Chemical CompoundsTransmission electron mCarbonyl compoundsAnalogsButaneReactivityCyclicBicyclicPyridineWhose moleculesIntermediatesReagentsSynthesis of newPhenylCycloadditionBenzeneDiels-AlderReactionsCompositionsEthylCompriseOrganic ChemistryMolecularReductionStructuresAsymmetricReactionInventionNaturallyCatalystCarbonWidelyPresentActivityFormulaStructureNatural productsGroupProcessPropertiesApplication
Chemical Compounds2
- Alkanes are chemical compounds that consist only of hydrogen and carbon atoms and are bonded exclusively by single bonds without any cycles. (absoluteastronomy.com)
- An organic compound is any member of a large class of gaseous, liquid, or solid chemical compounds whose molecules contain carbon. (absoluteastronomy.com)
Transmission electron m1
- Also, the morphological alterations induced in the yeasts by the experimental compounds were evaluated by fluorescence and transmission electron microscopy. (biomedcentral.com)
Carbonyl compounds1
- The review is summarized and systematized the published data on the multicomponent reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and nucleophilic reagents. (researchgate.net)
Analogs2
- gamma-Aminobutyric Acid/*analogs & derivatives. (reference.md)
- Analogs or derivatives of scopolamine. (nih.gov)
Butane2
- Bicyclo[1.1.0]butane carboxylic amides emerged as a new class of Cys-focused electrophiles. (enamine.net)
- The chemistry of bicyclo[1.1.0]butane (BCB) derivatives is vividly developing. (enamine.net)
Reactivity3
- In his study, the reactivity of bicyclo[1.1.0]butyl aryl sulfones was similar to that of acrylamides in GSH-assay. (enamine.net)
- PRMs of monoterpenes are challenging to produce due to the high chemical reactivity and low vapour pressures of monoterpenes and also their propensity to convert into other compounds, including other terpenes. (copernicus.org)
- Chapter 1 is an introduction to known annulation reactions employing the versatile reactivity of 2-pyrone derivatives. (escholarship.org)
Cyclic5
- The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases or disorders which are associated with a disturbed cGMP balance. (justia.com)
- 1 R *,2 R *,3 R *,4 S *)-3-Amino-6,6-bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ol ( 13 ) was prepared from (bicyclo[2.2.1]hept-5-ene-2,2-diyl)dimethyl dibenzoate ( 7 ) via cis -diol 8 , cyclic sulfate 10 , and azide 12 . (cas.cz)
- Certain cyclic sulfates (e.g. 23) together with various of their precursor sulfites (e.g. 21 and 22) have been prepared from the corresponding chiral, non-racemic bicyclo[2.2.2]octane-2,3-diols (e.g. 20). (edu.au)
- Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. (lookformedical.com)
- Nanoformulated calix[8]arenes functionalized with N -heterocyclic carbene (NHC)-palladium complexes were found to be efficient nano-reactors for Suzuki-Miyaura cross-coupling reactions of water soluble iodo- and bromoaryl compounds with cyclic triol arylborates at low temperature in water without any organic co-solvent. (mdpi.com)
Bicyclic1
- The present method has been employed to construct synthetically valuable bicyclo[3.3.1]alkenone derivatives and pyrrolidine-ring-containing bicyclic indole compounds. (researcher-app.com)
Pyridine4
- Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)
- These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
- The present invention relates to 5,6-diphenyl- pyridine-3-carboxamide derivatives, to the preparation thereof and to the application thereof in therapeutics. (allindianpatents.com)
- 5,6-Diphenyl-2-pyridine derivatives are described in the international patent application published under No. WO 92/02513. (allindianpatents.com)
Whose molecules1
- The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (lookformedical.com)
Intermediates2
- In addition, compound intermediates relating to these processes are also disclosed. (justia.com)
- 7-Substituted bicyclo[3.2.0]hept-2-en-6-one derivatives were identified as intermediates towards biologically interesting compounds. (princeton.edu)
Reagents1
- Raw materials and reagents used in the preparation method have the advantages of low cost, stable chemical property and convenience in long-term storage and the content of an impurity cis-isomer in the prepared afatinib compound is very low. (lookchem.com)
Synthesis of new3
- We offer over 700 compounds from stock and continuously work on the synthesis of new derivatives. (enamine.net)
- We are continuously working on the enumeration and synthesis of new strained bicyclobutane derivatives. (enamine.net)
- Taken together, our data demonstrate that arylquinuclidine derivatives could be useful as lead compounds for the rational synthesis of new antifungal drugs. (biomedcentral.com)
Phenyl1
- The most potent arylquinuclidine derivative (3-[1'-{4'-(benzyloxy)-phenyl}]-quinuclidine-2-ene) (WSP1267) had a MIC 50 of 2 μg/ml for all species tested and MIC 90 varying from 4 μg/ml to 8 μg/ml. (biomedcentral.com)
Cycloaddition3
- An improved synthesis of 7-alkyl-7-bromobicyclo[3.2.0]hept-2-en-6-ones by palladium- catalysed [π2a+π2s] cycloaddition of α-bromoalkyl ketenes to cyclopentadiene is described. (princeton.edu)
- Such diols are obtained by engaging the corresponding enzymatically derived and enantiomerically enriched or homochiral cis-1,2-dihydrocatechol (e.g. 10) or certain derivatives in either inter- or intra-molecular Diels-Alder cycloaddition reactions. (edu.au)
- 1-Acylbenzimidazoles undergo 1,3-dipolar cycloaddition with nitrileimine to produce derivatives of the 1 H ,9 H -1,2,4-triazolo[4,3-a]benzimidazole system, followed by a rapid in situ substitution at 9a-position by the benzhydrazidoyl moiety. (heterocycles.jp)
Benzene2
- Whereas 7 and 8 on direct irradiation in benzene gave rise exclusively to the bicyclo[2.2.0]hexane derivatives 9 and 10, respectively, from 3 in addition to the Diels-Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate (5) with benzvalene (4), norbornene, and norbornadiene afforded the azo compounds 7 and 8. (uni-wuerzburg.de)
- Whereas 7 and 8 on direct irradiation in benzene gave rise exclusively to the bicyclo[2.2.0]hexane derivatives 9 and 10, respectively, from 3 in addition to the bicyclo[2.2.0]hexane 11, the diolefin 1l was formed. (uni-wuerzburg.de)
Diels-Alder1
- Diels-Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate (5) with benzvalene (4), norbornene, and norbornadiene afforded the azo compounds 7 and 8. (uni-wuerzburg.de)
Reactions2
- A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. (absoluteastronomy.com)
- The proximity of the bicyclobutane systems in 1l causes unprecedented reactions leading to cage compounds. (uni-wuerzburg.de)
Compositions4
- The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. (justia.com)
- Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue. (justia.com)
- The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. (justia.com)
- Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. (justia.com)
Ethyl1
- Reaction of amines 13 , 18 , and 19 with ethyl N -((2 E )-3-ethoxymethacryloyl)carbamate afforded thymine derivatives 28a - 28c . (cas.cz)
Comprise1
- The compounds of formula (I) may comprise one or more asymmetric carbon atoms- They may therefore exist in the form of enantiomers or of diastereoisomers. (allindianpatents.com)
Organic Chemistry1
- In organic chemistry, a hydrocarbon is an organic compound consisting entirely of hydrogen and carbon. (absoluteastronomy.com)
Molecular3
- Molecular modelling was used to identify a spiro-bicyclo[2.2.2]octane skeleton as a suitable substitute for the rigid paclitaxel core. (lu.se)
- Hydrogenation, to treat with hydrogen, also a form of chemical reduction, is a chemical reaction between molecular hydrogen and another compound or element, usually in the presence of a catalyst. (absoluteastronomy.com)
- A chemical formula or molecular formula is a way of expressing information about the atoms that constitute a particular chemical compound. (absoluteastronomy.com)
Reduction2
- In addition, methodology for the synthesis of bridgehead substituted bicyclo[2.2.2]octane-2,6-diones were developed followed by evaluation of the products as substrates in the asymmetric baker's yeast reduction. (lu.se)
- It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group. (lookformedical.com)
Structures1
- The structures of these compounds are closely related both to each other and to the TlSe-structure. (degruyter.com)
Asymmetric1
- Herein we reported a palladium-catalyzed asymmetric intramolecular alkene-alkyne coupling of alkyne-tethered cyclopentenes, affording a library of enantionenriched bicyclo[3.2.1]octadienes in excellent yields and enantioselectivities (mostly >99 % ee). (bvsalud.org)
Reaction2
- The reaction is investigated in the field of piperidine, piperazine, and tropane derivatives. (heterocycles.jp)
- Both tungsten compounds are formed by reaction of water and oxygen with the acetylene complex PPh 4 [WCl 5 (Ph - C ≡ C - C (Br) = C(Br) -Ph)] in CH 2 Cl 2 solutions, and in the presence of PPh 4 Cl. (degruyter.com)
Invention7
- The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and disorders and for preparing pharmaceuticals for this purpose. (justia.com)
- The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. (justia.com)
- The compounds according to the present invention are useful as inhibitors of PERK. (justia.com)
- The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
- These salts are advantageously prepared with pharmaceutically acceptable salts, but the salts of other acids that are useful, for example, for purifying or isolating the compounds of formula (I) are also part of the invention. (allindianpatents.com)
- The invention discloses a preparation method of a quinazolinyl butylene amide compound, which effectively reduces the generation of impurities in the synthesis process by selecting a proper mixed alkali system and using a mixture of 1, 5-diaza-bicyclo [4.3. (lookchem.com)
- The invention provides a novel preparation method of an afatinib compound. (lookchem.com)
Naturally2
- They occur naturally as N-acetyl derivatives in peptidoglycan, the characteristic polysaccharide composing bacterial cell walls. (lookformedical.com)
- Terpenes are a large and diverse family of naturally occurring organic compounds that are a major biosynthetic building block (de Meijere et al. (copernicus.org)
Catalyst1
- In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
Carbon3
- For historical reasons discussed below, a few types of carbon-containing compounds such as carbides, carbonates, simple oxides of carbon, and cyanides, as well as the. (absoluteastronomy.com)
- A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. (lookformedical.com)
- If X, Y and Z were just carbon atom (with hydrogens), it would be bicyclo[3.3.1]nonane. (stackexchange.com)
Widely2
- The antifungal drugs most widely used to treated fungal infections are compounds that inhibit cytochrome P450-dependent C14α-demethylase (CYP51), but other enzymes of this pathway, such as squalene synthase (SQS) which catalyses the first committed step in sterol biosynthesis, could be viable targets. (biomedcentral.com)
- Metolachlor is an organic compound that is widely used as an herbicide. (chemrobotics.in)
Present1
- Other functionalities present within the title compounds can be chemoselectively manipulated without adversely affecting the associated sulfate residues. (edu.au)
Activity5
- Dose-dependent-Dependent manner with IC50 values of six.0 and 5.5 m, as well as the activity of t Mouse ACAT liver microsomes in the dose-Dependent manner Vargatef ic50 with IC50 values of one.five M for two compounds. (mirnamimics.com)
- The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
- All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
- Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
- These compounds are presented as having antithrombotic, vasodilating and anti- inflammatory activity. (allindianpatents.com)
Formula4
- Cyclobutane is an organic compound with the formula 4. (absoluteastronomy.com)
- Compound 3 crystallizes in space group P2 1 /n with lattice parameters a = 8.552(6) Å, b= 16.953(2) Å, c- 12.157(9) Å and β= 103.46(2)° with four formula units in the unit cell. (degruyter.com)
- The compounds of formula (I) may exist in the form of bases or of addition salts with acids. (allindianpatents.com)
- the compound of the formula VI and dimethylamine finally synthesize the compound of the formula VII, that is to say, an afatinib refined product is obtained. (lookchem.com)
Structure4
- An iptycene is an aromatic compound composed of varying number of arene subunits bound to a bridged bicyclo-octatriene core structure. (wikipedia.org)
- The structure of cage compound 10 was established by a singlc-crystal X-ray analysis of dialcohol 11 prepared from 20 and methyllithium. (uni-wuerzburg.de)
- The structural relations to the variants of the W-structure type of compounds in the system Li-Sn and Na-Sn are shown. (degruyter.com)
- The X-ray structure, IR, Raman, 1 H NMR , and 13 C NMR spectra of this first organogermyl magnesium compound are reported. (degruyter.com)
Natural products1
- Bicyclo[3.2.1]octadiene compounds and derivatives exist in a number of natural products and bioactive compounds. (bvsalud.org)
Group1
- the first group contains c. baileyanum, c. oliveri and one chemotype of c. laubatii, and they produce oils rich in Me eugenol and bicyclo- germacrene (c. baileyanum), safrole, Me eugenol elemicin and bicyclogermacrene (c. laubatii), camphor, safrole and Me eugenol (c. oliveri). (erowid.org)
Process2
- The process is commonly employed to reduce or saturate organic compounds. (absoluteastronomy.com)
- In contrast, bis(bicyclobutane) ll was converted by 1 equiv of thiophenol into cagc compound 30 in a process involving both the strained a systems. (uni-wuerzburg.de)
Properties1
- 1.6 What do standard heats of formation tell us about chemical bonding and ground-state properties of organic compounds? (dattanibookagency.in)
Application1
- Inverse agonist or antagonist 2,3-diphenylpyridine derivatives of cannabinoid CB1 receptors are described in international patent application WO 2003/082191. (allindianpatents.com)