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  • placebo
  • This will be a 2-panel, randomized ( participants are assigned different treatments based on chance), double-blind (neither investigator nor participant knows which treatment the participant receives), placebo-controlled (placebo is an inactive substance that is compared with a drug to test whether the drug has a real effect in a clinical trial), multicenter study. (clinicaltrials.gov)
  • severity
  • After 4 weeks, intranasal esketamine treatment sessions will be individualized to either once weekly or once every other week at the fixed 2-week interval (based on clinical global impression - severity [CGI-S] performed at that visit), and every 4 weeks for subjects dosed at the 4 week interval. (clinicaltrials.gov)
  • clinical
  • The study will involve a randomized, double blind, non-inferiority clinical trial with two treatment arms conducted in two international academic medical centers (the Centre for Addiction and Mental Health in Toronto, Canada and UT Southwestern in Dallas, Texas). (clinicaltrials.gov)
  • The investigators are pursuing a non-inferiority clinical trial in an effort to compare MST - a new treatment for TRD - to RUL-UB-ECT. (clinicaltrials.gov)
  • The study is a randomized, double blind, parallel--group clinical trial with two treatment arms conducted both at the University of Texas Southwestern in Dallas, Texas and at the Temerty Centre for Therapeutic Brain Intervention based at CAMH in Toronto, Canada. (clinicaltrials.gov)
  • inflammatory processes will be examined as a function of changes in clinical status and of treatment modality. (clinicaltrials.gov)
  • While current treatments are slow to act and only partially effective, new basic and clinical research focusing on the glutamate system is yielding promising new avenues for novel drug discovery. (clinicaltrials.gov)
  • Brain
  • This brain disorder has literally deteriorated my brain making me slowly lose my memory, cognitive abilities, and daily functionality. (gogetfunding.com)
  • Every little donation to sustain this life-saving treatment, a share of this fundraising page to your communities and friends, and most especially every small prayer not only for me but for everyone ravaged by severe mental illnesses (one of the most invalidated & stigmatized diseases - these are serious physical injuries to the brain, not emotional disturbances) will really help tremendously. (gogetfunding.com)
  • We predicted that the presence of brain white-matter hyperintensities would correlate with cardiovascular risk factors and with lower rates of treatment response. (rcpsych.org)
  • duration
  • Seasonal affective syndromes, including Seasonal Affective Disorder (because the duration of the study is long enough to expect 'spontaneous' [natural] remissions. (clinicaltrials.gov)