• The exception constitutes keratan sulphate whose uronic acid is substituted by galactose. (hindawi.com)
  • [ 1 ] The resulting incomplete degradation process leads to abnormal accumulation of heparan sulfate, dermatan sulfate, and keratan sulfate, and the abnormal accumulation of these compounds interferes with cell function. (medscape.com)
  • A previous study has shown that Lyme spirochetes do not recognize JSH-23 ic50 keratan sulfate [49]. (phosphatases.com)
  • Mucopolysaccharidosis (MPS) involves defective activity of the lysosomal enzymes, which blocks degradation of mucopolysaccharides and leads to abnormal accumulation of heparan sulfate, dermatan sulfate, and keratan sulfate. (medscape.com)
  • In addition, the ability of the three sulfated polysaccharides to simultaneously inhibit the generation of thrombin activity and to enhance the inactivation of the factor Xa added to initiate thrombin generation in plasma was determined. (mcmaster.ca)
  • In the present review, we describe a systematic study of the sulfated polysaccharides from marine invertebrates, which led to the discovery of a carbohydrate-based mechanism of sperm-egg recognition during sea urchin fertilization. (embrapa.br)
  • Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. (embrapa.br)
  • Low-molecular weight sulfated marine polysaccharides: Promising molecules to prevent neurodegeneration in mucopolysaccharidosis IIIA? (uu.se)
  • Glycosaminoglycan (GAG) is a class of highly sulfated, negatively charged and dispersed linear polysaccharides, usually composed of a backbone of repeating disaccharide units formed by uronic acid and glycosamine residue. (bioglyco.com)
  • Le Vivant repose pour son fonctionnement sur les propriétés structurales et fonctionnelles de grandes familles de biopolymères, parmi lesquelles celle des polysaccharides qui reste encore mal connue, et en particulier ceux exposés à la surface cellulaire ou constituant des glyco-conjugués avec les protéines. (hal.science)
  • The following GAGs were tested: sulodexide (Alfa Wassermann), the LMWH parnaparin (Alfa Wassermann), a commercial dermatan sulfate (DS) from Sigma (Sigma Aldrich C-3788), and the LMWH H2046 and dermatan sulfate D2047 (Opocrin). (healthyguide.info)
  • GAGs are primarily defined by their disaccharide repeats that are extensively sulfated in distinct patterns along the chain. (ku.dk)
  • The sulfated GAGs are classified as heparin [2-O-sulfo-D-glucuronic acid (GlcUA-2?S) or 2-O-sulfo-L-iduronic acid (IdoUA-2?S) associated to N-acetylglucosamine (GlcNAc) or N-sulfoglucosamine Acetylcholine iodide (GlcNS)], heparan sulfate [GlcUA, IdoUA or IdoUA-2? (greatlakeshighereducationnow.com)
  • GAGs, as heparan sulfate and dermatan sulfate, present in host tissue have been reported to influence the spp life cycle as well as of other parasites [19]. (greatlakeshighereducationnow.com)
  • In addition, GAGs, including heparin, can induce the proliferation of in the gut of the insect vector, increasing the parasite weight of experimentally infected bugs [21]. (greatlakeshighereducationnow.com)
  • An associated change with the cervical ripening process is an increase in cervical decorin (dermatan sulfate proteoglycan 2), leading to collagen fiber separation. (medscape.com)
  • Heparan sulfate proteoglycan in Alzheimer's disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism. (uu.se)
  • Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [Winnemoller et al. (embl.de)
  • Moreover, at molecular level, each heparan sulfate proteoglycan (HSPG) consists of a core protein linked to one or more linear heparan sulfate (HS) chains composed of alternating D-glucosamine and uronic acids, leading to N - or O -sulfated glycan [ 5 ]. (biomedcentral.com)
  • The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. (mcmaster.ca)
  • To study this, we measured the effects of standard heparin, an octasaccharide heparin fraction (anti-factor Xa activity only), and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoagulant effects in vivo in rabbits. (mcmaster.ca)
  • The organic inhibitors of the two proteases (Xa and IIa) are the serpins antithrombin (AT), and heparin cofactor II (HCII). (trpv1inhibitor.com)
  • The last step of heparin biosynthesis is thought to involve the action of 3-O-sulfotransferase resulting in the formation of an antithrombin III (ATIII) binding site required for heparin's anticoagulant activity. (rpi.edu)
  • Illustrating this conundrum is the widely used anti-coagulant drug heparin, a highly sulfated heparan sulfate (HS) isolated from animals, which is a heterogenous mixture lacking complete structural characterization. (ku.dk)
  • The affinity was increased similarly by heparin and HS at disaccharide concentrations above 10 and 100 μM respectively. (ecologicalsgardens.com)
  • Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin - dermatan sulphate blend, which is effective in the treatment of DN. (biomedcentral.com)
  • Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 μg/ml. (biomedcentral.com)
  • Sulodexide consists for 80% of LMWH and for 20% of dermatan sulfate (DS). (biomedcentral.com)
  • It has been Rabbit Polyclonal to p14 ARF shown that sulodexide and heparin-derived medicines are effective in the treatment of DN [19,20] and it has recently been suggested that inside a rat model of peritoneal dialysis sulodexide prevents EMT in the peritoneal membrane [21]. (healthyguide.info)
  • The octasaccharide heparin fraction, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 41%, had no effect on the TCT, and resulted in an anti-factor Xa level of 0.28 U/mL. (mcmaster.ca)
  • Heparin Sodium Injection, USP is a sterile, nonpyrogenic solution of heparin sodium (derived from porcine intestinal mucosa) in water for injection. (qjbchina.com)
  • Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells. (uu.se)
  • Interacting polymer-modification enzymes in heparan sulfate biosynthesis. (uu.se)
  • Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate. (uu.se)
  • Heparins, prepared before these adverse reactions, needed to be screened for impurities and contaminants. (rpi.edu)
  • Most pharmaceutical heparins prepared between 1941 and 2008 showed no impurities or contaminants. (rpi.edu)
  • Most of these heparinoids were stable to nitrous acid treatment suggesting its utility for evaluating impurities and contaminants in heparin API. (rpi.edu)
  • A major impurityin Heparin is Chondroitin and the major challenge in the analysis of heparin impurities is the detection and identification of structurally related impurities. (curriemarketing.co.uk)
  • Such as an anticoagulant in heparin-induced thrombocytopenias, assign severity to the area to cover oropharyngeal aerobes and anaerobes. (albionfoundation.org)
  • Structural specificity of heparin binding in the fibroblast growth factor family of proteins. (harvard.edu)
  • There is evidence that heparin-binding proteins (HBPs) present on the surface of spp may play important tasks in the parasites existence cycle, defining the success of parasite attachment to and invasion of cells of the mammalian and invertebrate hosts. (greatlakeshighereducationnow.com)
  • With the exception of HA, all GAG types are variably sulfated which contributes to the intricate complexity of their structures. (hindawi.com)
  • In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. (rpi.edu)
  • AXE STRUCTURAL**- Le progrès des connaissances dans ce domaine nécessite de lever des verrous analytiques en particulier pour la caractérisation structurale et le séquençage de séquences glucidiques bioactives, dont les méthodes font aujourd'hui encore défaut. (hal.science)
  • We have described unique polymers present in these organisms, especially sulfated fucose-rich compounds found in the egg jelly coat of sea urchins. (embrapa.br)
  • These results indicate that the antithrombotic effect achieved by inhibiting factor Xa is limited and that better antithrombotic effects are achieved by heparin or heparin- like substances capable of influencing the inactivation and/or the generation of thrombin. (mcmaster.ca)
  • Significance of the 2-O-sulfo group of L-iduronic acid residues in heparin on the growth inhibition of bovine pulmonary artery smooth muscle cells. (harvard.edu)
  • Is heparan sulfate a target for inhibition of RNA virus infection? (uu.se)
  • Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics. (uu.se)
  • Hence, altering expression of CS and heparan sulfate (HS) on surface of tumor cells is a potential molecular strategy to prevent malignant transformation and tumor metastasis [ 2 ]. (biomedcentral.com)
  • Whilst heparin is successful in preventing and treating thromboembolic events, a great variety of other biological effects are attributed to the heterogeneous heparin, including anti-inflammatory, anti-metastatic, and anti-viral properties. (ku.dk)
  • Comprehensive Landscape of Heparin Therapy for COVID-19. (uu.se)
  • Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (harvard.edu)
  • Although heparin is not found on the cell surface NR4A3 of the host, this GAG has been commonly used as a tool for studies on pathogen-host cell interactions. (greatlakeshighereducationnow.com)
  • Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. (biomedcentral.com)
  • Effects of sulfate deprivation on the production of chondroitin/dermatan sulfate by cultures of skin fibroblasts from normal and diabetic individuals. (harvard.edu)
  • It can be worth to mention that AT is often a heparin-binding protein with the BBXB motif of high-affinity to SPs. (trpv1inhibitor.com)
  • Celle que nous développons avec le marquage résolu en temps par rayonnement synchrotron et analyse MS permet de cartographier finement la surface protéique exposée au solvant et d'identifier sur la protéine en solution les domaines impliqués dans la liaison du ligand oligosaccharidique \[*[J. Synchr. (hal.science)