Derives affects. Medical search. Frequent questions

In an effort to reduce the negative effects of inflammatory cytokines on tendon fibroblasts, adipose-derived mesenchymal stem cells: ASCs) were incorporated into the two in vitro models and their ability to modulate inflammation was investigated. (wustl.edu)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived MSCs (BM-MSCs). (hindawi.com)
It is known that adipocytes are derived, at least in part, from multipotent mesenchymal stem cells (MSCs). (hindawi.com)
Here, we used phenotypically uniform trophoblast stage-derived mesenchymal stem cells (T-MSCs) from embryonic stem cells, which are capable of stable production, and their exosomes (T-MSCs-Exo) to explore the molecular mechanisms involved in dopaminergic (DA) neuron protection in PD models using experimental assays (e.g., western blotting, immunofluorescence and immunohistochemistry staining). (biomedcentral.com)
Recently, other groups demonstrated that a secreted antagonist of bone morphogenetic protein (BMP) signaling, Gremlin 2 (GREM2), inhibits the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into osteoblasts and the adipogenesis of 3T3-L1 cell. (fujita-hu.ac.jp)
This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)

Adipose-derived regenerative cells (ADRCs) are a relatively cheap and ethical source of SCs. (vfu.cz)
Introduction: Adipose-derived stromal/stem cells (ASCs) have attracted attention as a promising material for regenerative medicine. (fujita-hu.ac.jp)
M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. (biomedcentral.com)

We demonstrate that exosomes secreted by patient-derived CAFs can strikingly reprogram the metabolic machinery following their uptake by cancer cells. (elifesciences.org)
We find that CAF-derived exosomes (CDEs) inhibit mitochondrial oxidative phosphorylation, thereby increasing glycolysis and glutamine-dependent reductive carboxylation in cancer cells. (elifesciences.org)
Additionally, CAFs-derived exosomes were taken up by NSCLC cells. (dovepress.com)
Moreover, exosomal miRNA-130a was transferred from CAFs to recipient NSCLC cells and knockdown of miRNA-130a reversed the effect of CAFs-derived exosomes during chemoresistance of NSCLC cells. (dovepress.com)
Taken together, these results suggest that CAFs-derived exosomes confer cisplatin resistance of NSCLC cells through transferring miRNA-130a and that PUM2 is a critical factor for packaging miRNA-130a into exosomes. (dovepress.com)
There were decreases in ALT, liver necrotic areas, and the extent of apoptosis indicated by the single-stranded DNA index of groups that received multiple injections of MSC-derived exosomes, but an increase in the Ki-67 index. (biomedcentral.com)
In this study, we investigated the suppressive effect of exosomes on an immune-induced liver injury model. (biomedcentral.com)
The suppressive effects of MSC-derived exosomes and the MSCs in this injury model were evaluated by the level of plasma alanine aminotransferase (ALT), histopathological examinations, the messenger RNA (mRNA) expression of pro- and anti-inflammatory cytokines, and the population alteration of regulatory T cells (Treg) among non-parenchymal liver cells (NPCs). (biomedcentral.com)

Vaccine-derived polioviruses and children with primary immunodeficiency, Iran, 1995-2014. (cdc.gov)
Circulating vaccine-derived polioviruses (cVDPVs) can emerge and cause paralysis in areas with low population immunity to polioviruses. (cdc.gov)
Emergency outbreak response is continuing in all locations affected by circulating vaccine-derived polioviruses. (who.int)

Circulating vaccine-derived poliovirus (cVDPV) outbreaks* can occur when oral poliovirus vaccine (OPV, containing one or more Sabin-strain serotypes 1, 2, and 3) strains undergo prolonged circulation in under-vaccinated populations, resulting in genetically reverted neurovirulent virus ( 1 , 2 ). (cdc.gov)
cVDPV outbreaks affected 46 countries, 17 (37%) of which reported their first post-switch cVDPV2 outbreak. (cdc.gov)
However, on rare occasions, in under-immunized populations, the live attenuated virus originally contained in OPV can mutate into circulating vac- cine-derived poliovirus (cVDPV). (who.int)

The nociceptive effects of i.p administration of a synthetic peptide (CgA4-16) derived from chromogranin A (CgA) were studied on a model of inflammatory (somato-visceral) pain. (nih.gov)
While i.p CgA4-16 alone did not produce any effect, the peptide increased the number of abdominal constrictions induced by i.p AA administration in a dose-related manner. (nih.gov)
Taken together, these data suggest for the first time that a CgA-derived peptide may modulate inflammatory pain. (nih.gov)
derived peptide LPLLR through inhibiting a-glucosiase and a-amylase, and alleviating insulin resistance of heptic HepG2 cells, Journal of Functional Foods, 103944. (bioinfor.com)
We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). (unimib.it)
From the Clinical Editor: Bi-functionalized liposomes with phosphatidic acid and a modified ApoE-derived peptide were demonstrated to influence Aβ aggregation/disaggregation as a potential treatment in an Alzheimer's model. (unimib.it)

Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)

However, the pilot study was underpowered, and additional animals and assays are required to fully evaluate the effect of ASCs in vivo. (wustl.edu)
In addition, to assess whether GREM2 affects adipogenesis, ASCs (purchased from a vendor) were cultured to induce adipogenesis with recombinant GREM2 protein, and siRNA-induced GREM2 knockdown experiment was also performed using aged ASCs. (fujita-hu.ac.jp)

To examine the effect of inflammatory cytokines on tendon fibroblasts, the native cell type that must eventually re-build the injured tendon, we established two in vitro models of inflammation: one induced by exogenous IL-1β and one induced by macrophages: the primary cellular source of IL-1β). (wustl.edu)
We have here examined various cell-derived cytokines for their ability to enhance both the cellular outgrowth of newly infected B cells and the clonability of infected B cells and lymphoblastoid cell lines. (lu.se)

Depending on the way of exposure it can be necessary to specify different DNELs for affected persons (employees, consumer, children, pregnant women etc. (wikipedia.org)
Issues that were discussed concerned the usefulness and acceptability of precaution- based NRVs as a substitute for health-based occupational exposure limits (OELs) and derived no-effect levels (DNELs) for manufactured nanoparticles (NPs). (cdc.gov)

Effect of milk-derived bioactive peptides on the lipid stability and functional properties of beef nuggets. (bvsalud.org)

abstract = "Thorium oxalate is easy to prepare, but the derived oxide powders retain the platelet morphology of the primary oxalate. (sckcen.be)

In this study, we demonstrated that NSCLC-derived CAFs were innately resistant to cisplatin treatment and CAFs-conditioned medium significantly promoted the survival rate of NSCLC cells after cisplatin treatment. (dovepress.com)
This study indicates that CAFs-derived exosomal miRNA-130a may be a potential therapeutic target for cisplatin resistance in NSCLC. (dovepress.com)

It is difficult to consider or evaluate the effect of an individual measurement error (measurement of axle load) on performance predictions. (dot.gov)
This research is undertaken to evaluate the effect of MSC-derived exosome on concanavalin-A (con-A)-induced liver injury. (biomedcentral.com)

BDNF (brain-derived neurotrophic factor) is a biomarker of neuroplasticity linked with better functional outcomes after stroke. (edu.au)
Introduction and aims: Brain-Derived Neurotrophic Factor (BDNF) as one of the factors associated with neuromuscular performance and cognitive function is reduced with increasing age. (ac.ir)

Effect of antioxidant of PD-MSCs in TAA-treated ovary in ex vivo . (aging-us.com)
However, the effect of high glucose on adipogenic differentiation of human bone marrow and gestational tissue-derived MSCs is still poorly characterized. (hindawi.com)
This study aims to investigate the effects of high glucose on proliferation as well as adipogenic and osteogenic differentiation of human MSCs derived from bone marrow and several gestational tissues including chorion, placenta, and umbilical cord. (hindawi.com)
Although high glucose transiently downregulated the expression levels of some osteogenic genes examined, its effect on the osteogenic differentiation levels of the MSCs is not clearly demonstrated. (hindawi.com)
The knowledge gained from this study will increase our understanding about the effect of high glucose on adipogenic differentiation of MSCs and might lead to an improvement in the diabetic treatment in the future. (hindawi.com)
Although the effects of high glucose on the proliferation and differentiation of rat and mouse BM-MSCs have been previously reported, the effects of high glucose on biological properties of human MSCs derived from gestational tissues which, due to their ease of isolation by noninvasive procedure, are considered more suitable sources of MSCs for clinical applications have yet to be determined. (hindawi.com)

The pooled estimate for the effect of reducing amyloid levels by 0.1 standardized uptake value ratio units was an improvement in the mini-mental state examination score of 0.03 (95% confidence interval −0.06 to 0.1) points. (bmj.com)

Unlike the surface area of water-washed xerogel, that of the ethanol-washed xerogel was not affected by the silica concentration of initial solution. (psu.edu)
Park, M, Menon, VC & Komarneni, S 1998, ' Ethanol washing effect on textural properties of the sodium silicate-derived silica xerogel ', Journal of Sol-Gel Science and Technology , vol. 12, no. 1, pp. 15-20. (psu.edu)

Naturally derived tendon scaffolds have the potential to improve the treatment of flexor tendon injuries. (jsoaonline.com)
This study demonstrates that the tensile properties of seeded, naturally derived tendon scaffolds will degrade rapidly in the absence of cyclic strain. (jsoaonline.com)

The derived no-effect level (DNEL) is the level of exposure to a substance above which humans should not be exposed. (wikipedia.org)

Erasmus University Thesis Repository: How does transformational leadership and the risk deriving from customer concentration affect firm size and how does transformational leadership moderate this risk in nascent ventures? (eur.nl)
Alirocumab is a monoclonal antibody derived from biotechnological processes, the use of which will not alter the concentration or distribution of the substance in the environment. (janusinfo.se)

Poliomyelitis is a highly infectious viral disease, which mainly affects young children. (who.int)

At the same time, outbreak responses to both circulating vaccine-derived poliovirus type 1 and circulating vaccine-derived poliovirus type 2 are continuing in order to urgently stop outbreaks of all three strains. (who.int)

type 2 immunization programs in April 2016 in vaccine-derived, or Sabin) in any sample was eradicated in 1999, and type 3 was a global switch from trivalent OPV from any source is generally considered to last seen in 2012. (who.int)

Affected infants may have severe developmental delay, weak muscle tone (hypotonia), muscle stiffness, difficulty moving, and involuntary writhing movements of the limbs (athetosis). (medlineplus.gov)

This study indicates that the textural properties of sodium silicate-derived xerogels are further enhanced by using ethanol as washing solvent. (psu.edu)

That is the goal of this paper, where different precipitation strategies were used and their effect on powder characteristics and pellet synthesis was investigated. (sckcen.be)

The points in the figures showing noobserved-adverse-effect levels (NOAELS) or lowest-observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
Estimates of exposure levels posing minimal risk to humans (MRLs) have been made, where data were believed reliable, for the most sensitive noncancer effect for each exposure duration. (cdc.gov)

Fig. 2: Factors affecting CH 4 long-wave surface instantaneous radiative forcing. (nature.com)
This study addresses only factors affecting the reliability of axle loading data collected using WIM systems. (dot.gov)
Our results show that the murine thymoma cell line EL-4 is superior to peripheral blood mononuclear cells in both cellular outgrowth and cloning experiments, whereas monocyte-derived factors and monocyte cell lines were less capable than peripheral blood mononuclear cells in enhancing cellular outgrowth and cloning. (lu.se)
The Agency sought information about the overall utility, advantages, and limitations of hair analysis and how these factors would affect informed decisions on a site-specific basis. (cdc.gov)

This review focuses on the 'out-of-the-box' synthetic techniques capable of deriving HPC with superior application profiles. (nassg.org)

however, deeper understanding of their effect on the cellular level is needed. (vfu.cz)

Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)

Therefore, it is not expected to have an adverse effect on the environment. (janusinfo.se)

Chiu LC, Kong CK and Ooi VE: Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells. (spandidos-publications.com)
Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
However, animal models lack human genetic features and some brain region identities, such as outer subventricular zone, making it hard to figure out how these drugs affect central nervous system ( 7 , 8 ). (frontiersin.org)
This product category contains extracellular proteins of human, murine or rat sequence that, for the most part, initiate or otherwise affect signaling through cell surface receptors. (peprotech.com)
Conclusions: The data support the long-term therapeutic potential of ESC-derived human striatal progenitor grafts for the replacement of degenerated striatal neurons in HD and suggest that EE can effectively accelerate the maturation and promote the integration of human striatal cells. (lu.se)

Depending on the specific enzyme affected, porphyria may manifest clinically in an acute or non-acute manner, and the signs and symptoms may be predominantly neurovisceral, psychiatric, cutaneous, or some combination of those. (medscape.com)

have reported that IOC2 derived from EEG signals has also been proposed as a non-invasive guide to indicate the depth of anaesthesia [11, 12]. (researchgate.net)
Aromatic l-amino acid decarboxylase (AADC) deficiency is an inherited disorder that affects the way signals are passed between certain cells in the nervous system. (medlineplus.gov)

Attached properties can be used to define effect parameters that respond to runtime property changes. (microsoft.com)
This article demonstrates using attached properties to pass parameters to an effect, and changing a parameter at runtime. (microsoft.com)
Parameters can then be passed to the effect by adding the attached properties, and property values, to the appropriate control. (microsoft.com)

Background Dexmedetomidine has analgesic properties, but the intraoperative analgesic effect of dexmedetomidine is often masked by the effects of other general anaesthetics. (researchgate.net)
http://tools.oasis-open.org/issues/browse/ODATA-513?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel&focusedCommentId=34753#action_34753 ] Michael Pizzo commented on ODATA-513: ------------------------------------- I think this is a fall-out of the rule we had that your annotations only define mapping for the defined properties ,not the properties derived from the base type. (oasis-open.org)
For derived types this rule applies only to properties directly defined by the derived type. (oasis-open.org)

Recent decreases in fossil-fuel emissions of ethane and methane derived from firn air. (nature.com)

Of the observed changes, the most dramatic effect was the greater than 4000-fold up-regulation in the expression of the pro-inflammatory factor IL-1β. (wustl.edu)

Natural raw-materials such as biomass-biopolymer derived hierarchical nanostructured carbons are especially attractive for their uniform pore dimensions which can be adjustable over a wide range of length scales. (nassg.org)

Since this change doesn't affect already compiled code, extensions and plug-ins are typically not affected. (lu.se)

The present results also suggest that one potential role of the MP6-derived thioredoxin could be the up regulation of IL-6 receptor expression in EBV-infected B cells. (lu.se)
AADC deficiency may affect the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature. (medlineplus.gov)

Alirocumab is a protein derived from biotechnological processes. (janusinfo.se)

Furthermore, the breast carcinoma cells exhibited lower cyclin D1 and cyclin E levels but higher cyclin B1 level after incubation with the CHL showing that these cyclin changes may be important for the antiproliferative effect of the CHL. (spandidos-publications.com)
Although methods have been established to derive these levels (Barnes et al. (cdc.gov)

article{osti_1424718, title = {Effect of hydrodynamical-simulation-inspired dark matter velocity profile on directional detection of dark matter}, author = {Laha, Ranjan}, abstractNote = {Directional detection is an important way to detect dark matter. (osti.gov)

The standard errors used to define reliability in the MEPDG are distress-specific and were derived from the calibration of the transfer functions. (dot.gov)

One of the main biofuels type are the biofuels that is derived from vegetable oils. (akademiabaru.com)
I.e., we said that if I had a base complex type 'persontype' and derived types 'customertype' and 'salespersontype', then I would have separate 'person', 'customer' and 'salesperson' terms, and I would annotate an entity by applying each term separately, mapping only those PropertyValues defined in that type (not those derived from the base type). (oasis-open.org)
The Democratic Republic of the Congo continues to be affected by both type 1 and type 2 circulating vaccine-derived poliovirus, particularly in the east of the country. (who.int)

Hemin (plasma-derived intravenous heme) is the definitive treatment and mainstay of management. (medscape.com)

WHO's International Travel and Health recommends that all travellers to polio-affected areas be fully vaccinated against polio. (polioeradication.org)

Furthermore, ATSDR acknowledges additional uncertainties inherent in the application of the procedures to derive less than lifetime MRLs. (cdc.gov)

How will the House GOP health care bill affect individual market premiums? (brookings.edu)
Countries affected by poliovirus circulation are subject to temporary recommendations issued by the Emergency Committee of the International Health Regulations on Poliovirus, under the auspices of the Public Health Emergency of International Concern. (polioeradication.org)

While many reactions to the CBO analysis focused on how the AHCA would affect insurance coverage, the bill's effects on individual market insurance premiums have also received considerable attention. (brookings.edu)

To determine the possible mechanisms involved in CgA4-16 produced pronociceptive effect, i.p diltiazem or indomethacin were tested. (nih.gov)

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