• onset
  • BACKGROUND: Previous research has reported both a moderate degree of comorbidity between cannabis dependence and major depressive disorder (MDD) and that early-onset cannabis use is associated with increased risks for MDD. (mendeley.com)
  • substance
  • If the disorder is diagnosed before age 21, it is associated with a higher risk of the person having a personality disorder or substance use disorder. (psychcentral.com)
  • Risk factors include female gender, prior episode or suicide attempts, comorbid medical or substance-related disorder, death of a close family member, lack of social support, and other stressful events. (uspharmacist.com)