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  • mechanisms
  • Therefore, the goal of my thesis project has been to identify ligand-directed signaling mechanisms that contribute to JNK activation following morphine and fentanyl administration and better understand how JNK activation promotes MOR and KOR desensitization. (washington.edu)
  • While the different mechanisms for desensitization are still being characterized, there are currently four known mechanisms: uncoupling of receptors from associated G proteins, endocytosis, degradation, and downregulation. (wikipedia.org)
  • insulin
  • The desensitization by depolarizing secretagogues is mostly accompanied by a reduced content of immunoreactive insulin and a marked reduction of secretory granules in the β-cells. (diabetesjournals.org)
  • The concept of glucose desensitization of insulin secretion has attracted considerable interest in the last few years because it may be relevant for the natural history of type 2 diabetes, representing the link between functional abnormalities of insulin secretion and overt β-cell failure. (diabetesjournals.org)
  • However, the basic features are well worth presenting because the insights gained from investigations on glucose desensitization are also shaping the lines of thought in investigations of the desensisitization by nonnutrient, pharmacological insulin secretagogues. (diabetesjournals.org)
  • Therapy
  • evaluate after desensitization therapy the anti-aggregant effect of aspirin in these very particular patients : clinical outcome, PFA test, levels of the urinary metabolite of thromboxane A2 (11 dehydro thromboxane B2) and also usual aggregation tests. (clinicaltrials.gov)
  • There are two different techniques used for desensitization therapy, which we will describe below, but before you begin make sure you've written down on paper your view of how much the triggers bother you. (calmclinic.com)
  • research
  • Desensitization approaches for food allergies are generally at the research stage. (wikipedia.org)
  • You don't want to let your fear stop you from doing everything you need to do desensitize yourself, which means you also need to have a plan/project in place based on your research into desensitization that will help you prepare for the road ahead. (calmclinic.com)