Dermal fibroblasts and macrophages. Medical search. Frequent questions

The steady deterioration of the dermal and epidermal layers of the skin with age is caused by a combination of factors including reduced cellular proliferation and collagen synthesis, extracellular matrix remodeling, and changes in epidermal morphology (Crane 2015). (ernolaszlo.com)
Increasing evidence suggests there is a 2-way relationship between stress and skin quality, with direct impacts on keratinocyte and fibroblast number and function as well as on the composition of the extracellular matrix. (ernolaszlo.com)
In the skin, tissue injury results in fibrosis in the form of scars composed of dense extracellular matrix deposited by fibroblasts. (stanford.edu)
4 Heterologous type I collagen (HTIC) has been shown to promote cell and fibroblast proliferation and improve cutaneous extracellular matrix metabolism. (jcadonline.com)
It is a 2 to 4 mm-thick layer of connective tissue mainly composed of extracellular matrix (ECM) produced by fibroblasts. (biologiedelapeau.fr)

With our molecular lab partners, we intend to study the cellular effects of phytocompounds on the skin, specifically looking at the integumentary (i.e., skin's) Endocannabinoid System and cellular targets such as macrophages, keratinocytes, and dermal fibroblasts. (wishskinlabs.com)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
3 Furthermore, the disappearance of melanocytes has been suggested to be the final step of a complex scenario of deregulated biological events involving keratinocytes and fibroblasts as well. (jcadonline.com)

Results from immunohistochemical testing with antibodies to factor XIIIa, which label dermal dendritic cells, are frequently positive in dermatofibroma, while antibodies to MAC 387, which label monocyte-derived macrophages (histiocytes), show less consistent results. (medscape.com)
They have been made to contain dendritic cells, but so far no study on the incorporation of potentially anti-inflammatory dermal macrophages has been performed. (cnrs.fr)
Macrophage colony-stimulating factor has not been considered as a factor responsible for dendritic cell or Langerhans cell development from hematopoietic progenitor cells. (keyopinionleaders.com)
Human monocyte-derived dendritic cells (MoDCs) obtained from peripheral blood monocytes (PBMC) cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) can be activated in vitro by a variety of simple chemicals such as haptens and several metals. (keyopinionleaders.com)

Fli1 expression is suppressed in dermal fibroblasts, endothelial cells, and perivascular inflammatory cells in involved and noninvolved skin of patients with SSc [ 11 ]. (biomedcentral.com)
CD105 is expressed on vascular endothelial cells and placental syncytiotrophoblasts and at lower levels on stromal fibroblasts. (bdbiosciences.com)

The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. (worldwidewounds.com)
Exogenous recombinant angiogenin dose-dependently enhanced the proliferation and differentiation of dermal fibroblasts. (bvsalud.org)
We studied the effect of conditioned media of GM-CSF-differentiated human macrophages polarized in M1(LPS), M2a(IL-4), M2c(dexamethasone), and M2(low serum) phenotypes on proliferation, differentiation, and collagen-producing activity of dermal fibroblasts. (bvsalud.org)
On the contrary, M2(low serum) generated under conditions of growth factors deficiency had a pronounced stimulating effect on the differentiation of fibroblasts and production of type I collagen by these cells, but moderately stimulated the fibroblast proliferation. (bvsalud.org)
This has allowed us to reveal potential mechanisms controlling fibroblast fate during migration, proliferation, and differentiation following skin injury, and thereby reexamine the canonical phases of wound healing. (stanford.edu)

Those blood vessels provide nourishment and waste removal for both dermal and epidermal cells. (wikipedia.org)
Blood vessels in the dermal papillae nourish all hair follicles and bring nutrients and oxygen to the lower layers of epidermal cells. (wikipedia.org)
Additionally, the increase in the surface area prevents the dermal and epidermal layers from separating by strengthening the junction between them. (wikipedia.org)
Provision of the grip between the dermal and epidermal layers. (healthncare.info)
Besides, this expansion in the surface region fortifies the intersection between the layers by evacuating the danger of partition of dermal and epidermal layers. (healthncare.info)
The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. (biomedcentral.com)

It is the primary location of dermal elastic fibers. (wikipedia.org)
The lower area is quite dense and thick found under the papillary dermal region and generally composed of packed collagen fibers serving as a primary site for the dermal elastic fibers. (healthncare.info)

The team determined that the dead macrophages release the pigment into their surroundings, where, over the following weeks, it is taken up by new, monocyte-derived macrophages before it can disperse. (newswise.com)

The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly increase the surface area between the dermis and epidermis. (wikipedia.org)

Thus, the secretory activity of various functional phenotypes of macrophages is an important mechanism of fibrogenesis regulation. (bvsalud.org)

Another study has show that the fascial inflammatory infiltrate is predominately composed of CD8 + T lymphocytes, macrophages, and fewer eosinophils, suggesting a possible cytotoxic immune reaction in response to possible infectious or environmental agents. (medscape.com)

The dermis is composed of three major types of cells: fibroblasts, macrophages, and mast cells. (wikipedia.org)
The dermal papillae (DP) (singular papilla, diminutive of Latin papula, 'pimple') are small, nipple-like extensions (or interdigitations) of the dermis into the epidermis. (wikipedia.org)
More recently, however, researchers have suggested that macrophages-specialized immune cells that reside in the dermis-are attracted to the wound inflicted by the tattoo needle and gobble up the tattoo pigment just as they would normally engulf an invading pathogen or piece of a dying cell. (newswise.com)
A team of researchers led by Sandrine Henri and Bernard Malissen of the Centre d'Immunologie de Marseille-Luminy developed a genetically engineered mouse that allowed them to kill the macrophages that reside in the dermis and certain other tissues. (newswise.com)
The dermal papillae are situated in the highest layer of the dermis which is called papillary dermis. (healthncare.info)
Physically the dermal papillae show up as the fingerlike sharp projections of the dermis or corium layer of the skin and will, in general, insert their edges in the upper layer of skin known as the epidermis. (healthncare.info)
Dermal filler is a gel form that is injected directly into the deep dermis layer to produce an immediate filling effect and correct localized loss of skin volume. (dnaskinclinic.in)

The use of an acellular dermal regenerative tissue matrix in the treatment of lower extremity wounds: a prospective 16-week pilot study. (japmaonline.org)
For breast reconstruction surgeries, an allogenic acellular dermal matrix is highly preferred. (factmr.com)
Furthermore, products made of an acellular dermal matrix are used to treat diabetic lower extremity ulcers. (factmr.com)

Treatment of murine macrophages (J774A.1) with Mitsui-7 MWCNTsincreased the expression of Alox5 mRNA and protein in a concentration- and time-dependent manner. (cdc.gov)

Over the following few weeks, these cells are replaced by new macrophages derived from precursor cells known as monocytes. (newswise.com)
Because dermal macrophages stain for IL-10 in situ, we generated dermal-type macrophages from monocytes in the presence of IL-10 to study their infection by dengue virus. (cnrs.fr)

MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. (rndsystems.com)
We studied the effect of soluble factors derived from human macrophages polarized to M2 phenotype under conditions of serum deprivation (M2-SF) on behavioral pattern and cytokine production in various brain structures in mice with modeled stress-induced depression. (bvsalud.org)

Neutrophil elastase and skin fibroblast elastase are two types of elastase enzymes that can degrade elastin in the skin. (toxicolres.org)
The cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60), which was blocked by Acebilustat, a specific leukotriene A4 hydrolase inhibitor, or LY239111, an LTB4 receptor antagonist, but not NS-398, a cyclooxygenase 2 inhibitor, revealing LTB4 as a major mediator of neutrophil chemotaxis from MWCNT-polarized macrophages. (cdc.gov)

Here, we show that monocyte-derived dermal-type macrophages can be introduced into a rigid scaffold with dermal fibroblasts. (cnrs.fr)
Furthermore, the microspheres serve as a scaffold that promotes fibroblast activity and triggers collagen neogenesis. (dnaskinclinic.in)

At the same time, soluble factors of M2c(dexamethasone) significantly enhanced the proliferative response of fibroblasts, but not their differentiation and type I collagen production. (bvsalud.org)

In mucous membranes, the equivalent structures to dermal papillae are generally termed "connective tissue papillae", which interdigitate with the rete pegs of the superficial epithelium. (wikipedia.org)
Mucosal layers have comparable projections like dermal papillae and these are by and large called "connective tissue papillae" which will in general interlock with the rete pegs of the shallow epithelium. (healthncare.info)

These data indicate that the antidepressant potential of M2 type macrophages can be mediated by the anti-inflammatory effects of M2-SF. (bvsalud.org)

METHODS AND FINDINGS: Here, we showed that dermal macrophages bound recombinant envelope E glycoprotein fused to green fluorescent protein. (cnrs.fr)

The macrophages, once activated, set in motion a natural process by activating fibroblasts that activate collagen synthesis. (onlyyourx.com)
The objectives of this study were to evaluate the effects of Angelica acutiloba root ethanol extract (AAEE) to promote collagen synthesis and inhibit collagen degradation in human dermal fibroblasts. (toxicolres.org)
As the fibroblasts stretch out through the collagen network, it creates a mechanical tension that regulates collagen synthesis. (dnaskinclinic.in)

Keratinocyte hyperproliferation, condensed dermal collagen, and mononuclear perivascular infiltrate increased with lymphedema stage, which suggested progressive chronic inflammation and fibrosis. (cdc.gov)

The therapeutic goal of regenerative wound healing has remained elusive, in part because principles of fibroblast programming and adaptive response to injury remain incompletely understood. (stanford.edu)

The researchers found that dermal macrophages were the only cell type to take up pigment when they tattooed the mice's tails. (newswise.com)
For example, despite improvements in cell culture techniques and developments in dermal matrices, tissue-engineered skin substitutes have yet to achieve widespread use by clinicians. (worldwidewounds.com)
A recent study demonstrated the transdifferentiation of T helper type 2 cell (Th2)-like regulatory T cells (Tregs) in SSc lesional skin through interleukin (IL)-33 produced by fibroblasts. (biomedcentral.com)
Importantly, the IL-4-producing cell proportion was significantly higher in wild-type Tregs cocultured with Fli1 +/− fibroblasts than in those cocultured with wild-type fibroblasts, which were canceled by neutralizing anti-IL-33 antibody. (biomedcentral.com)
However, a recent study has demonstrated that activated fibroblasts regulate tissue-localized transdifferentiation of regulatory T cells (Tregs) into T helper type 2 cell (Th2)-like cells through IL-33 in SSc lesional skin [ 2 ], suggesting that activated dermal fibroblasts amplify an aberrant immune response characteristic of SSc. (biomedcentral.com)
7 macrophage and NIH 3T3 fibroblast cell lines and the acute dermal andoral toxicities of TBS were analyzed in rats. (academic-accelerator.com)
It is also expressed on mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells. (bdbiosciences.com)
Through integrated analysis of single cell chromatin landscapes and gene expression states, coupled with spatial transcriptomic profiling, we are able to impute fibroblast epigenomes with temporospatial resolution. (stanford.edu)
Modeling the influence of carbon nanotube and nanofiber physicochemical properties on key molecular initiating events and functional endpoints using epithelial, macrophage, and fibroblast cell models. (cdc.gov)

For many years, tattoos were thought to work by staining fibroblast cells in the dermal layer of the skin. (newswise.com)
Most of the spindle-shaped cells in all 28 cases of dermatofibroma, irrespective of histologic variant, stained positively with HSP47, indicating that skin fibroblasts are a major constituent of dermatofibroma. (medscape.com)
Fli1 haploinsufficiency increases the proportions of Th2- and Th17-like Tregs in bleomycin-induced profibrotic skin conditions, in which IL-33-producing dermal fibroblasts contribute to Th2-like Treg transdifferentiation, suggesting a critical role of Fli1 deficiency in the interaction of dermal fibroblasts with immune cells in pathological skin fibrosis. (biomedcentral.com)
The dermal papilla doesn't contribute any sort of cells to hair however it significantly adds to the flagging/enlistment. (healthncare.info)
fibroblasts, macrophages, and pole cells. (healthncare.info)
Triggers the Langerhans cells which triggers the LC to activate dermal macrophages (cells that recognize foreign matter). (onlyyourx.com)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
Histone adsorption on the surface of carbon particles significantly stimulates their ingestion by rat peritoneal macrophages, hamster kidney fibroblasts, and mouse L-cells [ 861 ], and the adsorption of polycyclic aromatic hydrocarbons (PAHs) and their nonpolar metabolites on the surface of carbon particles ingested by rat alveolar macrophages has been studied [ 862 ]. (nanomedicine.com)
In UVB-irradiated human fibroblast cells, gallic acid glucoside lowered matrix metalloproteinase-1 levels and increased the collagen content, which was indicative of a stronger anti-aging effect than that of gallic acid or arbutin. (springeropen.com)
In this study, we examined whether macrophage colony-stimulating factor could be used instead of granulocyte-macrophage colony-stimulating factor for the in vitro development of Langerhans cells from hematopoietic progenitor cells. (keyopinionleaders.com)

Integrated spatial multiomics reveals fibroblast fate during tissue repair. (stanford.edu)
We employ a stented wound model that recapitulates human tissue repair kinetics and multiple Rainbow transgenic lines to precisely track fibroblast fate during the physiologic response to skin injury. (stanford.edu)
In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)

Treatment with AAEE significantly increased type I procollagen production by cultured fibroblasts, as well as reduced ultraviolet-induced matrix metalloproteinase-1 (MMP-1) expression and MMP-2 activity in a dose-dependent manner ( p (toxicolres.org)

We think that, when tattoo pigment-laden macrophages die during the course of adult life, neighboring macrophages recapture the released pigments and insure in a dynamic manner the stable appearance and long-term persistence of tattoos," Henri explains. (newswise.com)
Tattoos and permanent make-up work by depositing insoluble pigments into the dermal skin layer (Fig. 1 ). (nature.com)

The interplay between mechanical strain and inflammation in pulmonary fibrosis remain incompletely understood.APPROACH: In this study, we used conditional KO mice to block mechanotransduction by knocking out FAK (Focal Adhesion Kinase) expression in fibroblasts, followed by induction of pulmonary fibrosis using bleomycin. (stanford.edu)
Taken together, these findings demonstrate the polarization of M1 macrophages by Mitsui-7 MWCNTs invitro and that induction of Alox5 is an important mechanism by which the MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory LMs. (cdc.gov)

Polarization of the macrophages regulates the production of proinflammatory and pro-resolving lipid mediators (LMs) to mediate acute inflammation and its resolution in a time-dependent manner. (cdc.gov)

In vitro fibroblasts from involved fascia produce increased levels of mRNA for collagen types I, III, and IV compared with adjacent dermal fibroblasts. (medscape.com)

The human lymphatic system generally includes superficial or primary lymphatic vessels that form a complex dermal network of capillary-like channels. (oncolink.org)

The addition of the angiogenin inhibitor to fibroblasts cultures suppressed the stimulating effect of exogenous angiogenin or M2(LS) conditioned media. (bvsalud.org)

While researchers agree on the abundance of Tregs in distinct dermal layers, the exact involvement of Tregs in cutaneous wound healing remains to be elucidated [ 18 ]. (biomedcentral.com)

It is named for its fingerlike projections called papillae or dermal papillae specifically, that extend toward the epidermis and contain either terminal networks of blood capillaries or tactile Meissner's corpuscles. (wikipedia.org)

These findings indicate the involvement of angiogenin in the macrophage-mediated paracrine regulation of skin fibroblasts. (bvsalud.org)

The filler regenerates the fibroblast collagen network and even stimulates elastin production. (dnaskinclinic.in)

We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. (bvsalud.org)

Although SSc pathogenesis has yet to be fully disclosed, the canonical wisdom is that dermal fibroblast activation is the final consequence of its sequential pathological processes, such as initial vascular injury due to autoimmune attack and subsequent chronic inflammation [ 1 ]. (biomedcentral.com)

Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation. (bdbiosciences.com)

Inhibiting Fibroblast Mechanotransduction Modulates Severity of Idiopathic Pulmonary Fibrosis. (stanford.edu)

Murine dermal fibroblasts and Tregs were cocultured with or without blocking antibodies against target cytokines. (biomedcentral.com)

It was found that M1(LPS) and M2a(IL-4) were characterized by moderate influence on functional activity of fibroblasts. (bvsalud.org)

Therefore, we investigated the role of Fli1 deficiency in dermal fibroblast-mediated transdifferentiation of Tregs. (biomedcentral.com)

Eosinophil degranulation may lead to fibroblast activation. (medscape.com)

Although the detailed mechanism explaining Fli1 downregulation in SSc is still unknown, an epigenetic mechanism is reported at least in dermal fibroblasts [ 12 ]. (biomedcentral.com)

The researchers transferred a piece of tattooed skin from one mouse to another and found that, after six weeks, most of the pigment-carrying macrophages were derived from the recipient, rather than the donor, animal. (newswise.com)

Dermal is additionally gotten from a Latin word meaning skin. (healthncare.info)

Anatomy39

Organisms9

Diseases17

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Extracellular matrix5

Keratinocytes3

Dendritic4

Endothelial cells2

Proliferation5

Epidermal6

Elastic fibers2

Monocyte-derived macrophages1

Uppermost layer of the dermis1

Phenotypes1

Lymphocytes1

Dermis7

Acellular dermal3

Murine Macrophages1

Monocytes2

Cytokine2

Neutrophil2

Scaffold2

Type I collag1

Connective tissue papillae2

Anti-inflammatory1

Recombinant1

Synthesis3

Keratinocyte1

Regenerative1

Cell9

Cells10

Tissue3

Significantly1

Pigments2

Induction2

Acute1

Vitro1

Superficial1

Cultures1

Cutaneous1

Fingerlike1

Findings1

Stimulates1

Human1

Subsequent1

Wound1

Fibrosis1

Antibodies1

Functional1

Tregs1

Activation1

Mechanism1

Found1

Latin1