Dermal skin human skin cell. Medical search. Frequent questions

Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). (biomedcentral.com)
GSE treatment proliferated and migrated human dermal papilla cells (hDPCs) more than treatment of 10 μM minoxidil. (biomedcentral.com)
Of all androgens, the one that most negatively influences dermal papilla cells to produce follicle-shrinking cytokines is 5-α-dihydrotestosterone (DHT), which is synthesized from testosterone by the enzyme 5-α-reductase. (antiaging-systems.com)
Communication between dermal papilla cells and the overlying epithelium is essential for differentiation of the hair follicle lineages. (biologists.com)
Using transgenic mice that express GFP under the control of the Sox2 promoter, we isolated Sox2 + (GFP + ) CD133 + cells and compared them with Sox2 - (GFP - ) CD133 + dermal papilla cells. (biologists.com)
We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types. (biologists.com)
The first is the difficulty in getting dermal papilla cells in humans to self-aggregate and form hair follicles and the second is the inability, thus far, of scientists to generate normal hairs and follicles. (bernsteinmedical.com)
Human dermal papilla cells, on the other hand, have never exhibited what they call the "aggregation phenomena," and instead they disperse in the skin in what appears to be a wound healing mechanism. (bernsteinmedical.com)

Fli1 expression is suppressed in dermal fibroblasts, endothelial cells, and perivascular inflammatory cells in involved and noninvolved skin of patients with SSc [ 11 ]. (biomedcentral.com)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
Organotypic fibroblast-endothelial cell cocultures and matrigel assays were employed to assess angiogenesis. (whiterose.ac.uk)

Dermal cells differentiate into myofibroblasts by altering their actin gene expression (which is silenced in dermal fibroblasts). (wikipedia.org)

Furthermore, these dermal fibroblasts produce the protein molecules including laminin and fibronectin which comprise the extracellular matrix. (wikipedia.org)
By creating the extracellular matrix between the dermis and epidermis, fibroblasts allow the epithelial cells of the epidermis to affix the matrix, thereby allowing the epidermal cells to effectively join together to form the top layer of the skin. (wikipedia.org)
Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. (wikipedia.org)
4 Heterologous type I collagen (HTIC) has been shown to promote cell and fibroblast proliferation and improve cutaneous extracellular matrix metabolism. (jcadonline.com)
Hypoxia enhanced MMP-2 and reduced TIMP-1 secretion, without affecting TIMP-2 levels, and compromised cell ability to migrate and invade the extracellular matrix. (unito.it)
UV radiation that causes oxidative stress and hence aging induces the expression of matrix metalloproteinases (MMPs) that degrade dermal collagen and other proteins from the extracellular matrix (Caravalhaes Lago, 2019). (promocell.com)
The age-related alteration of collagen-rich extracellular matrix - promoted by oxidative stress - impairs the skin's structural integrity and creates a tissue microenvironment that promotes age-related skin diseases such as poor wound healing and skin cancer. (promocell.com)

The first occurs by migration and proliferation of keratinocytes from the wound edges and by differentiation of stem cells from remaining hair follicle bulbs. (worldwidewounds.com)
But it hasn't been possible to generate sufficient number of hair-follicle-generating stem cells - until now. (scienceblog.com)
First, a hair follicle contains epithelial cells - a cell type that lines the body's vessels and cavities - as well as a specific kind of adult stem cell called dermal papillae. (scienceblog.com)
Before we discuss how Hair Pro can block the cascade of processes leading to alopecia, let's examine the micro-anatomy of the hair follicle and its key component, the dermal papilla. (antiaging-systems.com)
A third growth factor, VEGF, is essential for establishing a highly developed blood vessel network around the hair follicle dermal papillae during the anagen growth phase. (antiaging-systems.com)
The dermal papilla comprises the specialised mesenchymal cells at the base of the hair follicle. (biologists.com)
In mouse skin there are several distinct hair follicle types that differ in length, thickness and in the presence or absence of kinks in the hair shaft( Schlake, 2007 ). (biologists.com)
While multiple efforts to induce dermal papillae to form new hair follicles have failed, the research that Higgins and Jahoda have published on hair follicle neogenesis has resulted in a new technique to do just that. (bernsteinmedical.com)
The success of the 3-D culturing of dermal papillae to induce hair follicle neogenesis was a breakthrough in that the scientists have found a way to improve the intercellular communication that is essential to inducing follicle growth. (bernsteinmedical.com)
Another unanswered issue is how long the hair follicles will grow and whether or not they exhibit the cyclical hair follicle growth patterns of a typical human hair follicle. (bernsteinmedical.com)

However, a recent study has demonstrated that activated fibroblasts regulate tissue-localized transdifferentiation of regulatory T cells (Tregs) into T helper type 2 cell (Th2)-like cells through IL-33 in SSc lesional skin [ 2 ], suggesting that activated dermal fibroblasts amplify an aberrant immune response characteristic of SSc. (biomedcentral.com)

This model is reproduced by silencing Cav-1 in normal dermal fibroblasts. (whiterose.ac.uk)
This study evaluated the effect of matrix metalloproteinases-2 (MMP-2) gene silencing using MMP-2 shRNA expression plasmids (pMMP-2) on IR induced cytotoxicity and DNA damage by MTT, dead green, γH2AX and comet assays in human normal dermal fibroblasts (HDFs) and MCF-7 human breast cancer cells. (biomedcentral.com)
The aim of the present investigation is to study the effect of MMP-2 gene silencing by transfection of MMP-2 shRNA expression plasmids (pMMP-2on radiation-induced DNA damage in human normal dermal fibroblasts (HDFs) and MCF-7 cells. (biomedcentral.com)

The robotic finger was first submerged in a solution of collagen, which is a fibrous protein, and human dermal fibroblasts, the two major components that make up human skin. (cbs58.com)
His team put a collagen bandage on a part of the finger that had been inflicted with a wound to mend it, and the robot was able to move freely after the protein repaired the skin. (cbs58.com)
Collagen is a major component of human skin and has healing properties, according to a 2021 study. (cbs58.com)
A substantial reduction in the amount and quality of collagen leads to age-related deterioration of the elasticity and firmness of the skin. (dovepress.com)
There are approximately 28 different types of collagen in the human body, but four are considered the most common. (webmd.com)
Type I collagen is responsible for giving your skin a plump, youthful appearance. (webmd.com)
Several studies have linked the consumption of collagen supplements to improved skin elasticity in women 35 years of age and older. (webmd.com)
The process extracts collagen from the bones and skin and places it into the broth. (webmd.com)
Fish are an excellent source of collagen from food, as long as you leave the skin on. (webmd.com)
That's because much of the collagen found in fish is stored in the skin. (webmd.com)
Cedars Sinai: "Collagen for Your Skin: Healthy or Hype? (webmd.com)
Dr. Axe: "Chicken Collagen Benefits Digestion, Immunity & Skin Health. (webmd.com)
B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis. (ox.ac.uk)
We therefore investigated the involvement of B cells and BAFF in the expression of collagen and profibrotic markers by dermal fibroblasts. (ox.ac.uk)
RESULTS: Coculture of blood B cells and dermal fibroblasts isolated from SSc patients induced IL-6, TGF-β1, CCL2, and collagen secretion, as well as Alpha-SMA, TIMP1, and MMP9 expression in dermal fibroblasts. (ox.ac.uk)
B cell- and BAFF-induced collagen secretion was highly reduced by anti-TGF-β1 antibodies. (ox.ac.uk)
CONCLUSIONS: Our results showed for the first time a direct role of B cells on the production of collagen by dermal fibroblasts, which is further enhanced by BAFF. (ox.ac.uk)
The appearance of skin aging is caused by underlying damage to collagen and reduced fibroblast size, both caused by ROS which regulates collagen metabolism. (promocell.com)
Indirect immunofluorescence demonstrates the presence of IgG circulating autoantibodies in the patient's serum that target the skin basement membrane component, type VII collagen. (medscape.com)
This test detects a denatured 290-kd skin basement membrane protein or globular chain of the alpha chain (145 kd) of type VII collagen. (medscape.com)

One example of further differentiation of dermal fibroblasts is that upon injury, dermal fibroblasts can give rise to myofibroblasts, fibroblast cells with smooth muscle characteristics. (wikipedia.org)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Serial changes in the proliferation and differentiation of adipose-derived stem cells after ionizing radiation. (bioinst.com)
ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. (bioinst.com)
Lipids, proteins, carbohydrates and DNA are all susceptible to oxidative damage and this damage can change gene transcription along with cell proliferation and differentiation and is involved in several diseases including diabetes and obesity, cancer and neurological disorders (Kregel, 2007). (promocell.com)

Transwell assays demonstrated that this induction was dependent on cell-cell contact. (ox.ac.uk)
Cell assays and primary cells provide the tools researchers need to study the oxidative process and its association with skin aging. (promocell.com)
In skin reconstitution assays, hair follicles failed to form when dermis was depleted of both GFP + CD133 + and GFP - CD133 + cells. (biologists.com)

Here, we evaluated dermal toxicity of ionic liquids using human keratinocyte and fibroblast cell line, 3D reconstructed human epidermis, and full-thickness model to investigate underlying mechanisms. (elsevierpure.com)
In 3D reconstructed human epidermis and full-thickness model, a single application of [TFSI] induced toxicity although it was minimal and largely limited to epidermal layer. (elsevierpure.com)
Dermal fibroblasts are responsible for creating the ECM which organizes the stratified squamous epithelial cells of the epidermis into a unified tissue. (wikipedia.org)
A keratinocyte is the main type of cell that makes up the human epidermis, the outermost layer of skin, he said. (cbs58.com)
When they mixed those cells with mouse follicular inductive dermal cells and grafted them onto the skin of immunodeficient mice, they produced functional human epidermis (the outermost layers of skin cells) and follicles structurally similar to human hair follicles. (scienceblog.com)
The stem cells within the basal layer, which contact the basement membrane, continually divide during the lifetime of the organism, providing a source of cells which progressively migrate upwards through the epidermis, differentiating and stratifying to form the barrier layer of the skin [ 11 , 14 ]. (springer.com)
2 In order to become calcitriol, however, vitamin D must first undergo a complex series of biochemical reactions that begin in your epidermis, the outermost layer of your skin and the key to its youthful appearance. (lifeextension.com)
Keratinocytes account for about 95% of all cells in your epidermis. (lifeextension.com)
The dermis, the second layer of the skin just under the outer layer, the epidermis, contains tens of thousands of tiny and complex structures, the hair follicles, which enclose the hair root. (antiaging-systems.com)

iPS were generated via a platelet lysate or fetal bovine serum-based culturing protocol from matched dermal, buccal and gingival human fibroblasts, isolated from healthy donors ( n = 2) after informed consent, via episomal plasmid transfection. (biomedcentral.com)

Інфекция, спричинена вірусом папіломи людини (ВПЛ) Human papillomavirus (HPV) infects epithelial cells. (msdmanuals.com)

Dermal fibroblasts are derived from mesenchymal stem cells within the body. (wikipedia.org)

One of the newest ways to maintain a youthful experience and treat wrinkles is to use dermal fillers. (beautyandgroomingtips.com)
Dermal fillers, also called injectable fillers, are often referred to as the liquid facelift. (beautyandgroomingtips.com)
Dermal fillers, like Juvederm or Restylane, are used on both men and women to improve their appearance. (beautyandgroomingtips.com)
There are many benefits to using dermal fillers and lip fillers. (beautyandgroomingtips.com)
However, dermal fillers cannot take care of excessive sagging skin. (beautyandgroomingtips.com)
Dermal fillers are considered to be "minimally invasive procedures" according to PlasticSurgery.org. (beautyandgroomingtips.com)
Dermal fillers can enhance and improve your chin and cheeks, reshape your nose, get rid of bags under your eyes, reduce jowls and reshape your brows. (beautyandgroomingtips.com)
According to Forbes.com, the effects of dermal fillers will last up to one year, although some patients report that they need a follow-up procedure after a few months. (beautyandgroomingtips.com)
According to FaceClinicLondon.com, dermal fillers use hyaluronic acid, which is naturally found in the body. (beautyandgroomingtips.com)
According to DermaNetwork.org, some dermal fillers, like Juvederm and Restylane, are made of this acid, while others use different ingredients. (beautyandgroomingtips.com)
Fat fillers use either cow-based or human-based ingredients. (beautyandgroomingtips.com)
Different people will respond differently to ingredients, which makes the use of dermal fillers very personal. (beautyandgroomingtips.com)
The many types of injectable fillers include vampire injections, skin cell fillers and even Botox. (beautyandgroomingtips.com)
Also, dermal fillers are often used in conjunction with other treatments, either invasive or non-invasive. (beautyandgroomingtips.com)
Dermal fillers are a great way to improve your appearance so that you're more confident and happy with the way you look. (beautyandgroomingtips.com)
Along with other dermal fillers, Botox can help take years off your face with minimal risk and discomfort. (beautifulself.com)
Combined with dermal fillers , Botox delivers impressive, full-face rejuvenation! (beautifulself.com)
Additional applications of Histogenâ s technology span multiple therapeutic and aesthetic areas including skin care, orthopedics, wound healing, and dermal fillers. (inknowvation.com)

Nevertheless, the initial need for viral-mediated gene delivery renders this strategy unsafe in humans. (nih.gov)
The quantitative real-time PCR (qRT-PCR) was used to quantitatively analyze the gene expression changes in human dermal fibroblasts (HDFs) by hydroxytyrosol. (researchgate.net)
SALPs inhibited LP-induced phosphorylation of NF-κB p65 and p38 MAPK and reduced cytokine release and gene expression in primary human keratinocytes and dermal fibroblasts. (nature.com)
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression. (harvard.edu)
Comparison of the gene expression patterns of the human iPSC-derived epithelial stem cells with epithelial stem cells obtained from human hair follicles showed that the team had succeeded in producing the cells they set out to make in the first place. (scienceblog.com)
Free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), can lead to damage of biomolecules which then affects gene expression, cell metabolism and distinct physiological functions. (promocell.com)
Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsible for genomic instability, altered gene expression, and cell death. (biomedcentral.com)
In addition, MMP-2 gene silencing using pMMP-2 decreased comet tail length in irradiated HDFs but increased in irradiated MCF-7 cells. (biomedcentral.com)
In addition to the `core' dermal papilla gene signature, each subpopulation expressed distinct sets of genes. (biologists.com)

Large injuries are associated with a systemic response caused by a loss of the skin barrier, the release of vasoactive mediators from the wound, and subsequent infection. (medscape.com)
Friend leukemia virus integration 1 (Fli1) deficiency, a predisposing factor of systemic sclerosis (SSc), induces SSc-like phenotypes in various cell types. (biomedcentral.com)
Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and fibrosis of the skin and certain internal organs. (biomedcentral.com)
Mammalian acute systemic toxicity can be studied using computer models or human cells that assess the actions of toxic chemicals at the cellular level. (peta.org)
For example, for acute dermal toxicity, three-dimensional reconstructed human skin models can be used first to determine whether a substance will penetrate the skin, which is necessary for a substance to cause systemic (dermal) toxicity. (peta.org)
INTRODUCTION: B lymphocytes might play a pathogenic role in dermal fibrosis in systemic sclerosis (SSc). (ox.ac.uk)
Thus, these results demonstrate a new pathogenic role of B cells and BAFF in fibrosis and systemic sclerosis. (ox.ac.uk)
The dermal floor pattern of indirect immunofluorescence on salt-split skin substrate is also found in sera of patients with bullous systemic lupus erythematosus (SLE), antiepiligrin cicatricial pemphigoid (with autoantibodies to laminin-5 and laminin-6), and anti-p105 pemphigoid (with autoantibodies to a 105-kd lower lamina lucida protein). (medscape.com)
For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
This document provides the scientific rationale and framework for the assignment of multiple hazard-specific skin notations (SK) that clearly distinguish between the systemic effects, direct (localized) effects, and immune-mediated responses caused by skin contact with chemicals. (cdc.gov)
The primary cutaneous form of ALCL (PC-ALCL), seen in the image below, is defined by skin-only involvement without systemic dissemination at presentation. (medscape.com)

By pulling tissues closed differentiated myofibroblasts, seal the skin after an injury (thereby, preventing infection but inducing scar formation). (wikipedia.org)
GSE treatment significantly reduced the number of mast cells and the expression of transforming growth factor beta 1 in mouse skin tissues. (biomedcentral.com)
Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
An immune-centric view assumes that a particular priming of phagocytes then causes a particular type of pathology in target tissues, conceptually similar to antigen-specific T-cell priming. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
Connective tissues weave your different body parts - skin, bones, and organs - together and give your body shape. (webmd.com)
Histogen Inc (NASDAQ:HSTO) is a regenerative medicine company developing patented technologies designed to stimulate the bodyâ s stem cells to regenerate tissues and restore youthful function. (inknowvation.com)
Inflammation and loss of melanocytes have been described in a number of tissues, including the skin, inner ear, meninges, and uvea. (medscape.com)

Here, we provide evidence that exposure of human skin fibroblasts to a Radio Electric Asymmetric Conveyer (REAC), an innovative device delivering radio electric conveyed fields at a radiofrequency of 2.4 GHz, afforded remarkable commitment toward cardiac, neuronal, and skeletal muscle lineages. (nih.gov)
However, little is known about toxicity of ionic liquids on the skin, a major exposure portal to toxic substances. (elsevierpure.com)
Estimates of exposure levels posing minimal risk to humans (MRLs) have been made, where data were believed reliable, for the most sensitive noncancer effect for each exposure duration. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
No studies were located regarding the following health effects in humans or animals following inhalation exposure to diethyl phthalate. (cdc.gov)
To evaluate an in vitro generated human skin tissue culture model, cutaneous disposition of TCB under different exposure scenarios was investigated. (cdc.gov)
Occlusive or non-occlusive doses of 14C- TCB were applied at 4 or 40 ug/cm2 in different vehicles including acetone, methylene chloride , a wateracetone mixture, and a soil-based mixture in flow-through diffusion cell studies (n=6-7/exposure condition). (cdc.gov)
Significant exposure-dependent dermal absorption and disposition were observed. (cdc.gov)
Such observed exposure-dependent dermal disposition profiles need to be considered while assessing TCB dermal risk. (cdc.gov)
The problem is that while the body uses sunlight to make vitamin D, sun exposure itself accelerates skin aging. (lifeextension.com)
1 Your skin has the ability to manufacture as much as 10,000 IU of vitamin D after 20-30 minutes of summer sun exposure. (lifeextension.com)
2 But there are many limiting factors to internal vitamin D synthesis that include age, skin color, geographic latitude, seasonal variation in sunlight availability, and the widespread (but necessary) use of sunscreen, which all make it difficult for your body to produce the vitamin D it needs for optimal health through sun exposure alone. (lifeextension.com)
The most significant extrinsic factor causing accelerated skin aging is exposure to UV light leading to the production of ROS (Stojiljkovic, 2014) which cause oxidative damage. (promocell.com)
The exposure of humans to ionizing radiation (IR) induces several types of genetic and somatic mutations leading to several types of cancers including breast cancer [ 1 ]. (biomedcentral.com)
Queensland, Australia demonstrated premature mined and extrinsic ageing (or photo-ageing) that ageing of the skin in a population excessively is largely related to sun exposure (Jenkins, exposed to the sun (Green, 1991). (who.int)
The process tionship of artificial UV exposure to ageing in is undoubtedly complex, and one of the drives to humans. (who.int)
A wide variety of dermatoses are exacerbated by have addressed photo-ageing of the skin, not sun exposure, such as atopic eczema or psoria- least because of the difficulties of measuring it sis if sunburn occurs. (who.int)
Data on inhalational exposure to ricin in humans is extremely limited. (cdc.gov)
The key step within assignment of the hazard-specific SK is the determination of the hazard potential of the substance, or its potential for causing adverse health effects as a result of skin exposure. (cdc.gov)

Since dermal fibroblasts play a critical role in wound healing, researchers are attempting to generate mature dermal fibroblasts to repair second and third degree burns. (wikipedia.org)
When the body sustains a third degree burn, the skin's dermal layer is completely destroyed by heat (and the all fibroblast cells within the wound site perish). (wikipedia.org)
Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. (wikipedia.org)
Cell migration is a rate-limiting event in skin wound healing. (rupress.org)
As the wound heals, the cells experience a transition of serum back to plasma. (rupress.org)
Furthermore, SALPs markedly promoted cell migration via EGFR transactivation and ERK1/2 phosphorylation and accelerated artificial wound closure in keratinocytes. (nature.com)
Although inflammation is an important process to combat infections and to accelerate wound healing, overactivation of the immune system can lead to detrimental effects such as chronic skin inflammation 12 . (nature.com)
In a prospective, randomised, controlled porcine wound study, four different dressings were assessed with reference to the amount of epidermal cover gained and the histological quality of the regenerated skin at three weeks post-grafting. (worldwidewounds.com)
Adipose-derived stem cells (ADSC) have wound-healing and antioxidant effects on human skin via secretion of growth factors and activation of dermal fibroblasts. (bioinst.com)
Here, we investigated the effects of hypoxia and dextran-shelled OLNs on the pro-angiogenic phenotype and behavior of human dermal microvascular endothelium (HMEC-1 cell line), another cell population playing key roles during wound healing. (unito.it)
Collectively, these data provide new information on the effects of hypoxia on dermal endothelium and support the hypothesis that OLNs might be used as effective adjuvant tools to promote chronic wound healing processes. (unito.it)

For example, when a dermal fibroblast and a corneal fibroblasts are placed in the same concentrations of fibroblast growth factor, dermal fibroblast will not differentiate or change. (wikipedia.org)
The main property that sets ESC apart from other cells is their pluripotent nature, meaning they can give rise/differentiate to cells of the three primary germ layers (mesoderm, endoderm and ectoderm) [ 13 ]. (biomedcentral.com)
By adding three genes, they converted those cells into induced pluripotent stem cells (iPSCs), which have the capability to differentiate into any cell types in the body. (scienceblog.com)
During the anagen growth phase, stem cells migrate to the hair matrix and divide and differentiate in a process controlled by numerous cytokines produced by the dermal papillae. (antiaging-systems.com)
In fact, human papillae, when grown in a laboratory culture, can act as "mesenchymal stem cells" and differentiate into a variety of cell types. (bernsteinmedical.com)

Based on evidence of α-SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells. (wikipedia.org)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)

Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)
The skin comprises various cell types providing the potential to react to bacterial pathogenicity factors and can thus initiate inflammatory responses if exposed to these factors 5 . (nature.com)
Despite the fact that a common and clear definition of "berries" is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. (mdpi.com)
Psoriasis is a chronic immune-mediated inflammatory skin disease. (springer.com)
Histologically, the dermatosis is characterized by hyperproliferation of keratinocytes, impaired epidermal barrier function at the sites of skin lesions, and skin infiltration by activated inflammatory cells [ 5 ]. (springer.com)
Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune inflammatory disorder with ocular, auditory, skin, and neurologic involvement. (medscape.com)
In addition, histology also reveals a mixed inflammatory cell dermal infiltrate. (medscape.com)

Although SSc pathogenesis has yet to be fully disclosed, the canonical wisdom is that dermal fibroblast activation is the final consequence of its sequential pathological processes, such as initial vascular injury due to autoimmune attack and subsequent chronic inflammation [ 1 ]. (biomedcentral.com)

Skin is a living organism, so it needs to sustain itself by being constantly nourished while removing waste, Takeuchi said. (cbs58.com)

After the solution conformed around the finger, Takeuchi applied human epidermal keratinocytes to the outside. (cbs58.com)
Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells. (scienceblog.com)
Recently, we have shown that in human monocytes hypoxia reduces MMP-9 and increases TIMP-1 without affecting TIMP-2 secretion, whereas in human keratinocytes it reduces MMP-2, MMP-9, and TIMP-2, without affecting TIMP-1 release. (unito.it)
This constant loss of cells on your skin's surface must be offset naturally by an ongoing vitamin D- dependent renewal process that takes place in specialized cells called keratinocytes. (lifeextension.com)

The oral fibroblasts generally proved to be more difficult to reprogram than dermal fibroblasts. (biomedcentral.com)

In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)

Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. (wikipedia.org)
Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. (wikipedia.org)
Furthermore, dermal fibroblasts create long fibrous bands of connective tissue which anchor the skin to the fascia of the body. (wikipedia.org)
Dermal fibroblasts are the primary cell type in the connective tissue of the skin. (cbs58.com)

The on-and-off switch is operated by transforming growth factor (TGF) β3 levels, which are undetectable in plasma and high in serum, and by TGFβ receptor (TβR) type II levels, which are low in epidermal cells and high in dermal cells. (rupress.org)

The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. (biomedcentral.com)
He also wishes to develop additional details for the skin such as hair follicles, nails and sweat glands. (cbs58.com)
One potential approach to reversing hair loss uses stem cells to regenerate the missing or dying hair follicles. (scienceblog.com)
The epithelial stem cells, when implanted into immunocompromised mice, regenerated the different cell types of human skin and hair follicles, and even produced structurally recognizable hair shaft, raising the possibility that they may eventually enable hair regeneration in people. (scienceblog.com)
They then converted the iPS cells into epithelial stem cells, normally found at the bulge of hair follicles. (scienceblog.com)
This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles," Xu says. (scienceblog.com)
Xu and his team mixed iPSC-derived EpSCs and mouse dermal cells to generate hair follicles to achieve the growth of the follicles. (scienceblog.com)
In an animal study, mice administered DHT exhibited reduced expression of IGF-1, which resulted in a lower number of proliferating cells in hair follicles and decreased hair growth. (antiaging-systems.com)
In postnatal skin, Sox2 is only expressed in the dermal papillae of guard/awl/auchene follicles, whereas CD133 is expressed both in guard/awl/auchene and in zigzag dermal papillae. (biologists.com)
Higgins and Jahoda describe how it has been known for decades, through the work of Lille and Wang and others, that rat dermal papillae self-organize into new hair-producing follicles when they are injected or grafted into the skin. (bernsteinmedical.com)

My research is focused on investigating the function of the melanocortin 1 receptor (MC1R) , its agonists α-melanocyte stimulating hormone (α-MSH) and ACTH, and antagonists agouti signaling protein and human β-defensin 3 in regulating cutaneous pigmentation and the response to UV radiation. (uc.edu)
Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes. (uc.edu)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Merkel cell carcinoma (MCC) is a rare malignant and primary neuroendocrine carcinoma with several known risk factors. (bioinst.com)
Primary human dermal fibroblasts were isolated from skin biopsies obtained from plastic surgery by collagenase digestion and stored at -170°C in DMSO until usage. (nih.gov)
Vista green DNA dye and MMP-2 primary antibody was procured from Cell Biolabs, USA and Santa Cruz Biotechnology respectively. (biomedcentral.com)
As the largest organ of the body, the skin performs multiple critical functions, such as serving as the primary barrier to the external environment. (cdc.gov)

This acid binds water, acting as a lubricant, and regulates the amount of water in the skin. (beautyandgroomingtips.com)
My long-term goal is to identify the binding partner that regulates base excision and nucleotide excision repair during the chemotherapeutics-mediated DNA damage in cancer cells. (edu.in)
This linking regulates the expression of genes that turn different cell functions on or off. (lifeextension.com)
The dermal papilla regulates the growth of hair, which in humans occurs in unsynchronized cycles, with each hair entering a phase of the cycle at a different time. (antiaging-systems.com)

What's more, the process Xu used to create iPSCs involves genetic modification of human cells with genes encoding oncogenic proteins and so needs more refinement. (scienceblog.com)
The active form of vitamin D, calcitriol , is one of the most powerful hormones in the human body, endowed with the ability to activate over 2,000 genes (roughly 10% of the human genome). (lifeextension.com)

In conclusion, this human skin tissue culture model showed similar dermal absorption and disposition characteristics for TCB when compared to an in vitro porcine skin model. (cdc.gov)
Special attention has been paid to the absorption of parabens and their retention in the human body in the intact form, as well as to their toxicological characteristics. (nih.gov)

The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light-induced oxidative stress. (uc.edu)
Oxidative stress results from an imbalance of pro- and anti-oxidants and leads to faster skin aging, inflammation and disease. (promocell.com)

Murine dermal fibroblasts and Tregs were cocultured with or without blocking antibodies against target cytokines. (biomedcentral.com)

During the last decades, research has focused on the cell-type-specific properties of these cells in culture, which then led to an immunocentric view of their role in disease like if they were primed like T cells to infiltrate target organs to cause tissue damage and drive progressive scaring [ 2 , 3 ]. (hindawi.com)

In this article, you will discover the critical role vitamin D plays in skin cell development and repair, as well as how it mobilizes your skin's immune system and helps destroy free radicals that can cause premature aging. (lifeextension.com)
They are continuously providing new cells for replenishment of your skin's surface. (lifeextension.com)

Fli1 haploinsufficiency increases the proportions of Th2- and Th17-like Tregs in bleomycin-induced profibrotic skin conditions, in which IL-33-producing dermal fibroblasts contribute to Th2-like Treg transdifferentiation, suggesting a critical role of Fli1 deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis. (biomedcentral.com)

We need to figure out a way to also make new dermal papillae cells, and no one has figured that part out yet. (scienceblog.com)
Having made significant progress in improving this vital communication link between dermal papillae cells, scientists still have to contend with a series of obstacles that stand in the way of a hair cloning therapy for human hair loss. (bernsteinmedical.com)

However, the ability of B cells directly to stimulate dermal fibroblasts and the role of BAFF are not fully understood. (ox.ac.uk)

In this study, we report that human serum selectively promotes epidermal cell migration and halts dermal cell migration. (rupress.org)
In contrast, human plasma promotes dermal but not epidermal cell migration. (rupress.org)
When taken up by HMEC-1, nontoxic OLNs abrogated the effects of hypoxia, restoring normoxic MMP/TIMP levels and promoting cell migration, matrix invasion, and formation of microvessels. (unito.it)

Furthermore, dermal fibroblasts are less likely to replicate in either in vivo and in vitro environments than are other fibroblast types. (wikipedia.org)
Advances in microfabrication, stem cell technology, tissue engineering, and mathematical modeling have created unprecedented in vitro models-organs-on-a-chip (OOC) systems-to predict risk and efficacy of drugs candidates, and accelerate their steps to the market. (mdpi.com)
Results: PEDF is highly expressed in myofibroblasts and reticular fibroblasts with low Cav-1 expression in SSc skin biopsies, and it is induced by TGF-β in vitro. (whiterose.ac.uk)
Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)

My doctoral study investigates molecular mechanisms of UV radiation-mediated skin inflammation, photoaging, and skin cancer and its countermeasures. (edu.in)

IR has decreased the viability of HDFs and MCF-7 cells with increasing IR (2-10Gy). (biomedcentral.com)
IR induced DNA damage in both HDFs and MCF-7 cells. (biomedcentral.com)
However, pMMP-2 transfection has increased the viability of irradiated HDFs (10Gy) and significantly decreased the viability of irradiated MCF-7 cells (10Gy). (biomedcentral.com)
Further, DNA damage in terms of γH2AX foci decreased with pMMP-2 transfection in irradiated HDFs (10Gy) and increased in irradiated MCF-7 cells (10Gy). (biomedcentral.com)
The results conclude that pMMP-2 has protected HDFs and sensitized the MCF-7 cells from IR induced DNA damage. (biomedcentral.com)
This differential response might be due to IR induced MMP-2 distinctive ROS generation in HDFs and MCF-7 cells. (biomedcentral.com)

This is demonstrated on real data (human for segmentation and porcine for depth classification) and establishes the groundwork for further deep-learning thrusts in the area of burn analysis. (bvsalud.org)

METHODS: Cocultures of blood B cells from healthy blood donors and normal or SSc dermal fibroblasts stimulated with anti-IgM and BAFF were performed. (ox.ac.uk)

A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)

Immunobiologic: Immunobiologics include antigenic substances, such as vaccines and toxoids, or antibody-containing preparations, such as globulins and antitoxins, from human or animal donors. (cdc.gov)

Furthermore, we discuss how published data supports the view that changing tissue environments induce the well-known different phenotypes of mononuclear phagocytes, a process that not only enforces each of the different environments but also explains the contribution of these cells to the different tissue pathologies. (hindawi.com)

After examining the CD markers of the fibroblast cells, researchers at BioMed Central discovered that these cell lack "distinctive markers" confirming that these cells can be further differentiated. (wikipedia.org)
To gain pluripotency, the reprogramming process typically involves transfecting adult somatic cells with certain pluripotency markers. (biomedcentral.com)
GFP + CD133 + cells had upregulated Wnt, FGF and BMP pathways and expressed neural crest markers. (biologists.com)

Xeno-free dermal, buccal and gingival fibroblasts can successfully generate iPS with a comparable genotype/phenotype to their xenogenic counterparts. (biomedcentral.com)

Like corneal fibroblasts, dermal fibroblast proliferation can be stimulated by the presence of fibroblast growth factor (FGF). (wikipedia.org)
Dermal fibroblasts require far higher concentrations of fibroblast growth factor (FGF) in order to undergo cell replication. (wikipedia.org)
The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. (worldwidewounds.com)
3, 6-10) In addition, IGF-1 prevents cell death (apoptosis) in many cell types, which may be important in promoting the anagen growth phase and delaying the catagen (apoptosis-driven) phase. (antiaging-systems.com)
6) In a few fascinating studies, hair growth in humans with alopecia was promoted by inducing IGF-1 production. (antiaging-systems.com)
Benefits associated with the oil extract, they said, included cellular defence, antioxidation, anti-inflammation, anti-apoptosis, chemoprevention, hair growth promotion and skin health improvement - achieved via several different mechanisms and a variety of compounds. (cosmeticsdesign-europe.com)

Therefore, without dermal fibroblasts, the largest and heaviest organ would not tightly adhere to body's frame. (wikipedia.org)

Our results show for the first time the feasibility of using a physical stimulus to afford the expression of pluripotentiality in human adult somatic cells up to the attainment of three major target lineages for regenerative medicine. (nih.gov)

Those cells were then purified using the proteins they expressed on their surfaces. (scienceblog.com)
cell death results from the absence of proteins. (cdc.gov)

The synthesis and release of these cytokines is influenced by androgens which bind to receptors of the dermal papillae. (antiaging-systems.com)

Known as an adaptogen capable of stabilising physiological functions and enhancing body strength, the researchers said ginseng was also associated with many biological properties, including antioxidant, anti-inflammation, anti-cancer, anti-fatigue and anti-ageing, as well as its ability to boost the human immune system, enhance memory and improve blood circulation. (cosmeticsdesign-europe.com)
skin sensitization resulting in allergic con- based on analysis of immune responses induced in mice tact dermatitis and sensitization of the respiratory tract (and rats) by chemical allergens. (cdc.gov)
c) Immune globulin (IG): A sterile solution containing antibodies from human blood. (cdc.gov)
Three types of immunobiologics are administered for passive immunization: a) pooled human IG or IGIV, b) specific immune globulin preparations, and c) antitoxins. (cdc.gov)

Cytokine expression was assessed in Tregs by flow cytometry and in skin samples and cultivated cells by immunostaining, immunoblotting, and/or qRT-PCR. (biomedcentral.com)
B-cell activating factor (BAFF), a key cytokine for B-cell activation, is increased in the serum and the skin of patients with SSc. (ox.ac.uk)

At the base of each follicle is a bulb-like projection, the dermal papilla , surrounded by the hair matrix, a group of cells which divide to form the major structures of the hair fiber and root. (antiaging-systems.com)

In our results, significant cytotoxicity was induced by ionic liquids with [TFSI] in both cell lines. (elsevierpure.com)

For the first time, scientists learned to grow humanlike skin on a robotic finger using cells, a new study revealed . (cbs58.com)
When the scientists tried the same experiment with the water-repellent humanlike skin, the robotic finger could flick the foam beads away without them sticking, the authors said. (cbs58.com)

Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types. (wikipedia.org)
Both SALPs showed a low cytotoxicity in all investigated cell types. (nature.com)
Emerging dressing types include bioactive dressings and tissue-engineered skin substitutes. (worldwidewounds.com)
Considerations to be taken into account, both for novel dressing types and for skin substitutes include ease of use, patient satisfaction and cost-effectiveness. (worldwidewounds.com)
The following discussion focuses on novel types of 'bioactive' dressings, the tissue-engineered 'skin substitutes', and the trials used to test their effectiveness. (worldwidewounds.com)
In addition, "lung-chips"-which include relevant cell types and even mimic the breathing motion of the lung-can be used to model the human lung. (peta.org)
Induced pluripotent stem cells (iPS) can be generated from various somatic cells and can subsequently be differentiated to multiple cell types of the body. (biomedcentral.com)
When a person loses hair, they lose both types of cells. (scienceblog.com)
Different skin types respond to extrinsic factors in different ways, with type I and II (fair) skin experiencing increased extrinsic aging in response to the same stimuli (Naidoo, 2017). (promocell.com)
My research interest falls into the broad field of regenerative medicine, with emphasis on the way nerve cells and other cell types are affected by small, typically submicron artificial structures. (lu.se)

4,5 Hormones are chemical messengers produced by certain glands and cells in your body that bind to specific receptors in order to produce a targeted biological response. (lifeextension.com)

The dermal filler boosts the amount of this acid in the body, helping to plump up the skin. (beautyandgroomingtips.com)

Conclusively, our data suggest a novel therapeutic target for the treatment of patients with acute and chronic skin infections. (nature.com)
For acute inhalation toxicity, three-dimensional models constructed from human cells (such as those from Epithelix Sàrl ) can be used to study the effects of chemicals on specific parts of the lung. (peta.org)
The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. (harvard.edu)
Outbreak of Acute Respiratory Illness Associated with Human Adenovirus Type 4 at the U.S. Coast Guard Academy, 2019. (cdc.gov)

For example, despite improvements in cell culture techniques and developments in dermal matrices, tissue-engineered skin substitutes have yet to achieve widespread use by clinicians. (worldwidewounds.com)

In recent years, multiple compounds have been developed aimed at reversing the molecular features of dermal aging. (dovepress.com)
Because the use of cosmetics shows an increasing trend and some adverse health outcomes of parabens present in these products have been reported, the present review focused on the safety of dermal application of these compounds. (nih.gov)
Red ginseng oil extracts typically contained a high quantity of fatty acids, particularly unsaturated fatty acids, along with other lipophilic phytochemicals such as phytosterols, polyphenolic compounds, tocopherols, and polyacetylenes beneficial to human health. (cosmeticsdesign-europe.com)
NIOSH skin notation profile: Arsenic and inorganic arsenic containing compounds. (cdc.gov)
This Skin Notation Profile provides the SK assignments and supportive data for arsenic and inorganic arsenic containing compounds. (cdc.gov)

Th2- and Th17-like cell proportions in skin-homing Tregs were increased in bleomycin-treated Fli1 +/− mice compared with bleomycin-treated wild-type mice, whereas Th1-, Th2-, and Th17-like cell proportions in splenic Tregs were comparable. (biomedcentral.com)
As reported in a Penn news release , Xiaowei "George" Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice. (scienceblog.com)
Consistently, transgenic mice with TGF-β receptor hyperactivation show lower Cav-1 and higher PEDF expression levels in skin biopsies accompanied by reduced blood vessel density. (whiterose.ac.uk)

Anatomy16

Organisms6

Diseases22

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes24

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Health Care3

Papilla cells8

Endothelial7

Silenced in dermal fibroblasts1

EXTRACELLULAR MATRIX7

Hair follicle10

Activated dermal fibroblasts1

Normal dermal fibroblasts3

Collagen20

Differentiation5

Assays3

Epidermis9

Fibroblasts isolated1

Epithelial cells1

Derived from mesenchymal stem1

Fillers18

Gene9

Systemic11

Tissues9

Exposure19

Wound11

Differentiate5

Mesenchymal2

Inflammatory7

Fibroblast activation1

Living organism1

Keratinocytes4

Reprogram1

Dendritic cells2

Connective tissue4

Epidermal cells1

Follicles10

Cutaneous4

Primary4

Regulates4

Genes2

Characteristics2

Oxidative stress2

Murine1

Infiltrate1

Skin's2

Profibrotic1

Papillae cells2

Stimulate1

Migration3

Vitro4

Photoaging1

HDFs6

Porcine1

Cocultures1

Heterogeneity2

Donors1

Phenotypes1

Markers3

Phenotype1

Growth6

Body's1

Adult somatic cells1

Proteins2

Synthesis1

Immune4

Cytokine2

Follicle1

Significant1

Scientists2

Types10

Receptors1

Filler1

Acute4

Substitutes1

Compounds5

Mice3