Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. (wikipedia.org)
Calcium pyrophosphate deposition (CPPD) disease is a metabolic arthropathy caused by the deposition of calcium pyrophosphate dihydrate in and around joints, especially in articular cartilage and fibrocartilage (see the images below). (medscape.com)
Although the exact mechanism for the development of CPPD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. (medscape.com)
Changes in the cartilage matrix may play an important role in promoting CPPD deposition. (medscape.com)
Therefore, inorganic pyrophosphate can bind calcium, leading to CPPD deposition in the cartilage and synovium. (medscape.com)
Revised diagnostic criteria for calcium pyrophosphate deposition (CPPD) disease are from the Primer on Rheumatic Diseases (1997) and are used with permission from the Arthritis Foundation. (medscape.com)
Histologic changes associated with CPPD correspond to calcium deposits and to inflammation due to cartilage fragments. (medscape.com)
Such joint damage increases the tendency of CPPD deposition. (medlineplus.gov)
Which medications in the drug class Anti-Inflammatory Agents are used in the treatment of Calcium Pyrophosphate Deposition (CPPD) Disease? (medscape.com)
Calcific tendonitis may be confused with calcium pyrophosphate dihydrate deposition disease (CPPD, or pseudogout ) - a type of arthritis in which calcium phosphate crystals form in the joints. (clevelandclinic.org)
The Request for Applications (RFA) is based, in part, on the scientific opportunities identified in the NIAMS Roundtable held in 2003: "Opportunities for Translational Research on Articular Crystal Deposition Diseases: Gout, CPPD Crystal Deposition Disease, Hydroxyapatite Deposition Arthropathy. (nih.gov)
Non-urate calcium-containing crystal deposition diseases that affect the joints and surrounding structures include calcium pyrophosphate dihydrate (CPPD) crystal deposition disease and hydroxyapatite crystal deposition disease (also known as basic calcium phosphate crystallopathy). (nih.gov)
Discuss the clinical presentation, causes, relevant diagnostic tests, and management of Calcium Pyrophosphate Dihydrate (CPPD) Deposition Disease. (nih.gov)
Pseudogout has sometimes been referred to as calcium pyrophosphate deposition disease or CPPD.Pseudogout is clearly related to aging as it is more common in the elderly and is associated with degenerative arthritis. (clustermed.info)
The prevalence of MSU crystals in SF was noted in 89.1% of gout cases and 9.09% of cases of calcium pyrophosphate disease (CPPD). (acr.org)
Calcium hydroxyapatite (HA) crystals were identified in 5.45% of gout cases, 33.3% of rheumatoid arthritis (RA) cases, 57.1% of OA cases, and 63.6% of CPPD cases. (acr.org)
Definitions Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is an umbrella term encompassing all instances of calcium pyrophosphate dihydrate (CPP) crystal precipitation in connective tissues seen in asymptomatic patients or associated with several clinical syndromes. (pulmonologyadvisor.com)
Chondrocalcinosis, or cartilage calcification, is a common condition that usually results from deposition of crystals of calcium pyrophosphate dihydrate (CPPD) in articular hyaline and fibro-cartilage. (mendelian.co)
CPPD crystal deposition may be asymptomatic or associated with characteristic acute attacks ('pseudogout') or chronic arthritis. (mendelian.co)
Gout and pseudogout are the 2 most common crystalline arthropathies and are caused by deposition of monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals, respectively. (medscape.com)
Calcium pyrophosphate dihydrate (CPPD) crystals are shorter and less sharp than MSU crystals. (medscape.com)
Incubation of natural or synthetic calcium pyrophosphate dihydrate (CPPD) microcrystals with synovial fluid in vitro in the presence of (32P)PPi tracer showed no change in PPi specific activity in the supernate over a 19-h period so that exchange of PPi in solution with that in CPPD microcrystals could be ignored. (nih.gov)
We conclude that synovial PPi turnover and elevated PPi fluid concentrations are not specific for PG patients, and that these factors alone cannot be the only determinants of CPPD crystal deposition. (nih.gov)
It is quite similar to what in the past has been referred to as the radiographic form of calcium pyrophosphate deposition disease (CPPD) in humans. (omeka.net)
Pseudogout8
Calcium pyrophosphate (CPP) arthritis (previously called pseudogout) is a disorder caused by deposits of calcium pyrophosphate dihydrate crystals in the joint cartilage, leading to intermittent attacks of painful joint inflammation similar to gout or a chronic arthritis similar to rheumatoid arthritis. (msdmanuals.com)
With this microscope, the calcium pyrophosphate crystals are clearly identified by their characteristic shape and color (medically term weakly positively birefringent rhomboid crystals).The arthritis of pseudogout is common in older adults, particularly in the context of dehydration such as occurs with hospitalization or surgery. (clustermed.info)
Pseudogout is primarily caused by the precipitation of calcium pyrophosphate dihydrate crystals developing within a joint space. (clustermed.info)
Pseudogout can also be caused by the hormonal effects on calcium metabolism from hyperparathyroidism. (clustermed.info)
Pseudogout is a type of inflammation of joints (arthritis) that is caused by deposits of crystals, called calcium pyrophosphate, in and around the joints. (clustermed.info)
As those crystals accumulate and make their way into the joint fluid, they can irritate or damage the joints, leading to an arthritis known by different names: calcium pyrophosphate dihydrate deposition disease , acute CPP crystal arthritis, or pseudogout. (goutinfoclub.com)
Recent studies have shown elevated inorganic pyrophosphate (PPi) levels in most knee joint fluid supernates from patients with pseudogout (PG) or osteoarthritis (OA) and more modestly elevated levels in some supernates from patients with gout or rheumatoid arthritis (RA) relative to PPi levels found in the venous blood plasma of normal or arthritic subjects. (nih.gov)
Monosodium urate4
The responsible crystals include monosodium urate, calcium pyrophosphate dihydrate, basic calcium phosphate (including hydroxyapatite), and calcium oxalate. (medscape.com)
Monosodium urate crystal deposition occurs on the surface of hyaline cartilage, within the synovium, and in periarticular structures, including tendon sheaths and bursae. (medscape.com)
RESEARCH OBJECTIVES Gout is caused by the deposition of uric acid (monosodium urate) crystals in connective tissue and in the joint space. (nih.gov)
To assess the consistency between the clinical referring diagnosis and the identification of crystals, such as monosodium urate (MSU) and calcium pyrophosphate (CPP), in the synovial fluid (SF) of patients from a Mexican tertiary care institution. (acr.org)
Chondrocalcinosis4
X-ray, CT, or other imaging usually shows accumulation of calcium within the joint cartilage, known as chondrocalcinosis. (wikipedia.org)
citation needed] Medical imaging, consisting of x-ray, CT, MRI, or ultrasound may detect chondrocalcinosis within the affected joint, indicating a substantial amount of calcium crystal deposition within the cartilage or ligaments. (wikipedia.org)
Kleiber Balderrama C, Rosenthal AK, Lans D, Singh JA, Bartels CM. Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans. (medscape.com)
Paalanen K, Rannio K, Rannio T, Asikainen J, Hannonen P, Sokka T. Prevalence of calcium pyrophosphate deposition disease in a cohort of patients diagnosed with seronegative rheumatoid arthritis. (medscape.com)
11. The utility of alizarin red s staining in calcium pyrophosphate dihydrate crystal deposition disease. (nih.gov)
The basic calcium phosphate arthropathies include calcific periarthritis syndromes that can occur as primary or secondary disease manifestations and may occur in a familial fashion, in calcific tendonitis and bursitis, intraarticular arthropathies such as Milwaukee shoulder syndrome, and periarthropathies. (nih.gov)
Discuss the clinical presentation, causes, relevant diagnostic tests, and management of Basic Calcium Phosphate (BCP) Deposition Disease. (nih.gov)
Does this patient have basic calcium phosphate crystal/hydroxyapatite deposition disease? (pulmonologyadvisor.com)
The ANKH protein is involved in transport of inorganic pyrophosphate (PPi), which regulates calcification, bone mineralization, and bone resorption. (medscape.com)
Ryan LM, Wortmann RL, Karas B. Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. (medscape.com)
An inorganic pyrophosphate which affects calcium metabolism in mammals. (bvsalud.org)
Hydroxyapatite2
Basic calcium phosphate (BCP) crystals encompass three different types of calcium crystals: carbonate-substituted hydroxyapatite, octacalcium phosphate, and tricalcium phosphate. (pulmonologyadvisor.com)
It is believed to be a degenerative process with the deposition of calcium hydroxyapatite crystals following the metaplastic transformation of tenocytes to chondrocytes in the tendons of the rotator cuff. (jmaacms.com)
Theiler G, Quehenberger F, Rainer F, Neubauer M, Stettin M, Robier C. The detection of calcium pyrophosphate crystals in the synovial fluid of patients with rheumatoid arthritis using the cytospin technique: prevalence and clinical correlation. (medscape.com)
Cartilage6
Joint pain can have multiple causes, a reflection of the diverse joint diseases which arise from inflammation, cartilage degeneration, crystal deposition, infection, and trauma. (medscape.com)
Examples of pathologic processes that commonly coexist include crystal deposition in osteoarthritis, synovitis in enthesopathies, and cartilage destruction in chronic synovitis. (medscape.com)
Calcium pyrophosphate crystal deposition is confined to hyaline cartilage, fibrocartilage, and areas of chondroid metaplasia (ie, degenerated areas of tendons, ligaments, and the joint capsule) within the joint. (medscape.com)
Calcium pyrophosphate crystal deposition in hyaline cartilage. (medscape.com)
The prevalence and incidence of calcium crystal arthropathies are expected to increase as a result of the growing elderly population in the U.S. and increasing numbers of people with osteoarthritis predisposing cartilage to calcification disorders. (nih.gov)
When the mineral calcium phosphate is deposited onto the cartilage, a hard structure is created. (yourdictionary.com)
Joints5
the molecule used as energy currency in all living things), which results in increased pyrophosphate levels in joints, is thought to be one reason why crystals may develop. (wikipedia.org)
Instead, x-rays of affected joints such as knees show characteristic deposits of calcium. (medlineplus.gov)
Presence of CALCIUM PYROPHOSPHATE in the connective tissues such as the cartilaginous structures of joints. (nih.gov)
Imaging of the joint or joints that are bothering you can help your doctor inspect for injury or calcium buildup. (capitolptdc.com)
Calcium pyrophosphate is a normal chemical in the body that helps your bones and joints function. (goutinfoclub.com)
The crystal deposition arthropathies constitute significant public health problems. (nih.gov)
Calcific3
Calcific tendonitis develops when calcium deposits build up in your tendons or muscles. (clevelandclinic.org)
Calcific tendonitis is caused by calcium buildup in your tendons. (clevelandclinic.org)
The relation between calcium supplement consumption and calcific shoulder tendonitis. (jmaacms.com)
Bones6
The body stores more than 99% of its calcium in the bones and teeth to help make and keep them strong. (nih.gov)
Your body also needs calcium (as well as phosphorus) to make healthy bones. (nih.gov)
Calcium helps build strong bones and teeth. (nih.gov)
It occurs in the urine, blood, tissues, and bones of animals, calcium phosphate forming about 58% of bones, which owe their rigidity to its presence. (yourdictionary.com)
This method was generally adopted until 1775, when Scheele prepared it from bones, which had been shown by Gahn in 1769 to contain calcium phosphate . (yourdictionary.com)
Calcium and phosphorus are stored in the bones as crystals of calcium phosphate . (yourdictionary.com)
Deposits of calcium1
Calcium toxicity is rare, but overconsumption of calcium supplements may lead to deposits of calcium phosphate in the soft tissues of the body. (yourdictionary.com)
Bone3
Not only does PTH regulate the release of calcium from bone through its combined effects on osteoblasts and osteoclasts, it also stimulates bone remodeling. (mhmedical.com)
Knowing the structure of amorphous calcium phosphate will improve our knowledge of bone growth. (yourdictionary.com)
Prout, who on analysis found they consisted essentially of calcium phosphate and carbonate, and not infrequently contained fragments of unaltered bone. (yourdictionary.com)
Such deposition causes inflammation, pain, and destruction of the joint. (medscape.com)
Occur2
These calcium deposits can accumulate in one area or may occur in more than one location. (clevelandclinic.org)
Crystal deposition may be associated with a variety of metabolic disorders and can also occur as a result of trauma, injury or surgery. (nih.gov)
Carbonate3
is almost always caused by taking too many calcium supplements, usually in the form of calcium carbonate. (nih.gov)
Thus, prepared oystershells, coral, pearls, crabs' " eyes " and burnt hart's horn were regarded as specifics in different complaints, in ignorance of the fact that they all contain, as the chief ingredients, calcium phosphate and carbonate. (yourdictionary.com)
Calcium Phosphate - Less common than either calcium carbonate or citrate, calcium phosphate is less expensive than calcium citrate and may not cause the stomach upset some people experience when taking calcium carbonate. (yourdictionary.com)
Hyperparathyroidism2
Hyperparathyroidism In hypercalcemia, the level of calcium in blood is too high. (msdmanuals.com)
Tertiary hyperparathyroidism may result from long-standing secondary hyperparathyroidism, with the development of autonomous activity due to parathyroid hyperplasia and loss of the glands' response to levels of serum calcium. (mhmedical.com)
Phosphate crystals2
Moderate phosphate toxicity occurring over a period of months may result in the deposit of calcium phosphate crystals in various tissues of the body. (yourdictionary.com)
Toxicity due to the deposit of calcium phosphate crystals is not usually reversible. (yourdictionary.com)
Synthetic1
Another filler incorporating calcium hydroxlapatite, a synthetic calcium phosphate product, can be used to effectively treat facial lines. (yourdictionary.com)
Hypercalcemia1
Hypercalcemia means you have too much calcium in your blood. (nih.gov)
However, calcium deposits in a joint may not cause symptoms. (msdmanuals.com)
A 55-year-old female with a history of regular intake of calcium supplements came with complaints of excruciating pain and restricted mobility of the left shoulder joint. (jmaacms.com)
Parathyroid3
A high calcium level may result from a problem with the parathyroid glands, as well as from diet, cancer, or disorders affecting. (msdmanuals.com)
Parathyroid hormone (PTH) and Vitamin D help manage calcium balance in the body. (nih.gov)
Parathyroid hormone (PTH) is intimately involved in calcium homeostasis. (mhmedical.com)
Form1
The reason that CPP dihydrate crystals form in some people is unknown. (msdmanuals.com)