane and isoflurane appears to be insignificant). (wikipedia.org)
  • However, rapid increases in desflurane may induce a transient sympathetic response secondary to catecholamine release. (wikipedia.org)
  • At 2% desflurane, 578 active units were found. (asahq.org)
  • It will manufacture generic desflurane by 2016. (paperzz.com)