Chondroitin SulfateGlycosaminoglycansKeratanPolysaccharidesHyaluronicGAGsProteoglycansProteoglycanDecorinAntithrombinHighly sulfatedDisaccharideBindsSulodexideOligosaccharidesFondaparinuxOctasaccharideSodiumMetabolismInteractsBiosynthesisFacilitatesImpuritiesAnticoagulantInhibitorsUrineMicrobialProteinsStructuresFractionCollagenReactionsStructuralCompoundsThrombinSimilarlyComponentInhibitionMolecularBiologicalTherapyCellDiabeticBinding proteinSurfaceShown
Chondroitin Sulfate17
- Chondroitin sulfate also decreases. (medscape.com)
- hyaluronan (HA), chondroitin sulfate (CS) and dermatan sulfate (DS), heparin and heparan sulphate (HS), and keratan sulfate (KS). (hindawi.com)
- Other natural GAG agents of special interest include chondroitin sulfate (arthritis) and dermatan sulfate (anticoagulation). (selectbiosciences.com)
- The technology can be applied to prepare oligosaccharides belonging to the heparin-, heparan sulfate-, chondroitin sulfate-, keratan sulfate- or hyaluronic acid- class of GAGs. (selectbiosciences.com)
- We have confirmed that both cell types synthesize and secrete heparan sulfate and chondroitin sulfate. (embrapa.br)
- 1998), but only DbpB binds chondroitin sulfate ( Fischer, et al. (thenativeantigencompany.com)
- Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. (harvard.edu)
- Based on the degree of sulfation and the composition of the disaccharides, they are classified into heparin, heparan sulfate, chondroitin sulfate A, dermatan sulfate, chondroitin sulfate C, and keratan sulfate [48]. (phosphatases.com)
- Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a contaminant and dermatan sulfate (DS) as an impurity. (rpi.edu)
- GAG includes heparin (HP), heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), hyaluronic acid (HA) and keratan sulfate (KS). (bioglyco.com)
- The major chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans are aggrecan, versican, biglycan and decorin. (openbiochemistryjournal.com)
- Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). (icr.ac.uk)
- In the present study, we showed that skin DCN and bone DCN (chondroitin sulfate-rich proteoglycan) were quantitatively identical with respect to their ability to interact with TSP. (embl.de)
- Chondroitin sulfate-E (chondroitin-4, 6-disulfate) was prepared from chondroitin sulfate-A (chondroitin-4 - sulfate) by regioselective sulfonation, performed using trimethylamine sulfur trioxide in formamide under argon. (rpi.edu)
- TIMP-3 Binds to Heparan Sulfate and Chondroitin Sulfate E Utilizing a solid-phase binding assay we investigated TIMP-3 binding to several glycosaminoglycans. (ecologicalsgardens.com)
- bound strongly to chondroitin sulfate E (CSE) a 4 6 glycan. (ecologicalsgardens.com)
- GAGs also exert anti-cancer effects by altering structures of various tumor cells through sulfated modifications, including chondroitin sulfate (CS) and dermatan sulfate (DS). (biomedcentral.com)
Glycosaminoglycans10
- Intercalated among the collagen molecules are glycosaminoglycans and proteoglycans, predominantly dermatan sulfate, hyaluronic acid, and heparin sulfate. (medscape.com)
- Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
- We have studied the synthesis and secretion of sulfated glycosaminoglycans (GAGs) by the two cell types under control conditions and ß-D-xyloside-stimulated conditions, that stimulate the ability to synthesize and release GAGs. (embrapa.br)
- 1998). Both can mediate interaction with the glycosaminoglycans (GAGs) heparin and dermatan sulfate (Guo, et al. (thenativeantigencompany.com)
- Mammalian glycosaminoglycans (GAGs) are sulfated polysaccharides commonly exemplified by their most abundant forms: heparin, heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS). (ku.dk)
- Glycosaminoglycans such as heparin, heparan sulphate and dermatan sulphate, are distributed widely in the human body. (microbiologyresearch.org)
- Several glycosaminoglycans form part of the extracellular matrix and heparan sulphate is expressed on all eukaryotic surfaces. (microbiologyresearch.org)
- Heparin and other glycosaminoglycans may have potential uses as therapeutic agents in microbial infections and could form part of future vaccines against such infections. (microbiologyresearch.org)
- C6 glioma cells were derived from rat central nervous system and were previously shown to display glycosaminoglycans, heparan sulfate and chondroitin sulfates, on their surface [43, 61, 68]. (phosphatases.com)
- Sulodexide is a mixture of glycosaminoglycans: heparin and dermatan sulphate, which on one hand suppresses the intravascular inflammation and on the other hand have protective effect towards the endothelium. (viamedica.pl)
Keratan4
- The exception constitutes keratan sulphate whose uronic acid is substituted by galactose. (hindawi.com)
- [ 1 ] The resulting incomplete degradation process leads to abnormal accumulation of heparan sulfate, dermatan sulfate, and keratan sulfate, and the abnormal accumulation of these compounds interferes with cell function. (medscape.com)
- A previous study has shown that Lyme spirochetes do not recognize JSH-23 ic50 keratan sulfate [49]. (phosphatases.com)
- Mucopolysaccharidosis (MPS) involves defective activity of the lysosomal enzymes, which blocks degradation of mucopolysaccharides and leads to abnormal accumulation of heparan sulfate, dermatan sulfate, and keratan sulfate. (medscape.com)
Polysaccharides6
- In addition, the ability of the three sulfated polysaccharides to simultaneously inhibit the generation of thrombin activity and to enhance the inactivation of the factor Xa added to initiate thrombin generation in plasma was determined. (mcmaster.ca)
- In the present review, we describe a systematic study of the sulfated polysaccharides from marine invertebrates, which led to the discovery of a carbohydrate-based mechanism of sperm-egg recognition during sea urchin fertilization. (embrapa.br)
- Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. (embrapa.br)
- Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA? (uu.se)
- Glycosaminoglycan (GAG) is a class of highly sulfated, negatively charged and dispersed linear polysaccharides, usually composed of a backbone of repeating disaccharide units formed by uronic acid and glycosamine residue. (bioglyco.com)
- Le Vivant repose pour son fonctionnement sur les propriétés structurales et fonctionnelles de grandes familles de biopolymères, parmi lesquelles celle des polysaccharides qui reste encore mal connue, et en particulier ceux exposés à la surface cellulaire ou constituant des glyco-conjugués avec les protéines. (hal.science)
Hyaluronic1
- No binding to dermatan sulfate aggrecan hyaluronic acid chondroitin-4-sulfate (C-4-S) or chondroitin-6-sulfate (C-6-S) was detected. (ecologicalsgardens.com)
GAGs5
- The following GAGs were tested: sulodexide (Alfa Wassermann), the LMWH parnaparin (Alfa Wassermann), a commercial dermatan sulfate (DS) from Sigma (Sigma Aldrich C-3788), and the LMWH H2046 and dermatan sulfate D2047 (Opocrin). (healthyguide.info)
- GAGs are primarily defined by their disaccharide repeats that are extensively sulfated in distinct patterns along the chain. (ku.dk)
- The sulfated GAGs are classified as heparin [2-O-sulfo-D-glucuronic acid (GlcUA-2?S) or 2-O-sulfo-L-iduronic acid (IdoUA-2?S) associated to N-acetylglucosamine (GlcNAc) or N-sulfoglucosamine Acetylcholine iodide (GlcNS)], heparan sulfate [GlcUA, IdoUA or IdoUA-2? (greatlakeshighereducationnow.com)
- GAGs, as heparan sulfate and dermatan sulfate, present in host tissue have been reported to influence the spp life cycle as well as of other parasites [19]. (greatlakeshighereducationnow.com)
- In addition, GAGs, including heparin, can induce the proliferation of in the gut of the insect vector, increasing the parasite weight of experimentally infected bugs [21]. (greatlakeshighereducationnow.com)
Proteoglycans3
- Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures. (harvard.edu)
- Upon interaction with heparan sulfates and dermatansulfates of proteoglycans distributed all through the endothelial surface of blood vessels, AT and HCII turn out to be PKCγ Biological Activity activated for inhibiting actions. (trpv1inhibitor.com)
- HSPG and DSPG stand for heparan sulfate and dermatan sulfate proteoglycans, respectively. (trpv1inhibitor.com)
Proteoglycan4
- An associated change with the cervical ripening process is an increase in cervical decorin (dermatan sulfate proteoglycan 2), leading to collagen fiber separation. (medscape.com)
- Heparan sulfate proteoglycan in Alzheimer's disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism. (uu.se)
- Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [Winnemoller et al. (embl.de)
- Moreover, at molecular level, each heparan sulfate proteoglycan (HSPG) consists of a core protein linked to one or more linear heparan sulfate (HS) chains composed of alternating D-glucosamine and uronic acids, leading to N - or O -sulfated glycan [ 5 ]. (biomedcentral.com)
Decorin2
- In addition, the B. burgdorferi surface lipoproteins TSA HDAC cost decorin-binding proteins A and B (DbpA and DbpB) recognize both decorin and dermatan sulfate [43, 51, 52]. (phosphatases.com)
- The T/C-28a2 cell line was developed from human chondrocyte cells [69], which were shown to express fibronectin, decorin and dermatan sulfate [70, 71]. (phosphatases.com)
Antithrombin4
- The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. (mcmaster.ca)
- To study this, we measured the effects of standard heparin, an octasaccharide heparin fraction (anti-factor Xa activity only), and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoagulant effects in vivo in rabbits. (mcmaster.ca)
- The organic inhibitors of the two proteases (Xa and IIa) are the serpins antithrombin (AT), and heparin cofactor II (HCII). (trpv1inhibitor.com)
- The last step of heparin biosynthesis is thought to involve the action of 3-O-sulfotransferase resulting in the formation of an antithrombin III (ATIII) binding site required for heparin's anticoagulant activity. (rpi.edu)
Highly sulfated1
Disaccharide1
- The affinity was increased similarly by heparin and HS at disaccharide concentrations above 10 and 100 μM respectively. (ecologicalsgardens.com)
Binds1
- that binds heparin and dermatan sulfate, and facilitates binding of B. burgdorferi to epithelial cells and glial cells [50]. (phosphatases.com)
Sulodexide4
- Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin - dermatan sulphate blend, which is effective in the treatment of DN. (biomedcentral.com)
- Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 μg/ml. (biomedcentral.com)
- Sulodexide consists for 80% of LMWH and for 20% of dermatan sulfate (DS). (biomedcentral.com)
- It has been Rabbit Polyclonal to p14 ARF shown that sulodexide and heparin-derived medicines are effective in the treatment of DN [19,20] and it has recently been suggested that inside a rat model of peritoneal dialysis sulodexide prevents EMT in the peritoneal membrane [21]. (healthyguide.info)
Oligosaccharides2
- Prepared by controlled partial depolymerisation of UF heparin by Heparinase I and separation of the derived oligosaccharides using high resolution gel filtration. (galenmolecular.com)
- The products cover the entire range of oligosaccharides present in Low Molecular Weight Heparins. (galenmolecular.com)
Fondaparinux1
- Agents derived from the use of heparin include enoxaparin, dalteparin, tinzaparin and fondaparinux. (selectbiosciences.com)
Octasaccharide1
- The octasaccharide heparin fraction, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 41%, had no effect on the TCT, and resulted in an anti-factor Xa level of 0.28 U/mL. (mcmaster.ca)
Sodium1
- Heparin Sodium Injection, USP is a sterile, nonpyrogenic solution of heparin sodium (derived from porcine intestinal mucosa) in water for injection. (qjbchina.com)
Biosynthesis1
- Interacting polymer-modification enzymes in heparan sulfate biosynthesis. (uu.se)
Facilitates1
- Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate. (uu.se)
Impurities4
- Heparins, prepared before these adverse reactions, needed to be screened for impurities and contaminants. (rpi.edu)
- Most pharmaceutical heparins prepared between 1941 and 2008 showed no impurities or contaminants. (rpi.edu)
- Most of these heparinoids were stable to nitrous acid treatment suggesting its utility for evaluating impurities and contaminants in heparin API. (rpi.edu)
- A major impurityin Heparin is Chondroitin and the major challenge in the analysis of heparin impurities is the detection and identification of structurally related impurities. (curriemarketing.co.uk)
Anticoagulant1
- Such as an anticoagulant in heparin-induced thrombocytopenias, assign severity to the area to cover oropharyngeal aerobes and anaerobes. (albionfoundation.org)
Inhibitors1
- They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. (lookformedical.com)
Urine1
- Heparan sulfate and dermatan sulfate in urine. (albionfoundation.org)
Microbial1
- Microbial binding of heparin may interfere with heparin-dependent growth factors. (microbiologyresearch.org)
Proteins2
- Structural specificity of heparin binding in the fibroblast growth factor family of proteins. (harvard.edu)
- There is evidence that heparin-binding proteins (HBPs) present on the surface of spp may play important tasks in the parasites existence cycle, defining the success of parasite attachment to and invasion of cells of the mammalian and invertebrate hosts. (greatlakeshighereducationnow.com)
Structures1
- With the exception of HA, all GAG types are variably sulfated which contributes to the intricate complexity of their structures. (hindawi.com)
Fraction1
- The heparin fraction has a molecular weight of 7000 D and a low degree of sulfation. (biomedcentral.com)
Collagen1
- The amount of dermatan sulfate decreases, leading to reduced bridging among the collagen fibers and a corresponding decrease in cervical firmness. (medscape.com)
Reactions1
Structural1
- AXE STRUCTURAL**- Le progrès des connaissances dans ce domaine nécessite de lever des verrous analytiques en particulier pour la caractérisation structurale et le séquençage de séquences glucidiques bioactives, dont les méthodes font aujourd'hui encore défaut. (hal.science)
Compounds1
- We have described unique polymers present in these organisms, especially sulfated fucose-rich compounds found in the egg jelly coat of sea urchins. (embrapa.br)
Thrombin1
- These results indicate that the antithrombotic effect achieved by inhibiting factor Xa is limited and that better antithrombotic effects are achieved by heparin or heparin- like substances capable of influencing the inactivation and/or the generation of thrombin. (mcmaster.ca)
Similarly1
- So Heparin and Chondroitin are very similar products produced from similar animal tissues and thus we say Chondroitin and heparin should be similarly classified. (curriemarketing.co.uk)
Component1
- Component of dermatan sulfate. (harvard.edu)
Inhibition3
- Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells. (harvard.edu)
- Is heparan sulfate a target for inhibition of RNA virus infection? (uu.se)
- Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics. (uu.se)
Molecular1
- Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
Biological1
Cell2
- Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (harvard.edu)
- Although heparin is not found on the cell surface NR4A3 of the host, this GAG has been commonly used as a tool for studies on pathogen-host cell interactions. (greatlakeshighereducationnow.com)
Diabetic2
- Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. (biomedcentral.com)
- Effects of sulfate deprivation on the production of chondroitin/dermatan sulfate by cultures of skin fibroblasts from normal and diabetic individuals. (harvard.edu)
Binding protein1
- It can be worth to mention that AT is often a heparin-binding protein with the BBXB motif of high-affinity to SPs. (trpv1inhibitor.com)
Surface1
- Celle que nous développons avec le marquage résolu en temps par rayonnement synchrotron et analyse MS permet de cartographier finement la surface protéique exposée au solvant et d'identifier sur la protéine en solution les domaines impliqués dans la liaison du ligand oligosaccharidique \[*[J. Synchr. (hal.science)
Shown1
- It has been previously shown that amastigotes of and have a greater ability to bind to heparin than promastigotes of these same varieties [20]. (greatlakeshighereducationnow.com)