• The exception constitutes keratan sulphate whose uronic acid is substituted by galactose. (hindawi.com)
  • HTA samples contained keratan sulfate (KS), chondroitin/dermatan sulfate (CS/DS), and hyaluronan (HA), whereas heparan sulfate (HS) was not detected. (nih.gov)
  • Their protein backbones are linked to different glycosaminoglycans, such as dermatan-, chondroitin-, keratan- or heparan sulphate. (lu.se)
  • They are divided in four groups: hyaluronic acid, keratan sulfate, chondroitin/dermatan sulfate, andheparan sulfate. (premiumbeautynews.com)
  • The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. (planteome.org)
  • Out of the 5 major glycosaminoglycans only one is not sulfated. (biologywise.com)
  • DESCRIPTION (provided by applicant): Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-linked recessive inherited disorder caused by absence of iduronate-2-sulfatase, resulting in systemic accumulation of glycosaminoglycans heparan sulphate and dermatan sulphate. (sbir.gov)
  • Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder characterized by an accumulation of glycosaminoglycans (GAGs), including heparan sulfate, in the body. (bvsalud.org)
  • Here, we investigated the immunohistochemical distribution of hybrid CS/dermatan sulphate (DS) GAGs in the periphery of the adult chicken cornea, which is the location of the cornea's stem cell niche in a number of species, using a monoclonal antibody, 6C3, that recognises a sulphation motif-specific CS/DS GAG epitope. (cardiff.ac.uk)
  • Artificial GAGs like sulfated hyaluronan (sHA) exhibit pro-osteogenic properties and boost healing processes. (degruyter.com)
  • Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative interaction partners is scarce. (degruyter.com)
  • Chondroitin and dermatan sulfate, an important class of GAGs, are linear macromolecules consisting of disaccharide building blocks of N-acetylgalactosamine and two different uronic acids. (fu-berlin.de)
  • Purpose: To determine the genetic basis of autosomal dominant cornea plana (CNA1) through the performance of a genome-wide linkage analysis and screening of the decorin (DCN), dermatan sulfate proteoglycan 3 (DSPG3), forkhead box C1 (FOXC1), keratocan (KERA), lumican (LUM,) and paired-like homeodomain transcription factor 2 (PITX2) genes in members of an affected multigenerational family. (llu.edu)
  • Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [Winnemoller et al. (embl.de)
  • Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging problem to study genetically. (scilifelab.se)
  • Chondroitin sulphate (CS) proteoglycans with variable sulphation-motifs along their glycosaminoglycan (GAG) chains are closely associated with the stem cell niche of articular cartilage, where they are believed to influence the characteristics of the resident stem cells. (cardiff.ac.uk)
  • Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures. (harvard.edu)
  • It is the only non-sulfated glycosaminoglycan, and hence, does not bind to proteins to form proteoglycans. (biologywise.com)
  • Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs. (wikipedia.org)
  • Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the polymer level, a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. (scilifelab.se)
  • Key enzyme activity for the initiation of chondroitin and dermatan sulfates, transferring GalNAc to the GlcA-Gal-Gal-Xyl-Ser core. (expasy.org)
  • Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
  • Dive into the research topics of 'Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. (lu.se)
  • abstract = "The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials. (lu.se)
  • Iduronic acid in chondroitin/dermatan sulfate influences multiple cellular properties such as migration, proliferation, differentiation, angiogenesis and regulation of cytokine/growth factor activities. (lu.se)
  • The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients with a new type of Ehler-Danlos syndrome, adducted thumb-clubfoot syndrome. (lu.se)
  • Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) - Iduronate 2-sulfatase (IDS) is a sulfatase enzyme associated with Hunter syndrome. (bharatbook.com)
  • Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. (bharatbook.com)
  • Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) pipeline Target constitutes close to 13 molecules. (bharatbook.com)
  • The latest report Iduronate 2 Sulfatase - Drugs In Development, 2022, outlays comprehensive information on the Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (bharatbook.com)
  • It also reviews key players involved in Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) targeted therapeutics development with respective active and dormant or discontinued projects. (bharatbook.com)
  • In 1976, the enzyme deficiency in Morquio syndrome type IVA (galactosamine-6-sulfatase deficiency [ie, N -acetyl-galactosamine-6-sulfate sulfatase deficiency]) was identified. (medscape.com)
  • Mucopolysaccharidosis Type 1 (MPSI) is a lysosomal storage disease caused by deficient activity of the alpha-L-iduronidase enzyme, which is used to break down dermatan and heparan sulfates. (wisdompanel.com)
  • With the exception of HA, all GAG types are variably sulfated which contributes to the intricate complexity of their structures. (hindawi.com)
  • Effects of sulfate deprivation on the production of chondroitin/dermatan sulfate by cultures of skin fibroblasts from normal and diabetic individuals. (harvard.edu)
  • OBJECTIVES: The expression patterns of various cell-associated heparan and chondroitin/dermatan-sulphate PGs in human skin and chronic venous ulcers were investigated. (lu.se)
  • Further, a better definition of chondroitin/dermatan sulfate functions using different knock-out models is needed. (lu.se)
  • Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. (biomedcentral.com)
  • The amino sugars are mostly sulfated and possess carboxyl groups. (biologywise.com)
  • The results show that the degree and position of charged sulfate groups define the size of the conformational landscape in the gas phase. (fu-berlin.de)
  • These repeating units are sulfated at a variety of positions. (wikipedia.org)
  • Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (harvard.edu)
  • Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development. (scilifelab.se)