Deposition of monoclonal light chains tissue chains. Medical search. Frequent questions

Amyloidosis is any of a group of disparate conditions characterized by extracellular deposition of insoluble fibrils composed of misaggregated proteins. (msdmanuals.com)
Localized forms of amyloidosis appear to be caused by local production and deposition of an amyloidogenic protein (most often immunoglobulin light chains) within the affected organ rather than by deposition of circulating proteins. (msdmanuals.com)
In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain (LC) that forms amyloid deposits. (elsevierpure.com)
On the other hand, a patient with AL (light chain) Amyloidosis who shows cardiomyopathy symptoms will often be treated with chemotherapy - and this treatment is harmful to wild-type ATTR patients with cardiomyopathy. (amyloidosis.org)
These scans need to be coupled with blood tests to evaluate for the substrate for AL amyloid (e.g. light chains) and in the absence of any evidence of light chains and a positive scan, are able to diagnose ATTR cardiac amyloidosis. (amyloidosis.org)
However, if there is evidence of light chains on blood testing, then a biopsy is still needed to establish the diagnosis and type of amyloidosis. (amyloidosis.org)
Amyloidosis is caused by the deposition and aggregation of insoluble, misfolded B-pleated protein fibrils in tissue, causing progressive organ dysfunction. (medscape.com)
The two most common types of systemic acquired disease are wild-type transthyretin (ATTR) amyloidosis and monoclonal Ig light chain (AL) amyloidosis . (medscape.com)
AL amyloidosis often occurs in persons with monoclonal gammopathy and typically affects the heart and kidneys, although the peripheral and autonomic nervous systems, gastrointestinal tract, and other organs may be involved. (medscape.com)
Cardiac amyloidosis (CA) is defined by the presence of extracellular amyloid deposition within the myocardium of the whole heart, leading to biventricular wall thickening with impaired relaxation and the loss of ventricular elasticity [ 1 ]. (hindawi.com)
All patients were diagnosed with light chain amyloidosis. (hindawi.com)
A diagnosis of light chain amyloidosis was made based on a biopsy of subcutaneous fat or an involved organ with the demonstration of typical Congo red birefringence, the detection of a monoclonal protein in the serum or urine and/or a monoclonal population of plasma cells in the bone marrow [ 13 ]. (hindawi.com)
Amyloidosis is a term used to describe fibril deposition of proteins.AL amyloidosis is due to deposition of protein from immunoglobulin light chain fragments. (contemporaryobgyn.net)
Amyloidosis is a rare group of diseases characterized by abnormal folding of proteins and extracellular deposition of insoluble fibrils. (highwire.org)
The two most common types of renal amyloidosis are immunoglobulin light chain-derived amyloidosis (AL) and reactive amyloidosis (AA). (highwire.org)
ALECT2 may be confused with amyloidosis associated with light and heavy chain monoclonal gammopathy if the immunofluorescence is positive with anti-light chain and anti-AA sera. (highwire.org)
Nephrotoxic effects often develop from overproduction of monoclonal immunoglobulins and free light chains, leading to cast nephropathy (the most common cause of acute kidney injury), light-chain-related proximal tubular injury, and various glomerulopathies such as light-chain deposition disease and amyloid light-chain (AL) amyloidosis. (nejm.org)
In primary amyloidosis, a monoclonal population of bone marrow cells produces fragments of light chains or entire light chains that can be processed abnormally to form amyloid. (dawasante.net)
In the case of one of these types, AL-amyloidosis, there are abnormal chains of antibodies in the lymph in the blood that can build up in various organs (such as the heart muscle and kidneys). (dawasante.net)
The scientists obtained samples of light antibodies from nine patients with pathologies of the bone marrow, which led to multiple myeloma or amyloidosis. (dawasante.net)
Presuming an connected amyloidosis, a biopsy from the small salivary glands was completed as well as the histological exam discovered amorphous eosinophilic materials, colored by reddish colored Congo (Shape?5) and dealing with a birefringent element to polarized light. (morainetownshipdems.org)
It had been, therefore, an AL amyloidosis complicating a kappa light string MM presenting with rheumatoid macroglossia and joint disease\like. (morainetownshipdems.org)
Different light chains are responsible for two diseases with diametrically opposite mesangial alterations: Light chain deposition disease which results in the expansion of the mesangium due to accumulation of matrix proteins not present in the normal mesangium and AL (light chain-associated) amyloidosis where the native mesangial matrix is replaced by fibrils (amyloid). (heraldopenaccess.us)
The glomerulopathies associated with monoclonal light chains are Light Chain Deposition Disease (LCDD) and AL (light chainrelated) amyloidosis, each creating completely different alterations in the mesangium. (heraldopenaccess.us)
This birefringence is the most widely available gold standard for diagnosis of amyloidosis, however neither light nor electron microscopy can distinguish different types of amyloidosis. (renalfellow.org)
Plasma cell dyscrasias leading to AL amyloidosis may range from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). (renalfellow.org)
Involvement of other soft tissues (macroglossia, muscular pseudohypertrophy, salivary gland enlargement) is unique to AL amyloidosis. (renalfellow.org)

Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS. (lookformedical.com)
This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY. (lookformedical.com)
In addition, light and heavy chains (the building blocks of antibodies) may be secreted in isolation: κ- or λ-light chains or any of the five types of heavy chains (α-, γ-, δ-, ε- or μ-heavy chains). (the-medical-dictionary.com)
Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Traditional polyclonal and monoclonal antibodies are the product of normal B cell development and genetic recombination. (cellsignal.com)
While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals originate from a single B cell clone and are specific for just one epitope. (cellsignal.com)
Recombinant antibodies are monoclonal, but their production involves in vitro genetic manipulation. (cellsignal.com)
In contrast, hybridoma-based systems for producing monoclonal antibodies are subject to genetic drift and instability, increasing the potential for lot-to-lot variability or loss of antibody expression. (cellsignal.com)
Where polyclonal antibodies are purified directly from the serum of the immunized host, and monoclonals are purified from either hybridoma-derived tissue culture supernatant or ascites, recombinant antibodies are instead purified from the tissue culture supernatants of transfected host cell lines. (cellsignal.com)
Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)
Treatment includes plasma exchange as needed for hyperviscosity and systemic therapy with alkylating drugs, corticosteroids, nucleoside analogs, Bruton's tyrosine kinase (BTK) inhibitors, venetoclax , or monoclonal antibodies. (merckmanuals.com)
4 Monoclonalanti-Fy6 At least two monoclonal antibodies produced by im- Race and phenotype All races Fy(ab) Fy(ab) Fy(ab) Cord cells Papain- treated cells Black Fy(ab) White Fy(ab) Fy(abw) (FyxFyx) Rhnull D Anti-Fy3 Black Other Anti-Fy5 Anti-Fy6 or w ww w w nt Internztional SYSTEM Not Fy(ab) cells. (forextrading-madeeasy.com)
Table?1 Properties of the acquired anti-WDV monoclonal antibodies. (thetechnoant.info)

Monoclonal gammopathy of undetermined significance (MGUS): where is the hidden danger? (springermedizin.at)
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant hematological condition arising from B‑cells, characterized by the presence of monoclonal immunoglobulin production, also known as paraprotein. (springermedizin.at)
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant B‑cell neoplasia usually arising from plasma cells and less frequently from lymphoplasmacytic cells. (springermedizin.at)

The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. (lookformedical.com)
The monoclonal antibody must be present at a concentration of at least 0.5 g/dL in order to be accurately identified using SPEP. (medscape.com)
Because recombinant antibody production involves sequencing the antibody light and heavy chains, it is a highly controlled and reliable process. (cellsignal.com)
Regardless of whether an antibody is polyclonal, monoclonal or recombinant, it must always be properly validated in the intended application prior to experimental use. (cellsignal.com)
The immunohistochemistry was carried out on neutral buffered formalin-fixed paraffin-embedded tissue sections by using the monoclonal antibody of HIF-1α. (ijpmonline.org)
Specifically, the LM2 monoclonal antibody (which recognized -GlcA epitopes on AGPs) showed a weak signal for the endothecium, microspores, and pollen tube apex. (exposed-skin-care.net)
Toward this final end, we first ready a book monoclonal antibody (mAb) of GCA. (eprf.ca)

Background: The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. (elsevierpure.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (merckmanuals.com)
As with hereditary forms of the disease (hATTR) wild-type ATTR causes problems due to the breaking apart, misfolding and deposition of amyloid protein fibrils in healthy tissue. (amyloidosis.org)
Serum immunofixation revealed an IgA lambda monoclonal band despite normal findings on serum and urine protein electrophoresis. (medscape.com)
however, there was insufficient tissue to determine the type of amyloid protein. (medscape.com)
A dense narrow band that is composed of a single class of immunoglobulins secreted by an abnormally expanded clone of plasma cells is known as M-protein (paraprotein, monoclonal protein or M-component). (medscape.com)
Monoclonal pattern serum protein electrophoresis (SPEP). (medscape.com)
A doctor will then order protein electrophoresis of the blood and urine, on which a paraprotein (monoclonal protein, or M protein) band can be noticed. (the-medical-dictionary.com)
A type of paraprotein is the Bence Jones protein which is paraprotein composed of free light chains (see below). (the-medical-dictionary.com)
Disorders characterized by abnormal proliferation of immunoglobulin-producing cells and abnormal proliferation of immunoglobulin monoclonal (M protein)represent part of the spectrum of disease due to the neoplastic behavior of the B lymphocyte series. (emedicodiary.com)
The corrected serum calcium mineral was high at 3.1?mmol/L with normal proteinemia (69?g/L) and serum creatinine was 82?mol/L. In regards to to immunological examinations, serum proteins electrophoresis demonstrated hypogammaglobulinemia at 6.35?g/L with the current presence of a kappa light string monoclonal band for the immunofixation of serum and urinary protein (Shape?2). (morainetownshipdems.org)
ATTR amyloid cardiomyopathy is a disease of protein misfolding, leading to amyloid fibril deposition in organs and tissues. (pcna.net)
Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
Immunoprecipitation of APP protein from mouse brain tissue extracts. (cellsignal.com)
The mRNA expression of MMP-2 and MMP-9 was determined by reverse transcription-polymerase chain reaction, and the protein expression of MMP-2 and MMP-9 by gelatin zymography analysis and qualified by the gel electrophoresis image analysis in different HA concentrations. (molvis.org)
We investigated the effects of different level of HA concentrations on mRNA and protein expressions of MMP-2 and MMP-9 in cultured trabecular meshwork cells using reverse transcription-polymerase chain reaction (RT-PCR) method and gelatin zymography analysis. (molvis.org)
Excessive amounts of IgM M-proteins (monoclonal immunoglobulin protein, which may consist of both heavy and light chains or of only one type of chain) can also accumulate in other disorders, causing manifestations similar to macroglobulinemia. (merckmanuals.com)
proteinopathic adj ), or proteopathy , protein conformational disorder , or protein misfolding disease , is a class of diseases in which certain proteins become structurally abnormal, and thereby disrupt the function of cells , tissues and organs of the body. (wikipedia.org)

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. (lookformedical.com)
Monoclonal IgD-was not really measurable on serum proteins electrophoresis, and total IgD level had not been measured at period of diagnosis. (isct-eu2018.com)
Paraproteinaemia is a disorder characterized by abnormal proliferation of immunoglobulin-producing cells due to the neoplastic behavior of B-Lymphocytic series with an increase in serum level of homogenous immunoglobulin (monoclonal IG) or its fragments. (emedicodiary.com)
Paraprotein is the presence of a monoclonal immunoglobulin band (M-band) in the serum. (emedicodiary.com)
Open up in another window Shape 2 Serum proteins electrophoresis displaying lack of monoclonal maximum with hypogammaglobulinemia (A). Existence of monoclonal music group for the kappa light string track towards the immunofixation of serum (B) and urinary (C) proteins on agarose gel X\rays from the hands (Shape?3) and pelvis (Shape?4) showed diffuse bone tissue demineralization without erosion or participation of joint areas. (morainetownshipdems.org)

Smithline et al first used the term light-chain nephropathy in 1976 to describe a case of renal tubular dysfunction with light-chain proteinuria. (medscape.com)
The analysis of IgD deposition disease underscores the worthiness of laser beam microdissection and mass spectrometry in additional analyzing renal biopsies when regular assessment does not reach a precise diagnosis. (isct-eu2018.com)
Used using the renal biopsy results collectively, the analysis was supported by the info of IgD heavy-chain deposition disease. (isct-eu2018.com)
In 2008, Benson et al reported a case in which a patient presenting with nephrotic syndrome and renal failure leading to dialysis was found to have isolated deposition of amyloid in the glomerulus. (highwire.org)
2 The deposition of LECT-2 was different from other types of renal amyloid in demonstrating congophilia within all compartments of the kidney including mesangium, glomerular basement membrane, interstitium, arterioles, and arteries. (highwire.org)
Additional findings are: a raised calcium (when myeloma cells are breaking down bone, releasing calcium into the bloodstream) and decreased renal function, which may be due to paraprotein deposition in the kidney). (the-medical-dictionary.com)
Approximately 85% of the monoclonal proteins in patients with plasma cell dyscrasia are associated with renal disease. (heraldopenaccess.us)
In all these, light chains purified from the urine of patients with renal biopsy-proven conditions have been used. (heraldopenaccess.us)
Here, we take the opportunity to report an unusual association of heavy chain deposition disease (HCDD) with clear cell subtypes of renal cell carcinoma in a 48-year-old male of Indian ethnicity. (ijpmonline.org)
To the best of our knowledge, this is one of the first reports demonstrating concurrent heavy chain deposition disease (HCDD) with clear cell subtypes of renal cell carcinoma in a 48- year-old male of Indian ethnicity. (ijpmonline.org)

extracellular deposition of free of charge light chains (even more rarely weighty chains) of monoclonal immunoglobulins made by a lymphoplasmacytic inhabitants. (morainetownshipdems.org)

The presence of light-chain proteins in the urine is associated with a number of systemic diseases (see Causes). (medscape.com)
Dialogue Monoclonal gammopathy includes a heterogeneous band of disorders seen as a clonal proliferation of Ig creating B lymphocytes or plasma cells.5,6 The proliferating cells secrete Ig, which may be detected in the blood or urine as monoclonal Ig (M proteins). (isct-eu2018.com)
The M proteins usually includes a weighty string and a light string ( em /em - or em /em -light chains), although occasionally, the neoplastic cells might synthesize just the heavy or light chain alone. (isct-eu2018.com)
Normal light chains are small molecular weight proteins that are filtered through the peripheral capillary walls and are delivered to the proximal tubules where they are catabolized by endosomal activity in the apical portions of the tubules and their amino acids are then returned to the circulation. (heraldopenaccess.us)
Less commonly, patients develop hyperviscosity due to the large amounts of high molecular weight monoclonal IgM proteins circulating in plasma, but most patients do not develop problems related to high IgM levels. (merckmanuals.com)
The anti-GCA mAb contains light chains, heavy chains, and other proteins. (eprf.ca)
Amyloidoses are a group of diseases resulting from deposition of amyloid, insoluble fibrils derived from various precursor proteins, into extracellular tissues. (renalfellow.org)
Two general families of chaperones are reconized: Molecular chaperones, which bind and stabilize un- folded or partly folded proteins, thereby preventing these proteins from aggregating and being degraded Chaperonins, which directly facilitate the folding of proteins Molecular chaperones consist of Tradee and its homologs: Hsp70 in the cytosol and mitochondrial matrix, BiP in the en- doplasmic reticulum, and DnaK in bacteria. (forextrading-madeeasy.com)
[9] Subsequent research has shown that many different proteins can form amyloid, and that all amyloids show birefringence in cross- polarized light after staining with the dye Congo red , as well as a fibrillar ultrastructure when viewed with an electron microscope . (wikipedia.org)

A 24-hour urine collection revealed the current presence of a monoclonal (IgD) C area (typical spectra amount of 58) and moderate spectra amounts of elements of complement elements, Isoliensinine indicating accumulation and activation of the different parts of the classic and terminal pathways of enhance. (isct-eu2018.com)

The deposition of these abnormal amyloid fibrils in various tissues can ultimately lead to organ damage. (highwire.org)
The β-pleated sheet formation of fibrils gives them the ability to bind Congo red dye (seen on light microscopy) in an organized, intercalated way that emits apple-green birefringence under polarized light. (renalfellow.org)
AL fibrils are most often lambda light chains (four times more likely than kappa light chains). (renalfellow.org)

Both patients had monoclonal IgG paraproteins in the plasma and one excreted monoclonal lambda light chains in the urine. (ox.ac.uk)
Of patients producing either IgG or IgA, 40% also have Bence Jones proteinuria, which is free monoclonal kappa ( κ ) or lambda ( λ ) light chains in the urine. (merckmanuals.com)
Lambda light chains usually exist as dimers (44,000 d) and, therefore, are less likely to be filtered and appear in urine. (medscape.com)

No abnormal plasma cells were found in the bone marrow and there was no evidence of amyloid deposition in the tissues. (ox.ac.uk)
A tactical difference could be appreciated between the abnormal and normal tissue. (contemporaryobgyn.net)
MGUS (monoclonal gammopathy of uncertain significance) and smoldering myeloma cause no symptoms but refer to the development of abnormal cells that can eventually lead to multiple myeloma or related cancers. (dukehealth.org)
The physicochemical and conformational characteristics of the abnormal light chains are primarily responsible for the downstream events affecting the mesangial milieu. (heraldopenaccess.us)
Investigations performed in the last 20 years have provided detailed insights into how these abnormal light chains interact with the mesangium to produce glomerular injury. (heraldopenaccess.us)

Light chains (molecular weight 22,000 d) are polypeptides synthesized by plasma cells and assembled with heavy chains to form the various classes of immunoglobulins, for example, immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA). (medscape.com)
Individual immunoglobulins have either kappa or lambda light chains, but not both. (medscape.com)

If ATTR-wt was suspected a biopsy of the heart tissue was needed to get an accurate diagnosis. (amyloidosis.org)
If a biopsy of the heart tissue is obtained, then this biopsy tissue is sent to a lab for Congo-red staining. (amyloidosis.org)
D) Immunohistochemistry displaying plasma cells staining for IgD on bone tissue marrow biopsy. (isct-eu2018.com)
Kidney Biopsy Analysis The kidney biopsy analysis was IgD heavy-chain deposition disease. (isct-eu2018.com)
Bone marrow biopsy showed Kappa light chain myeloma with t(11;14). (contemporaryobgyn.net)

Light chains are divided into 2 major classes based on the amino acid sequence in the constant portion of the polypeptide chain and are designated as kappa and lambda. (medscape.com)
These are further divided into at least 10 subtypes (4 kappa and 6 lambda) based on the amino acid sequence in the variable region of the polypeptide chain. (medscape.com)
Each Ig molecules have either 2 kappa or 2 lambda light chains. (emedicodiary.com)

Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
In myeloma, plasma cells produce monoclonal (M) Ig of a single heavy and light chain commonly referred to as a paraprotein. (emedicodiary.com)

Multiple myeloma is a chronic, progressive and fatal malignant condition in which the fundamental abnormality is a neoplastic proliferation of plasma cells that infiltrate the bone marrow and often other body tissues. (emedicodiary.com)
Clinical features of Multiple Myeloma developed due to tissue infiltration, production of a large number of paraprotein, and impairment of immunity. (emedicodiary.com)
6. Nervous system manifestations like quadriplegia, and paraplegia due to compression by collapsed vertebrae or myeloma tissue. (emedicodiary.com)
After myeloma, macroglobulinemia is the 2nd most common malignant disorder associated with a monoclonal gammopathy. (merckmanuals.com)

Depending on the immunoglobulin subtype, the rate of progression can vary from 0.3% per year in light-chain MGUS to 1.5% in IgM MGUS. (springermedizin.at)

Tumors of the hematopoietic and lymphoid tissues (American English) or tumours of the haematopoietic and lymphoid tissues (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. (wikipedia.org)

For the analysis of a suspected hematological malignancy, a complete blood count and blood film are essential, as malignant cells can show in characteristic ways on light microscopy. (wikipedia.org)
Every case of monoclonal gammopathy warrants careful investigation to rule out the presence of a malignant form. (springermedizin.at)
Targeted agents, defined as drugs designed to target specific gene mutations in malignant tissue, inhibit oncogenic signaling cascades associated with tumor growth. (nejm.org)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)

Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. (wikipedia.org)
INTRODUCTION: Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. (hal.science)
CASE REPORT: We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation. (hal.science)
CONCLUSION: Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. (hal.science)
Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations. (hal.science)
The most characteristic histologic lesion of light chain deposition disease (LCDD) is nodular glomerulosclerosis, which must be identified from diabetic glomerulosclerosis by using electron microscopy. (medscape.com)
Risk of injury to surrounding tissue, especially anus/rectum given proximity of disease was reviewed. (contemporaryobgyn.net)
Despite our efforts with the laser, mechanical dissection was ultimately needed in order to separate the planes of disease and normal tissue. (contemporaryobgyn.net)

Even though chronic urinary retention due to the neurogenic bladder and incomplete recovery from recurrent episodes of prerenal azotemia may explain his CKD, the patient's autonomic dysfunction symptoms, such as orthostatic hypotension and bowel and bladder dysfunction in an individual with a prior monoclonal gammopathy, raise concerns about an evolving systemic process. (medscape.com)

Direct thrombin activation of platelets through protease-activated receptor-4 did not contribute to hepatocyte proliferation after PHx, indicating that thrombin contributes to liver regeneration primarily by driving intrahepatic fibrin(ogen) deposition. (ashpublications.org)
Moreover, they could modulate immune response, attenuate inflammation, and regulate the release of proinflammatory and profibrotic molecules involved in fibroblast proliferation and extracellular matrix excess deposition [ 2 , 11 - 13 ]. (hindawi.com)

In this rare acquired disorder of bone, normal lamellar collagen is replaced by structurally unsound collagen-deficient tissue, which leads to extreme bone fragility and ununited fractures. (ox.ac.uk)
By immunofluorescence, we investigated collagen IV chain composition of the glomerular basement membrane (GBM). (stanford.edu)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)

Its pathophysiology includes immune complex deposition and a wide range of skin lesions. (lookformedical.com)

Amyloid deposits stain pink with hematoxylin and eosin, contain carbohydrate constituents that stain with periodic acid-Schiff dye or with Alcian blue, but most characteristically have apple-green birefringence under polarized light microscopy after Congo red staining. (msdmanuals.com)
Light microscopy (hematoxylin and eosin stain at 25X power) showing nodular glomerulosclerosis (arrow) and thickening of the basement membrane. (medscape.com)
LMD/MS. Light microscopy displaying (A) glomeruli designated for dissection and (B) clear space after microdissection (hematoxylin and eosin, 20). (isct-eu2018.com)
In optical microscopy, amyloid appears as a homogeneous, highly refractive substance, with affinity for the Congo red dye both in fixed tissues and in vivo. (dawasante.net)
On light microscopy, the Bowman layer is disrupted or absent and replaced by a sheetlike connective tissue layer with granular deposits that stain red with Masson trichrome stain. (aao.org)
Light microscopy shows irregular thickening and thinning of the epithelial layer, which offset the ridges and furrows in the underlying stroma and the focal absences of the epithelial basement membrane. (aao.org)
3. Congo red stain shows orange-colored positivity by regular microscopy and apple-green birefringence under polarized light. (renalfellow.org)
This can sometimes be seen by silver stain on light microscopy. (renalfellow.org)

Plasma cells normally produce a slight excess of light chains that are either excreted or catabolized by the kidney. (medscape.com)
Plasma cells are derived from B lymphocytes and produce immunoglobulin (Ig) which contains heavy and light chains. (emedicodiary.com)
Pathogenesis - Clonal plasma cells make monoclonal light chains. (renalfellow.org)

Kappa light chains usually exist as monomers (22,000 d) and are therefore small enough to be filtered through the glomerulus, but they may exist as dimers. (medscape.com)
The excess light chains are secreted into the extracellular fluid and readily pass through the glomerulus. (emedicodiary.com)

Mesangial injury represents a crucial event in the pathogenesis of light chain-associated glomerulopathies in patients with plasma cell dyscrasias. (heraldopenaccess.us)

Open in another window Shape 3 X\ray of the proper (D) and remaining (G) hands displaying diffuse bone tissue demineralization Open up in another window CP 31398 dihydrochloride Shape 4 X\ray from the pelvis displaying diffuse bone tissue demineralization The analysis of light chains MM was maintained before medullar plasmocytosis, hypercalcemia, anemia, bone tissue demineralization, lack of monoclonal maximum, and existence of kappa light chains at immunoelectrophoresis. (morainetownshipdems.org)
This is in contrast to MM, in which kappa light chains are more predominant. (renalfellow.org)

Normally Ig molecule consists of 4 polypeptide chains 2 heavy chains and 2 light chains. (emedicodiary.com)
The most common abnormality is the production of excess of light chains over heavy chains. (emedicodiary.com)
Light and heavy chains are about 25kD and about 50C70 kD in size, respectively. (eprf.ca)

IHC-P: Human kidney tissue. (abcam.com)

Pollen tube tips also displayed excessive callose deposition. (exposed-skin-care.net)

Western blot analysis of extracts from various tissues and cell lines using APP (E4H1U) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). (cellsignal.com)

A reduction of MMPs in aqueous humor can alter the balance between MMPs and the tissue inhibitors of metalloproteinases (TIMPs). (molvis.org)

Isotypes of the four MAbs were determined to be IgG1, light chain. (thetechnoant.info)

Anatomy14

Organisms11

Diseases8

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes36

Disciplines and Occupations2

Information Science3

Health Care1

Amyloidosis27

Antibodies13

Gammopathy of undetermined significance3

Antibody7

Protein19

Serum5

Renal10

Extracellular deposition1

Proteins9

Presence of a monoclonal1

Fibrils3

Urine3

Abnormal5

Immunoglobulins2

Biopsy5

Lambda3

Produce monoclonal2

Myeloma4

MGUS1

Haematopoietic and lymphoid1

Malignant4

Disease8

Systemic1

Proliferation2

Collagen3

Pathophysiology1

Microscopy8

Plasma cells3

Glomerulus2

Glomerulopathies1

Kappa light chains2

Heavy chains3

Kidney1

Excessive1

Various tissues1

Inhibitors1

IgG11