• β-cyclodextrin (β-CD) and its derivatives have been widely used to prepare inclusion complexes. (uitm.edu.my)
  • Physico-Chemical and Pharmaco-Technical Characterization of Inclusion Complexes Formed by Rutoside with β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin Used to Develop Solid Dosage Forms by: Teodora Balaci, et al. (uitm.edu.my)
  • Characterization of pioglitazone cyclodextrin complexes: Molecular modeling to in vivo evaluation by: Dinesh M Bramhane, et al. (uitm.edu.my)
  • With a hydrophobic interior and hydrophilic exterior, cyclodextrins form complexes with hydrophobic compounds. (wikipedia.org)
  • In contrast, the exterior is sufficiently hydrophilic to impart cyclodextrins (or their complexes) water solubility. (wikipedia.org)
  • This twofold alkylation was performed in aqueous solution, whereby α-, and randomly methylated β-cyclodextrin were used as adequate phase transfer catalysts and the cyclodextrin-guest complexes were characterized by 1 H NMR and 2D NMR ROESY spectroscopy. (beilstein-journals.org)
  • The invention also concerns a method for preparing said derivatives, inclusion complexes and organized surfactant systems containing same. (cea.fr)
  • Yet, Lee goes on to explain that as cyclodextrin formulations are intended to be solutions, the complexes are governed by thermodynamics and have different equilibrium binding constants. (pharmtech.com)
  • MD simulation indicated that ibuprofen could form the stable complexes with β -, γ -, and HP- β -cyclodextrins, but not for alpha cyclodextrin. (hindawi.com)
  • For example, ibuprofen and cyclodextrin complexes have been studied using different experimental techniques [ 11 , 12 ]. (hindawi.com)
  • Simultaneously, experiments on solubilization of the first chromone-2-carboxamides with cyclodextrins, cyclic oligosacharides known to form water-soluble inclusion complexes, were performed. (uni-wuerzburg.de)
  • Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is an alkylated derivative of beta-CD with the capacity to form inclusion complexes with suitable molecules. (scite.ai)
  • Typical cyclodextrins contain a number of glucose monomers ranging from six to eight units in a ring, creating a cone shape: α (alpha)-cyclodextrin: 6 glucose subunits β (beta)-cyclodextrin: 7 glucose subunits γ (gamma)-cyclodextrin: 8 glucose subunits The largest well-characterized cyclodextrin contains 32 1,4-anhydroglucopyranoside units. (wikipedia.org)
  • In a mouse model of atherosclerosis, subcutaneous injections of beta-cyclodextrin polymer (βCDP) significantly inhibited plaque growth compared to monomeric hydroxypropyl-beta-cyclodextrin (HPβCD) at the same dose (1 g/kg). (pharmaexcipients.com)
  • Monosubstituted derivatives of γ-cyclodextrin (γ-CD) are suitable building blocks for supramolecular polymers, and can also serve as precursors for the synthesis of other regioselectively monosubstituted γ-CD derivatives. (beilstein-journals.org)
  • CGTases produce mixtures of cyclodextrins, thus the product of the conversion results in a mixture of the three main types of cyclic molecules, in ratios that are strictly dependent on the enzyme used: each CGTase has its own characteristic α:β:γ synthesis ratio. (wikipedia.org)
  • The complex formation drives the conversion of starch towards the synthesis of the precipitated cyclodextrin, thus enriching its content in the final mixture of products. (wikipedia.org)
  • 3. Rather, MY, Ara KZG, Nordberg Karlsson E, Adlercreutz P. ( 2015 ) Characterization of cyclodextrin glycosyltransferases (CGTases) and their application for synthesis of alkyl glycosides with oligomeric head group. (lu.se)
  • Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds. (wikipedia.org)
  • Gamma-cyclodextrin (γ-CD) is a cyclic α-1,4-glucan linked oligosaccharide that is widely used in the food and pharmaceutical industries. (sigmaaldrich.com)
  • HYDRODEX cyclodextrin phases are made of cyclic. (mn-net.com)
  • HYDRODEX cyclodextrin phases are made of cyclic oligosaccharides consisting of seven (β-cyclodextrin) or eight (γ-cyclodextrin) glucose units bonded through α-1,4-linkages. (mn-net.com)
  • We describe here the impact of linear (maltodextrin) or cyclic (cyclodextrins, CDs) dextrins and their interaction with two fungicides (difenoconazole and tebuconazole), through measurements of growth in 20 A. fumigatus strains. (fortunejournals.com)
  • The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. (hindawi.com)
  • Docking results from AutoDock Vina program showed that the scoring of complexation capability between ibuprofen and cyclodextrins is alpha ( α ), gamma ( γ ), beta ( β ), and HP-beta-cyclodextrins, which indicated similar ranking with the results from phase, solubility diagram experiments. (hindawi.com)
  • From the search of Web of Science, there are over 700 research papers about theoretical calculations on cyclodextrins complexation with various drugs until 2014. (hindawi.com)
  • There are also a few theoretical research papers on the complexation of ibuprofen and cyclodextrins [ 13 , 14 ]. (hindawi.com)
  • 5. Rather, MY, Nordberg Karlsson E, Adlercreutz P. ( 2015 ) Complexation of alkyl glycosides with α-cyclodextrin can have drastically different effects on their conversion by glycoside hydrolases. (lu.se)
  • The inclusion compounds of cyclodextrins with hydrophobic molecules are able to penetrate body tissues, these can be used to release biologically active compounds under specific conditions. (wikipedia.org)
  • Purification of the three types of cyclodextrins takes advantage of the different water solubility of the molecules: β-CD which is poorly water-soluble (18.5 mg/L or 16.3 mM at 25 °C) can be easily retrieved through crystallization while the more soluble α- and γ-CDs (145 and 232 g/L respectively) are usually purified by means of expensive and time consuming chromatography techniques. (wikipedia.org)
  • Results from all three modeling approaches showed similar ranking between ibuprofen and four cyclodextrin molecules as the experimental data. (hindawi.com)
  • On the whole, the experimental results point to the adsorption of methylated cyclodextrins on the surface of the formed decanoate micelles and are consonant with the existence of an equilibrium between the molecules in aqueous solution and those adsorbed by the micelles. (ua.pt)
  • By targeting oxidised cholesterol using rationally-designed molecules, it aims to provide the first true disease-modifying treatments for common age-related conditions such as atherosclerosis, heart attack and stroke using products based on novel derivatives of a well-known, safe compound. (longevity.technology)
  • These toxic molecules have no known biological function, and the cyclodextrins are able to capture and remove them from cells. (longevity.technology)
  • As an alternative a "complexing agent" can be added during the enzymatic conversion step: such agents (usually organic solvents like toluene, acetone or ethanol) form a complex with the desired cyclodextrin which subsequently precipitates. (wikipedia.org)
  • The solubility of hydrophobic reactants in water can be increased significantly by cyclodextrins (CD) and thereby the use of organic solvents can be reduced [16-18] . (beilstein-journals.org)
  • However, cyclodextrins are poor across most of the biological membranes due to their high molecular weight and inherent hydrophilicity [ 2 ]. (hindawi.com)
  • The relevance of the use of cyclodextrins for the design of molecular devices is discussed. (rsc.org)
  • Those observations were more investigated thanks to molecular modeling in order to clarify cyclodextrin/fungicide interactions. (fortunejournals.com)
  • Water-soluble cyclodextrin thioethers derivatives for the transportation of hydrophobic drugs. (sigmaaldrich.com)
  • Owing to high material costs necessary for the appropriate cyclodextrin amounts, the aim focused on structural modification of the hydrophobic products. (uni-wuerzburg.de)
  • Molecule modeling method is able to investigate the structure, dynamics, and energetics of cyclodextrin systems. (hindawi.com)
  • Cyclodextrins are produced from starch by enzymatic conversion. (wikipedia.org)
  • Cyclodextrins are composed of 5 or more α-D-glucopyranoside units linked 1->4, as in amylose (a fragment of starch). (wikipedia.org)
  • Cyclodextrins are prepared by enzymatic treatment of starch. (wikipedia.org)
  • Other starch derivatives, such as cyclodextrins, would probably be even better for this task than maltodextrin, but those aren't as easy to find. (popsci.com)
  • The study used a dissolved simple sugar called β-cyclodextrin, a derivative of starch, to enhance battery longevity and capacity. (techspot.com)
  • The cyclodextrin confers solubility and stability to these drugs. (wikipedia.org)
  • The complex of cyclodextrin increases the aqueous solubility and dissolution rate of the drug, which is useful for the delivery of the medical agent to a biological system. (sigmaaldrich.com)
  • Cyclodextrins have mainly been used as complexing agents to increase the aqueous solubility of poorly soluble actives," Lee says. (pharmtech.com)
  • Cyclodextrins (CDs) are natural pharmaceutical ingredients for the solubility-enhancement of poorly soluble drugs for over half century. (hindawi.com)
  • 8. von Schantz L, Schagerlöf H, Nordberg-Karlsson E, Ohlin M. ( 2014 ) Characterization of the substitution pattern of cellulose derivatives using carbohydrate-binding modules. (lu.se)
  • butyl dimethylsilyl-2,3-diacylated cyclodextrin derivatives as chiral selectors. (researcher-app.com)
  • The influence of the nature and position of derivatization of the cyclodextrin moiety revealed a strong impact on the chiral recognition mechanism, as the investigated alkylated derivatives heptakis-(2,6-di- O - iso -pentyl-3- O -allyl)-β-cyclodextrin and octakis-(2,3-di- O -pentyl-6- O -methyl)-γ-cyclodextrin did not provide any or only minor chiral selectivity for the two lactones. (researcher-app.com)
  • β-cyclodextrins are used to produce stationary phase media for HPLC separations. (wikipedia.org)
  • They are the main ingredient in Febreze which claims that the β-cyclodextrins "trap" odor-causing compounds, thereby reducing the odor. (wikipedia.org)
  • Important advantage of cyclodextrin phases - many compounds can be analyzed without derivatization (however, for certain substances enantioselectivity can be favorably influenced by formation of derivatives). (mn-net.com)
  • Preparation, characterization and in vitro dissolution study of Nitrazepam: Cyclodextrin inclusion complex by: J S Patel, et al. (uitm.edu.my)
  • Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. (hindawi.com)
  • Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery by: Anxo Fernández-Ferreiro, et al. (uitm.edu.my)
  • The use of cyclodextrins is a promising approach for limiting the emergence of resistance to triazole antifungal drugs. (fortunejournals.com)
  • Mouse studies indicated that subcutaneous administration of oligosaccharide 2-hydroxypropyl-β-cyclodextrin (2HPβCD) can solubilize cholesterol, removing it from the atheromatous plaque that causes atherosclerosis. (wikipedia.org)
  • Thus, MD simulation with MM-PBSA method may be fit to in silico screen for cyclodextrin formulations. (hindawi.com)
  • There are over 35 commercially available pharmaceutical formulations including various natural or chemically modified cyclodextrins [ 1 ]. (hindawi.com)
  • The analysis of the conformational behaviour of several derivatives strongly suggests that a slow exchange occurs between C 7 and C 1 conformers, the C 1 probably involving insertion of one of the primary rim substituents in the cyclodextrin cavity. (rsc.org)
  • Determine bonding characteristics of a hydrophilic monomer formulation containing PCDs (Polymerizable Cyclodextrin Derivatives). (nist.gov)
  • Octakis-(2,3-di- O -methyl-6- O -carboxymethyl)-γ-cyclodextrin sodium salt (ODMCM). (sigmaaldrich.com)
  • CICECO Publication » Why Do Methylated and Unsubstituted Cyclodextrins Interact So Differently with Sodium Decanoate Micelles in Water? (ua.pt)
  • Small-angle neutron scattering is used to study the influence that methylated and unsubstituted cyclodextrins might have on sodium decanoate micelles in D(2)O aqueous solution. (ua.pt)
  • When the concentration of the cyclodextrin is varied in a 200 mM sodium decanoate solution (CMC approximate to 116 mM), it is found that methylated and unsubstituted cyclodextrins exhibit distinct behaviors. (ua.pt)
  • When a cyclodextrin is added to the 200 mM perdeuterated sodium decanoate NaDec(d(19)) solution in D(2)O ([CD](o) = 30 mM), methylated cyclodextrins show correlation peaks in the I(Q) distributions, whereas alpha CD and beta CD do not originate any correlation maximum. (ua.pt)
  • Chemical composition of cyclodextrin consists of D-glucopyranoses, which are linked by alpha 1,4-glycosidic bonds to form the macrocyclic ring conformations. (hindawi.com)
  • A cationic cyclodextrin derivative-lipid hybrid nanoparticles for gene delivery effectively promotes stability and transfection efficiency. (bvsalud.org)
  • In this account, we developed the α- cyclodextrin -conjugated generation-2 polyamidoamine dendrimers - lipids hybrid nanoparticles (CDG2-LHNPs) for gene delivery. (bvsalud.org)
  • Of these patients, 18 received T enanthate 200 mg im every 20 days, 16 received sublingual T cyclodextrin (SLT) at a dose of 2.5 mg three times daily, and 17 received SLT at a dose of 5.0 mg three times daily. (nih.gov)
  • This is a relatively high dose of cyclodextrin and may be associated with real or perceived toxicity. (pharmtech.com)
  • In October 2002, the Russian Military reportedly used "a fentanyl derivative" to neutralize terrorists holding hostages at the Moscow Dubrovka Theater Center. (medscape.com)
  • Fentanyl and its derivatives (ie, sufentanil, alfentanil, remifentanil, carfentanil) are the only opioids that have been described as potential aerosolized opioid agents. (medscape.com)
  • However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. (hindawi.com)
  • However, current cyclodextrin formulation development mainly depends on trial-and-error by formulation scientists in the laboratory, which is time-consuming and high cost. (hindawi.com)
  • Research studies in both humans and animals have shown that cyclodextrins and their derivatives can be used to improve the drug delivery system for almost any type of drug formulation from anti-cancer drugs to anti-viral drugs. (addiandcassi.com)
  • Supramolecular properties of these derivatives were studied by DLS, ITC, NMR, and Cryo-TEM. (beilstein-journals.org)
  • Formation of supramolecular structures of bile salt derivatives. (lu.se)
  • Preparation and Physicochemical Properties of the Complex of Naringenin with Hydroxypropyl-β-Cyclodextrin by: Jiping Wen, et al. (uitm.edu.my)
  • This protocol describes the use 1-(p-tosyl)-imidazole as the precursor to react with β-cyclodextrin, affording highly pure mono-substituted product with an acceptable yield. (researchsquare.com)
  • A key step of the first synthetic procedure is a cross-metathesis between previously described regioisomers of mono- O -allyl derivatives of γ-CD and 2-vinylnaphthalene which gives yields of about 16-25% (2-5% starting from γ-CD). (beilstein-journals.org)
  • In particular, permethyl-alpha CD, dimethyl-beta CD, and permethyl-beta CD display linear increases of the specific surface area S/V obtained from the Porod equation with slopes following the degree of methylation of the cyclodextrins, whereas alpha CD and beta CD present close S/V values which are approximately independent of the cyclodextrin concentration at least for the considered concentration range (from 5 mM up to 45 mM). (ua.pt)
  • As the cyclodextrin concentration increases, this equilibrium leads to the shifting of the multiple equilibria involving micelles of successive aggregation numbers toward those of smaller dimensions and to the decrease of the average intermicellar distance. (ua.pt)
  • Several functionalized β-cyclodextrins have been shown to exhibit conformational isomerism. (rsc.org)
  • Cyclodextrins are ingredients in more than 30 different approved medicines. (wikipedia.org)
  • Mono-6-tosyl-β-cyclodextrin (TsO-CD) is considered an important cyclodextrin (CD) intermediate for easy introduction of various functional groups such as halides, azide, amine and imidazole groups to afford functionalized CD derivatives. (researchsquare.com)
  • The experiments with cyclodextrin in combination with DMSO were ineffective. (uni-wuerzburg.de)
  • Different cyclodextrin derivatives are available, and successful development relies on the ability to select the best analogue at the right concentration. (pharmtech.com)
  • Recently, cyclodextrin (CD) has shown the potential for effective treatment of atherosclerotic plaques in mice by solubilizing plaque cholesterol. (pharmaexcipients.com)
  • custom-engineered cyclodextrins (polysaccharides that have existing industrial and pharmaceutical uses) tackle cholesterol derivatives such as 7-ketocholesterol. (longevity.technology)
  • Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems. (cyclodextrinnews.com)
  • The significance of the structural features of cyclodextrin substituents for the occurrence of conformational isomerism is examined. (rsc.org)
  • Precise structural data have been obtained from the solved crystal structures of three chromone derivatives: the screening hit GS-71 (3b), its trimethylammonium salt (18) and 6-nitro-substituted N-benzyl-N-methyl-chromone-2-carboxamide (9i). (uni-wuerzburg.de)
  • Binding free energies from the MD simulation for β -, γ -, and HP- β -cyclodextrins were −3.67, −0.67, and −3.87 kcal/mol, individually. (hindawi.com)
  • The enthalpies of QM simulation for β -, γ -, and HP- β -cyclodextrins were −17.22, −14.75, and −20.28 kcal/mol, respectively. (hindawi.com)
  • However, MD simulation with entropy calculation had the closest value to experimental data for β and HP-beta-cyclodextrins. (hindawi.com)