• Her 1954 paper that quantified the synergistic effects of purine antagonists with pyrimidine and folic acid antagonists has become a classic in the field. (cuny.edu)
  • Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. (pharmacycode.com)
  • Nucleoside analogues (NAs) are a family of compounds which include a variety of purine and pyrimidine derivatives, widely used as anticancer and antiviral agents. (bvsalud.org)
  • it inhibits the enzyme dihydrofolate reductase, which is essential for purine and pyrimidine synthesis. (medscape.com)
  • The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. (lookformedical.com)
  • Horton Derek, Sakata Masakatsu: Synthesis of purine and pyrimidine 2′-deoxynucleosides from a 1,2-dithio sugar precursor. (iupac.org)
  • Hitchings, who would later become a member of the National Academy of Sciences, "talked about purines and pyrimidines, which I must confess I'd never even heard of up to that point, and it was really to attack a whole variety of diseases by interfering with DNA synthesis. (cuny.edu)
  • For their ability to compete with physiological nucleosides, NAs act as antimetabolites exerting their activity by interfering with the synthesis of nucleic acids. (bvsalud.org)
  • 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5′-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. (illnesshacker.com)
  • Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis. (illnesshacker.com)
  • Azathioprine antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and proteins. (illnesshacker.com)
  • Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. (illnesshacker.com)
  • Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)
  • Some agents function as antimetabolites to decrease DNA and RNA synthesis and are used to treat a number of autoimmune conditions. (medscape.com)
  • Inhibits purine synthesis and proliferation of human lymphocytes. (medscape.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
  • Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism. (lookformedical.com)
  • Baker David C., Horton Derek: Synthesis and stereochemical characterization of a series of five-carbon, acyclic-sugar derivatives of 1,6-dihydro-6-thioxopurine (6-mercaptopurine). (iupac.org)
  • An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. (targetmol.com)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in. (targetmol.com)
  • While other cell types are able to use salvage pathways, T- and B-lymphocyte proliferation is a mechanism heavily dependent on the de novo synthesis of purines. (drugbank.com)
  • Azathioprine is a purine analog with cytotoxic and immunosuppressive activity. (illnesshacker.com)
  • Azathioprine (AZA), one of the antimetabolite drugs, is a purine analog that is more potent than the prototype 6-mercaptopurine, as an inhibitor of cell replication. (illnesshacker.com)
  • [4] Azathioprine belongs to the purine analogues subclass of antimetabolites family of medications. (wikizero.com)
  • Mycophenolic acid is a potent immunosuppressant agent that inhibits de novo purine biosynthesis. (drugbank.com)
  • Immunosuppression likely occurs because of the ability of the drug to inhibit purine biosynthesis. (illnesshacker.com)
  • Blieszner Kathleen C., Horton Derek, Markovs Robert A.: Acyclic-sugar purine nucleosides derived from d-glucose: stereochemical correlations in acyclic-sugar derivatives unequally substituted at c-1. (iupac.org)
  • A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. (medindex.am)
  • Mycophenolic acid is an antimetabolite immunosuppressant indicated for prophylaxis of organ rejection in adult patients receiving kidney transplants and in pediatric patients at least 5 years of age and older who are at least 6 months post kidney transplant. (drugbank.com)
  • From her first publication in 1939 to her last in 1998, Trudy was involved in the investigation of purines and purine analogs as chemotherapeutic agents. (cuny.edu)
  • Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogs such as allopurinol. (illnesshacker.com)
  • Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. (pharmacycode.com)
  • A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety. (lookformedical.com)
  • The most interesting opening was at Burroughs Wellcome, where biochemist George Hitchings was trying to make antagonists to nucleic acid derivatives. (cuny.edu)
  • She elucidated some alterations in metabolic pathways that led to resistance to the purine antagonists. (cuny.edu)
  • Inosine monophosphate is oxidised by the enzyme inosine monophosphate dehydrogenase , yielding xanthosine monophosphate , a key precursor in purine metabolism. (wikidoc.org)
  • It is a derivative of the amino acid tryptophan and has been found to exhibit various biological activities. (thebiotek.com)
  • It is used in the treatment of a variety of autoimmune diseases including granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from Inherited Metabolic Diseases (IMD) inhibition. (wikidoc.org)
  • Working in collaboration with George H. Hitchings, she synthesized a large number of purines, including 6-mercaptopurine and thioguanine, and investigated their loci of action in microbiological systems. (cuny.edu)
  • Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities. (targetmol.com)
  • The results of his scientific research include: Determination of the effect of substitution of hydroxyl group by fluorine atom in a series of compounds, including (R,R)-tartaric acid derivatives and D-glucose, on their conformational freedom. (wikipedia.org)
  • A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. (lookformedical.com)
  • his thesis Theoretical analysis of selected (R,R)-tartaric acid derivatives, supervised by Jacek Rychlewski, was awarded the first prize in Faculty's Contest for the best MSc dissertation of that year. (wikipedia.org)
  • Beta-carotene derivatives have marked effects on keratinizing epithelia. (medscape.com)
  • A benzoic acid derivative belonging to the meglitinide class of antidiabetic agents. (medindex.am)